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UniProtKB - P70170 (ABCC9_MOUSE)

Entry version 173 (02 Dec 2020)
Sequence version 2 (01 Nov 1999)
Previous versions | rss
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Protein

ATP-binding cassette sub-family C member 9

Gene

Abcc9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi702 – 709ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1343 – 1350ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-1296025, ATP sensitive Potassium channels
R-MMU-382556, ABC-family proteins mediated transport
R-MMU-5578775, Ion homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family C member 9
Alternative name(s):
Sulfonylurea receptor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abcc9
Synonyms:Sur2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1352630, Abcc9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 51Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini52 – 72CytoplasmicSequence analysisAdd BLAST21
Transmembranei73 – 93Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini94 – 101ExtracellularSequence analysis8
Transmembranei102 – 122Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini123 – 132CytoplasmicSequence analysis10
Transmembranei133 – 153Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini154 – 167ExtracellularSequence analysisAdd BLAST14
Transmembranei168 – 188Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini189 – 301CytoplasmicSequence analysisAdd BLAST113
Transmembranei302 – 322Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini323 – 348ExtracellularSequence analysisAdd BLAST26
Transmembranei349 – 369Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini370 – 421CytoplasmicSequence analysisAdd BLAST52
Transmembranei422 – 442Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini443 – 453ExtracellularSequence analysisAdd BLAST11
Transmembranei454 – 474Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini475 – 529CytoplasmicSequence analysisAdd BLAST55
Transmembranei530 – 550Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini551 – 569ExtracellularSequence analysisAdd BLAST19
Transmembranei570 – 590Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini591 – 987CytoplasmicSequence analysisAdd BLAST397
Transmembranei988 – 1008Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini1009 – 1031ExtracellularSequence analysisAdd BLAST23
Transmembranei1032 – 1052Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1053 – 1124CytoplasmicSequence analysisAdd BLAST72
Transmembranei1125 – 1145Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1146 – 1242ExtracellularSequence analysisAdd BLAST97
Transmembranei1243 – 1263Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1264 – 1546CytoplasmicSequence analysisAdd BLAST283

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000934031 – 1546ATP-binding cassette sub-family C member 9Add BLAST1546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P70170

MaxQB - The MaxQuant DataBase

More...MaxQBi		P70170

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P70170

PRoteomics IDEntifications database

More...PRIDEi		P70170

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P70170, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P70170

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P70170

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoforms SUR2A and SUR2B are found in cerebellum, eye, atrium, ventricle, urinary bladder and skeletal muscle. Isoform SUR2B is also found in forebrain, liver, lung, pancreas, kidney, spleen, stomach, small intestine, colon, uterus, ovary and fat tissue. Isoform SUR2C is expressed exclusively in the heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000030249, Expressed in aorta and 255 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P70170, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P70170, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KCNJ11.

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		203578, 4 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-196, Inward rectifying potassium channel complex, Kir6.2-SUR2A [P70170-1]
CPX-198, Inward rectifying potassium channel complex, Kir6.2-SUR2B [P70170-2]

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P70170

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000084805

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P70170, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P70170

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini297 – 595ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST299
Domaini669 – 909ABC transporter 1PROSITE-ProRule annotationAdd BLAST241
Domaini991 – 1271ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST281
Domaini1309 – 1543ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0054, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156680

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000604_27_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P70170

Identification of Orthologs from Complete Genome Data

More...OMAi		CWCYLSS

Database of Orthologous Groups

More...OrthoDBi		138195at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P70170

TreeFam database of animal gene trees

More...TreeFami		TF105201

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR001475, ABCC9
IPR027417, P-loop_NTPase
IPR000388, Sulphorea_rcpt

