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Entry version 96 (11 Dec 2019)
Sequence version 1 (24 May 2005)
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Protein

GTP 3',8-cyclase

Gene

moaA

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] cluster1 PublicationNote: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.045 min(-1).2 Publications
  1. KM=1.4 µM for GTP1 Publication
  2. KM=3.1 µM for GTP1 Publication
  3. KM=4.1 µM for S-adenosyl-L-methionine1 Publication
  4. KM=5.1 µM for S-adenosyl-L-methionine1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: molybdopterin biosynthesis

    This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
    View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei17GTPCombined sources1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi24Iron-sulfur 1 (4Fe-4S-S-AdoMet)Combined sources1 Publication1
    Metal bindingi28Iron-sulfur 1 (4Fe-4S-S-AdoMet)Combined sources1 Publication1
    Binding sitei30S-adenosyl-L-methionineCombined sources1 Publication1
    Metal bindingi31Iron-sulfur 1 (4Fe-4S-S-AdoMet)Combined sources1 Publication1
    Binding sitei71GTPCombined sources1 Publication1
    Binding sitei75S-adenosyl-L-methionine; via carbonyl oxygenCombined sources1 Publication1
    Binding sitei102GTPCombined sources1 Publication1
    Binding sitei126S-adenosyl-L-methionineCombined sources1 Publication1
    Binding sitei163GTPCombined sources1 Publication1
    Binding sitei197S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenCombined sources1 Publication1
    Metal bindingi261Iron-sulfur 2 (4Fe-4S-substrate)Combined sources1 Publication1
    Metal bindingi264Iron-sulfur 2 (4Fe-4S-substrate)Combined sources1 Publication1
    Metal bindingi278Iron-sulfur 2 (4Fe-4S-substrate)Combined sources1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi266 – 268GTPCombined sources1 Publication3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLyase
    Biological processMolybdenum cofactor biosynthesis
    Ligand4Fe-4S, GTP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    GCF_000013425:G1I0R-2397-MONOMER
    SAUR93061:G1G5Y-2397-MONOMER

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00344

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    GTP 3',8-cyclase1 Publication (EC:4.1.99.221 Publication)
    Alternative name(s):
    Molybdenum cofactor biosynthesis protein A
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:moaA
    Ordered Locus Names:SAOUHSC_02536
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureus (strain NCTC 8325)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri93061 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000008816 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    GO - Cellular componenti

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi17R → A: Loss of activity. 1 Publication1
    Mutagenesisi24C → A: Loss of activity; when associated with A-28 and A-31. 1 Publication1
    Mutagenesisi28C → A: Loss of activity; when associated with A-24 and A-31. 1 Publication1
    Mutagenesisi30Y → A: Reduces activity by over 80%. 1 Publication1
    Mutagenesisi31C → A: Loss of activity; when associated with A-24 and A-28. 1 Publication1
    Mutagenesisi69K → A: Reduces activity by about 60%. 1 Publication1
    Mutagenesisi71R → A: Strongly reduced affinity for GTP. Reduces activity by about 80%. 1 Publication1
    Mutagenesisi73T → A: Reduces activity by over 80%. 1 Publication1
    Mutagenesisi126S → A: Reduces activity by over 80%. 1 Publication1
    Mutagenesisi192R → A: Reduces activity by about 80%. 1 Publication1
    Mutagenesisi198D → A: Loss of activity by 92%. 1 Publication1
    Mutagenesisi260F → A: Alters stability of FeS cluster and alters protein stability. 1 Publication1
    Mutagenesisi260F → L: Reduces activity by about 80%. 1 Publication1
    Mutagenesisi266R → A: Loss of activity. Strongly reduced affinity for GTP. 1 Publication1
    Mutagenesisi268R → A: Loss of activity. 1 Publication1
    Mutagenesisi330 – 332RKK → AAA: Loss of activity by 92%. 1 Publication3
    Mutagenesisi339G → A, S or V: Loss of activity. 1 Publication1
    Mutagenesisi340G → A, S or V: Loss of activity. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001529951 – 340GTP 3',8-cyclaseAdd BLAST340

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer and homodimer.

    2 Publications

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    1280.SAXN108_2517

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1340
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P69848

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P69848

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The central core of the structure is composed of a partial TIM-barrel fold deviating from the canonical TIM-barrel topology.

