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Entry version 104 (08 May 2019)
Sequence version 2 (01 Jul 1997)
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Protein

Adenomatous polyposis coli homolog

Gene

apc

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenomatous polyposis coli homolog
Short name:
Protein APC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:apc
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-480859 apc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000646301 – 2829Adenomatous polyposis coli homologAdd BLAST2829

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P70039

PRoteomics IDEntifications database

More...
PRIDEi
P70039

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
100780, 2 interactors

Protein interaction database and analysis system

More...
IntActi
P70039, 10 interactors

Molecular INTeraction database

More...
MINTi
P70039

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P70039

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati343 – 384ARM 1Add BLAST42
Repeati462 – 504ARM 2Add BLAST43
Repeati516 – 555ARM 3Add BLAST40
Repeati559 – 599ARM 4Add BLAST41
Repeati603 – 646ARM 5Add BLAST44
Repeati652 – 691ARM 6Add BLAST40
Repeati694 – 733ARM 7Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili4 – 58Sequence analysisAdd BLAST55
Coiled coili133 – 244Sequence analysisAdd BLAST112
Coiled coili1545 – 1578Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1345 – 1428Ser-richAdd BLAST84
Compositional biasi2202 – 2634Ser-richAdd BLAST433
Compositional biasi2749 – 2823Ser-richAdd BLAST75

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K02085

Database of Orthologous Groups

More...
OrthoDBi
31524at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026836 APC
IPR009240 APC_15aa_rpt
IPR009234 APC_basic_dom
IPR026831 APC_dom
IPR026818 Apc_fam
IPR032038 APC_N
IPR036149 APC_N_sf
IPR041257 APC_rep
IPR009223 APC_rpt
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR009232 EB1-bd
IPR009224 SAMP

