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Entry version 119 (18 Sep 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Acid sphingomyelinase-like phosphodiesterase 3a

Gene

Smpdl3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:26792860). Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity (By similarity).By similarity1 Publication

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+1 PublicationNote: Binds 2 Zn2+ per subunit.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Requires micromolar levels of Zn2+ for activity. Inhibited by millimolar levels of Zn2+.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=107 µM for ATP at pH 51 Publication
  2. KM=330 µM for ATP at pH 7.51 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi42Zinc 11 Publication1
    Metal bindingi44Zinc 11 Publication1
    Metal bindingi107Zinc 11 Publication1
    Metal bindingi107Zinc 21 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei111Substrate1 Publication1
    Metal bindingi148Zinc 21 Publication1
    Binding sitei148Substrate1 Publication1
    Binding sitei149Substrate1 Publication1
    Metal bindingi249Zinc 21 Publication1
    Binding sitei257Substrate1 Publication1
    Metal bindingi290Zinc 21 Publication1
    Metal bindingi292Zinc 11 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P70158

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Acid sphingomyelinase-like phosphodiesterase 3a (EC:3.1.4.-1 Publication)
    Short name:
    ASM-like phosphodiesterase 3a
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Smpdl3a
    Synonyms:Asml3a
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:1931437 Smpdl3a

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi111H → A or Q: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi149H → A: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi149H → Q: Nearly abolishes enzyme activity. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000232923 – 445Acid sphingomyelinase-like phosphodiesterase 3aAdd BLAST423

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi59 ↔ 781 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1 Publication1
    Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1 Publication1
    Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi235N-linked (GlcNAc...) asparagineSequence analysis1 Publication1
    Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1 Publication1
    Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1 Publication1
    Disulfide bondi417 ↔ 421Sequence analysis
    Disulfide bondi427 ↔ 4401 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P70158

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P70158

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P70158

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P70158

    PeptideAtlas

    More...
    PeptideAtlasi
    P70158

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P70158

    PTM databases

    GlyConnect protein glycosylation platform

    More...
    GlyConnecti
    2103

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P70158

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P70158

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in blood serum (at protein level).1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000019872 Expressed in 286 organ(s), highest expression level in proximal tubule

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P70158 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P70158 MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    P70158, 2 interactors

    Molecular INTeraction database

    More...
    MINTi
    P70158

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000020022

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1445
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P70158

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the acid sphingomyelinase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410KDJ7 Eukaryota
    ENOG410XRWF LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00950000183182

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000294197

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P70158

    KEGG Orthology (KO)

    More...
    KOi
    K01128

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    KYYNYYF

    Database of Orthologous Groups

    More...
    OrthoDBi
    1142100at2759

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313674

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00842 MPP_ASMase, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.60.21.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR017064 ASM-like_Pdiesterase_prd
    IPR041805 ASMase/PPN1_MPP
    IPR004843 Calcineurin-like_PHP_ApaH
    IPR029052 Metallo-depent_PP-like

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00149 Metallophos, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF036767 ASM-like_PDE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    P70158-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MALLGNFLCC LLVAWLCGPG LGVPLAPADR APAVGQFWHV TDLHLDPTYH
    60 70 80 90 100
    ITDDRTKVCA SSKGANASNP GPFGDVLCDS PYQLILSAFD FIKNSGQEAS
    110 120 130 140 150
    FMIWTGDSPP HVPVPELSTG TVIKVITNMT MTVQNLFPNL QVFPALGNHD
    160 170 180 190 200
    YWPQDQLPIV TSKVYSAVAD LWKPWLGEEA ISTLKKGGFY SQKVASNPGL
    210 220 230 240 250
    RIISLNTNLY YGPNIMTLNK TDPANQFEWL ENTLNSSLWN KEKVYIIAHV
    260 270 280 290 300
    PVGYLPYATD TPAIRQYYNE KLLDIFRRYS SVIAGQFYGH THRDSLMVLS
    310 320 330 340 350
    DKNGNPLNSV FVAPAVTPVK GVLQKETNNP GVRLFQYKPG DYTLLDMVQY
    360 370 380 390 400
    YLNLTEANLK GESNWTLEYV LTQAYSVADL QPKSLYALVQ QFATKDSKQF
    410 420 430 440
    LKYYHYYFVS YDSSATCDQH CKTLQVCAIM NLDSMSYDDC LKQHL
    Length:445
    Mass (Da):49,858
    Last modified:July 27, 2011 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20D986E3463CB720
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    D3Z1B4D3Z1B4_MOUSE
    Acid sphingomyelinase-like phosphod...
    Smpdl3a
    104Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    Y08135 mRNA Translation: CAA69329.1
    AK151683 mRNA Translation: BAE30607.1
    AK152282 mRNA Translation: BAE31096.1
    CH466540 Genomic DNA Translation: EDL05124.1
    BC139288 mRNA Translation: AAI39289.1
    BC139289 mRNA Translation: AAI39290.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS23857.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_065586.3, NM_020561.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000020022; ENSMUSP00000020022; ENSMUSG00000019872