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the radical SAM superfamily. MoaA family.UniRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4105CM1 Bacteria
    COG2896 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000228681

    KEGG Orthology (KO)

    More...
    KOi
    K03639

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    IEFMPIG

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.20.20.70, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01225_B MoaA_B, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013785 Aldolase_TIM
    IPR006638 Elp3/MiaB/NifB
    IPR013483 MoaA
    IPR000385 MoaA_NifB_PqqE_Fe-S-bd_CS
    IPR010505 Mob_synth_C
    IPR007197 rSAM

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF06463 Mob_synth_C, 1 hit
    PF04055 Radical_SAM, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00729 Elp3, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR02666 moaA, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS01305 MOAA_NIFB_PQQE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P69848-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MVEQIKDKLG RPIRDLRLSV TDRCNFRCDY CMPKEVFGDD FVFLPKNELL
    60 70 80 90 100
    TFDEMARIAK VYAELGVKKI RITGGEPLMR RDLDVLIAKL NQIDGIEDIG
    110 120 130 140 150
    LTTNGLLLKK HGQKLYDAGL RRINVSLDAI DDTLFQSINN RNIKATTILE
    160 170 180 190 200
    QIDYATSIGL NVKVNVVIQK GINDDQIIPM LEYFKDKHIE IRFIEFMDVG
    210 220 230 240 250
    NDNGWDFSKV VTKDEMLTMI EQHFEIDPVE PKYFGEVAKY YRHKDNGVQF
    260 270 280 290 300
    GLITSVSQSF CSTCTRARLS SDGKFYGCLF ATVDGFNVKA FIRSGVTDEE
    310 320 330 340
    LKEQFKALWQ IRDDRYSDER TAQTVANRQR KKINMNYIGG
    Length:340
    Mass (Da):39,078
    Last modified:May 24, 2005 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBDCDFE1014E98306
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    CP000253 Genomic DNA Translation: ABD31551.1

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_000230173.1, NZ_LS483365.1
    YP_501000.1, NC_007795.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    ABD31551; ABD31551; SAOUHSC_02536

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    3921126

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    sao:SAOUHSC_02536

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|93061.5.peg.2287

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CP000253 Genomic DNA Translation: ABD31551.1
    RefSeqiWP_000230173.1, NZ_LS483365.1
    YP_501000.1, NC_007795.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1TV7X-ray2.80A/B1-340[»]
    1TV8X-ray2.20A/B1-340[»]
    2FB2X-ray2.25A/B1-340[»]
    2FB3X-ray2.35A/B1-340[»]
    SMRiP69848
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    STRINGi1280.SAXN108_2517

    Genome annotation databases

    EnsemblBacteriaiABD31551; ABD31551; SAOUHSC_02536
    GeneIDi3921126
    KEGGisao:SAOUHSC_02536
    PATRICifig|93061.5.peg.2287

    Phylogenomic databases

    eggNOGiENOG4105CM1 Bacteria
    COG2896 LUCA
    HOGENOMiHOG000228681
    KOiK03639
    OMAiIEFMPIG

    Enzyme and pathway databases

    UniPathwayiUPA00344
    BioCyciGCF_000013425:G1I0R-2397-MONOMER
    SAUR93061:G1G5Y-2397-MONOMER

    Miscellaneous databases

    EvolutionaryTraceiP69848

    Protein Ontology

    More...
    PROi
    PR:P69848

    Family and domain databases

    Gene3Di3.20.20.70, 1 hit
    HAMAPiMF_01225_B MoaA_B, 1 hit
    InterProiView protein in InterPro
    IPR013785 Aldolase_TIM
    IPR006638 Elp3/MiaB/NifB
    IPR013483 MoaA
    IPR000385 MoaA_NifB_PqqE_Fe-S-bd_CS
    IPR010505 Mob_synth_C
    IPR007197 rSAM
    PfamiView protein in Pfam
    PF06463 Mob_synth_C, 1 hit
    PF04055 Radical_SAM, 1 hit
    SMARTiView protein in SMART
    SM00729 Elp3, 1 hit
    TIGRFAMsiTIGR02666 moaA, 1 hit
    PROSITEiView protein in PROSITE
    PS01305 MOAA_NIFB_PQQE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOAA_STAA8
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P69848
    Secondary accession number(s): Q2FVY5
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: December 11, 2019
    This is version 96 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
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