The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P69796 (PTQB_ECOL6)
Protein
PTS system N,N'-diacetylchitobiose-specific EIIB component
Gene
chbB
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Functioni
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2).
By similarityCatalytic activityi
- Nπ-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) = diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]By similarityEC:2.7.1.196By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 10 | Phosphocysteine intermediateBy similarity | 1 |
GO - Molecular functioni
- kinase activity Source: UniProtKB-KW
- protein-N(PI)-phosphohistidine-sugar phosphotransferase activity Source: InterPro
GO - Biological processi
- phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Phosphotransferase system, Sugar transport, Transport |
Enzyme and pathway databases
BioCyci | ECOL199310:C2137-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: PTS system N,N'-diacetylchitobiose-specific EIIB componentBy similarityAlternative name(s): EIIB-ChbBy similarity IVcelBy similarity N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIB componentBy similarity (EC:2.7.1.196By similarity) |
Gene namesi | Name:chbB Synonyms:celA Ordered Locus Names:c2137 |
Organismi | Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) |
Taxonomic identifieri | 199310 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186490 | 1 – 106 | PTS system N,N'-diacetylchitobiose-specific EIIB componentAdd BLAST | 106 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 10 | Phosphocysteine; by EIIAPROSITE-ProRule annotation | 1 |
Keywords - PTMi
PhosphoproteinExpressioni
Inductioni
By GlcNAc2, GlcNAc3 and beta-N,N'-diacetylchitobiose (Me-TCB).By similarity
Interactioni
Subunit structurei
Forms a complex with ChbA (EIIA). ChbB is a monomer in both its unphosphorylated and phosphorylated forms.
By similarityProtein-protein interaction databases
STRINGi | 199310.c2137 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 106 | PTS EIIB type-3PROSITE-ProRule annotationAdd BLAST | 104 |
Domaini
The PTS EIIB type-3 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-3 domain.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | COG1440, Bacteria |
HOGENOMi | CLU_147323_2_0_6 |
OMAi | DAEIFAC |
Family and domain databases
InterProi | View protein in InterPro IPR036095, PTS_EIIB-like_sf IPR003501, PTS_EIIB_2/3 IPR013012, PTS_EIIB_3 |
Pfami | View protein in Pfam PF02302, PTS_IIB, 1 hit |
SUPFAMi | SSF52794, SSF52794, 1 hit |
TIGRFAMsi | TIGR00853, pts-lac, 1 hit |
PROSITEi | View protein in PROSITE PS51100, PTS_EIIB_TYPE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P69796-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKKHIYLFC SAGMSTSLLV SKMRAQAEKY EVPVIIEAFP ETLAGEKGQN
60 70 80 90 100
ADVVLLGPQI AYMLPEIQRL LPNKPVEVID SLLYGKVDGL GVLKAAVAAI
KKAAAN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014075 Genomic DNA Translation: AAN80596.1 |
RefSeqi | WP_000412169.1, NC_004431.1 |
Genome annotation databases
EnsemblBacteriai | AAN80596; AAN80596; c2137 |
GeneIDi | 67415558 |
KEGGi | ecc:c2137 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014075 Genomic DNA Translation: AAN80596.1 |
RefSeqi | WP_000412169.1, NC_004431.1 |
3D structure databases
AlphaFoldDBi | P69796 |
BMRBi | P69796 |
SMRi | P69796 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 199310.c2137 |
Genome annotation databases
EnsemblBacteriai | AAN80596; AAN80596; c2137 |
GeneIDi | 67415558 |
KEGGi | ecc:c2137 |
Phylogenomic databases
eggNOGi | COG1440, Bacteria |
HOGENOMi | CLU_147323_2_0_6 |
OMAi | DAEIFAC |
Enzyme and pathway databases
BioCyci | ECOL199310:C2137-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR036095, PTS_EIIB-like_sf IPR003501, PTS_EIIB_2/3 IPR013012, PTS_EIIB_3 |
Pfami | View protein in Pfam PF02302, PTS_IIB, 1 hit |
SUPFAMi | SSF52794, SSF52794, 1 hit |
TIGRFAMsi | TIGR00853, pts-lac, 1 hit |
PROSITEi | View protein in PROSITE PS51100, PTS_EIIB_TYPE_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PTQB_ECOL6 | |
Accessioni | P69796Primary (citable) accession number: P69796 Secondary accession number(s): P17409 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | May 25, 2022 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |