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Entry version 89 (29 Sep 2021)
Sequence version 1 (01 Feb 1997)
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Protein

Myelin transcription factor 1

Gene

myt1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator which is essential for neuronal differentiation. Can promote ectotopic neuronal differentiation and confers insensitivity to lateral inhibition, but only in cooperation with bHLH transcription factors.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi403Zinc 1PROSITE-ProRule annotation1
Metal bindingi408Zinc 1PROSITE-ProRule annotation1
Metal bindingi421Zinc 1PROSITE-ProRule annotation1
Metal bindingi427Zinc 1PROSITE-ProRule annotation1
Metal bindingi447Zinc 2PROSITE-ProRule annotation1
Metal bindingi452Zinc 2PROSITE-ProRule annotation1
Metal bindingi465Zinc 2PROSITE-ProRule annotation1
Metal bindingi471Zinc 2PROSITE-ProRule annotation1
Metal bindingi797Zinc 3PROSITE-ProRule annotation1
Metal bindingi802Zinc 3PROSITE-ProRule annotation1
Metal bindingi815Zinc 3PROSITE-ProRule annotation1
Metal bindingi821Zinc 3PROSITE-ProRule annotation1
Metal bindingi841Zinc 4PROSITE-ProRule annotation1
Metal bindingi846Zinc 4PROSITE-ProRule annotation1
Metal bindingi859Zinc 4PROSITE-ProRule annotation1
Metal bindingi865Zinc 4PROSITE-ProRule annotation1
Metal bindingi890Zinc 5PROSITE-ProRule annotation1
Metal bindingi895Zinc 5PROSITE-ProRule annotation1
Metal bindingi908Zinc 5PROSITE-ProRule annotation1
Metal bindingi914Zinc 5PROSITE-ProRule annotation1
Metal bindingi943Zinc 6PROSITE-ProRule annotation1
Metal bindingi948Zinc 6PROSITE-ProRule annotation1
Metal bindingi961Zinc 6PROSITE-ProRule annotation1
Metal bindingi967Zinc 6PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri394 – 437CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri438 – 481CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri788 – 831CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri832 – 875CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri881 – 924CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri934 – 977CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin transcription factor 1
Short name:
X-MyT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:myt1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-1009978, myt1.S

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000966781 – 1122Myelin transcription factor 1Add BLAST1122

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First expressed at mid-late gastrulation within the dorsal ectoderm. By the completion of gastrulation its expression is clearly restricted to 3 groups of cells arranged in a radially symmetrical pattern on either side of the dorsal midline of the posterior neural plate, where the ventral, intermediate and dorsal groups of cells differentiate into motor neurons, interneurons and sensory neurons respectively. The same pattern of expression is maintained in later-stage neurula embryos.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Positively regulated by X-NGNR-1 and negatively regulated by lateral inhibition.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P70047

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 139DisorderedSequence analysisAdd BLAST139
Regioni208 – 334DisorderedSequence analysisAdd BLAST127
Regioni479 – 499DisorderedSequence analysisAdd BLAST21
Regioni566 – 595DisorderedSequence analysisAdd BLAST30
Regioni634 – 770DisorderedSequence analysisAdd BLAST137

