Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 152 (02 Jun 2021)
Sequence version 2 (25 Oct 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Gene

Pip5k1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:8798574, PubMed:9535851).

PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity).

PIP5K1A-mediated phosphorylation of PtdIns4P is the predominant pathway for PtdIns(4,5)P2 synthesis (PubMed:18772378).

Can also use phosphatidylinositol (PtdIns) as substrate in vitro (By similarity).

Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (PubMed:19153220).

Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (PubMed:19153220).

Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (PubMed:18772378).

Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (By similarity).

Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (PubMed:27739494).

Together with PIP5K1C has a role during embryogenesis (PubMed:20622009).

Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:10679324).

Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (By similarity).

1 PublicationBy similarity7 Publications

Caution

There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by phosphatidic acid.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=26 µM for phosphatidylinositol-4-phosphate/PtdIns4P1 Publication
  2. KM=33 µM for ATP1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.1.68, 3474

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-MMU-1660499, Synthesis of PIPs at the plasma membrane
    R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P70182

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha2 Publications (EC:2.7.1.681 Publication)
    Short name:
    PIP5K1-alpha2 Publications
    Short name:
    PtdIns(4)P-5-kinase 1 alpha2 Publications
    Alternative name(s):
    68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha1 Publication
    Phosphatidylinositol 4-phosphate 5-kinase type I alpha2 Publications
    Short name:
    PIP5KIalpha1 Publication1 Publication
    Phosphatidylinositol 4-phosphate 5-kinase type I betaImported
    Short name:
    PI4P5KIbeta
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Pip5k1aImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:107929, Pip5k1a

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Survive to adulthood, but bred poorly and display reduced fertility. Failed to form any vessel occlusion after chemical-induced carotid injury. Platelets have defective aggregation. Bone marrow-derived macrophages are defective in actin polymerization during phagocytosis. PIP5K1A and PIP5K1C double mutant mice are embryonic lethal.3 Publications

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001854571 – 546Phosphatidylinositol 4-phosphate 5-kinase type-1 alphaAdd BLAST546

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P70182

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P70182

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P70182

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P70182

    PeptideAtlas

    More...
    PeptideAtlasi
    P70182

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P70182

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    289568 [P70182-1]
    289569 [P70182-2]
    289570 [P70182-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P70182

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P70182

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Highest expression in brain. Also detected in skeletal muscle, testis, brain and lung.2 Publications

    <p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    Expression is highest during early embryogenesis and slightly decreases over time.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000028126, Expressed in placenta labyrinth and 336 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P70182, MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with RAC1 (PubMed:10679324).

    Interacts with TUT1 (By similarity).

    Forms a complex with CDH1/E-cadherin, CTNNB1/beta-catenin and CTNND1 at the plasma membrane upon calcium stimulation (By similarity).

    Found in a ternary complex with IRS1 and DGKZ in the absence of insulin stimulation (PubMed:27739494).

    Interacts with DGKZ (By similarity).

    Interacts with PIP4K2C; the interaction inhibits PIP5K1A kinase activity (By similarity).

    By similarity2 Publications

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    202172, 7 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000102852

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P70182

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P70182, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P70182

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini66 – 434PIPKPROSITE-ProRule annotationAdd BLAST369

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni442 – 475DisorderedSequence analysisAdd BLAST34
    Regioni491 – 518DisorderedSequence analysisAdd BLAST28

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi448 – 475Polar residuesSequence analysisAdd BLAST28

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0229, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000154703

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P70182

    Database of Orthologous Groups

    More...
    OrthoDBi
    1562683at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P70182

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF319618

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.800.10, 1 hit
    3.30.810.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR023610, PInositol-4-P-5-kinase
    IPR027483, PInositol-4-P-5-kinase_C
    IPR002498, PInositol-4-P-5-kinase_core
    IPR027484, PInositol-4-P-5-kinase_N

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR23086, PTHR23086, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01504, PIP5K, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00330, PIPKc, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51455, PIPK, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P70182-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MASASSGPAA AGFSSLDAGA PAGTAAASGI KRATVSEGPS ASVMPVKKIG
    60 70 80 90 100
    HRSVDSSGET TYKKTTSSAL KGAIQLGITH TVGSLSTKPE RDVLMQDFYV
    110 120 130 140 150
    VESIFFPSEG SNLTPAHHYN DFRFKTYAPV AFRYFRELFG IRPDDYLYSL
    160 170 180 190 200
    CSEPLIELSN SGASGSLFYV SSDDEFIIKT VQHKEAEFLQ KLLPGYYMNL
    210 220 230 240 250
    NQNPRTLLPK FYGLYCVQAG GKNIRIVVMN NLLPRSVKMH MKYDLKGSTY
    260 270 280 290 300
    KRRASQKERE KTLPTFKDLD FLQDIPDGLF LDADMYSALC KTLQRDCLVL
    310 320 330 340 350
    QSFKIMDYSL LMSIHNMDHA QREPTSNDTQ YSADTRRPAP QKALYSTAME
    360 370 380 390 400
    SIQGEARRGG TVETEDHMGG IPARNNKGER LLLYIGIIDI LQSYRFVKKL
    410 420 430 440 450
    EHSWKALVHD GDTVSVHRPG FYAERFQRFM CNTVFKKIPL KPSPTKKFRS
    460 470 480 490 500
    GPSFSRRSGP SGNSCTSQLM ASGEHRAQVT TKAEVEPDVH LGRPDVLPQT
    510 520 530 540
    PPLEEISEGS PVPGPSFSPV VGQPLQILNL SSTLEKLDVA ESEFTH
    Length:546
    Mass (Da):60,485
    Last modified:October 25, 2005 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E895F22A75B7140
    GO
    Isoform 2 (identifier: P70182-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         27-27: A → AA
         238-431: Missing.

