UniProtKB - P70175 (DLG3_MOUSE)
Disks large homolog 3
Dlg3
Functioni
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
By similarityGO - Molecular functioni
- ionotropic glutamate receptor binding Source: MGI
- kinase binding Source: MGI
- PDZ domain binding Source: MGI
- phosphatase binding Source: UniProtKB
- protein C-terminus binding Source: MGI
- protein domain specific binding Source: MGI
- protein phosphatase binding Source: MGI
- structural constituent of postsynaptic density Source: MGI
- ubiquitin protein ligase binding Source: MGI
GO - Biological processi
- cell-cell adhesion Source: GO_Central
- establishment of planar polarity Source: MGI
- establishment or maintenance of epithelial cell apical/basal polarity Source: MGI
- positive regulation of protein tyrosine kinase activity Source: MGI
- receptor clustering Source: GO_Central
- receptor localization to synapse Source: GO_Central
- regulation of postsynaptic membrane neurotransmitter receptor levels Source: SynGO
Enzyme and pathway databases
Reactomei | R-MMU-438066, Unblocking of NMDA receptors, glutamate binding and activation R-MMU-451308, Activation of Ca-permeable Kainate Receptor R-MMU-5673001, RAF/MAP kinase cascade R-MMU-6794361, Neurexins and neuroligins R-MMU-8849932, Synaptic adhesion-like molecules |
Names & Taxonomyi
Protein namesi | Recommended name: Disks large homolog 3Alternative name(s): Synapse-associated protein 102 Short name: SAP-102 Short name: SAP102 |
Gene namesi | Name:Dlg3 Synonyms:Dlgh3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1888986, Dlg3 |
VEuPathDBi | HostDB:ENSMUSG00000000881 |
Subcellular locationi
Plasma Membrane
- AMPA glutamate receptor complex Source: MGI
- basolateral plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Other locations
- bicellular tight junction Source: MGI
- cell junction Source: GO_Central
- cell-cell junction Source: MGI
- cytoplasm Source: MGI
- dendritic shaft Source: MGI
- glutamatergic synapse Source: MGI
- growth cone Source: MGI
- neuronal cell body Source: MGI
- postsynaptic density Source: MGI
- postsynaptic density, intracellular component Source: MGI
- synapse Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094558 | 1 – 849 | Disks large homolog 3Add BLAST | 849 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 157 | PhosphoserineCombined sources | 1 | |
Modified residuei | 705 | PhosphotyrosineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P70175 |
PaxDbi | P70175 |
PeptideAtlasi | P70175 |
PRIDEi | P70175 |
ProteomicsDBi | 279683 |
PTM databases
iPTMneti | P70175 |
PhosphoSitePlusi | P70175 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000000881, Expressed in brain and 289 other tissues |
ExpressionAtlasi | P70175, baseline and differential |
Genevisiblei | P70175, MM |
Interactioni
Subunit structurei
Interacts through its PDZ domains with NETO1, GRIN2B, SYNGAP1 and APC.
Interacts through its first two PDZ domains with ERBB4.
Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3.
Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4 (By similarity).
Interacts with FRMPD4 (via C-terminus) (By similarity).
Interacts with LRFN1, LRFN2 and LRFN4 (By similarity).
Interacts with FLTP.
Interacts with GPR85 (PubMed:25780553).
Interacts with DGKI (via PDZ-binding motif) (PubMed:21119615).
