UniProtKB - P70170 (ABCC9_MOUSE)
ATP-binding cassette sub-family C member 9
Abcc9
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 702 – 709 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1343 – 1350 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: MGI
- ATPase-coupled cation transmembrane transporter activity Source: MGI
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: MGI
- ion channel binding Source: MGI
- potassium channel activity Source: Ensembl
- potassium channel regulator activity Source: MGI
- small molecule binding Source: MGI
- sulfonylurea receptor activity Source: MGI
- syntaxin binding Source: MGI
GO - Biological processi
- cardiac conduction Source: MGI
- cation transmembrane transport Source: MGI
- defense response to virus Source: MGI
- inorganic cation transmembrane transport Source: MGI
- potassium ion import across plasma membrane Source: MGI
- potassium ion transmembrane transport Source: MGI
- potassium ion transport Source: MGI
- response to ATP Source: MGI
- transmembrane transport Source: GO_Central
Keywordsi
Molecular function | Receptor |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-1296025, ATP sensitive Potassium channels R-MMU-382556, ABC-family proteins mediated transport R-MMU-5578775, Ion homeostasis |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-binding cassette sub-family C member 9Alternative name(s): Sulfonylurea receptor 2 |
Gene namesi | Name:Abcc9 Synonyms:Sur2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1352630, Abcc9 |
Subcellular locationi
Other locations
- Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation
Mitochondrion
- mitochondrion Source: MGI
Plasma Membrane
- inward rectifying potassium channel Source: MGI
- plasma membrane Source: MGI
- sarcolemma Source: MGI
- T-tubule Source: MGI
Other locations
- acrosomal vesicle Source: MGI
- membrane Source: GO_Central
- sarcomere Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 30 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 31 – 51 | Helical; Name=1PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 52 – 72 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 73 – 93 | Helical; Name=2PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 94 – 101 | ExtracellularSequence analysis | 8 | |
Transmembranei | 102 – 122 | Helical; Name=3PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 123 – 132 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 133 – 153 | Helical; Name=4PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 154 – 167 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 168 – 188 | Helical; Name=5PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 189 – 301 | CytoplasmicSequence analysisAdd BLAST | 113 | |
Transmembranei | 302 – 322 | Helical; Name=6PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 323 – 348 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 349 – 369 | Helical; Name=7PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 370 – 421 | CytoplasmicSequence analysisAdd BLAST | 52 | |
Transmembranei | 422 – 442 | Helical; Name=8PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 443 – 453 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 454 – 474 | Helical; Name=9PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 475 – 529 | CytoplasmicSequence analysisAdd BLAST | 55 | |
Transmembranei | 530 – 550 | Helical; Name=10PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 551 – 569 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 570 – 590 | Helical; Name=11PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 591 – 987 | CytoplasmicSequence analysisAdd BLAST | 397 | |
Transmembranei | 988 – 1008 | Helical; Name=12PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1009 – 1031 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 1032 – 1052 | Helical; Name=13PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1053 – 1124 | CytoplasmicSequence analysisAdd BLAST | 72 | |
Transmembranei | 1125 – 1145 | Helical; Name=14PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1146 – 1242 | ExtracellularSequence analysisAdd BLAST | 97 | |
Transmembranei | 1243 – 1263 | Helical; Name=15PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1264 – 1546 | CytoplasmicSequence analysisAdd BLAST | 283 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093403 | 1 – 1546 | ATP-binding cassette sub-family C member 9Add BLAST | 1546 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 9 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 330 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | P70170 |
MaxQBi | P70170 |
PaxDbi | P70170 |
PRIDEi | P70170 |
PTM databases
GlyGeni | P70170, 2 sites |
iPTMneti | P70170 |
PhosphoSitePlusi | P70170 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000030249, Expressed in aorta and 255 other tissues |
ExpressionAtlasi | P70170, baseline and differential |
Genevisiblei | P70170, MM |
Interactioni
Subunit structurei
Interacts with KCNJ11.
