UniProtKB - P69789 (PTXB_ECOLI)
Protein
Phosphotransferase enzyme IIB component GlvB
Gene
glvB
Organism
Escherichia coli (strain K12)
Status
Functioni
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This operon may be cryptic in wild-type K12 strains (Probable).By similarity1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 92 | Phosphocysteine intermediateBy similarity | 1 |
GO - Molecular functioni
- kinase activity Source: UniProtKB-KW
- protein-N(PI)-phosphohistidine-sugar phosphotransferase activity Source: InterPro
GO - Biological processi
- phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Phosphotransferase system, Sugar transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:GLVB-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphotransferase enzyme IIB component GlvB (EC:2.7.1.-)Alternative name(s): PTS system EIIB component |
Gene namesi | Name:glvB1 Publication Synonyms:glvC, yidN Ordered Locus Names:b3682, JW3659 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane Curated; Single-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 10 – 32 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186580 | 1 – 161 | Phosphotransferase enzyme IIB component GlvBAdd BLAST | 161 |
Proteomic databases
PRIDEi | P69789 |
Interactioni
Protein-protein interaction databases
IntActi | P69789, 2 interactors |
STRINGi | 316407.85676362 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 70 – 152 | PTS EIIB type-1PROSITE-ProRule annotationAdd BLAST | 83 |
Domaini
The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1263, Bacteria COG1264, Bacteria |
HOGENOMi | CLU_012312_8_1_6 |
PhylomeDBi | P69789 |
Family and domain databases
CDDi | cd00212, PTS_IIB_glc, 1 hit |
Gene3Di | 3.30.1360.60, 1 hit |
InterProi | View protein in InterPro IPR036878, Glu_permease_IIB IPR018113, PTrfase_EIIB_Cys IPR001996, PTS_IIB_1 |
Pfami | View protein in Pfam PF00367, PTS_EIIB, 1 hit |
SUPFAMi | SSF55604, SSF55604, 1 hit |
TIGRFAMsi | TIGR00826, EIIB_glc, 1 hit |
PROSITEi | View protein in PROSITE PS51098, PTS_EIIB_TYPE_1, 1 hit PS01035, PTS_EIIB_TYPE_1_CYS, 1 hit |
i Sequence
Sequence statusi: Complete.
P69789-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFSNHADMML TQIAIGLCFT LLYFVVFRTL ILQFNMCTPG REDAEVKLYS
60 70 80 90 100
KAEYKASRGQ TTAAEPKKEL DQAAGILQAL GGVGNISSIN NCATRLRIAL
110 120 130 140 150
HDMSQTLDDE VFKKLGAHGV FRSGDAIQVI IGLHVSQLRE QLDSLINSHQ
160
SAENVAITEA V
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10328 Genomic DNA Translation: AAA62034.1 U00096 Genomic DNA Translation: AYC08252.1 AP009048 Genomic DNA Translation: BAE77612.1 |
PIRi | C65170 |
RefSeqi | WP_000492410.1, NZ_CP047127.1 |
Genome annotation databases
EnsemblBacteriai | AYC08252; AYC08252; b3682 BAE77612; BAE77612; BAE77612 |
KEGGi | ecj:JW3659 |
PATRICi | fig|83333.103.peg.4617 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10328 Genomic DNA Translation: AAA62034.1 U00096 Genomic DNA Translation: AYC08252.1 AP009048 Genomic DNA Translation: BAE77612.1 |
PIRi | C65170 |
RefSeqi | WP_000492410.1, NZ_CP047127.1 |
3D structure databases
SMRi | P69789 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P69789, 2 interactors |
STRINGi | 316407.85676362 |
Proteomic databases
PRIDEi | P69789 |
Genome annotation databases
EnsemblBacteriai | AYC08252; AYC08252; b3682 BAE77612; BAE77612; BAE77612 |
KEGGi | ecj:JW3659 |
PATRICi | fig|83333.103.peg.4617 |
Organism-specific databases
EchoBASEi | EB1660 |
Phylogenomic databases
eggNOGi | COG1263, Bacteria COG1264, Bacteria |
HOGENOMi | CLU_012312_8_1_6 |
PhylomeDBi | P69789 |
Enzyme and pathway databases
BioCyci | EcoCyc:GLVB-MONOMER |
Miscellaneous databases
PROi | PR:P69789 |
Family and domain databases
CDDi | cd00212, PTS_IIB_glc, 1 hit |
Gene3Di | 3.30.1360.60, 1 hit |
InterProi | View protein in InterPro IPR036878, Glu_permease_IIB IPR018113, PTrfase_EIIB_Cys IPR001996, PTS_IIB_1 |
Pfami | View protein in Pfam PF00367, PTS_EIIB, 1 hit |
SUPFAMi | SSF55604, SSF55604, 1 hit |
TIGRFAMsi | TIGR00826, EIIB_glc, 1 hit |
PROSITEi | View protein in PROSITE PS51098, PTS_EIIB_TYPE_1, 1 hit PS01035, PTS_EIIB_TYPE_1_CYS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTXB_ECOLI | |
Accessioni | P69789Primary (citable) accession number: P69789 Secondary accession number(s): A0A385XNH2, P31451, Q2M7Z4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |