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Protein

Histamine H1 receptor

Gene

Hrh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Involved in circadian rhythm of locomotor activity and exploratory behavior. Also involved in responsiveness to pertussis toxin through its control of susceptibility to histamine hypersensitivity and enhancement of antigen-specific delayed-type hypersensitivity responses.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBiological rhythms

Enzyme and pathway databases

ReactomeiR-MMU-390650 Histamine receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H1 receptor
Short name:
H1R
Short name:
HH1R
Gene namesi
Name:Hrh1
Synonyms:Bphs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107619 Hrh1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularBy similarityAdd BLAST29
Transmembranei30 – 52Helical; Name=1By similarityAdd BLAST23
Topological domaini53 – 62CytoplasmicBy similarity10
Transmembranei63 – 83Helical; Name=2By similarityAdd BLAST21
Topological domaini84 – 101ExtracellularBy similarityAdd BLAST18
Transmembranei102 – 123Helical; Name=3By similarityAdd BLAST22
Topological domaini124 – 143CytoplasmicBy similarityAdd BLAST20
Transmembranei144 – 164Helical; Name=4By similarityAdd BLAST21
Topological domaini165 – 189ExtracellularBy similarityAdd BLAST25
Transmembranei190 – 210Helical; Name=5By similarityAdd BLAST21
Topological domaini211 – 417CytoplasmicBy similarityAdd BLAST207
Transmembranei418 – 439Helical; Name=6By similarityAdd BLAST22
Topological domaini440 – 451ExtracellularBy similarityAdd BLAST12
Transmembranei452 – 471Helical; Name=7By similarityAdd BLAST20
Topological domaini472 – 488CytoplasmicBy similarityAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4322

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696771 – 488Histamine H1 receptorAdd BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi100 ↔ 180PROSITE-ProRule annotation
Modified residuei140PhosphothreonineBy similarity1
Modified residuei142PhosphothreonineBy similarity1
Modified residuei230PhosphoserineBy similarity1
Modified residuei344PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei397PhosphoserineBy similarity1
Modified residuei399PhosphoserineBy similarity1
Disulfide bondi442 ↔ 445PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP70174
PaxDbiP70174
PRIDEiP70174

PTM databases

iPTMnetiP70174
PhosphoSitePlusiP70174

Expressioni

Gene expression databases

BgeeiENSMUSG00000053004 Expressed in 107 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_HRH1
ExpressionAtlasiP70174 baseline and differential
GenevisibleiP70174 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086383

Chemistry databases

BindingDBiP70174

Structurei

3D structure databases

ProteinModelPortaliP70174
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 112Important for agonist bindingBy similarity6
Regioni425 – 429Important for agonist bindingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4220 Eukaryota
ENOG410YCQR LUCA
GeneTreeiENSGT00780000121874
HOGENOMiHOG000273869
HOVERGENiHBG101103
InParanoidiP70174
KOiK04149
OMAiHMFTIWL
OrthoDBiEOG091G06VI
PhylomeDBiP70174
TreeFamiTF333432

Family and domain databases

CDDicd15050 7tmA_Histamine_H1R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000921 Histamine_H1_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00530 HISTAMINEH1R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P70174-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLPNTSSAS EDKMCEGNRT AMASPQLLPL VVVLSSISLV TVGLNLLVLY
60 70 80 90 100
AVRSERKLHT VGNLYIVSLS VADLIVGAVV MPMNILYLIM TKWSLGRPLC
110 120 130 140 150
LFWLSMDYVA STASIFSVFI LCIDRYRSVQ QPLRYLRYRT KTRASATILG
160 170 180 190 200
AWFLSFLWVI PILGWHHFTP LAPELREDKC ETDFYNVTWF KIMTAIINFY
210 220 230 240 250
LPTLLMLWFY VKIYKAVRRH CQHRQLTNGS LPTFLEIKLR SEDAKEGAKK
260 270 280 290 300
PGKESPWGVQ KRPSRDPTGG LDQKSTSEDP KVTSPTVFSQ EGERETVTRP
310 320 330 340 350
CFRLDVMQTQ PVPEGDARGS KANDQTLSQP KMDEQSLSTC RRISETSEDQ
360 370 380 390 400
TLVDRQSFSR TTDSDTSIEP GLGKVKARSR SNSGLDYIKV TWKRLRSHSR
410 420 430 440 450
QYVSGLHLNR ERKAAKQLGC IMAAFILCWI PYFIFFMVIA FCNSCCSEPV
460 470 480
HMFTIWLGYI NSTLNPLIYP LCNENFKKTF KKILHIRS
Length:488
Mass (Da):55,682
Last modified:May 9, 2003 - v2
Checksum:i82612DF712998B41
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CXH0E0CXH0_MOUSE
Histamine H1 receptor
Hrh1
35Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2S → R in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti47L → G in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti79V → I in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti215 – 216KA → NG in BAA08791 (PubMed:8812432).Curated2
Sequence conflicti224R → P in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti242E → D in AAK66778 (PubMed:12142541).Curated1
Sequence conflicti244A → S in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti261K → T in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti278E → A in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti379S → R in BAA08791 (PubMed:8812432).Curated1