    Show »
    Length:353
    Mass (Da):38,098
    Checksum:i99BDCE9D767BE901
    GO
    Isoform 3 (identifier: P70182-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         27-27: A → AA

    Show »
    Length:547
    Mass (Da):60,556
    Checksum:i65889A83CE3F2B32
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F8WI18F8WI18_MOUSE
    Phosphatidylinositol 4-phosphate 5-...
    Pip5k1a
    545Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D3YUY3D3YUY3_MOUSE
    Phosphatidylinositol 4-phosphate 5-...
    Pip5k1a
    497Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti107P → R in BAE29943 (PubMed:16141072).Curated1
    Sequence conflicti107P → R in BAE30850 (PubMed:16141072).Curated1
    Sequence conflicti120N → S in AAH03763 (PubMed:15489334).Curated1
    Sequence conflicti258E → D in BAA13031 (PubMed:8798574).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05343727A → AA in isoform 2 and isoform 3. 2 Publications1
    Alternative sequenceiVSP_016009238 – 431Missing in isoform 2. 1 PublicationAdd BLAST194

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    D86177 mRNA Translation: BAA13031.1
    AK150898 mRNA Translation: BAE29943.1
    AK151984 mRNA Translation: BAE30850.1
    AK158062 mRNA Translation: BAE34344.1
    AC087062 Genomic DNA No translation available.
    AC131769 Genomic DNA No translation available.
    BC003763 mRNA Translation: AAH03763.1
    BC031774 mRNA Translation: AAH31774.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS38542.1 [P70182-1]
    CCDS79980.1 [P70182-3]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001280636.1, NM_001293707.1 [P70182-3]
    NP_032873.2, NM_008847.3 [P70182-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000107233; ENSMUSP00000102852; ENSMUSG00000028126 [P70182-3]
    ENSMUST00000107236; ENSMUSP00000102855; ENSMUSG00000028126 [P70182-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    18720

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:18720

    UCSC genome browser

    More...
    UCSCi
    uc008qhx.3, mouse [P70182-1]
    uc008qhy.3, mouse [P70182-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D86177 mRNA Translation: BAA13031.1
    AK150898 mRNA Translation: BAE29943.1
    AK151984 mRNA Translation: BAE30850.1
    AK158062 mRNA Translation: BAE34344.1
    AC087062 Genomic DNA No translation available.
    AC131769 Genomic DNA No translation available.
    BC003763 mRNA Translation: AAH03763.1
    BC031774 mRNA Translation: AAH31774.1
    CCDSiCCDS38542.1 [P70182-1]
    CCDS79980.1 [P70182-3]
    RefSeqiNP_001280636.1, NM_001293707.1 [P70182-3]
    NP_032873.2, NM_008847.3 [P70182-1]

    3D structure databases

    SMRiP70182
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi202172, 7 interactors
    STRINGi10090.ENSMUSP00000102852

    Chemistry databases

    BindingDBiP70182

    PTM databases

    iPTMnetiP70182
    PhosphoSitePlusiP70182

    Proteomic databases

    EPDiP70182
    jPOSTiP70182
    MaxQBiP70182
    PaxDbiP70182
    PeptideAtlasiP70182
    PRIDEiP70182
    ProteomicsDBi289568 [P70182-1]
    289569 [P70182-2]
    289570 [P70182-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    34058, 188 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    18720

    Genome annotation databases

    EnsembliENSMUST00000107233; ENSMUSP00000102852; ENSMUSG00000028126 [P70182-3]
    ENSMUST00000107236; ENSMUSP00000102855; ENSMUSG00000028126 [P70182-1]
    GeneIDi18720
    KEGGimmu:18720
    UCSCiuc008qhx.3, mouse [P70182-1]
    uc008qhy.3, mouse [P70182-3]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    8394
    MGIiMGI:107929, Pip5k1a

    Phylogenomic databases

    eggNOGiKOG0229, Eukaryota
    GeneTreeiENSGT00940000154703
    InParanoidiP70182
    OrthoDBi1562683at2759
    PhylomeDBiP70182
    TreeFamiTF319618

    Enzyme and pathway databases

    BRENDAi2.7.1.68, 3474
    ReactomeiR-MMU-1660499, Synthesis of PIPs at the plasma membrane
    R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
    SABIO-RKiP70182

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    18720, 2 hits in 53 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    Pip5k1a, mouse

    Protein Ontology

    More...
    PROi
    PR:P70182
    RNActiP70182, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000028126, Expressed in placenta labyrinth and 336 other tissues
    GenevisibleiP70182, MM

    Family and domain databases

    Gene3Di3.30.800.10, 1 hit
    3.30.810.10, 2 hits
    InterProiView protein in InterPro
    IPR023610, PInositol-4-P-5-kinase
    IPR027483, PInositol-4-P-5-kinase_C
    IPR002498, PInositol-4-P-5-kinase_core
    IPR027484, PInositol-4-P-5-kinase_N
    PANTHERiPTHR23086, PTHR23086, 1 hit
    PfamiView protein in Pfam
    PF01504, PIP5K, 1 hit
    SMARTiView protein in SMART
    SM00330, PIPKc, 1 hit
    PROSITEiView protein in PROSITE
    PS51455, PIPK, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI51A_MOUSE
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70182
    Secondary accession number(s): F8WIX5
    , Q3U917, Q8K0D3, Q99L80
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: October 25, 2005
    Last modified: June 2, 2021
    This is version 152 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again