Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-binding cassette sub-family C member 9

Gene

Abcc9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi702 – 709ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1343 – 1350ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1296025 ATP sensitive Potassium channels
R-MMU-382556 ABC-family proteins mediated transport
R-MMU-5578775 Ion homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family C member 9
Alternative name(s):
Sulfonylurea receptor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abcc9
Synonyms:Sur2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1352630 Abcc9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 51Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini52 – 72CytoplasmicSequence analysisAdd BLAST21
Transmembranei73 – 93Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini94 – 101ExtracellularSequence analysis8
Transmembranei102 – 122Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini123 – 132CytoplasmicSequence analysis10
Transmembranei133 – 153Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini154 – 167ExtracellularSequence analysisAdd BLAST14
Transmembranei168 – 188Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini189 – 301CytoplasmicSequence analysisAdd BLAST113
Transmembranei302 – 322Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini323 – 348ExtracellularSequence analysisAdd BLAST26
Transmembranei349 – 369Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini370 – 421CytoplasmicSequence analysisAdd BLAST52
Transmembranei422 – 442Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini443 – 453ExtracellularSequence analysisAdd BLAST11
Transmembranei454 – 474Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini475 – 529CytoplasmicSequence analysisAdd BLAST55
Transmembranei530 – 550Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini551 – 569ExtracellularSequence analysisAdd BLAST19
Transmembranei570 – 590Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini591 – 987CytoplasmicSequence analysisAdd BLAST397
Transmembranei988 – 1008Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini1009 – 1031ExtracellularSequence analysisAdd BLAST23
Transmembranei1032 – 1052Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1053 – 1124CytoplasmicSequence analysisAdd BLAST72
Transmembranei1125 – 1145Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1146 – 1242ExtracellularSequence analysisAdd BLAST97
Transmembranei1243 – 1263Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1264 – 1546CytoplasmicSequence analysisAdd BLAST283

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000934031 – 1546ATP-binding cassette sub-family C member 9Add BLAST1546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P70170

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P70170

PRoteomics IDEntifications database

More...
PRIDEi
P70170

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P70170

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P70170

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoforms SUR2A and SUR2B are found in cerebellum, eye, atrium, ventricle, urinary bladder and skeletal muscle. Isoform SUR2B is also found in forebrain, liver, lung, pancreas, kidney, spleen, stomach, small intestine, colon, uterus, ovary and fat tissue. Isoform SUR2C is expressed exclusively in the heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030249 Expressed in 240 organ(s), highest expression level in aorta

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P70170 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P70170 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KCNJ11.

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-196 Inward rectifying potassium channel complex, Kir6.2-SUR2A [P70170-1]
CPX-198 Inward rectifying potassium channel complex, Kir6.2-SUR2B [P70170-2]

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P70170

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000084805

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P70170

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini297 – 595ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST299
Domaini669 – 909ABC transporter 1PROSITE-ProRule annotationAdd BLAST241
Domaini991 – 1271ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST281
Domaini1309 – 1543ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156680

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG101342

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P70170

KEGG Orthology (KO)

More...
KOi
K05033

Identification of Orthologs from Complete Genome Data

More...
OMAi
YAAQKSW

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00IN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P70170