The PANTHER Classification System

More...PANTHERi		PTHR24223:SF173, PTHR24223:SF173, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01094, SULFNYLUR2
PR01092, SULFNYLUREAR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform SUR2A (identifier: P70170-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLSFCGNNI SSYNIYYGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG 
        60         70         80         90        100
SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSHRASR 
       110        120        130        140        150
HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI 
       160        170        180        190        200
KLVKYWQLGW GVSDLRFCIT GVMVILNGLL MAVEINVIRV RRYVFFMNPQ 
       210        220        230        240        250
KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR KPIDLKAIGK 
       260        270        280        290        300
LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS 
       310        320        330        340        350
STFRYLADLL GFAGPLCISG IVQRVNEKTN TTREMFPETL SSKEFLENAH 
       360        370        380        390        400
VLAVLLFLAL ILQRTFLQAS YYVTIETGIN LRGALLAMIY NKILRLSTSN 
       410        420        430        440        450
LSMGEMTLGQ INNLVAIETN QLMWFLFLCP NLWAMPVQII MGVILLYNLL 
       460        470        480        490        500
GSSALVGAAV IVLLAPIQYF IATKLAEAQK STLDYSTERL KKTNEILKGI 
       510        520        530        540        550
KLLKLYAWEH IFCKSVEETR MKELSSLKTF ALYTSLSIFM NAAIPIAAVL 
       560        570        580        590        600
ATFVTHAYAS GNNLKPAEAF ASLSLFHILV TPLFLLSTVV RFAVKAIISV 
       610        620        630        640        650
QKLNEFLLSD EIGEDSWRAG EGTLPFESCK KHTGVQSKPI NRKQPGRYHL 
       660        670        680        690        700
DSYEQARRLR PAETEDIAIK VTNGYFSWGS GLATLSNIDI RIPTGQLTMI 
       710        720        730        740        750
VGQVGCGKSS LLLAILGEMQ TLEGKVYWNN VNESEPSFEA TRSRSRYSVA 
       760        770        780        790        800
YAAQKPWLLN ATVEENITFG SPFNRQRYKA VTDACSLQPD IDLLPFGDQT 
       810        820        830        840        850
EIGERGINLS GGQRQRICVA RALYQNTNIV FLDDPFSALD IHLSDHLMQE 
       860        870        880        890        900
GILKFLQDDK RTVVLVTHKL QYLTHADWII AMKDGSVLRE GTLKDIQTKD 
       910        920        930        940        950
VELYEHWKTL MNRQDQELEK DMEADQTTLE RKTLRRAMYS REAKAQMEDE 
       960        970        980        990       1000
DEEEEEEEDE EDNMSTVMRL RTKMPWKTCW WYLTSGGFFL LFLMIFSKLL 
      1010       1020       1030       1040       1050
KHSVIVAIDY WLATWTSEYS INHPGKADQT FYVAGFSILC GAGIFLCLVT 
      1060       1070       1080       1090       1100
SLTVEWMGLT AAKNLHHNLL NKIILGPIRF FDTTPLGLIL NRFSADTNII 
      1110       1120       1130       1140       1150
DQHIPPTLES LTRSTLLCLS AIGMISYATP VFLVALAPLG VAFYFIQKYF 
      1160       1170       1180       1190       1200
RVASKDLQEL DDSTQLPLLC HFSETAEGLT TIRAFRHETR FKQRMLELTD 
      1210       1220       1230       1240       1250
TNNIAYLFLS AANRWLEVRT DYLGACIVLT ASIASISGSS NSGLVGLGLL 
      1260       1270       1280       1290       1300
YALTITNYLN WVVRNLADLE VQMGAVKKVN SFLTMESENY EGTMDPSQVP 
      1310       1320       1330       1340       1350
EHWPQEGEIK IHDLCVRYEN NLKPVLKHVK AYIKPGQKVG ICGRTGSGKS 
      1360       1370       1380       1390       1400
SLSLAFFRMV DIFDGKIVID GIDISKLPLH TLRSRLSIIL QDPILFSGSI 
      1410       1420       1430       1440       1450
RFNLDPECKC TDDRLWEALE IAQLKNMVKS LPGGLDATVT EGGENFSVGQ 
      1460       1470       1480       1490       1500
RQLFCLARAF VRKSSILIMD EATASIDMAT ENILQKVVMT AFADRTVVTI 
      1510       1520       1530       1540 
AHRVSSIVDA GLVLVFSEGI LVECDTGPNL LQHKNGLFST LVMTNK
Length:1,546
Mass (Da):174,239
Last modified:November 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91EEDFA2ECD9DBC2
GO
Isoform SUR2B (identifier: P70170-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1505-1546: SSIVDAGLVL...LFSTLVMTNK → HTILTADLVI...VFASFVRADM

Show »
Length:1,546
Mass (Da):174,458
Checksum:i17C23B6B8F739E7C
GO
Isoform SUR2C (identifier: P70170-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-670: Missing.

Show »
Length:1,511
Mass (Da):170,091
Checksum:iFFA9A2736D51F190
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PUE8E9PUE8_MOUSE
ATP-binding cassette sub-family C m...
Abcc9
1,533Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SWE6A0A0N4SWE6_MOUSE
ATP-binding cassette sub-family C m...
Abcc9
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000059636 – 670Missing in isoform SUR2C. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_0000601505 – 1546SSIVD…VMTNK → HTILTADLVIVMKRGNILEY DTPESLLAQEDGVFASFVRA DM in isoform SUR2B. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D86037 mRNA Translation: BAA12969.2
D86038 mRNA Translation: BAA12970.2
AF003531 mRNA Translation: AAB58753.1
U97066 mRNA Translation: AAB58701.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS39696.1 [P70170-2]
CCDS39697.1 [P70170-3]
CCDS39699.1 [P70170-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T42711
T42728

