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Protein

Ribosome maturation protein SBDS

Gene

Sbds

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome maturation protein SBDS
Alternative name(s):
Protein 22A3
Shwachman-Bodian-Diamond syndrome protein homolog
Gene namesi
Name:Sbds
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1913961 Sbds

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality. Embryos cease to develop prior to 6.5 dpc. Reduced assembly of 60S ribosomes and accumulation of halfmer ribosomes.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001237632 – 250Ribosome maturation protein SBDSAdd BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei238PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP70122
MaxQBiP70122
PaxDbiP70122
PeptideAtlasiP70122
PRIDEiP70122

PTM databases

iPTMnetiP70122
PhosphoSitePlusiP70122

Expressioni

Tissue specificityi

Detected in adult liver, brain, heart, spleen, pancreas, kidney, lung and testis (at protein level). Detected in heart, brain, lung, liver, kidney and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000025337 Expressed in 289 organ(s), highest expression level in brain
CleanExiMM_SBDS
ExpressionAtlasiP70122 baseline and differential
GenevisibleiP70122 MM

Interactioni

Subunit structurei

Associates with the 60S ribosomal subunit. Interacts with NPM1, RPA1 and PRKDC. May interact with NIP7. Found in a complex consisting of the 60S ribosomal subunit, SBDS and EFL1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211663, 2 interactors
IntActiP70122, 2 interactors
MINTiP70122
STRINGi10090.ENSMUSP00000026387

Structurei

3D structure databases

ProteinModelPortaliP70122
SMRiP70122
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SDO1/SBDS family.Curated

Phylogenomic databases

eggNOGiKOG2917 Eukaryota
COG1500 LUCA
GeneTreeiENSGT00390000008135
HOGENOMiHOG000216685
HOVERGENiHBG039762
InParanoidiP70122
KOiK14574
OMAiAVNPQMD
OrthoDBiEOG091G0GOU
PhylomeDBiP70122
TreeFamiTF300881

Family and domain databases

Gene3Di1.10.10.900, 1 hit
3.30.1250.10, 1 hit
InterProiView protein in InterPro
IPR018978 Ribosome_mat_SBDS_C
IPR018023 Ribosome_mat_SBDS_CS
IPR019783 Ribosome_mat_SBDS_N
IPR036786 Ribosome_mat_SBDS_N_sf
IPR002140 Sdo1/SBDS
IPR039100 Sdo1/SBDS-like
IPR037188 Sdo1/SBDS_central_sf
PANTHERiPTHR10927 PTHR10927, 1 hit
PfamiView protein in Pfam
PF01172 SBDS, 1 hit
PF09377 SBDS_C, 1 hit
SUPFAMiSSF109728 SSF109728, 1 hit
SSF89895 SSF89895, 1 hit
TIGRFAMsiTIGR00291 RNA_SBDS, 1 hit
PROSITEiView protein in PROSITE
PS01267 UPF0023, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P70122-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIFTPTNQI RLTNVAVVRM KRGGKRFEIA CYKNKVVGWR SGVEKDLDEV
60 70 80 90 100
LQTHSVFVNV SKGQVAKKED LISAFGTDDQ TEICKQILTK GEVQVSDKER
110 120 130 140 150
HTQLEQMFRD IATIVADKCV NPETKRPYTV ILIERAMKDI HYSVKPNKST
160 170 180 190 200
KQQALEVIKQ LKEKMKIERA HMRLRFILPV NEGKKLKEKL KPLMKVVESE
210 220 230 240 250
DYSQQLEIVC LIDPGCFREI DELIKKETKG RGSLEVLSLK DVEEGDEKFE
Length:250
Mass (Da):28,781
Last modified:January 23, 2007 - v4
Checksum:i3137CA2807DD250A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TN03F6TN03_MOUSE
Ribosome maturation protein SBDS
Sbds
173Annotation score:
D6REV5D6REV5_MOUSE
Ribosome maturation protein SBDS
Sbds
43Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005079 mRNA Translation: BAB23803.1
AK014648 mRNA Translation: BAB29487.1
AK019228 mRNA Translation: BAB31612.1
AK168847 mRNA Translation: BAE40670.1
BC003849 mRNA Translation: AAH03849.1
X99668 mRNA Translation: CAA67982.1 Sequence problems.
CCDSiCCDS19710.1
RefSeqiNP_075737.1, NM_023248.2
UniGeneiMm.280484

Genome annotation databases

EnsembliENSMUST00000026387; ENSMUSP00000026387; ENSMUSG00000025337
GeneIDi66711
KEGGimmu:66711
UCSCiuc008zuj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005079 mRNA Translation: BAB23803.1
AK014648 mRNA Translation: BAB29487.1
AK019228 mRNA Translation: BAB31612.1
AK168847 mRNA Translation: BAE40670.1
BC003849 mRNA Translation: AAH03849.1
X99668 mRNA Translation: CAA67982.1 Sequence problems.
CCDSiCCDS19710.1
RefSeqiNP_075737.1, NM_023248.2
UniGeneiMm.280484

3D structure databases

ProteinModelPortaliP70122
SMRiP70122
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211663, 2 interactors
IntActiP70122, 2 interactors
MINTiP70122
STRINGi10090.ENSMUSP00000026387

PTM databases

iPTMnetiP70122
PhosphoSitePlusiP70122

Proteomic databases

EPDiP70122
MaxQBiP70122
PaxDbiP70122
PeptideAtlasiP70122
PRIDEiP70122

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026387; ENSMUSP00000026387; ENSMUSG00000025337
GeneIDi66711
KEGGimmu:66711
UCSCiuc008zuj.1 mouse

Organism-specific databases

CTDi51119
MGIiMGI:1913961 Sbds

Phylogenomic databases

eggNOGiKOG2917 Eukaryota
COG1500 LUCA
GeneTreeiENSGT00390000008135
HOGENOMiHOG000216685
HOVERGENiHBG039762
InParanoidiP70122
KOiK14574
OMAiAVNPQMD
OrthoDBiEOG091G0GOU
PhylomeDBiP70122
TreeFamiTF300881

Miscellaneous databases

PROiPR:P70122
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025337 Expressed in 289 organ(s), highest expression level in brain
CleanExiMM_SBDS
ExpressionAtlasiP70122 baseline and differential
GenevisibleiP70122 MM

Family and domain databases

Gene3Di1.10.10.900, 1 hit
3.30.1250.10, 1 hit
InterProiView protein in InterPro
IPR018978 Ribosome_mat_SBDS_C
IPR018023 Ribosome_mat_SBDS_CS
IPR019783 Ribosome_mat_SBDS_N
IPR036786 Ribosome_mat_SBDS_N_sf
IPR002140 Sdo1/SBDS
IPR039100 Sdo1/SBDS-like
IPR037188 Sdo1/SBDS_central_sf
PANTHERiPTHR10927 PTHR10927, 1 hit
PfamiView protein in Pfam
PF01172 SBDS, 1 hit
PF09377 SBDS_C, 1 hit
SUPFAMiSSF109728 SSF109728, 1 hit
SSF89895 SSF89895, 1 hit
TIGRFAMsiTIGR00291 RNA_SBDS, 1 hit
PROSITEiView protein in PROSITE
PS01267 UPF0023, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSBDS_MOUSE
AccessioniPrimary (citable) accession number: P70122
Secondary accession number(s): Q3TG78, Q9CR18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 136 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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