GO - Molecular functioni
- identical protein binding Source: MGI
- ion channel binding Source: MGI
- syntaxin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203578, 4 interactors |
ComplexPortali | CPX-196, Inward rectifying potassium channel complex, Kir6.2-SUR2A [P70170-1] CPX-198, Inward rectifying potassium channel complex, Kir6.2-SUR2B [P70170-2] |
CORUMi | P70170 |
STRINGi | 10090.ENSMUSP00000084805 |
Miscellaneous databases
RNActi | P70170, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 297 – 595 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 299 | |
Domaini | 669 – 909 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 241 | |
Domaini | 991 – 1271 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 281 | |
Domaini | 1309 – 1543 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 235 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0054, Eukaryota |
GeneTreei | ENSGT00940000156680 |
HOGENOMi | CLU_000604_27_4_1 |
InParanoidi | P70170 |
OMAi | CWCYLSS |
OrthoDBi | 138195at2759 |
PhylomeDBi | P70170 |
TreeFami | TF105201 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR001475, ABCC9 IPR027417, P-loop_NTPase IPR000388, Sulphorea_rcpt |
PANTHERi | PTHR24223:SF173, PTHR24223:SF173, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
PRINTSi | PR01094, SULFNYLUR2 PR01092, SULFNYLUREAR |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLSFCGNNI SSYNIYYGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG
60 70 80 90 100
SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSHRASR
110 120 130 140 150
HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI
160 170 180 190 200
KLVKYWQLGW GVSDLRFCIT GVMVILNGLL MAVEINVIRV RRYVFFMNPQ
210 220 230 240 250
KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR KPIDLKAIGK
260 270 280 290 300
LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS
310 320 330 340 350
STFRYLADLL GFAGPLCISG IVQRVNEKTN TTREMFPETL SSKEFLENAH
360 370 380 390 400
VLAVLLFLAL ILQRTFLQAS YYVTIETGIN LRGALLAMIY NKILRLSTSN
410 420 430 440 450
LSMGEMTLGQ INNLVAIETN QLMWFLFLCP NLWAMPVQII MGVILLYNLL
460 470 480 490 500
GSSALVGAAV IVLLAPIQYF IATKLAEAQK STLDYSTERL KKTNEILKGI
510 520 530 540 550
KLLKLYAWEH IFCKSVEETR MKELSSLKTF ALYTSLSIFM NAAIPIAAVL
560 570 580 590 600
ATFVTHAYAS GNNLKPAEAF ASLSLFHILV TPLFLLSTVV RFAVKAIISV
610 620 630 640 650
QKLNEFLLSD EIGEDSWRAG EGTLPFESCK KHTGVQSKPI NRKQPGRYHL
660 670 680 690 700
DSYEQARRLR PAETEDIAIK VTNGYFSWGS GLATLSNIDI RIPTGQLTMI
710 720 730 740 750
VGQVGCGKSS LLLAILGEMQ TLEGKVYWNN VNESEPSFEA TRSRSRYSVA
760 770 780 790 800
YAAQKPWLLN ATVEENITFG SPFNRQRYKA VTDACSLQPD IDLLPFGDQT
810 820 830 840 850
EIGERGINLS GGQRQRICVA RALYQNTNIV FLDDPFSALD IHLSDHLMQE
860 870 880 890 900
GILKFLQDDK RTVVLVTHKL QYLTHADWII AMKDGSVLRE GTLKDIQTKD
910 920 930 940 950
VELYEHWKTL MNRQDQELEK DMEADQTTLE RKTLRRAMYS REAKAQMEDE
960 970 980 990 1000
DEEEEEEEDE EDNMSTVMRL RTKMPWKTCW WYLTSGGFFL LFLMIFSKLL
1010 1020 1030 1040 1050
KHSVIVAIDY WLATWTSEYS INHPGKADQT FYVAGFSILC GAGIFLCLVT
1060 1070 1080 1090 1100
SLTVEWMGLT AAKNLHHNLL NKIILGPIRF FDTTPLGLIL NRFSADTNII
1110 1120 1130 1140 1150
DQHIPPTLES LTRSTLLCLS AIGMISYATP VFLVALAPLG VAFYFIQKYF
1160 1170 1180 1190 1200
RVASKDLQEL DDSTQLPLLC HFSETAEGLT TIRAFRHETR FKQRMLELTD
1210 1220 1230 1240 1250
TNNIAYLFLS AANRWLEVRT DYLGACIVLT ASIASISGSS NSGLVGLGLL
1260 1270 1280 1290 1300
YALTITNYLN WVVRNLADLE VQMGAVKKVN SFLTMESENY EGTMDPSQVP
1310 1320 1330 1340 1350
EHWPQEGEIK IHDLCVRYEN NLKPVLKHVK AYIKPGQKVG ICGRTGSGKS
1360 1370 1380 1390 1400
SLSLAFFRMV DIFDGKIVID GIDISKLPLH TLRSRLSIIL QDPILFSGSI
1410 1420 1430 1440 1450
RFNLDPECKC TDDRLWEALE IAQLKNMVKS LPGGLDATVT EGGENFSVGQ
1460 1470 1480 1490 1500
RQLFCLARAF VRKSSILIMD EATASIDMAT ENILQKVVMT AFADRTVVTI
1510 1520 1530 1540
AHRVSSIVDA GLVLVFSEGI LVECDTGPNL LQHKNGLFST LVMTNK
The sequence of this isoform differs from the canonical sequence as follows:
1505-1546: SSIVDAGLVL...LFSTLVMTNK → HTILTADLVI...VFASFVRADM
The sequence of this isoform differs from the canonical sequence as follows:
636-670: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PUE8 | E9PUE8_MOUSE | ATP-binding cassette sub-family C m... | Abcc9 | 1,533 | Annotation score: | ||
A0A0N4SWE6 | A0A0N4SWE6_MOUSE | ATP-binding cassette sub-family C m... | Abcc9 | 159 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000059 | 636 – 670 | Missing in isoform SUR2C. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_000060 | 1505 – 1546 | SSIVD…VMTNK → HTILTADLVIVMKRGNILEY DTPESLLAQEDGVFASFVRA DM in isoform SUR2B. 1 PublicationAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D86037 mRNA Translation: BAA12969.2 D86038 mRNA Translation: BAA12970.2 AF003531 mRNA Translation: AAB58753.1 U97066 mRNA Translation: AAB58701.1 |
CCDSi | CCDS39696.1 [P70170-2] CCDS39697.1 [P70170-3] CCDS39699.1 [P70170-1] |
PIRi | T42711 T42728 |
RefSeqi | NP_001038185.1, NM_001044720.1 NP_035641.1, NM_011511.2 [P70170-2] NP_066378.1, NM_021041.2 [P70170-1] NP_066379.2, NM_021042.2 [P70170-3] XP_006507011.1, XM_006506948.3 [P70170-2] XP_006507012.1, XM_006506949.3 [P70170-2] XP_006507013.1, XM_006506950.3 [P70170-2] XP_006507014.1, XM_006506951.3 [P70170-2] |
Genome annotation databases
Ensembli | ENSMUST00000073173; ENSMUSP00000072914; ENSMUSG00000030249 [P70170-3] ENSMUST00000087527; ENSMUSP00000084805; ENSMUSG00000030249 [P70170-1] ENSMUST00000100827; ENSMUSP00000098390; ENSMUSG00000030249 [P70170-2] ENSMUST00000205202; ENSMUSP00000144779; ENSMUSG00000030249 [P70170-3] |
GeneIDi | 20928 |
KEGGi | mmu:20928 |
UCSCi | uc009epm.1, mouse [P70170-1] uc009epo.1, mouse [P70170-3] uc009epp.1, mouse [P70170-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D86037 mRNA Translation: BAA12969.2 D86038 mRNA Translation: BAA12970.2 AF003531 mRNA Translation: AAB58753.1 U97066 mRNA Translation: AAB58701.1 |
