Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PTS system mannose-specific EIIC component

Gene

manY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (PubMed:2951378, PubMed:2999119). The enzyme II ManXYZ PTS system is involved in mannose transport (PubMed:2951378, PubMed:2999119). Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA (PubMed:4604906, PubMed:353494).4 Publications

GO - Molecular functioni

GO - Biological processi

  • glucose import across plasma membrane Source: EcoCyc
  • mannose transmembrane transport Source: EcoCyc
  • phosphoenolpyruvate-dependent sugar phosphotransferase system Source: EcoCyc

Keywordsi

Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:MANY-MONOMER
MetaCyc:MANY-MONOMER

Protein family/group databases

TCDBi4.A.6.1.1 the pts mannose-fructose-sorbose (man) family

Names & Taxonomyi

Protein namesi
Recommended name:
PTS system mannose-specific EIIC component1 Publication
Alternative name(s):
EII-P-Man1 Publication
EIIC-Man1 Publication
Mannose permease IIC component1 Publication
Gene namesi
Name:manY
Synonyms:pel, ptsP
Ordered Locus Names:b1818, JW1807
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10568 manY

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4Cytoplasmic1 Publication4
Transmembranei5 – 24Helical1 PublicationAdd BLAST20
Topological domaini25 – 49Periplasmic1 PublicationAdd BLAST25
Transmembranei50 – 69Helical1 PublicationAdd BLAST20
Topological domaini70 – 83Cytoplasmic1 PublicationAdd BLAST14
Transmembranei84 – 102Helical1 PublicationAdd BLAST19
Topological domaini103 – 105Periplasmic1 Publication3
Transmembranei106 – 124Helical1 PublicationAdd BLAST19
Topological domaini125 – 150Cytoplasmic1 PublicationAdd BLAST26
Transmembranei151 – 170Helical1 PublicationAdd BLAST20
Topological domaini171 – 181Periplasmic1 PublicationAdd BLAST11
Transmembranei182 – 201Helical1 PublicationAdd BLAST20
Topological domaini202 – 266Cytoplasmic1 PublicationAdd BLAST65

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • membrane Source: UniProtKB
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001866461 – 266PTS system mannose-specific EIIC componentAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-formylmethionine1 Publication1

Keywords - PTMi

Formylation

Proteomic databases

PaxDbiP69801
PRIDEiP69801

Interactioni

Protein-protein interaction databases

BioGridi4259145, 502 interactors
IntActiP69801, 1 interactor
STRINGi316385.ECDH10B_1956

Structurei

3D structure databases

ProteinModelPortaliP69801
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 237PTS EIIC type-4PROSITE-ProRule annotationAdd BLAST235

Domaini

The PTS EIIC type-4 domain forms the PTS system translocation channel and contains the specific substrate-binding site.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105ETZ Bacteria
COG3715 LUCA
HOGENOMiHOG000097554
InParanoidiP69801
KOiK02795
OMAiLSWIHVS
PhylomeDBiP69801

Family and domain databases

InterProiView protein in InterPro
IPR004700 PTS_IIC_man
PfamiView protein in Pfam
PF03609 EII-Sor, 1 hit
TIGRFAMsiTIGR00822 EII-Sor, 1 hit
PROSITEiView protein in PROSITE
PS51106 PTS_EIIC_TYPE_4, 1 hit

Sequencei

Sequence statusi: Complete.

P69801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEITTLQIVL VFIVACIAGM GSILDEFQFH RPLIACTLVG IVLGDMKTGI
60 70 80 90 100
IIGGTLEMIA LGWMNIGAAV APDAALASII STILVIAGHQ SIGAGIALAI
110 120 130 140 150
PLAAAGQVLT IIVRTITVAF QHAADKAADN GNLTAISWIH VSSLFLQAMR
160 170 180 190 200
VAIPAVIVAL SVGTSEVQNM LNAIPEVVTN GLNIAGGMIV VVGYAMVINM
210 220 230 240 250
MRAGYLMPFF YLGFVTAAFT NFNLVALGVI GTVMAVLYIQ LSPKYNRVAG
260
APAQAAGNND LDNELD
Length:266
Mass (Da):27,636
Last modified:August 1, 1988 - v1
Checksum:iEAFDD9E4B809AF23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02699 Genomic DNA Translation: AAA24444.1
U00096 Genomic DNA Translation: AAC74888.1
AP009048 Genomic DNA Translation: BAA15625.1
M36404 Genomic DNA Translation: AAA24111.1 Different termination.
PIRiA30285 WQECMP
RefSeqiNP_416332.1, NC_000913.3
WP_000406926.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74888; AAC74888; b1818
BAA15625; BAA15625; BAA15625
GeneIDi946332
KEGGiecj:JW1807
eco:b1818
PATRICifig|1411691.4.peg.433

Entry informationi

Entry nameiPTNC_ECOLI
AccessioniPrimary (citable) accession number: P69801
Secondary accession number(s): P08187, Q47351
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 25, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health