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Protein

Nitrogen regulatory protein

Gene

ptsN

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to have a role in regulating nitrogen assimilation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Tele-phosphohistidine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • enzyme inhibitor activity Source: EcoCyc
  • kinase activity Source: UniProtKB-KW
  • protein kinase activator activity Source: EcoCyc
  • protein-N(PI)-phosphohistidine-sugar phosphotransferase activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase

Enzyme and pathway databases

BioCyciEcoCyc:EG11682-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrogen regulatory protein
Alternative name(s):
Enzyme IIA-NTR
PTS system EIIA component
Phosphotransferase enzyme IIA component
Gene namesi
Name:ptsN
Synonyms:rpoP, yhbI
Ordered Locus Names:b3204, JW3171
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11682 ptsN

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001866941 – 163Nitrogen regulatory proteinAdd BLAST163

Proteomic databases

EPDiP69829
PaxDbiP69829
PRIDEiP69829

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi4259284, 21 interactors
DIPiDIP-10604N
IntActiP69829, 10 interactors
STRINGi316385.ECDH10B_3378

Structurei

Secondary structure

1163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP69829
SMRiP69829
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP69829

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 156PTS EIIA type-2PROSITE-ProRule annotationAdd BLAST145

Domaini

The EIIA domain is phosphorylated by phospho-NPr on a histidyl residue.

Phylogenomic databases

eggNOGiENOG4107RM2 Bacteria
COG1762 LUCA
HOGENOMiHOG000227559
InParanoidiP69829
KOiK02806
PhylomeDBiP69829

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR016152 PTrfase/Anion_transptr
IPR002178 PTS_EIIA_type-2_dom
IPR006320 PTS_Nitro_regul
PfamiView protein in Pfam
PF00359 PTS_EIIA_2, 1 hit
SUPFAMiSSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR01419 nitro_reg_IIA, 1 hit
PROSITEiView protein in PROSITE
PS51094 PTS_EIIA_TYPE_2, 1 hit
PS00372 PTS_EIIA_TYPE_2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

P69829-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNNDTTLQL SSVLNRECTR SRVHCQSKKR ALEIISELAA KQLSLPPQVV
60 70 80 90 100
FEAILTREKM GSTGIGNGIA IPHGKLEEDT LRAVGVFVQL ETPIAFDAID
110 120 130 140 150
NQPVDLLFAL LVPADQTKTH LHTLSLVAKR LADKTICRRL RAAQSDEELY
160
QIITDTEGTP DEA
Length:163
Mass (Da):17,960
Last modified:May 10, 2005 - v1
Checksum:i57240CF2C550AC80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12684 Genomic DNA Translation: AAB60165.1
D12938 Genomic DNA Translation: BAA02317.1
Z27094 Genomic DNA Translation: CAA81619.1
U18997 Genomic DNA Translation: AAA58006.1
U00096 Genomic DNA Translation: AAC76236.1
AP009048 Genomic DNA Translation: BAE77248.1
PIRiI76720
RefSeqiNP_417671.1, NC_000913.3
WP_000183676.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76236; AAC76236; b3204
BAE77248; BAE77248; BAE77248
GeneIDi947721
KEGGiecj:JW3171
eco:b3204
PATRICifig|1411691.4.peg.3527

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12684 Genomic DNA Translation: AAB60165.1
D12938 Genomic DNA Translation: BAA02317.1
Z27094 Genomic DNA Translation: CAA81619.1
U18997 Genomic DNA Translation: AAA58006.1
U00096 Genomic DNA Translation: AAC76236.1
AP009048 Genomic DNA Translation: BAE77248.1
PIRiI76720
RefSeqiNP_417671.1, NC_000913.3
WP_000183676.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A6JX-ray2.35A/B1-163[»]
ProteinModelPortaliP69829
SMRiP69829
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259284, 21 interactors
DIPiDIP-10604N
IntActiP69829, 10 interactors
STRINGi316385.ECDH10B_3378

Proteomic databases

EPDiP69829
PaxDbiP69829
PRIDEiP69829

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76236; AAC76236; b3204
BAE77248; BAE77248; BAE77248
GeneIDi947721
KEGGiecj:JW3171
eco:b3204
PATRICifig|1411691.4.peg.3527

Organism-specific databases

EchoBASEiEB1633
EcoGeneiEG11682 ptsN

Phylogenomic databases

eggNOGiENOG4107RM2 Bacteria
COG1762 LUCA
HOGENOMiHOG000227559
InParanoidiP69829
KOiK02806
PhylomeDBiP69829

Enzyme and pathway databases

BioCyciEcoCyc:EG11682-MONOMER

Miscellaneous databases

EvolutionaryTraceiP69829
PROiPR:P69829

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR016152 PTrfase/Anion_transptr
IPR002178 PTS_EIIA_type-2_dom
IPR006320 PTS_Nitro_regul
PfamiView protein in Pfam
PF00359 PTS_EIIA_2, 1 hit
SUPFAMiSSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR01419 nitro_reg_IIA, 1 hit
PROSITEiView protein in PROSITE
PS51094 PTS_EIIA_TYPE_2, 1 hit
PS00372 PTS_EIIA_TYPE_2_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTSN_ECOLI
AccessioniPrimary (citable) accession number: P69829
Secondary accession number(s): P31222, Q2M908
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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