CCDSi | CCDS39696.1 [P70170-2] CCDS39697.1 [P70170-3] CCDS39699.1 [P70170-1] |
PIRi | T42711 T42728 |
RefSeqi | NP_001038185.1, NM_001044720.1 NP_035641.1, NM_011511.2 [P70170-2] NP_066378.1, NM_021041.2 [P70170-1] NP_066379.2, NM_021042.2 [P70170-3] XP_006507011.1, XM_006506948.3 [P70170-2] XP_006507012.1, XM_006506949.3 [P70170-2] XP_006507013.1, XM_006506950.3 [P70170-2] XP_006507014.1, XM_006506951.3 [P70170-2] |
3D structure databases
SMRi | P70170 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203578, 4 interactors |
ComplexPortali | CPX-196, Inward rectifying potassium channel complex, Kir6.2-SUR2A [P70170-1] CPX-198, Inward rectifying potassium channel complex, Kir6.2-SUR2B [P70170-2] |
CORUMi | P70170 |
STRINGi | 10090.ENSMUSP00000084805 |
PTM databases
GlyGeni | P70170, 2 sites |
iPTMneti | P70170 |
PhosphoSitePlusi | P70170 |
Proteomic databases
jPOSTi | P70170 |
MaxQBi | P70170 |
PaxDbi | P70170 |
PRIDEi | P70170 |
Protocols and materials databases
ABCDi | P70170, 5 sequenced antibodies |
Antibodypediai | 12381, 223 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000073173; ENSMUSP00000072914; ENSMUSG00000030249 [P70170-3] ENSMUST00000087527; ENSMUSP00000084805; ENSMUSG00000030249 [P70170-1] ENSMUST00000100827; ENSMUSP00000098390; ENSMUSG00000030249 [P70170-2] ENSMUST00000205202; ENSMUSP00000144779; ENSMUSG00000030249 [P70170-3] |
GeneIDi | 20928 |
KEGGi | mmu:20928 |
UCSCi | uc009epm.1, mouse [P70170-1] uc009epo.1, mouse [P70170-3] uc009epp.1, mouse [P70170-2] |
Organism-specific databases
CTDi | 10060 |
MGIi | MGI:1352630, Abcc9 |
Phylogenomic databases
eggNOGi | KOG0054, Eukaryota |
GeneTreei | ENSGT00940000156680 |
HOGENOMi | CLU_000604_27_4_1 |
InParanoidi | P70170 |
OMAi | CWCYLSS |
OrthoDBi | 138195at2759 |
PhylomeDBi | P70170 |
TreeFami | TF105201 |
Enzyme and pathway databases
Reactomei | R-MMU-1296025, ATP sensitive Potassium channels R-MMU-382556, ABC-family proteins mediated transport R-MMU-5578775, Ion homeostasis |
Miscellaneous databases
BioGRID-ORCSi | 20928, 0 hits in 17 CRISPR screens |
ChiTaRSi | Abcc9, mouse |
PROi | PR:P70170 |
RNActi | P70170, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030249, Expressed in aorta and 255 other tissues |
ExpressionAtlasi | P70170, baseline and differential |
Genevisiblei | P70170, MM |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR001475, ABCC9 IPR027417, P-loop_NTPase IPR000388, Sulphorea_rcpt |
PANTHERi | PTHR24223:SF173, PTHR24223:SF173, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
PRINTSi | PR01094, SULFNYLUR2 PR01092, SULFNYLUREAR |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ABCC9_MOUSE | |
Accessioni | P70170Primary (citable) accession number: P70170 Secondary accession number(s): O08902, O08920, P70171 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families