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Entry version 171 (02 Jun 2021)
Sequence version 2 (09 May 2003)
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Protein

Histamine H1 receptor

Gene

Hrh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Involved in circadian rhythm of locomotor activity and exploratory behavior. Also involved in responsiveness to pertussis toxin through its control of susceptibility to histamine hypersensitivity and enhancement of antigen-specific delayed-type hypersensitivity responses.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBiological rhythms

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-390650, Histamine receptors
R-MMU-416476, G alpha (q) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histamine H1 receptor
Short name:
H1R
Short name:
HH1R
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hrh1
Synonyms:Bphs
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107619, Hrh1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 29ExtracellularBy similarityAdd BLAST29
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 52Helical; Name=1By similarityAdd BLAST23
Topological domaini53 – 62CytoplasmicBy similarity10
Transmembranei63 – 83Helical; Name=2By similarityAdd BLAST21
Topological domaini84 – 101ExtracellularBy similarityAdd BLAST18
Transmembranei102 – 123Helical; Name=3By similarityAdd BLAST22
Topological domaini124 – 143CytoplasmicBy similarityAdd BLAST20
Transmembranei144 – 164Helical; Name=4By similarityAdd BLAST21
Topological domaini165 – 189ExtracellularBy similarityAdd BLAST25
Transmembranei190 – 210Helical; Name=5By similarityAdd BLAST21
Topological domaini211 – 417CytoplasmicBy similarityAdd BLAST207
Transmembranei418 – 439Helical; Name=6By similarityAdd BLAST22
Topological domaini440 – 451ExtracellularBy similarityAdd BLAST12
Transmembranei452 – 471Helical; Name=7By similarityAdd BLAST20
Topological domaini472 – 488CytoplasmicBy similarityAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4322

Drug and drug target database

More...
DrugBanki
DB11160, Phenyltoloxamine
DB00512, Vancomycin

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000696771 – 488Histamine H1 receptorAdd BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi100 ↔ 180PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei140PhosphothreonineBy similarity1
Modified residuei142PhosphothreonineBy similarity1
Modified residuei230PhosphoserineBy similarity1
Modified residuei344PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei397PhosphoserineBy similarity1
Modified residuei399PhosphoserineBy similarity1
Disulfide bondi442 ↔ 445PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P70174

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P70174

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P70174

PRoteomics IDEntifications database

More...
PRIDEi
P70174

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
273382

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P70174, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P70174

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P70174

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000053004, Expressed in supraoptic nucleus and 140 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P70174, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P70174, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000086383

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P70174

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P70174, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni107 – 112Important for agonist bindingBy similarity6
Regioni245 – 337DisorderedSequence analysisAdd BLAST93
Regioni425 – 429Important for agonist bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi245 – 260Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi269 – 293Polar residuesSequence analysisAdd BLAST25
Compositional biasi321 – 337Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4220, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160690

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009579_11_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P70174

Identification of Orthologs from Complete Genome Data

More...
OMAi
YRSVRQP

Database of Orthologous Groups

More...
OrthoDBi
1245472at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P70174

TreeFam database of animal gene trees

More...
TreeFami
TF333432

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR000921, Histamine_H1_rcpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237, GPCRRHODOPSN
PR00530, HISTAMINEH1R

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P70174-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLPNTSSAS EDKMCEGNRT AMASPQLLPL VVVLSSISLV TVGLNLLVLY
60 70 80 90 100
AVRSERKLHT VGNLYIVSLS VADLIVGAVV MPMNILYLIM TKWSLGRPLC
110 120 130 140 150
LFWLSMDYVA STASIFSVFI LCIDRYRSVQ QPLRYLRYRT KTRASATILG
160 170 180 190 200
AWFLSFLWVI PILGWHHFTP LAPELREDKC ETDFYNVTWF KIMTAIINFY
210 220 230 240 250
LPTLLMLWFY VKIYKAVRRH CQHRQLTNGS LPTFLEIKLR SEDAKEGAKK
260 270 280 290 300
PGKESPWGVQ KRPSRDPTGG LDQKSTSEDP KVTSPTVFSQ EGERETVTRP
310 320 330 340 350
CFRLDVMQTQ PVPEGDARGS KANDQTLSQP KMDEQSLSTC RRISETSEDQ
360 370 380 390 400
TLVDRQSFSR TTDSDTSIEP GLGKVKARSR SNSGLDYIKV TWKRLRSHSR
410 420 430 440 450
QYVSGLHLNR ERKAAKQLGC IMAAFILCWI PYFIFFMVIA FCNSCCSEPV
460 470 480
HMFTIWLGYI NSTLNPLIYP LCNENFKKTF KKILHIRS
Length:488
Mass (Da):55,682
Last modified:May 9, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82612DF712998B41
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CXH0E0CXH0_MOUSE
Histamine H1 receptor
Hrh1
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2S → R in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti47L → G in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti79V → I in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti215 – 216KA → NG in BAA08791 (PubMed:8812432).Curated2
Sequence conflicti224R → P in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti242E → D in AAK66778 (PubMed:12142541).Curated1
Sequence conflicti244A → S in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti261K → T in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti278E → A in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti379S → R in BAA08791 (PubMed:8812432).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Strains C3H/HeJ and CBA/J are resistant to vasoactive amine sensitization elicited by histamine (VAASH) which is induced by pertussis toxin.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti263P → L in strain: C3H/HeJ and CBA/J. 1 Publication1
Natural varianti312V → M in strain: C3H/HeJ and CBA/J. 1 Publication1
Natural varianti330P → S in strain: C3H/HeJ and CBA/J. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D50095 Genomic DNA Translation: BAA08791.1
AF387890 mRNA Translation: AAK71654.1
AF387891 mRNA Translation: AAK71655.1
AF387892 mRNA Translation: AAK71656.1
AF387893 mRNA Translation: AAK71657.1
AF387894 mRNA Translation: AAK71658.1
AF387895 mRNA Translation: AAK71659.1
AF387896 mRNA Translation: AAK71660.1
AF388052 mRNA Translation: AAK66774.2
AF388053 mRNA Translation: AAK66775.1
AF388054 mRNA Translation: AAK66776.1
AF388055 mRNA Translation: AAK66777.1
AF388056 mRNA Translation: AAK66778.1
AF388057 mRNA Translation: AAK66779.1
AF388058 mRNA Translation: AAK66780.1
AK032763 mRNA Translation: BAC28011.1
AK038480 mRNA Translation: BAC30013.1
AK046607 mRNA Translation: BAC32805.1
AK047070 mRNA Translation: BAC32950.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20435.1