The PANTHER Classification System

More...
PANTHERi
PTHR12607 PTHR12607, 1 hit
PTHR12607:SF11 PTHR12607:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05972 APC_15aa, 2 hits
PF05956 APC_basic, 1 hit
PF16689 APC_N_CC, 1 hit
PF05923 APC_r, 7 hits
PF18797 APC_rep, 1 hit
PF00514 Arm, 1 hit
PF05937 EB1_binding, 1 hit
PF05924 SAMP, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185 ARM, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF58050 SSF58050, 1 hit
SSF82931 SSF82931, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P70039-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAASYDQLV KQVEALTMEN TNLRQELEDN SNHLTKLETE ATNMKEVLKQ
60 70 80 90 100
LQGSIEDEAM ASSGPIDLLE RFKDLNLDSS NIPAGKARPK MSMRSYGSRE
110 120 130 140 150
GSLSGHSGEC SPVPVGSFQR RGLLNGSRES AGYMEELEKE RLLLIAEHEK
160 170 180 190 200
EEKEKRWYYA QLQNLTKRID SLPLTENFSM QTDMTRRQLE YEARQIRAAM
210 220 230 240 250
EEQLGTCQDM EKRVQTRVGK IHQIEEEILR IRQLLQSQVA EAAERTPQSK
260 270 280 290 300
HDAGSRDAEK LPDGQGTSEI TASGNVGSGQ GSSSRADHDT TSVMSSNSTY
310 320 330 340 350
SVPRRLTSHL GTKVEMVYSL LSMLGTHDKD DMSRTLLAMS SSQDSCIAMR
360 370 380 390 400
QSGCLPLLIQ LLHGNDKDSV LLGNSRGSKE ARASGSAALD NIIHSQPDDK
410 420 430 440 450
RGRREIRVLH LLEQIRAYCE TCWEWQEAHE QGMDQDKNPM PAPVDHQICP
460 470 480 490 500
AVCVLMKLSF DEEHRHAMNE LGGLQAIAEL LQVDCEMYGL INDHYSVTLR
510 520 530 540 550
RYAGMALTNL TFGDVANKAT LCSMKSCMRA LVAQLKSESE DLQQVIASVL
560 570 580 590 600
RNLSWRADVN SKKTLREVGS VKALMECALD VKKESTLKSV LSALWNLSAH
610 620 630 640 650
CTENKADICS VDGALAFLVS TLTYRSQTNT LAIIESGGGI LRNVSSLIAT
660 670 680 690 700
NEDHRQILRE NNCLQTLLQH LKSHSLTIVS NACGTLWNLS ARNAKDQEGL
710 720 730 740 750
WDMGAVSMLK NLIHSKHKMI AMGSAAALRN LMANRPAKYK DANIMSPGSS
760 770 780 790 800
VPSLHVRKQK ALEAELDAQH LSETFDNIDN LSPKTTHRNK QRHKQNLCSE
810 820 830 840 850
YALDSSRHDD SICRSDNFSI GNLTVLSPYI NTTVLPGSSS PRPTMDGSRP
860 870 880 890 900
EKDRERTAGL GNYHSTTESS GNSSKRIGIQ LSTTAQISKV MDEVSNIHLV
910 920 930 940 950
QENRSSGSAS EMHCMSDERN SQRKPSSNHP QSNPFTFTKA ESSTRGCPVA
960 970 980 990 1000
FMKMEYKMAS NDSLNSVSST EGYGKRGQVK PSVESYSEDD ESKFFSYGQY
1010 1020 1030 1040 1050
PAGLAHKIQS ANHMDDNDTE LDTPINYSLK YSDEQLNSGR QSPTQNERWS
1060 1070 1080 1090 1100
RPKHIIDSEM KQSEQRQPRT TKTTYSSYTE NKEEKHKKFP PHFNQSENVP
1110 1120 1130 1140 1150
AYTRSRGANN QVDQSRVSSN LSNNSKASKP HCQVDDYDDD KTTNFSERYS
1160 1170 1180 1190 1200
EEEQQEDETE RQNKYNIKAY ASEEHHGEQP IDYSRKYSTD VPSSAQKPSF
1210 1220 1230 1240 1250
PYSNNSSKQK PKKEQVSSNS NTPTPSPNSN RQNQLHPNSA QSRPGLNRPK
1260 1270 1280 1290 1300
QIPNKPPSIN QETIQTYCVE DTPICFSRGS SLSSLSSAED EIEGRERNSR
1310 1320 1330 1340 1350
GQESNNTLQI TEPKEISAVS KDGAVNETRS SVHHTRTKNN RLQTSNISPS
1360 1370 1380 1390 1400
DSSRHKSVEF SSGAKSPSKS GAQTPKSPPE HYVQETPLMF SRCTSGSSLD
1410 1420 1430 1440 1450
SFESHSIASS IASSVASEHM ISGIISPSDL PDSPGQTMPP SRSKTPPPPQ
1460 1470 1480 1490 1500
TVQAKKDGSK PIVPDEERGK VAKTAVHSAI QRVQVLQEAD TLLHFATEST
1510 1520 1530 1540 1550
PDGFSCASSL SALSLDEPYI QKDVQLKIMP PVLENDQGNK AEPEKEFIDN
1560 1570 1580 1590 1600
KAKKEDKRSE QEKDMLDDTD DDIDILEECI ISAMPRKPSR KNKKVPQPTP
1610 1620 1630 1640 1650
GKPPPPVARK PSQLPVYKLL SSQNRLQTQK HVNFTHSDDM PRVYCVEGTP
1660 1670 1680 1690 1700
INFSTATSLS DLTIESPPSE PTNDQPNTDS LSTDLEKRDT IPTEGRSTDD
1710 1720 1730 1740 1750
TDASKPLNPT TVLDEDKAEE GDILAECIHS AMPKGKSHKP YRVKKIMDQI
1760 1770 1780 1790 1800
NHTSAATSSG NSRSMQETDK NKPTSPVKPM PQSIGFKERL KKNTELKLNP
1810 1820 1830 1840 1850
NSENQYCDPR KPSSKKPSKV ANEKIPNNEE RTKGFAFDSP HHYTPIEGTP
1860 1870 1880 1890 1900
YCFSRNDSLS SLDFEDDDID LSKEKAELRK EKGTKDTDQK VKYKHENRAI
1910 1920 1930 1940 1950
NPMGKQDQTG PKSLGGRDQP KALVQKPTSF SSAAKGTQDR GGATDEKMEN
1960 1970 1980 1990 2000
FAIENTPVCF SRNSSLSSLS DIDQENNNKE TEPLKQTGTS ETQLGLRRPQ
2010 2020 2030 2040 2050
TSGYAPKSFH VEDTPVCFSR NSSLSSLSID SEDDLLQECI SSAMPKKRKP
2060 2070 2080 2090 2100
SKIKNEVGKS RSNSVGGILA EEPDLTLDLR DIQSPDSENA FSPDSENFDW
2110 2120 2130 2140 2150
KAIQEGANSI VSRLHQAAAA GSLSRQGSSD SDSILSLKSG ISLGSPFHLT
2160 2170 2180 2190 2200
LDKEEKTITS NKGPKILKPA EKSALENKKT EEEPKGIKGG KKVYKSLITG
2210 2220 2230 2240 2250
KSRSSSDFSS HCKQSVQTNM PSISRGRTMI HIPGVRASSP STSPVSKKGP
2260 2270 2280 2290 2300
VFKNVPSKGS NENPSSSSSP KGTKPLKSEL VYGSRPSSTP GGSSKGNSRS
2310 2320 2330 2340 2350
GSRDSASSRP SPQPLSRPLQ SPGRNSISPG KNGISPPNKF SQLPRTTSPS
2360 2370 2380 2390 2400
TASTKSSGSG RMSYTSPGRQ LSQPNLSKQS GLPKTHSSIP RSESASKSLN
2410 2420 2430 2440 2450
QNVNTGSNKK VELSRMSSTK SSGSESDRSE RPALVRQSTF IKEAPSPTLR
2460 2470 2480 2490 2500
RKLEESASFE SLSSSSRADS PPRSQTQTPA LSPSLPDMAL STHSIQAGGW
2510 2520 2530 2540 2550
RKMPPNLNPA AEHGDSRRRH DISRSHSESP SRLPITRSGT WKREHSKHSS
2560 2570 2580 2590 2600
SLPRVSTWRR TGSSSSILSA SSESSEKAKS EDEKQQVCSF PGPRSECSSS
2610 2620 2630 2640 2650
AKGTWRKIKE SEILETPSNG SSSTIAESNC SLESKTLVYQ MAPAVSKTED
2660 2670 2680 2690 2700
VWVRIEDCPI NNPRSGRSPT GNSPPVIDNV LDQGQKEEAA KDCHTRHNSG
2710 2720 2730 2740 2750
NGNVPLLENR QKSFIKVDGL DTKGTDPKSL INNQQETNEN TVAERTAFSS
2760 2770 2780 2790 2800
SSSSKHSSPS GTVAARVTPF NYNPSPRKSN GENSTSRPSQ IPTPVTNSTK
2810 2820
KRDSKTETTD SSGSQSPKRH SGSYLVTSV
Length:2,829
Mass (Da):310,882
Last modified:July 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A2BABDB7706E496
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U64442 mRNA Translation: AAB41671.1