Polymorphismi

Strains C3H/HeJ and CBA/J are resistant to vasoactive amine sensitization elicited by histamine (VAASH) which is induced by pertussis toxin.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti263P → L in strain: C3H/HeJ and CBA/J. 1 Publication1
Natural varianti312V → M in strain: C3H/HeJ and CBA/J. 1 Publication1
Natural varianti330P → S in strain: C3H/HeJ and CBA/J. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50095 Genomic DNA Translation: BAA08791.1
AF387890 mRNA Translation: AAK71654.1
AF387891 mRNA Translation: AAK71655.1
AF387892 mRNA Translation: AAK71656.1
AF387893 mRNA Translation: AAK71657.1
AF387894 mRNA Translation: AAK71658.1
AF387895 mRNA Translation: AAK71659.1
AF387896 mRNA Translation: AAK71660.1
AF388052 mRNA Translation: AAK66774.2
AF388053 mRNA Translation: AAK66775.1
AF388054 mRNA Translation: AAK66776.1
AF388055 mRNA Translation: AAK66777.1
AF388056 mRNA Translation: AAK66778.1
AF388057 mRNA Translation: AAK66779.1
AF388058 mRNA Translation: AAK66780.1
AK032763 mRNA Translation: BAC28011.1
AK038480 mRNA Translation: BAC30013.1
AK046607 mRNA Translation: BAC32805.1
AK047070 mRNA Translation: BAC32950.1
CCDSiCCDS20435.1
RefSeqiNP_001239571.1, NM_001252642.2
NP_001239572.1, NM_001252643.2
NP_001304053.1, NM_001317124.1
NP_001304054.1, NM_001317125.1
NP_001304055.1, NM_001317126.1
NP_032311.2, NM_008285.4
UniGeneiMm.333327

Genome annotation databases

EnsembliENSMUST00000088987; ENSMUSP00000086383; ENSMUSG00000053004
ENSMUST00000160780; ENSMUSP00000124320; ENSMUSG00000053004
ENSMUST00000161220; ENSMUSP00000124037; ENSMUSG00000053004
ENSMUST00000161650; ENSMUSP00000124460; ENSMUSG00000053004
GeneIDi15465
KEGGimmu:15465
UCSCiuc009dhw.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50095 Genomic DNA Translation: BAA08791.1
AF387890 mRNA Translation: AAK71654.1
AF387891 mRNA Translation: AAK71655.1
AF387892 mRNA Translation: AAK71656.1
AF387893 mRNA Translation: AAK71657.1
AF387894 mRNA Translation: AAK71658.1
AF387895 mRNA Translation: AAK71659.1
AF387896 mRNA Translation: AAK71660.1
AF388052 mRNA Translation: AAK66774.2
AF388053 mRNA Translation: AAK66775.1
AF388054 mRNA Translation: AAK66776.1
AF388055 mRNA Translation: AAK66777.1
AF388056 mRNA Translation: AAK66778.1
AF388057 mRNA Translation: AAK66779.1
AF388058 mRNA Translation: AAK66780.1
AK032763 mRNA Translation: BAC28011.1
AK038480 mRNA Translation: BAC30013.1
AK046607 mRNA Translation: BAC32805.1
AK047070 mRNA Translation: BAC32950.1
CCDSiCCDS20435.1
RefSeqiNP_001239571.1, NM_001252642.2
NP_001239572.1, NM_001252643.2
NP_001304053.1, NM_001317124.1
NP_001304054.1, NM_001317125.1
NP_001304055.1, NM_001317126.1
NP_032311.2, NM_008285.4
UniGeneiMm.333327

3D structure databases

ProteinModelPortaliP70174
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086383

Chemistry databases

BindingDBiP70174
ChEMBLiCHEMBL4322

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP70174
PhosphoSitePlusiP70174

Proteomic databases

MaxQBiP70174
PaxDbiP70174
PRIDEiP70174

Protocols and materials databases

DNASUi15465
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088987; ENSMUSP00000086383; ENSMUSG00000053004
ENSMUST00000160780; ENSMUSP00000124320; ENSMUSG00000053004
ENSMUST00000161220; ENSMUSP00000124037; ENSMUSG00000053004
ENSMUST00000161650; ENSMUSP00000124460; ENSMUSG00000053004
GeneIDi15465
KEGGimmu:15465
UCSCiuc009dhw.1 mouse

Organism-specific databases

CTDi3269
MGIiMGI:107619 Hrh1

Phylogenomic databases

eggNOGiKOG4220 Eukaryota
ENOG410YCQR LUCA
GeneTreeiENSGT00780000121874
HOGENOMiHOG000273869
HOVERGENiHBG101103
InParanoidiP70174
KOiK04149
OMAiHMFTIWL
OrthoDBiEOG091G06VI
PhylomeDBiP70174
TreeFamiTF333432

Enzyme and pathway databases

ReactomeiR-MMU-390650 Histamine receptors
R-MMU-416476 G alpha (q) signalling events

Miscellaneous databases

PROiPR:P70174
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053004 Expressed in 107 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_HRH1
ExpressionAtlasiP70174 baseline and differential
GenevisibleiP70174 MM

Family and domain databases

CDDicd15050 7tmA_Histamine_H1R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000921 Histamine_H1_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00530 HISTAMINEH1R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHRH1_MOUSE
AccessioniPrimary (citable) accession number: P70174
Secondary accession number(s): Q91V75
, Q91XN0, Q91XN1, Q91XN2, Q91XN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 9, 2003
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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