sugE

Functionⁱ

Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations.1 Publication

Miscellaneous

Unlike the other members of the SMR family, SugE exhibits a narrow specificity for a very specific class of compounds.

Caution

Was originally (PubMed:8096175) thought to suppress a groEL mutation and mimic the effect of groE overexpression. This was later shown (PubMed:11948170) to be probably due to an artifact.2 Publications

GO - Molecular functionⁱ

drug transmembrane transporter activity
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 11948170
transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

drug export
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 11948170
transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

BioCycⁱ	EcoCyc:SUGE-MONOMER

BioCycⁱ

EcoCyc:SUGE-MONOMER

Protein family/group databases

TCDBⁱ	2.A.7.1.4 the drug/metabolite transporter (dmt) superfamily

TCDBⁱ

2.A.7.1.4 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Quaternary ammonium compound-resistance protein SugE
Gene namesⁱ	Name:sugE Ordered Locus Names:b4148, JW5738
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG11616 sugE

EcoGeneⁱ

EG11616 sugE

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	1 – 21	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	22 – 28	CytoplasmicSequence analysis	7
Transmembraneⁱ	29 – 49	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	50 – 57	PeriplasmicSequence analysis	8
Transmembraneⁱ	58 – 78	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	79 – 81	CytoplasmicSequence analysis	3
Transmembraneⁱ	82 – 102	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	103 – 105	PeriplasmicSequence analysis	3

GO - Cellular componentⁱ

integral component of plasma membrane
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000108095	1 – 105	Quaternary ammonium compound-resistance protein SugEAdd BLAST		105

Proteomic databases

PaxDbⁱ	P69937
PRIDEⁱ	P69937

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4262698, 178 interactors
STRINGⁱ	316385.ECDH10B_4343

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P69937
SMRⁱ	P69937
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the small multidrug resistance (SMR) protein family. SugE (TC 2.A.7.1.4) subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105KPY Bacteria COG2076 LUCA
HOGENOMⁱ	HOG000268007
InParanoidⁱ	P69937
KEGG Orthology (KO) More...KOⁱ	K11741
PhylomeDBⁱ	P69937

Family and domain databases

InterProⁱ	View protein in InterPro IPR000390 Small_multidrug_res
PANTHERⁱ	PTHR30561 PTHR30561, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00893 Multi_Drug_Res, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P69937-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSWIILVIAG LLEVVWAVGL KYTHGFSRLT PSVITVTAMI VSMALLAWAM 
        60         70         80         90        100
KSLPVGTAYA VWTGIGAVGA AITGIVLLGE SANPMRLASL ALIVLGIIGL 

KLSTH

Length:105

Mass (Da):10,900

Last modified:January 4, 2005 - v1

Checksum:ⁱC4686D9EDC1B7D08

GO

Sequence cautionⁱ

The sequence AAA97047 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAA49570 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X69949 Genomic DNA Translation: CAA49570.1 Different initiation. X69949 Genomic DNA Translation: CAA49571.1 U21726 Genomic DNA Translation: AAC46453.1 U14003 Genomic DNA Translation: AAA97047.1 Different initiation. U00096 Genomic DNA Translation: AAC77108.2 AP009048 Genomic DNA Translation: BAE78152.1
PIRⁱ	S56376
NCBI Reference Sequences More...RefSeqⁱ	NP_418572.4, NC_000913.3 WP_000118482.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC77108; AAC77108; b4148 BAE78152; BAE78152; BAE78152
GeneIDⁱ	948671
KEGGⁱ	ecj:JW5738 eco:b4148
PATRICⁱ	fig\|1411691.4.peg.2550

Protein	Similar proteins		Species	Score	Length	Source
P69937	Quaternary ammonium compound-resistance protein SugE		ECO57		105	UniRef100_Q8XDQ5
Quaternary ammonium compound-resistance protein SugE		SHIFL		105
Suppresses groEL may be chaperone		ECOLX		162
Small_Multi_Drug_Res (Fragment)		uncultured bacterium		69
Quaternary ammonium compound-resistance protein SugE		Shigella sp.		105
+126

Protein	Similar proteins		Species	Score	Length	Source
P69937	Quaternary ammonium compound-resistance protein SugE		ECO57		105	UniRef90_Q8XDQ5
Quaternary ammonium compound-resistance protein SugE		SHIFL		105
Quaternary ammonium compound-resistance protein SugE		ECOL6		105
Suppresses groEL may be chaperone		ECOLX		162
Small_Multi_Drug_Res (Fragment)		uncultured bacterium		69
+191

Protein	Similar proteins		Species	Score	Length	Source
P69937	Quaternary ammonium compound-resistance protein SugE		ECO57		105	UniRef50_Q8XDQ5
Quaternary ammonium compound-resistance protein SugE		SHIFL		105
Quaternary ammonium compound-resistance protein SugE		ECOL6		105
Suppresses groEL may be chaperone		ECOLX		162
Small_Multi_Drug_Res (Fragment)		uncultured bacterium		69
+236

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X69949 Genomic DNA Translation: CAA49570.1 Different initiation. X69949 Genomic DNA Translation: CAA49571.1 U21726 Genomic DNA Translation: AAC46453.1 U14003 Genomic DNA Translation: AAA97047.1 Different initiation. U00096 Genomic DNA Translation: AAC77108.2 AP009048 Genomic DNA Translation: BAE78152.1
PIRⁱ	S56376
RefSeqⁱ	NP_418572.4, NC_000913.3 WP_000118482.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P69937
SMRⁱ	P69937
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4262698, 178 interactors
STRINGⁱ	316385.ECDH10B_4343

Protein family/group databases

TCDBⁱ	2.A.7.1.4 the drug/metabolite transporter (dmt) superfamily

TCDBⁱ

2.A.7.1.4 the drug/metabolite transporter (dmt) superfamily

Proteomic databases

PaxDbⁱ	P69937
PRIDEⁱ	P69937

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC77108; AAC77108; b4148 BAE78152; BAE78152; BAE78152
GeneIDⁱ	948671
KEGGⁱ	ecj:JW5738 eco:b4148
PATRICⁱ	fig\|1411691.4.peg.2550

Organism-specific databases

EchoBASEⁱ	EB1573
EcoGeneⁱ	EG11616 sugE

Phylogenomic databases

eggNOGⁱ	ENOG4105KPY Bacteria COG2076 LUCA
HOGENOMⁱ	HOG000268007
InParanoidⁱ	P69937
KOⁱ	K11741
PhylomeDBⁱ	P69937

Enzyme and pathway databases

BioCycⁱ	EcoCyc:SUGE-MONOMER

BioCycⁱ

EcoCyc:SUGE-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P69937

PROⁱ

PR:P69937

Family and domain databases

InterProⁱ	View protein in InterPro IPR000390 Small_multidrug_res
PANTHERⁱ	PTHR30561 PTHR30561, 1 hit
Pfamⁱ	View protein in Pfam PF00893 Multi_Drug_Res, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SUGE_ECOLI
Accessionⁱ	P69937Primary (citable) accession number: P69937 Secondary accession number(s): P30743, Q2M6F4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
	Last sequence update:	January 4, 2005
	Last modified:	November 7, 2018
	This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P69937 (SUGE_ECOLI)

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Quaternary ammonium compound-resistance protein SugE

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