TreeFam database of animal gene trees

More...
TreeFami
TF105201

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR001475 ABCC9
IPR027417 P-loop_NTPase
IPR000388 Sulphorea_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR24223:SF173 PTHR24223:SF173, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01094 SULFNYLUR2
PR01092 SULFNYLUREAR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform SUR2A (identifier: P70170-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLSFCGNNI SSYNIYYGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG
60 70 80 90 100
SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSHRASR
110 120 130 140 150
HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI
160 170 180 190 200
KLVKYWQLGW GVSDLRFCIT GVMVILNGLL MAVEINVIRV RRYVFFMNPQ
210 220 230 240 250
KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR KPIDLKAIGK
260 270 280 290 300
LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS
310 320 330 340 350
STFRYLADLL GFAGPLCISG IVQRVNEKTN TTREMFPETL SSKEFLENAH
360 370 380 390 400
VLAVLLFLAL ILQRTFLQAS YYVTIETGIN LRGALLAMIY NKILRLSTSN
410 420 430 440 450
LSMGEMTLGQ INNLVAIETN QLMWFLFLCP NLWAMPVQII MGVILLYNLL
460 470 480 490 500
GSSALVGAAV IVLLAPIQYF IATKLAEAQK STLDYSTERL KKTNEILKGI
510 520 530 540 550
KLLKLYAWEH IFCKSVEETR MKELSSLKTF ALYTSLSIFM NAAIPIAAVL
560 570 580 590 600
ATFVTHAYAS GNNLKPAEAF ASLSLFHILV TPLFLLSTVV RFAVKAIISV
610 620 630 640 650
QKLNEFLLSD EIGEDSWRAG EGTLPFESCK KHTGVQSKPI NRKQPGRYHL
660 670 680 690 700
DSYEQARRLR PAETEDIAIK VTNGYFSWGS GLATLSNIDI RIPTGQLTMI
710 720 730 740 750
VGQVGCGKSS LLLAILGEMQ TLEGKVYWNN VNESEPSFEA TRSRSRYSVA
760 770 780 790 800
YAAQKPWLLN ATVEENITFG SPFNRQRYKA VTDACSLQPD IDLLPFGDQT
810 820 830 840 850
EIGERGINLS GGQRQRICVA RALYQNTNIV FLDDPFSALD IHLSDHLMQE
860 870 880 890 900
GILKFLQDDK RTVVLVTHKL QYLTHADWII AMKDGSVLRE GTLKDIQTKD
910 920 930 940 950
VELYEHWKTL MNRQDQELEK DMEADQTTLE RKTLRRAMYS REAKAQMEDE
960 970 980 990 1000
DEEEEEEEDE EDNMSTVMRL RTKMPWKTCW WYLTSGGFFL LFLMIFSKLL
1010 1020 1030 1040 1050
KHSVIVAIDY WLATWTSEYS INHPGKADQT FYVAGFSILC GAGIFLCLVT
1060 1070 1080 1090 1100
SLTVEWMGLT AAKNLHHNLL NKIILGPIRF FDTTPLGLIL NRFSADTNII
1110 1120 1130 1140 1150
DQHIPPTLES LTRSTLLCLS AIGMISYATP VFLVALAPLG VAFYFIQKYF
1160 1170 1180 1190 1200
RVASKDLQEL DDSTQLPLLC HFSETAEGLT TIRAFRHETR FKQRMLELTD
1210 1220 1230 1240 1250
TNNIAYLFLS AANRWLEVRT DYLGACIVLT ASIASISGSS NSGLVGLGLL
1260 1270 1280 1290 1300
YALTITNYLN WVVRNLADLE VQMGAVKKVN SFLTMESENY EGTMDPSQVP
1310 1320 1330 1340 1350
EHWPQEGEIK IHDLCVRYEN NLKPVLKHVK AYIKPGQKVG ICGRTGSGKS
1360 1370 1380 1390 1400
SLSLAFFRMV DIFDGKIVID GIDISKLPLH TLRSRLSIIL QDPILFSGSI
1410 1420 1430 1440 1450
RFNLDPECKC TDDRLWEALE IAQLKNMVKS LPGGLDATVT EGGENFSVGQ
1460 1470 1480 1490 1500
RQLFCLARAF VRKSSILIMD EATASIDMAT ENILQKVVMT AFADRTVVTI
1510 1520 1530 1540
AHRVSSIVDA GLVLVFSEGI LVECDTGPNL LQHKNGLFST LVMTNK
Length:1,546
Mass (Da):174,239
Last modified:November 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91EEDFA2ECD9DBC2
GO
Isoform SUR2B (identifier: P70170-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1505-1546: SSIVDAGLVL...LFSTLVMTNK → HTILTADLVI...VFASFVRADM

Show »
Length:1,546
Mass (Da):174,458
Checksum:i17C23B6B8F739E7C
GO
Isoform SUR2C (identifier: P70170-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-670: Missing.

Show »
Length:1,511
Mass (Da):170,091
Checksum:iFFA9A2736D51F190
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PUE8E9PUE8_MOUSE
ATP-binding cassette sub-family C m...
Abcc9
1,533Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SWE6A0A0N4SWE6_MOUSE
ATP-binding cassette sub-family C m...
Abcc9
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000059636 – 670Missing in isoform SUR2C. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_0000601505 – 1546SSIVD…VMTNK → HTILTADLVIVMKRGNILEY DTPESLLAQEDGVFASFVRA DM in isoform SUR2B. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D86037 mRNA Translation: BAA12969.2
D86038 mRNA Translation: BAA12970.2
AF003531 mRNA Translation: AAB58753.1
U97066 mRNA Translation: AAB58701.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39696.1 [P70170-2]
CCDS39697.1 [P70170-3]
CCDS39699.1 [P70170-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T42711
T42728