NCBI Reference Sequences

More...
RefSeqi
NP_001084351.1, NM_001090882.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
399455

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:399455

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64442 mRNA Translation: AAB41671.1
RefSeqiNP_001084351.1, NM_001090882.1

3D structure databases

SMRiP70039
ModBaseiSearch...

Protein-protein interaction databases

BioGridi100780, 2 interactors
IntActiP70039, 10 interactors
MINTiP70039

Proteomic databases

MaxQBiP70039
PRIDEiP70039

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399455
KEGGixla:399455

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
399455
XenbaseiXB-GENE-480859 apc

Phylogenomic databases

KOiK02085
OrthoDBi31524at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P70039

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR026836 APC
IPR009240 APC_15aa_rpt
IPR009234 APC_basic_dom
IPR026831 APC_dom
IPR026818 Apc_fam
IPR032038 APC_N
IPR036149 APC_N_sf
IPR041257 APC_rep
IPR009223 APC_rpt
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR009232 EB1-bd
IPR009224 SAMP
PANTHERiPTHR12607 PTHR12607, 1 hit
PTHR12607:SF11 PTHR12607:SF11, 1 hit
PfamiView protein in Pfam
PF05972 APC_15aa, 2 hits
PF05956 APC_basic, 1 hit
PF16689 APC_N_CC, 1 hit
PF05923 APC_r, 7 hits
PF18797 APC_rep, 1 hit
PF00514 Arm, 1 hit
PF05937 EB1_binding, 1 hit
PF05924 SAMP, 3 hits
SMARTiView protein in SMART
SM00185 ARM, 6 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF58050 SSF58050, 1 hit
SSF82931 SSF82931, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPC_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70039
Secondary accession number(s): P79934
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 1, 1997
Last modified: May 8, 2019
This is version 104 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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