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    57319

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:57319

    UCSC genome browser

    More...
    UCSCi
    uc007fcu.1 mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    Y08135 mRNA Translation: CAA69329.1
    AK151683 mRNA Translation: BAE30607.1
    AK152282 mRNA Translation: BAE31096.1
    CH466540 Genomic DNA Translation: EDL05124.1
    BC139288 mRNA Translation: AAI39289.1
    BC139289 mRNA Translation: AAI39290.1
    CCDSiCCDS23857.1
    RefSeqiNP_065586.3, NM_020561.2

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    5FC1X-ray1.39A23-445[»]
    5FC5X-ray1.68A23-445[»]
    5FC6X-ray1.66A23-445[»]
    5FC7X-ray1.46A23-445[»]
    5FCAX-ray1.92A/B23-445[»]
    5FCBX-ray1.55A23-445[»]
    SMRiP70158
    ModBaseiSearch...

    Protein-protein interaction databases

    IntActiP70158, 2 interactors
    MINTiP70158
    STRINGi10090.ENSMUSP00000020022

    PTM databases

    GlyConnecti2103
    iPTMnetiP70158
    PhosphoSitePlusiP70158

    Proteomic databases

    EPDiP70158
    jPOSTiP70158
    MaxQBiP70158
    PaxDbiP70158
    PeptideAtlasiP70158
    PRIDEiP70158

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMUST00000020022; ENSMUSP00000020022; ENSMUSG00000019872
    GeneIDi57319
    KEGGimmu:57319
    UCSCiuc007fcu.1 mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    10924
    MGIiMGI:1931437 Smpdl3a

    Phylogenomic databases

    eggNOGiENOG410KDJ7 Eukaryota
    ENOG410XRWF LUCA
    GeneTreeiENSGT00950000183182
    HOGENOMiHOG000294197
    InParanoidiP70158
    KOiK01128
    OMAiKYYNYYF
    OrthoDBi1142100at2759
    TreeFamiTF313674

    Enzyme and pathway databases

    SABIO-RKiP70158

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    Smpdl3a mouse

    Protein Ontology

    More...
    PROi
    PR:P70158

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000019872 Expressed in 286 organ(s), highest expression level in proximal tubule
    ExpressionAtlasiP70158 baseline and differential
    GenevisibleiP70158 MM

    Family and domain databases

    CDDicd00842 MPP_ASMase, 1 hit
    Gene3Di3.60.21.10, 1 hit
    InterProiView protein in InterPro
    IPR017064 ASM-like_Pdiesterase_prd
    IPR041805 ASMase/PPN1_MPP
    IPR004843 Calcineurin-like_PHP_ApaH
    IPR029052 Metallo-depent_PP-like
    PfamiView protein in Pfam
    PF00149 Metallophos, 1 hit
    PIRSFiPIRSF036767 ASM-like_PDE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASM3A_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70158
    Secondary accession number(s): Q3U8C2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: July 27, 2011
    Last modified: September 18, 2019
    This is version 119 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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