NCBI Reference Sequences

More...
RefSeqi
NP_001239571.1, NM_001252642.2
NP_001239572.1, NM_001252643.2
NP_001304053.1, NM_001317124.1
NP_001304054.1, NM_001317125.1
NP_001304055.1, NM_001317126.1
NP_032311.2, NM_008285.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000088987; ENSMUSP00000086383; ENSMUSG00000053004
ENSMUST00000160780; ENSMUSP00000124320; ENSMUSG00000053004
ENSMUST00000161220; ENSMUSP00000124037; ENSMUSG00000053004
ENSMUST00000161650; ENSMUSP00000124460; ENSMUSG00000053004

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
15465

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:15465

UCSC genome browser

More...
UCSCi
uc009dhw.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50095 Genomic DNA Translation: BAA08791.1
AF387890 mRNA Translation: AAK71654.1
AF387891 mRNA Translation: AAK71655.1
AF387892 mRNA Translation: AAK71656.1
AF387893 mRNA Translation: AAK71657.1
AF387894 mRNA Translation: AAK71658.1
AF387895 mRNA Translation: AAK71659.1
AF387896 mRNA Translation: AAK71660.1
AF388052 mRNA Translation: AAK66774.2
AF388053 mRNA Translation: AAK66775.1
AF388054 mRNA Translation: AAK66776.1
AF388055 mRNA Translation: AAK66777.1
AF388056 mRNA Translation: AAK66778.1
AF388057 mRNA Translation: AAK66779.1
AF388058 mRNA Translation: AAK66780.1
AK032763 mRNA Translation: BAC28011.1
AK038480 mRNA Translation: BAC30013.1
AK046607 mRNA Translation: BAC32805.1
AK047070 mRNA Translation: BAC32950.1
CCDSiCCDS20435.1
RefSeqiNP_001239571.1, NM_001252642.2
NP_001239572.1, NM_001252643.2
NP_001304053.1, NM_001317124.1
NP_001304054.1, NM_001317125.1
NP_001304055.1, NM_001317126.1
NP_032311.2, NM_008285.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086383

Chemistry databases

BindingDBiP70174
ChEMBLiCHEMBL4322
DrugBankiDB11160, Phenyltoloxamine
DB00512, Vancomycin

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

GlyGeniP70174, 2 sites
iPTMnetiP70174
PhosphoSitePlusiP70174

Proteomic databases

jPOSTiP70174
MaxQBiP70174
PaxDbiP70174
PRIDEiP70174
ProteomicsDBi273382

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
10679, 536 antibodies

The DNASU plasmid repository

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DNASUi
15465

Genome annotation databases

EnsembliENSMUST00000088987; ENSMUSP00000086383; ENSMUSG00000053004
ENSMUST00000160780; ENSMUSP00000124320; ENSMUSG00000053004
ENSMUST00000161220; ENSMUSP00000124037; ENSMUSG00000053004
ENSMUST00000161650; ENSMUSP00000124460; ENSMUSG00000053004
GeneIDi15465
KEGGimmu:15465
UCSCiuc009dhw.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3269
MGIiMGI:107619, Hrh1

Phylogenomic databases

eggNOGiKOG4220, Eukaryota
GeneTreeiENSGT00940000160690
HOGENOMiCLU_009579_11_2_1
InParanoidiP70174
OMAiYRSVRQP
OrthoDBi1245472at2759
PhylomeDBiP70174
TreeFamiTF333432

Enzyme and pathway databases

ReactomeiR-MMU-390650, Histamine receptors
R-MMU-416476, G alpha (q) signalling events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
15465, 1 hit in 53 CRISPR screens

Protein Ontology

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PROi
PR:P70174
RNActiP70174, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000053004, Expressed in supraoptic nucleus and 140 other tissues
ExpressionAtlasiP70174, baseline and differential
GenevisibleiP70174, MM

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR000921, Histamine_H1_rcpt
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR00530, HISTAMINEH1R
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHRH1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70174
Secondary accession number(s): Q91V75
, Q91XN0, Q91XN1, Q91XN2, Q91XN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 9, 2003
Last modified: June 2, 2021
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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