NCBI Reference Sequences

More...
RefSeqi
NP_001038185.1, NM_001044720.1
NP_035641.1, NM_011511.2 [P70170-2]
NP_066378.1, NM_021041.2 [P70170-1]
NP_066379.2, NM_021042.2 [P70170-3]
XP_006507011.1, XM_006506948.3 [P70170-2]
XP_006507012.1, XM_006506949.3 [P70170-2]
XP_006507013.1, XM_006506950.3 [P70170-2]
XP_006507014.1, XM_006506951.3 [P70170-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.35670
Mm.395475

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000073173; ENSMUSP00000072914; ENSMUSG00000030249 [P70170-3]
ENSMUST00000087527; ENSMUSP00000084805; ENSMUSG00000030249 [P70170-1]
ENSMUST00000100827; ENSMUSP00000098390; ENSMUSG00000030249 [P70170-2]
ENSMUST00000205202; ENSMUSP00000144779; ENSMUSG00000030249 [P70170-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20928

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20928

UCSC genome browser

More...
UCSCi
uc009epm.1 mouse [P70170-1]
uc009epo.1 mouse [P70170-3]
uc009epp.1 mouse [P70170-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86037 mRNA Translation: BAA12969.2
D86038 mRNA Translation: BAA12970.2
AF003531 mRNA Translation: AAB58753.1
U97066 mRNA Translation: AAB58701.1
CCDSiCCDS39696.1 [P70170-2]
CCDS39697.1 [P70170-3]
CCDS39699.1 [P70170-1]
PIRiT42711
T42728
RefSeqiNP_001038185.1, NM_001044720.1
NP_035641.1, NM_011511.2 [P70170-2]
NP_066378.1, NM_021041.2 [P70170-1]
NP_066379.2, NM_021042.2 [P70170-3]
XP_006507011.1, XM_006506948.3 [P70170-2]
XP_006507012.1, XM_006506949.3 [P70170-2]
XP_006507013.1, XM_006506950.3 [P70170-2]
XP_006507014.1, XM_006506951.3 [P70170-2]
UniGeneiMm.35670
Mm.395475

3D structure databases

ProteinModelPortaliP70170
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-196 Inward rectifying potassium channel complex, Kir6.2-SUR2A [P70170-1]
CPX-198 Inward rectifying potassium channel complex, Kir6.2-SUR2B [P70170-2]
CORUMiP70170
STRINGi10090.ENSMUSP00000084805

PTM databases

iPTMnetiP70170
PhosphoSitePlusiP70170

Proteomic databases

MaxQBiP70170
PaxDbiP70170
PRIDEiP70170

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073173; ENSMUSP00000072914; ENSMUSG00000030249 [P70170-3]
ENSMUST00000087527; ENSMUSP00000084805; ENSMUSG00000030249 [P70170-1]
ENSMUST00000100827; ENSMUSP00000098390; ENSMUSG00000030249 [P70170-2]
ENSMUST00000205202; ENSMUSP00000144779; ENSMUSG00000030249 [P70170-3]
GeneIDi20928
KEGGimmu:20928
UCSCiuc009epm.1 mouse [P70170-1]
uc009epo.1 mouse [P70170-3]
uc009epp.1 mouse [P70170-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10060
MGIiMGI:1352630 Abcc9

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000156680
HOVERGENiHBG101342
InParanoidiP70170
KOiK05033
OMAiYAAQKSW
OrthoDBiEOG091G00IN
PhylomeDBiP70170
TreeFamiTF105201

Enzyme and pathway databases

ReactomeiR-MMU-1296025 ATP sensitive Potassium channels
R-MMU-382556 ABC-family proteins mediated transport
R-MMU-5578775 Ion homeostasis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P70170

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030249 Expressed in 240 organ(s), highest expression level in aorta
ExpressionAtlasiP70170 baseline and differential
GenevisibleiP70170 MM

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR001475 ABCC9
IPR027417 P-loop_NTPase
IPR000388 Sulphorea_rcpt
PANTHERiPTHR24223:SF173 PTHR24223:SF173, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PRINTSiPR01094 SULFNYLUR2
PR01092 SULFNYLUREAR
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCC9_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70170
Secondary accession number(s): O08902, O08920, P70171
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: December 5, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again