NCBI Reference Sequences

More...RefSeqi		NP_001038185.1, NM_001044720.1
NP_035641.1, NM_011511.2 [P70170-2]
NP_066378.1, NM_021041.2 [P70170-1]
NP_066379.2, NM_021042.2 [P70170-3]
XP_006507011.1, XM_006506948.3 [P70170-2]
XP_006507012.1, XM_006506949.3 [P70170-2]
XP_006507013.1, XM_006506950.3 [P70170-2]
XP_006507014.1, XM_006506951.3 [P70170-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000073173; ENSMUSP00000072914; ENSMUSG00000030249 [P70170-3]
ENSMUST00000087527; ENSMUSP00000084805; ENSMUSG00000030249 [P70170-1]
ENSMUST00000100827; ENSMUSP00000098390; ENSMUSG00000030249 [P70170-2]
ENSMUST00000205202; ENSMUSP00000144779; ENSMUSG00000030249 [P70170-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		20928

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:20928

UCSC genome browser

More...UCSCi		uc009epm.1, mouse [P70170-1]
uc009epo.1, mouse [P70170-3]
uc009epp.1, mouse [P70170-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86037 mRNA Translation: BAA12969.2
D86038 mRNA Translation: BAA12970.2
AF003531 mRNA Translation: AAB58753.1
U97066 mRNA Translation: AAB58701.1
CCDSiCCDS39696.1 [P70170-2]
CCDS39697.1 [P70170-3]
CCDS39699.1 [P70170-1]
PIRiT42711
T42728
RefSeqiNP_001038185.1, NM_001044720.1
NP_035641.1, NM_011511.2 [P70170-2]
NP_066378.1, NM_021041.2 [P70170-1]
NP_066379.2, NM_021042.2 [P70170-3]
XP_006507011.1, XM_006506948.3 [P70170-2]
XP_006507012.1, XM_006506949.3 [P70170-2]
XP_006507013.1, XM_006506950.3 [P70170-2]
XP_006507014.1, XM_006506951.3 [P70170-2]

3D structure databases

SMRiP70170
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi203578, 4 interactors
ComplexPortaliCPX-196, Inward rectifying potassium channel complex, Kir6.2-SUR2A [P70170-1]
CPX-198, Inward rectifying potassium channel complex, Kir6.2-SUR2B [P70170-2]
CORUMiP70170
STRINGi10090.ENSMUSP00000084805

PTM databases

GlyGeniP70170, 2 sites
iPTMnetiP70170
PhosphoSitePlusiP70170

Proteomic databases

jPOSTiP70170
MaxQBiP70170
PaxDbiP70170
PRIDEiP70170

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P70170, 5 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12381, 223 antibodies

Genome annotation databases

EnsembliENSMUST00000073173; ENSMUSP00000072914; ENSMUSG00000030249 [P70170-3]
ENSMUST00000087527; ENSMUSP00000084805; ENSMUSG00000030249 [P70170-1]
ENSMUST00000100827; ENSMUSP00000098390; ENSMUSG00000030249 [P70170-2]
ENSMUST00000205202; ENSMUSP00000144779; ENSMUSG00000030249 [P70170-3]
GeneIDi20928
KEGGimmu:20928
UCSCiuc009epm.1, mouse [P70170-1]
uc009epo.1, mouse [P70170-3]
uc009epp.1, mouse [P70170-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10060
MGIiMGI:1352630, Abcc9

Phylogenomic databases

eggNOGiKOG0054, Eukaryota
GeneTreeiENSGT00940000156680
HOGENOMiCLU_000604_27_4_1
InParanoidiP70170
OMAiCWCYLSS
OrthoDBi138195at2759
PhylomeDBiP70170
TreeFamiTF105201

Enzyme and pathway databases

ReactomeiR-MMU-1296025, ATP sensitive Potassium channels
R-MMU-382556, ABC-family proteins mediated transport
R-MMU-5578775, Ion homeostasis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		20928, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Abcc9, mouse

Protein Ontology

More...PROi		PR:P70170
RNActiP70170, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000030249, Expressed in aorta and 255 other tissues
ExpressionAtlasiP70170, baseline and differential
GenevisibleiP70170, MM

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR001475, ABCC9
IPR027417, P-loop_NTPase
IPR000388, Sulphorea_rcpt
PANTHERiPTHR24223:SF173, PTHR24223:SF173, 1 hit
PfamiView protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits
PRINTSiPR01094, SULFNYLUR2
PR01092, SULFNYLUREAR
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCC9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70170
Secondary accession number(s): O08902, O08920, P70171
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: December 2, 2020
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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