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Protein

Zinc fingers and homeoboxes protein 1

Gene

Zhx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 93C2H2-type 1PROSITE-ProRule annotationCuratedAdd BLAST24
Zinc fingeri102 – 125C2H2-type 2PROSITE-ProRule annotationCuratedAdd BLAST24
DNA bindingi284 – 346Homeobox 1PROSITE-ProRule annotationCuratedAdd BLAST63
DNA bindingi464 – 526Homeobox 2PROSITE-ProRule annotationCuratedAdd BLAST63
DNA bindingi569 – 630Homeobox 3PROSITE-ProRule annotationCuratedAdd BLAST62
DNA bindingi660 – 722Homeobox 4PROSITE-ProRule annotationCuratedAdd BLAST63
DNA bindingi777 – 832Homeobox 5PROSITE-ProRule annotationCuratedAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc fingers and homeoboxes protein 1
Gene namesi
Name:Zhx1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:109271 Zhx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493891 – 873Zinc fingers and homeoboxes protein 1Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphothreonineBy similarity1
Modified residuei45PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Cross-linki159Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei202PhosphoserineBy similarity1
Cross-linki441Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki485Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki629Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei648PhosphoserineCombined sources1
Modified residuei774PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP70121
MaxQBiP70121
PaxDbiP70121
PeptideAtlasiP70121
PRIDEiP70121

PTM databases

iPTMnetiP70121
PhosphoSitePlusiP70121

Expressioni

Tissue specificityi

Widely expressed with highest levels in brain.1 Publication

Inductioni

By interleukin-2.1 Publication

Gene expression databases

BgeeiENSMUSG00000022361 Expressed in 42 organ(s), highest expression level in thymus
CleanExiMM_ZHX1
ExpressionAtlasiP70121 baseline and differential
GenevisibleiP70121 MM

Interactioni

Subunit structurei

Forms homodimers. Heterodimer (via HD1 domain) with ZHX2 (via HD1 domain). Also forms a heterodimer with ZHX3 which is a prerequisite for repressor activity. Interacts with ATF7IP and NFYA. Interacts (via homeobox domains) with DNMT3B (via PWWP domain) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066201

Structurei

3D structure databases

ProteinModelPortaliP70121
SMRiP70121
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni272 – 564Required for interaction with NFYABy similarityAdd BLAST293
Regioni272 – 432Required for dimerizationBy similarityAdd BLAST161
Regioni734 – 768Required for nuclear localizationBy similarityAdd BLAST35
Regioni831 – 873Required for repressor activityBy similarityAdd BLAST43

Sequence similaritiesi

Belongs to the ZHX family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 93C2H2-type 1PROSITE-ProRule annotationCuratedAdd BLAST24
Zinc fingeri102 – 125C2H2-type 2PROSITE-ProRule annotationCuratedAdd BLAST24

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHET Eukaryota
ENOG410Z8A2 LUCA
GeneTreeiENSGT00530000063149
HOVERGENiHBG007920
InParanoidiP70121
OMAiKWYYYYQ
OrthoDBiEOG091G02WT
PhylomeDBiP70121
TreeFamiTF333363

