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Protein

Epiphycan

Gene

Epyc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Epiphycan
Alternative name(s):
Dermatan sulfate proteoglycan 3
Proteoglycan-Lb
Short name:
PG-Lb
Small chondroitin/dermatan sulfate proteoglycan
Gene namesi
Name:Epyc
Synonyms:Dspg3, Pglb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:107942 Epyc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003276920 – 322EpiphycanAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64O-linked (Xyl...) (dermatan sulfate) serineBy similarity1
Glycosylationi96O-linked (GalNAc...) serineBy similarity1
Disulfide bondi118 ↔ 130By similarity
Disulfide bondi279 ↔ 312By similarity
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The O-linked polysaccharide on Ser-96 is probably the mucin type linked to GalNAc. There is one glycosaminoglycan chain, known to be dermatan sulfate, and it is probably the O-glycosylation at Ser-64 (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP70186
PRIDEiP70186

PTM databases

iPTMnetiP70186
PhosphoSitePlusiP70186

Expressioni

Tissue specificityi

Confined to the middle zone of embryonic epiphyseal cartilage consisting of flattened chondrocytes and the ossifying region in the limb buds of chick embryos. Has also been detected in testis.1 Publication

Developmental stagei

Expression starts at E12.5 dpc and is restricted to developing cartilage.

Gene expression databases

BgeeiENSMUSG00000019936
CleanExiMM_EPYC
GenevisibleiP70186 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020094

Structurei

3D structure databases

ProteinModelPortaliP70186
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 143LRRNTAdd BLAST38
Repeati144 – 165LRR 1Add BLAST22
Repeati168 – 189LRR 2Add BLAST22
Repeati192 – 213LRR 3Add BLAST22
Repeati238 – 258LRR 4Add BLAST21
Repeati259 – 280LRR 5Add BLAST22
Repeati290 – 310LRR 6Add BLAST21

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00730000110781
HOGENOMiHOG000273909
HOVERGENiHBG006850
InParanoidiP70186
KOiK08127
OMAiCDDHELD
OrthoDBiEOG091G0C68
PhylomeDBiP70186
TreeFamiTF351924

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR027217 Epiphycan
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PANTHERiPTHR24373:SF123 PTHR24373:SF123, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMLARVALG LIIIDAVLAA PTTELFNYDS EVYDAILEDT GTFYNYEHIP
60 70 80 90 100
DNHVENEKVS ERLSGNRELL TPGPQLGDNQ DEDKDEESTP RLIDGSSPQE
110 120 130 140 150
PEFPGLLGPH TNEDFPTCLL CTCISTTVYC DDHELDAIPP LPKKTTYFYS
160 170 180 190 200
RFNRIKKINK NDFASLNDLK RIDLTSNLIS EIDEDAFRKL PHLQELVLRD
210 220 230 240 250
NKIKQLPELP NTLTFIDISN NRLGRKGIKQ EAFKDMYDLH HLYITDNSLD
260 270 280 290 300
HIPLPLPESL RALHLQNNDI LEMHEDTFCN VKNLTYVRKA LEDIRLDGNP
310 320
INLSRTPQAY MCLPRLPIGS FI
Length:322
Mass (Da):36,763
Last modified:February 1, 1997 - v1
Checksum:iC9C8CBEBECDAC19A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78274 mRNA Translation: BAA11337.1
D87187 Genomic DNA Translation: BAA28770.1
BC012695 mRNA Translation: AAH12695.1
AK015223 mRNA Translation: BAB29756.1
CCDSiCCDS24143.1
PIRiS72271
RefSeqiNP_031910.1, NM_007884.2
UniGeneiMm.148886

Genome annotation databases

EnsembliENSMUST00000020094; ENSMUSP00000020094; ENSMUSG00000019936
ENSMUST00000105285; ENSMUSP00000100922; ENSMUSG00000019936
GeneIDi13516
KEGGimmu:13516
UCSCiuc007gxb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiEPYC_MOUSE
AccessioniPrimary (citable) accession number: P70186
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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