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Protein

Serpin B5

Gene

Serpinb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei340 – 341Reactive bond homologBy similarity2

GO - Molecular functioni

GO - Biological processi

  • extracellular matrix organization Source: MGI
  • morphogenesis of an epithelium Source: MGI
  • prostate gland morphogenesis Source: MGI
  • regulation of epithelial cell proliferation Source: MGI

Protein family/group databases

MEROPSiI04.980

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B5
Alternative name(s):
Maspin
Peptidase inhibitor 5
Short name:
PI-5
Gene namesi
Name:Serpinb5
Synonyms:Pi5, Spi5, Spi7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:109579 Serpinb5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000324871 – 375Serpin B5Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP70124
PaxDbiP70124
PeptideAtlasiP70124
PRIDEiP70124

PTM databases

iPTMnetiP70124
PhosphoSitePlusiP70124

Expressioni

Gene expression databases

BgeeiENSMUSG00000067006
ExpressionAtlasiP70124 baseline and differential
GenevisibleiP70124 MM

Interactioni

Subunit structurei

Interacts with IRF6.By similarity

Protein-protein interaction databases

BioGridi203447, 1 interactor
STRINGi10090.ENSMUSP00000083908

Structurei

3D structure databases

ProteinModelPortaliP70124
SMRiP70124
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiP70124
KOiK10139
OMAiIHRVCLE
OrthoDBiEOG091G0ION
PhylomeDBiP70124
TreeFamiTF352619

Family and domain databases

CDDicd02057 maspin_like, 1 hit
InterProiView protein in InterPro
IPR000240 Serpin_B9/Maspin
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
IPR033836 SERPINB5
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
PRINTSiPR00676 MASPIN
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

P70124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDALRLANSA FAVDLFKQLC ERDPAGNILF SPICLSTSLS LAQVGTKGDT
60 70 80 90 100
ANEIGQVLHF ENVKDVPFGF QTVTSDVNKL SSFYSLKLVK RLYIDKSLNP
110 120 130 140 150
STEFISSTKR PYAKELETVD FKDKLEETKG QINSSIKELT DGHFEDILSE
160 170 180 190 200
NSISDQTKIL VVNAAYFVGK WMKKFPESET KECPFRISKT DTKPVQMMNL
210 220 230 240 250
EATFCLGNID DISCKIIELP FQNKHLSMLI VLPKDVEDES TGLEKIEQQL
260 270 280 290 300
NPETLLQWTN PSTMANAKVK LSLPKFKVEK MIDPKASLES LGLKSLFNES
310 320 330 340 350
TSDFSGMSET KGVSLSNVIH RVCLEITEDG GESIEVPGSR ILQHKDEFNA
360 370
DHPFIYIIRH NKTRNIIFFG KFCSP
Length:375
Mass (Da):42,111
Last modified:February 1, 1997 - v1
Checksum:i5894DD8B9A76F9A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U54705 mRNA Translation: AAB06042.1
AK136532 mRNA Translation: BAE23032.1
AK145220 mRNA Translation: BAE26308.1
CH466520 Genomic DNA Translation: EDL39856.1
CH466520 Genomic DNA Translation: EDL39857.1
BC005434 mRNA Translation: AAH05434.1
CCDSiCCDS35684.1
RefSeqiNP_033283.1, NM_009257.3
UniGeneiMm.268618

Genome annotation databases

EnsembliENSMUST00000086701; ENSMUSP00000083908; ENSMUSG00000067006
ENSMUST00000112729; ENSMUSP00000108349; ENSMUSG00000067006
ENSMUST00000112730; ENSMUSP00000108350; ENSMUSG00000067006
GeneIDi20724
KEGGimmu:20724
UCSCiuc007cha.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSPB5_MOUSE
AccessioniPrimary (citable) accession number: P70124
Secondary accession number(s): Q3ULZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: February 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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