Family and domain databases

CDDicd00086 homeodomain, 5 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR024578 Homez_homeobox_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00046 Homeobox, 4 hits
PF11569 Homez, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 5 hits
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF46689 SSF46689, 5 hits
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P70121-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRRKSTTP CMVLASEQDP DLELISDLDE GPPILTPVEN AKAESVSSDE
60 70 80 90 100
EVHGSVDSDN QQNKKVEGGY ECKYCTFQTP DLNMFTFHVD SEHPNVVLNS
110 120 130 140 150
SYVCVECNFL TKRYDALSEH NLKYHPGEEN FKLTMVKRNN QTIFEQTIND
160 170 180 190 200
LTFDGSFVKE ENTEQGESID VSSSGISISK TPIMKMMKNK VENKRITVHH
210 220 230 240 250
NSAEGTSEEK ENGVKASQEE NAESVSSSAL ESNTSTSTIN RVHPSPASTV
260 270 280 290 300
VTPTAVLPGL AQVITAVSAQ QNSNLLPKVL IPVNSIPTYN AALDNNPLLL
310 320 330 340 350
NTYNKFPYPT MSEITVLSAQ AKYTEEQIKI WFSAQRLKHG VSWTPEEVEE
360 370 380 390 400
ARRKQFNGTV HTVPQTITVI PTHISTGSNG LPSILQTCQI VGQPGLVLTQ
410 420 430 440 450
VAGTNTLPVT APIALTVAGV PNQTNVQKSQ VPAAQPATDT KPATAAVPSS
460 470 480 490 500
PSVRPEAALV NPDSFGIRAK KTKEQLAELK VSYLKNQFPH DSEIIRLMKI
510 520 530 540 550
TGLTKGEIKK WFSDTRYNQR NSKSNQCLHL NNDSSATIII DSSDETPEPP
560 570 580 590 600
AAAASQQKQS WNPFPDFAPQ KFKEKTAEQL RALQASFLNS SVLTDEEVNR
610 620 630 640 650
LRAQTKLTRR EIDAWFTEKN KTKALKDEKI EVDESNVGSS KEEPGESSPG
660 670 680 690 700
DETVAPKSGG TGKICKKTPE QLHMLKSAFV RTQWPSAEEY DKLAEESGLA
710 720 730 740 750
RTDIVSWFGD TRYAWKNGNL KWYYYYQSSN SSSLNGLSSL RRRGRGRPKG
760 770 780 790 800
RGRGRPRGRP RGGKRMNTWD RVPSLIKFKT GTAILKDYYL KHKFLNEQDL
810 820 830 840 850
DELVNRSHMG YEQVREWFAE RQRRSELGIE LFEENEEEDE VVDDQEEDEE
860 870
ETDDSDTWEP PRHVKRKLSK SDD
Length:873
Mass (Da):97,551
Last modified:February 16, 2004 - v2
Checksum:i98C5D5714D479364
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BK31H3BK31_MOUSE
Zinc fingers and homeoboxes protein...
Zhx1
623Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti375S → T (PubMed:8713137).Curated1
Sequence conflicti375S → T (PubMed:12527199).Curated1
Sequence conflicti388C → Y in BAC34629 (PubMed:16141072).Curated1
Sequence conflicti553A → R in CAA90905 (PubMed:8713137).Curated1
Sequence conflicti867 – 868KL → NV in CAA90905 (PubMed:8713137).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54200 mRNA Translation: CAA90905.1
AB078421 Genomic DNA Translation: BAC22110.1
AK051410 mRNA Translation: BAC34629.1
AK053191 mRNA Translation: BAC35306.1
BC054543 mRNA Translation: AAH54543.1
CCDSiCCDS27488.1
PIRiJC4863
RefSeqiNP_001035903.1, NM_001042438.2
NP_033598.2, NM_009572.4
UniGeneiMm.244931

Genome annotation databases

EnsembliENSMUST00000070143; ENSMUSP00000066201; ENSMUSG00000022361
ENSMUST00000110168; ENSMUSP00000105797; ENSMUSG00000022361
ENSMUST00000175805; ENSMUSP00000134844; ENSMUSG00000022361
ENSMUST00000229354; ENSMUSP00000155504; ENSMUSG00000116334
ENSMUST00000229420; ENSMUSP00000155709; ENSMUSG00000116334
ENSMUST00000229748; ENSMUSP00000154900; ENSMUSG00000116334
GeneIDi22770
KEGGimmu:22770
UCSCiuc007vtd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54200 mRNA Translation: CAA90905.1
AB078421 Genomic DNA Translation: BAC22110.1
AK051410 mRNA Translation: BAC34629.1
AK053191 mRNA Translation: BAC35306.1
BC054543 mRNA Translation: AAH54543.1
CCDSiCCDS27488.1
PIRiJC4863
RefSeqiNP_001035903.1, NM_001042438.2
NP_033598.2, NM_009572.4
UniGeneiMm.244931

3D structure databases

ProteinModelPortaliP70121
SMRiP70121
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066201

PTM databases

iPTMnetiP70121
PhosphoSitePlusiP70121

Proteomic databases

EPDiP70121
MaxQBiP70121
PaxDbiP70121
PeptideAtlasiP70121
PRIDEiP70121

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070143; ENSMUSP00000066201; ENSMUSG00000022361
ENSMUST00000110168; ENSMUSP00000105797; ENSMUSG00000022361
ENSMUST00000175805; ENSMUSP00000134844; ENSMUSG00000022361
ENSMUST00000229354; ENSMUSP00000155504; ENSMUSG00000116334
ENSMUST00000229420; ENSMUSP00000155709; ENSMUSG00000116334
ENSMUST00000229748; ENSMUSP00000154900; ENSMUSG00000116334
GeneIDi22770
KEGGimmu:22770
UCSCiuc007vtd.2 mouse

Organism-specific databases

CTDi11244
MGIiMGI:109271 Zhx1

Phylogenomic databases

eggNOGiENOG410IHET Eukaryota
ENOG410Z8A2 LUCA
GeneTreeiENSGT00530000063149
HOVERGENiHBG007920
InParanoidiP70121
OMAiKWYYYYQ
OrthoDBiEOG091G02WT
PhylomeDBiP70121
TreeFamiTF333363

Miscellaneous databases

PROiPR:P70121
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022361 Expressed in 42 organ(s), highest expression level in thymus
CleanExiMM_ZHX1
ExpressionAtlasiP70121 baseline and differential
GenevisibleiP70121 MM

Family and domain databases

CDDicd00086 homeodomain, 5 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR024578 Homez_homeobox_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00046 Homeobox, 4 hits
PF11569 Homez, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 5 hits
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF46689 SSF46689, 5 hits
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZHX1_MOUSE
AccessioniPrimary (citable) accession number: P70121
Secondary accession number(s): Q8BQ68, Q8C6T4, Q8CJG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: February 16, 2004
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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