By similarity3 PublicationsBinary interactionsi
GO - Molecular functioni
- ionotropic glutamate receptor binding Source: MGI
- kinase binding Source: MGI
- PDZ domain binding Source: MGI
- phosphatase binding Source: UniProtKB
- protein C-terminus binding Source: MGI
- protein domain specific binding Source: MGI
- protein phosphatase binding Source: MGI
- ubiquitin protein ligase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 207274, 19 interactors |
CORUMi | P70175 |
DIPi | DIP-31585N |
IntActi | P70175, 12 interactors |
MINTi | P70175 |
STRINGi | 10090.ENSMUSP00000085299 |
Miscellaneous databases
RNActi | P70175, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 149 – 235 | PDZ 1PROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 244 – 330 | PDZ 2PROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 404 – 484 | PDZ 3PROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 519 – 589 | SH3PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 659 – 834 | Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST | 176 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 32 – 101 | DisorderedSequence analysisAdd BLAST | 70 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 48 – 68 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Repeat, SH3 domainPhylogenomic databases
eggNOGi | KOG0708, Eukaryota |
GeneTreei | ENSGT00940000159565 |
InParanoidi | P70175 |
OrthoDBi | 807583at2759 |
PhylomeDBi | P70175 |
TreeFami | TF323171 |
Family and domain databases
CDDi | cd12029, SH3_DLG3, 1 hit |
Gene3Di | 2.30.42.10, 3 hits 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR016313, DLG1-like IPR019590, DLG1_PEST_dom IPR035763, DLG3_SH3 IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR020590, Guanylate_kinase_CS IPR027417, P-loop_NTPase IPR001478, PDZ IPR019583, PDZ_assoc IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF10608, MAGUK_N_PEST, 1 hit PF00595, PDZ, 3 hits PF10600, PDZ_assoc, 1 hit PF00018, SH3_1, 1 hit |
PIRSFi | PIRSF001741, MAGUK_DLGH, 1 hit |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM01277, MAGUK_N_PEST, 1 hit SM00228, PDZ, 3 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 3 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00856, GUANYLATE_KINASE_1, 1 hit PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 3 hits PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MHKHQHCCKC PECYEVTRLA ALRRLEPPGY GDWQVPDPYG PSGGNGASSG
60 70 80 90 100
YGGYSSQTLP SQAGATPTPR TKAKLIPTGR DVGPVPPKPV PGKSTPKLNG
110 120 130 140 150
SGPGWWPECT CTNRDWYEQA SPAPLLVNPE ALEPSLSVNG SDGMFKYEEI
160 170 180 190 200
VLERGNSGLG FSIAGGIDNP HVPDDPGIFI TKIIPGGAAA MDGRLGVNDC
210 220 230 240 250
VLRVNEVDVS EVVHSRAVEA LKEAGPVVRL VVRRRQPPPE TIMEVNLLKG
260 270 280 290 300
PKGLGFSIAG GIGNQHIPGD NSIYITKIIE GGAAQKDGRL QIGDRLLAVN
310 320 330 340 350
NTNLQDVRHE EAVASLKNTS DMVYLKVAKP GSIHLNDMYA PPDYASTFTA
360 370 380 390 400
LADNHISHNS SLGYLGAVES KVTYPAPPQV PPTRYSPIPR HMLAEEDFTR
410 420 430 440 450
EPRKIILHKG STGLGFNIVG GEDGEGIFVS FILAGGPADL SGELRRGDRI
460 470 480 490 500
LSVNGVNLRN ATHEQAAAAL KRAGQSVTIV AQYRPEEYSR FESKIHDLRE
510 520 530 540 550
QMMNSSMSSG SGSLRTSEKR SLYVRALFDY DRTRDSCLPS QGLSFSYGDI
560 570 580 590 600
LHVINASDDE WWQARLVTPH GESEQIGVIP SKKRVEKKER ARLKTVKFHA
610 620 630 640 650
RTGMIESNRD FPGLSDDYYG AKNLKGVTSN TSDSESSSKG QEDAILSYEP
660 670 680 690 700
VTRQEIHYAR PVIILGPMKD RVNDDLISEF PHKFGSCVPH TTRPRRDNEV
710 720 730 740 750
DGQDYHFVVS REQMEKDIQD NKFIEAGQFN DNLYGTSIQS VRAVAERGKH
760 770 780 790 800
CILDVSGNAI KRLQQAQLYP IAIFIKPKSI EALMEMNRRQ TYEQANKIFD
810 820 830 840
