manZ

Functionⁱ

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (PubMed:2951378, PubMed:2999119). The enzyme II ManXYZ PTS system is involved in mannose transport (PubMed:2951378, PubMed:2999119). Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA (PubMed:4604906, PubMed:353494).4 Publications

GO - Molecular functionⁱ

protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity
Source: EcoCyc
Inferred from direct assayⁱ
- 2999119

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

glucose import across plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 5545083
mannose transmembrane transport
Source: EcoCyc
Inferred from direct assayⁱ
- 5545083
phosphoenolpyruvate-dependent sugar phosphotransferase system
Source: EcoCyc
Inferred from direct assayⁱ
- 2999119

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Phosphotransferase system, Sugar transport, Transport

Biological process

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCycⁱ	EcoCyc:MANZ-MONOMER MetaCyc:MANZ-MONOMER

BioCycⁱ

EcoCyc:MANZ-MONOMER
MetaCyc:MANZ-MONOMER

Protein family/group databases

TCDBⁱ	4.A.6.1.1 the pts mannose-fructose-sorbose (man) family

TCDBⁱ

4.A.6.1.1 the pts mannose-fructose-sorbose (man) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PTS system mannose-specific EIID component1 Publication Alternative name(s): EII-M-Man1 Publication EIID-Man1 Publication Mannose permease IID component1 Publication
Gene namesⁱ	Name:manZ Synonyms:gptB, ptsM Ordered Locus Names:b1819, JW1808
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10569 manZ

EcoGeneⁱ

EG10569 manZ

Subcellular locationⁱ

Cell inner membrane
1 Publication
Manual assertion inferred by curator fromⁱ
- Ref.9
  "Membrane topology of the mannose transporter of Escherichia coli K12."
  Huber F., Erni B.
  Eur. J. Biochem. 239:810-817(1996) [PubMed] [Europe PMC] [Abstract]
  Cited for: TOPOLOGY, SUBCELLULAR LOCATION.
; Single-pass membrane protein
1 Publication
Manual assertion inferred by curator fromⁱ
- Ref.9
  "Membrane topology of the mannose transporter of Escherichia coli K12."
  Huber F., Erni B.
  Eur. J. Biochem. 239:810-817(1996) [PubMed] [Europe PMC] [Abstract]
  Cited for: TOPOLOGY, SUBCELLULAR LOCATION.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 258	Cytoplasmic1 PublicationAdd BLAST	258
Transmembraneⁱ	259 – 278	Helical1 PublicationAdd BLAST	20
Topological domainⁱ	279 – 283	Periplasmic1 Publication	5

GO - Cellular componentⁱ

integral component of plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 2999119
membrane
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 16858726
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996
- 17309111

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000186650	1 – 283	PTS system mannose-specific EIID componentAdd BLAST		283

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-formylmethionine1 Publication		1

Keywords - PTMⁱ

Formylation

Proteomic databases

EPDⁱ	P69805
PaxDbⁱ	P69805
PRIDEⁱ	P69805

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4259146, 324 interactors
IntActⁱ	P69805, 1 interactor
STRINGⁱ	316385.ECDH10B_1957

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P69805
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	11 – 281	PTS EIIDPROSITE-ProRule annotationAdd BLAST		271

Domainⁱ

The EIID domain, with its homologous EIIC domain, forms the PTS system translocation channel and contains part of its specific substrate-binding site.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105F3R Bacteria COG3716 LUCA
HOGENOMⁱ	HOG000098670
InParanoidⁱ	P69805
KEGG Orthology (KO) More...KOⁱ	K02796

Family and domain databases

InterProⁱ	View protein in InterPro IPR004704 PTS_IID_man
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03613 EIID-AGA, 1 hit
TIGRFAMsⁱ	TIGR00828 EIID-AGA, 1 hit
PROSITEⁱ	View protein in PROSITE PS51108 PTS_EIID, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P69805-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVDTTQTTTE KKLTQSDIRG VFLRSNLFQG SWNFERMQAL GFCFSMVPAI 
        60         70         80         90        100
RRLYPENNEA RKQAIRRHLE FFNTQPFVAA PILGVTLALE EQRANGAEID 
       110        120        130        140        150
DGAINGIKVG LMGPLAGVGD PIFWGTVRPV FAALGAGIAM SGSLLGPLLF 
       160        170        180        190        200
FILFNLVRLA TRYYGVAYGY SKGIDIVKDM GGGFLQKLTE GASILGLFVM 
       210        220        230        240        250
GALVNKWTHV NIPLVVSRIT DQTGKEHVTT VQTILDQLMP GLVPLLLTFA 
       260        270        280 
CMWLLRKKVN PLWIIVGFFV IGIAGYACGL LGL