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17Polar residuesSequence analysisAdd BLAST17
Compositional biasi33 – 61Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi74 – 89Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi118 – 132Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi223 – 240Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi241 – 275Acidic residuesSequence analysisAdd BLAST35
Compositional biasi307 – 328Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi645 – 670Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi671 – 716Polar residuesSequence analysisAdd BLAST46
Compositional biasi717 – 736Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYT1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri394 – 437CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri438 – 481CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri788 – 831CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri832 – 875CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri881 – 924CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri934 – 977CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
116799at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013681, Myelin_TF
IPR002515, Znf_C2H2C
IPR036060, Znf_C2H2C_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08474, MYT1, 1 hit
PF01530, zf-C2HC, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103637, SSF103637, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51802, ZF_CCHHC, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P70047-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVDNVNKGT HTRSKASRVI PSDLIEQEVS LESCPLSRKR KLQESEQENP
60 70 80 90 100
LSKRKSHPLK LALDEGFNVD SNGSEETEMK ERDSGTEESE ATLEEIEEDS
110 120 130 140 150
EPTKPKEAPS PQTAEAESSD KVEPEETETK TESSPPAKAT YSSYHEIIAN
160 170 180 190 200
SLLNLGQVAK EALVSEGHLK ESELNNEKPT SVKSGQAEIE QLMVEEACEK
210 220 230 240 250
EIIIQTEDAE EVIEVTSEPI SESGTEPRDE VNCEDTEKLQ KDMIDEEEEE
260 270 280 290 300
EDDDVDEEDD DDLEEDEEEE EEHSSEMANQ DLPHASQDSP KPHCEGHFSP
310 320 330 340 350
KPEYSVIVEV RSDDDKDDDS HSQKSAVTDE SEMYDMMTRG NLGLLEQAIA
360 370 380 390 400
LKAEQVKVVR EPSRSSLDNM KNFSADEKQN RPIDTMRKSF YDAGRPEKRD
410 420 430 440 450
IKCPTPGCDG TGHVTGLYPH HRSLSGCPHK DRIPPEILAM HENVLKCPTP
460 470 480 490 500
GCTGQGHVNS NRNTHRSLSG CPIAAAEKLT RSHEKQQQPG DLSKSSSNSD
510 520 530 540 550
RILRPMCFVK QLEIPQYGSY RPNMAPATPR ANLAKELEKY SKVTFDYASF
560 570 580 590 600
DAQVFGKRLL APKIPSSETS PKAFKSKPFP KASSPCHSPS SSYIKSTSSS
610 620 630 640 650
SSSGFDYTHD AEAAHMAATA ILNLSTRCWE MPENLSTKQQ DTPSKSSEIE
660 670 680 690 700
VDENGTLDLS MNKHRKREST FPSSSSCSSS PSMKSPDQSQ RQNCTSATSS
710 720 730 740 750
NMTSPHSSQT SRQDDWDGPI DYTKPNRQRE EEPEEMEPAA ASFASSEVDE
760 770 780 790 800
QEMQEMQEMQ EMQEESYEDR KYPGDVTLTN FKLKFLSKDS KKELLSCPTP
810 820 830 840 850
GCDGSGHITG NYASHRSLSG CPLADKSLRN LMAAHSADLK CPTPGCDGSG
860 870 880 890 900
HITGNYASHR SLSGCPRAKK SGLKITPTKD DKDDPDLMKC PVPGCDGLGH
910 920 930 940 950
ISGKYASHRS ASGCPLAARR QKEGALNGSA FSWKSLKTEG PSCPTPGCDG
960 970 980 990 1000
SGHANGSFLT HRSLSGCPRA SFAGKKGKIS GDELLGTNFK TSDVLENDEE
1010 1020 1030 1040 1050
IKQLNKEINE LNESNSEMEA DMVNLQSQIT TMEKNLKNIE EENKVIEEQN
1060 1070 1080 1090 1100
EALFVELSGL SQALIRSLTN IRLPQMEPIS EQNFDAYVNT LTDMYTNQEC
1110 1120
YQNPENKALL ESIKQAVKGI KV
Length:1,122
Mass (Da):123,862
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70DDA905FF5E8B93
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U67078 mRNA Translation: AAB40719.1

NCBI Reference Sequences

More...
RefSeqi
NP_001081661.1, NM_001088192.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397982

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:397982

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67078 mRNA Translation: AAB40719.1
RefSeqiNP_001081661.1, NM_001088192.1

3D structure databases

SMRiP70047
ModBaseiSearch...

Genome annotation databases

GeneIDi397982
KEGGixla:397982

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
397982
XenbaseiXB-GENE-1009978, myt1.S

Phylogenomic databases

OrthoDBi116799at2759

Family and domain databases

InterProiView protein in InterPro
IPR013681, Myelin_TF
IPR002515, Znf_C2H2C
IPR036060, Znf_C2H2C_sf
PfamiView protein in Pfam
PF08474, MYT1, 1 hit
PF01530, zf-C2HC, 6 hits
SUPFAMiSSF103637, SSF103637, 6 hits
PROSITEiView protein in PROSITE
PS51802, ZF_CCHHC, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYT1_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70047
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: February 1, 1997
Last modified: September 29, 2021
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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