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Protein

PTS system mannose-specific EIID component

Gene

manZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (PubMed:2951378, PubMed:2999119). The enzyme II ManXYZ PTS system is involved in mannose transport (PubMed:2951378, PubMed:2999119). Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA (PubMed:4604906, PubMed:353494).4 Publications

GO - Molecular functioni

GO - Biological processi

  • glucose import across plasma membrane Source: EcoCyc
  • mannose transmembrane transport Source: EcoCyc
  • phosphoenolpyruvate-dependent sugar phosphotransferase system Source: EcoCyc

Keywordsi

Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:MANZ-MONOMER
MetaCyc:MANZ-MONOMER

Protein family/group databases

TCDBi4.A.6.1.1 the pts mannose-fructose-sorbose (man) family

Names & Taxonomyi

Protein namesi
Recommended name:
PTS system mannose-specific EIID component1 Publication
Alternative name(s):
EII-M-Man1 Publication
EIID-Man1 Publication
Mannose permease IID component1 Publication
Gene namesi
Name:manZ
Synonyms:gptB, ptsM
Ordered Locus Names:b1819, JW1808
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10569 manZ

Subcellular locationi

  • Cell inner membrane 1 Publication; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 258Cytoplasmic1 PublicationAdd BLAST258
Transmembranei259 – 278Helical1 PublicationAdd BLAST20
Topological domaini279 – 283Periplasmic1 Publication5

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • membrane Source: UniProtKB
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001866501 – 283PTS system mannose-specific EIID componentAdd BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-formylmethionine1 Publication1

Keywords - PTMi

Formylation

Proteomic databases

EPDiP69805
PaxDbiP69805
PRIDEiP69805

Interactioni

Protein-protein interaction databases

BioGridi4259146, 324 interactors
IntActiP69805, 1 interactor
STRINGi316385.ECDH10B_1957

Structurei

3D structure databases

ProteinModelPortaliP69805
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 281PTS EIIDPROSITE-ProRule annotationAdd BLAST271

Domaini

The EIID domain, with its homologous EIIC domain, forms the PTS system translocation channel and contains part of its specific substrate-binding site.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105F3R Bacteria
COG3716 LUCA
HOGENOMiHOG000098670
InParanoidiP69805
KOiK02796

Family and domain databases

InterProiView protein in InterPro
IPR004704 PTS_IID_man
PfamiView protein in Pfam
PF03613 EIID-AGA, 1 hit
TIGRFAMsiTIGR00828 EIID-AGA, 1 hit
PROSITEiView protein in PROSITE
PS51108 PTS_EIID, 1 hit

Sequencei

Sequence statusi: Complete.

P69805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDTTQTTTE KKLTQSDIRG VFLRSNLFQG SWNFERMQAL GFCFSMVPAI
60 70 80 90 100
RRLYPENNEA RKQAIRRHLE FFNTQPFVAA PILGVTLALE EQRANGAEID
110 120 130 140 150
DGAINGIKVG LMGPLAGVGD PIFWGTVRPV FAALGAGIAM SGSLLGPLLF
160 170 180 190 200
FILFNLVRLA TRYYGVAYGY SKGIDIVKDM GGGFLQKLTE GASILGLFVM
210 220 230 240 250
GALVNKWTHV NIPLVVSRIT DQTGKEHVTT VQTILDQLMP GLVPLLLTFA
260 270 280
CMWLLRKKVN PLWIIVGFFV IGIAGYACGL LGL
Length:283
Mass (Da):30,955
Last modified:November 16, 2011 - v2
Checksum:iE29ED1D7040AE67D
GO

Sequence cautioni

The sequence AAA24445 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA15631 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02699 Genomic DNA Translation: AAA24445.1 Different initiation.
U00096 Genomic DNA Translation: AAC74889.2
AP009048 Genomic DNA Translation: BAA15631.1 Different initiation.
PIRiA30288 WQECMM
RefSeqiNP_416333.4, NC_000913.3
WP_000228655.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74889; AAC74889; b1819
BAA15631; BAA15631; BAA15631
GeneIDi946342
KEGGiecj:JW1808
eco:b1819
PATRICifig|511145.12.peg.1896

Similar proteinsi

Entry informationi

Entry nameiPTND_ECOLI
AccessioniPrimary (citable) accession number: P69805
Secondary accession number(s): P08188
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 16, 2011
Last modified: April 25, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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