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Protein

Rab3 GTPase-activating protein catalytic subunit

Gene

Rab3gap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • Rab GTPase binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Rab3 GTPase-activating protein catalytic subunit
Alternative name(s):
RAB3 GTPase-activating protein 130 kDa subunit
Rab3-GAP p130
Short name:
Rab3-GAP
Gene namesi
Name:Rab3gap1
Synonyms:Rab3gap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306487 Rab3gap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001916572 – 775Rab3 GTPase-activating protein catalytic subunitAdd BLAST774

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1
Modified residuei373PhosphoserineBy similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei384PhosphoserineBy similarity1
Modified residuei458PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP69735
PRIDEiP69735

PTM databases

iPTMnetiP69735
PhosphoSitePlusiP69735

Interactioni

Subunit structurei

The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2 (PubMed:11809763, PubMed:9733780). Interacts with LMAN1 (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiP69735, 1 interactor
STRINGi10116.ENSRNOP00000005289

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab3-GAP catalytic subunit family.Curated

Phylogenomic databases

eggNOGiKOG2390 Eukaryota
ENOG410Y2R4 LUCA
HOGENOMiHOG000253924
HOVERGENiHBG079116
InParanoidiP69735
PhylomeDBiP69735

Family and domain databases

InterProiView protein in InterPro
IPR026147 Rab3-GAP_cat_su
PANTHERiPTHR21422 PTHR21422, 1 hit
PfamiView protein in Pfam
PF13890 Rab3-GTPase_cat, 1 hit

Sequence (1+)i

Sequence statusi: Fragments.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P69735-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAADSEPESE VGCPLTPLPP VSIAIRFTYV LQDWQQYFWP QQPPDIDALV
60 70 80 90 100
GGEVGGLEFG KLPFGACEDP ISELHLATTW PHLTEGIIVD NDVYSDLDPV
110 120 130 140 150
QAPHWSVRVR KADNPQCLLG DFVTEFLKIC RRKESTDEIL GRSTFEEEGR
160 170 180 190 200
VADITHALSK LTEPAPVPIH KLSVSNMVHT AKKKIRKHRG EESPLNNDVL
210 220 230 240 250
NTILLFLFPD AASEKPLDGT TSVDNSNPAA EAGDYTLYNQ FKSAPSDSLT
260 270 280 290 300
YKLALCLCMI NFYHGGLKGV AHLWQEFVLE MRFRWENNFL IPGLASGPPD
310 320 330 340 350
LRCCLLHQKL QMLNCCIERK KARDEGKKTS PSDSMTKAYP ADAGKAGGQL
360 370 380 390 400
GLDHLRDTEK EKGEAGKSWD SWSDSEEEFF ECLSDAEDLR GNGQESTKKG
410 420 430 440 450
GPKDMAPLKP EGRLHQHGKL TLLRNGEPLY IPVTQEPAPM TEDLLEEQSE
460 470 480 490 500
VLAKLGTSAE GAHLRARMQS ACLLSDMESF KAANPGCCLE DFVRWYSPRD
510 520 530 540 550
YIEEEVTDEK GNVVLKGELS ARMKIPSNMW VEAWETAKPV PARRQRRLFD
560 570 580 590 600
DTREAEKVLH YLAMQKPADL ARHLLPCVIH AAVLKVKEEE SLENIPSVKK
610 620 630 640 650
IIKQIIAHSS KVLRFPSPED KKLEEIILQI TTVEAIIARA RSLKAKFGTE
660 670 680 690 700
KCEHEEEKED LERFVSCLLE QPEVAVTGAG RGHAGRIIHK LFVNAQRAAA
710 720 730 740 750
VALPEEELKR SGCPEERRQT LVSDFPPPAG RELILRATVP RPAPYSKALP
760 770
QRMYSVLTKE DFRLAGAFSS DTSFF
Length:775
Mass (Da):86,587
Last modified:January 23, 2007 - v2
Checksum:iDF836260D18EC380
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JXA1A0A0G2JXA1_RAT
Rab3 GTPase-activating protein cata...
Rab3gap1
769Annotation score:
F1LP59F1LP59_RAT
Rab3 GTPase-activating protein cata...
Rab3gap1 RGD1306487
767Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-adjacent residuesi11 – 12Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03085327 Genomic DNA No translation available.
AABR03086784 Genomic DNA No translation available.
UniGeneiRn.226341
Rn.92067

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03085327 Genomic DNA No translation available.
AABR03086784 Genomic DNA No translation available.
UniGeneiRn.226341
Rn.92067

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP69735, 1 interactor
STRINGi10116.ENSRNOP00000005289

PTM databases

iPTMnetiP69735
PhosphoSitePlusiP69735

Proteomic databases

PaxDbiP69735
PRIDEiP69735

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi1306487 Rab3gap1

Phylogenomic databases

eggNOGiKOG2390 Eukaryota
ENOG410Y2R4 LUCA
HOGENOMiHOG000253924
HOVERGENiHBG079116
InParanoidiP69735
PhylomeDBiP69735

Family and domain databases

InterProiView protein in InterPro
IPR026147 Rab3-GAP_cat_su
PANTHERiPTHR21422 PTHR21422, 1 hit
PfamiView protein in Pfam
PF13890 Rab3-GTPase_cat, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRB3GP_RAT
AccessioniPrimary (citable) accession number: P69735
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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