KAMKLEQEFG EYFTAIVQGD SLEEIYNKIK QIIEDQSGHY IWVPSPEKL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ52KF7 | Q52KF7_MOUSE | Disks large homolog 3 | Dlg3 Dlgh3 | 817 | Annotation score: | ||
A2BEE9 | A2BEE9_MOUSE | Disks large homolog 3 | Dlg3 | 835 | Annotation score: | ||
A2BEF2 | A2BEF2_MOUSE | Disks large homolog 3 | Dlg3 | 512 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87117 mRNA Translation: BAA13249.1 |
CCDSi | CCDS30307.1 |
RefSeqi | NP_001171249.1, NM_001177778.2 NP_058027.1, NM_016747.4 |
Genome annotation databases
Ensembli | ENSMUST00000087984; ENSMUSP00000085299; ENSMUSG00000000881 |
GeneIDi | 53310 |
KEGGi | mmu:53310 |
UCSCi | uc009twm.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87117 mRNA Translation: BAA13249.1 |
CCDSi | CCDS30307.1 |
RefSeqi | NP_001171249.1, NM_001177778.2 NP_058027.1, NM_016747.4 |
3D structure databases
SMRi | P70175 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 207274, 19 interactors |
CORUMi | P70175 |
DIPi | DIP-31585N |
IntActi | P70175, 12 interactors |
MINTi | P70175 |
STRINGi | 10090.ENSMUSP00000085299 |
PTM databases
iPTMneti | P70175 |
PhosphoSitePlusi | P70175 |
Proteomic databases
MaxQBi | P70175 |
PaxDbi | P70175 |
PeptideAtlasi | P70175 |
PRIDEi | P70175 |
ProteomicsDBi | 279683 |
Protocols and materials databases
ABCDi | P70175, 3 sequenced antibodies |
Antibodypediai | 342, 330 antibodies from 34 providers |
DNASUi | 53310 |
Genome annotation databases
Ensembli | ENSMUST00000087984; ENSMUSP00000085299; ENSMUSG00000000881 |
GeneIDi | 53310 |
KEGGi | mmu:53310 |
UCSCi | uc009twm.3, mouse |
Organism-specific databases
CTDi | 1741 |
MGIi | MGI:1888986, Dlg3 |
VEuPathDBi | HostDB:ENSMUSG00000000881 |
Phylogenomic databases
eggNOGi | KOG0708, Eukaryota |
GeneTreei | ENSGT00940000159565 |
InParanoidi | P70175 |
OrthoDBi | 807583at2759 |
PhylomeDBi | P70175 |
TreeFami | TF323171 |
Enzyme and pathway databases
Reactomei | R-MMU-438066, Unblocking of NMDA receptors, glutamate binding and activation R-MMU-451308, Activation of Ca-permeable Kainate Receptor R-MMU-5673001, RAF/MAP kinase cascade R-MMU-6794361, Neurexins and neuroligins R-MMU-8849932, Synaptic adhesion-like molecules |
Miscellaneous databases
BioGRID-ORCSi | 53310, 1 hit in 65 CRISPR screens |
ChiTaRSi | Mpp3, mouse |
PROi | PR:P70175 |
RNActi | P70175, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000000881, Expressed in brain and 289 other tissues |
ExpressionAtlasi | P70175, baseline and differential |
Genevisiblei | P70175, MM |
Family and domain databases
CDDi | cd12029, SH3_DLG3, 1 hit |
Gene3Di | 2.30.42.10, 3 hits 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR016313, DLG1-like IPR019590, DLG1_PEST_dom IPR035763, DLG3_SH3 IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR020590, Guanylate_kinase_CS IPR027417, P-loop_NTPase IPR001478, PDZ IPR019583, PDZ_assoc IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF10608, MAGUK_N_PEST, 1 hit PF00595, PDZ, 3 hits PF10600, PDZ_assoc, 1 hit PF00018, SH3_1, 1 hit |
PIRSFi | PIRSF001741, MAGUK_DLGH, 1 hit |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM01277, MAGUK_N_PEST, 1 hit SM00228, PDZ, 3 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 3 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00856, GUANYLATE_KINASE_1, 1 hit PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 3 hits PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DLG3_MOUSE | |
Accessioni | P70175Primary (citable) accession number: P70175 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 185 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families