Length:283

Mass (Da):30,955

Last modified:November 16, 2011 - v2

Checksum:ⁱE29ED1D7040AE67D

GO

Sequence cautionⁱ

The sequence AAA24445 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAA15631 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J02699 Genomic DNA Translation: AAA24445.1 Different initiation. U00096 Genomic DNA Translation: AAC74889.2 AP009048 Genomic DNA Translation: BAA15631.1 Different initiation.
PIRⁱ	A30288 WQECMM
NCBI Reference Sequences More...RefSeqⁱ	NP_416333.4, NC_000913.3 WP_000228655.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC74889; AAC74889; b1819 BAA15631; BAA15631; BAA15631
GeneIDⁱ	946342
KEGGⁱ	ecj:JW1808 eco:b1819
PATRICⁱ	fig\|511145.12.peg.1896

Protein	Similar proteins		Species	Score	Length	Source
P69805	PTS system mannose-specific EIID component		ECO57		286	UniRef100_P69807
PTS system mannose-specific EIID component		ECOL6		286
Mannose-specific PTS enzyme IID		ECOLX		286
Mannose-specific enzyme IID component of PTS		ECOLU		286
Mannose-specific enzyme IID component of PTS		ECO81		286
+170

Protein	Similar proteins		Species	Score	Length	Source
P69805	PTS system mannose-specific EIID component		ECO57		286	UniRef90_P69807
PTS system mannose-specific EIID component		ECOL6		286
Mannose-specific PTS enzyme IID		ECOLX		286
Mannose-specific enzyme IID component of PTS		ECOLU		286
Mannose-specific enzyme IID component of PTS		ECO81		286
+309

Protein	Similar proteins		Species	Score	Length	Source
P69805	Fructose permease IID component		BACSU		275	UniRef50_P26382
PTS system mannose-specific EIID component		ECO57		286
PTS system mannose-specific EIID component		ECOL6		286
PTS system sorbose-specific EIID component		KLEPN		274
Phosphotransferase system (PTS) fructose-specific enzyme IID component		BACNB		281
+2499

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J02699 Genomic DNA Translation: AAA24445.1 Different initiation. U00096 Genomic DNA Translation: AAC74889.2 AP009048 Genomic DNA Translation: BAA15631.1 Different initiation.
PIRⁱ	A30288 WQECMM
RefSeqⁱ	NP_416333.4, NC_000913.3 WP_000228655.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P69805
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4259146, 324 interactors
IntActⁱ	P69805, 1 interactor
STRINGⁱ	316385.ECDH10B_1957

Protein family/group databases

TCDBⁱ	4.A.6.1.1 the pts mannose-fructose-sorbose (man) family

TCDBⁱ

4.A.6.1.1 the pts mannose-fructose-sorbose (man) family

Proteomic databases

EPDⁱ	P69805
PaxDbⁱ	P69805
PRIDEⁱ	P69805

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC74889; AAC74889; b1819 BAA15631; BAA15631; BAA15631
GeneIDⁱ	946342
KEGGⁱ	ecj:JW1808 eco:b1819
PATRICⁱ	fig\|511145.12.peg.1896

Organism-specific databases

EchoBASEⁱ	EB0564
EcoGeneⁱ	EG10569 manZ

Phylogenomic databases

eggNOGⁱ	ENOG4105F3R Bacteria COG3716 LUCA
HOGENOMⁱ	HOG000098670
InParanoidⁱ	P69805
KOⁱ	K02796

Enzyme and pathway databases

BioCycⁱ	EcoCyc:MANZ-MONOMER MetaCyc:MANZ-MONOMER

BioCycⁱ

EcoCyc:MANZ-MONOMER
MetaCyc:MANZ-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P69805

PROⁱ

PR:P69805

Family and domain databases

InterProⁱ	View protein in InterPro IPR004704 PTS_IID_man
Pfamⁱ	View protein in Pfam PF03613 EIID-AGA, 1 hit
TIGRFAMsⁱ	TIGR00828 EIID-AGA, 1 hit
PROSITEⁱ	View protein in PROSITE PS51108 PTS_EIID, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PTND_ECOLI
Accessionⁱ	P69805Primary (citable) accession number: P69805 Secondary accession number(s): P08188
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	November 16, 2011
	Last modified:	April 25, 2018
	This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P69805 (PTND_ECOLI)

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PTS system mannose-specific EIID component

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