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Protein

Transcription factor HES-5

Gene

Hes5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-5
Alternative name(s):
Hairy and enhancer of split 5
Gene namesi
Name:Hes5
Synonyms:Hes-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:104876 Hes5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272121 – 167Transcription factor HES-5Add BLAST167

Proteomic databases

PaxDbiP70120
PeptideAtlasiP70120
PRIDEiP70120

PTM databases

iPTMnetiP70120
PhosphoSitePlusiP70120

Expressioni

Gene expression databases

BgeeiENSMUSG00000048001 Expressed in 192 organ(s), highest expression level in rostral migratory stream
CleanExiMM_HES5
ExpressionAtlasiP70120 baseline and differential
GenevisibleiP70120 MM

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200278, 1 interactor
ELMiP70120
STRINGi10090.ENSMUSP00000051118

Structurei

3D structure databases

ProteinModelPortaliP70120
SMRiP70120
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 72bHLHPROSITE-ProRule annotationAdd BLAST57
Domaini88 – 119OrangePROSITE-ProRule annotationAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi164 – 167WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 31Arg/Lys-rich (basic)Add BLAST18
Compositional biasi74 – 79Poly-Ala6
Compositional biasi122 – 141Pro-richAdd BLAST20
Compositional biasi146 – 152Poly-Ala7

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Phylogenomic databases

eggNOGiENOG410IWTV Eukaryota
ENOG41120DD LUCA
GeneTreeiENSGT00910000144201
HOGENOMiHOG000236346
HOVERGENiHBG005960
InParanoidiP70120
KOiK06055
OMAiHKLRKPM
OrthoDBiEOG091G0V3D
PhylomeDBiP70120
TreeFamiTF351373

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequencei

Sequence statusi: Complete.

P70120-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPSTVAVEM LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH
60 70 80 90 100
QPNSKLEKAD ILEMAVSYLK HSKAFAAAAG PKSLHQDYSE GYSWCLQEAV
110 120 130 140 150
QFLTLHAASD TQMKLLYHFQ RPPAPAAPAK EPPAPGAAPQ PARSSAKAAA
160
AAVSTSRQPA CGLWRPW
Length:167
Mass (Da):18,425
Last modified:February 1, 1997 - v1
Checksum:iCA0E697094F4E760
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22P → S in BAC37159 (PubMed:16141072).Curated1
Sequence conflicti94W → L in BAC37159 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32132 Genomic DNA Translation: BAA06858.1
AK078170 mRNA Translation: BAC37159.1
AK087508 mRNA Translation: BAC39904.1
CCDSiCCDS19018.1
PIRiA55438
RefSeqiNP_034549.1, NM_010419.4
UniGeneiMm.137268

Genome annotation databases

EnsembliENSMUST00000049621; ENSMUSP00000051118; ENSMUSG00000048001
GeneIDi15208
KEGGimmu:15208
UCSCiuc008wck.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32132 Genomic DNA Translation: BAA06858.1
AK078170 mRNA Translation: BAC37159.1
AK087508 mRNA Translation: BAC39904.1
CCDSiCCDS19018.1
PIRiA55438
RefSeqiNP_034549.1, NM_010419.4
UniGeneiMm.137268

3D structure databases

ProteinModelPortaliP70120
SMRiP70120
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200278, 1 interactor
ELMiP70120
STRINGi10090.ENSMUSP00000051118

PTM databases

iPTMnetiP70120
PhosphoSitePlusiP70120

Proteomic databases

PaxDbiP70120
PeptideAtlasiP70120
PRIDEiP70120

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049621; ENSMUSP00000051118; ENSMUSG00000048001
GeneIDi15208
KEGGimmu:15208
UCSCiuc008wck.1 mouse

Organism-specific databases

CTDi388585
MGIiMGI:104876 Hes5

Phylogenomic databases

eggNOGiENOG410IWTV Eukaryota
ENOG41120DD LUCA
GeneTreeiENSGT00910000144201
HOGENOMiHOG000236346
HOVERGENiHBG005960
InParanoidiP70120
KOiK06055
OMAiHKLRKPM
OrthoDBiEOG091G0V3D
PhylomeDBiP70120
TreeFamiTF351373

Miscellaneous databases

PROiPR:P70120
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048001 Expressed in 192 organ(s), highest expression level in rostral migratory stream
CleanExiMM_HES5
ExpressionAtlasiP70120 baseline and differential
GenevisibleiP70120 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHES5_MOUSE
AccessioniPrimary (citable) accession number: P70120
Secondary accession number(s): Q8BVI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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