Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleoprotein

Gene

N

Organism
Avian infectious bronchitis virus (strain Beaudette) (IBV)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.UniRule annotation

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
NucleoproteinUniRule annotation
Alternative name(s):
Nucleocapsid proteinUniRule annotation
Short name:
NCUniRule annotation
Short name:
Protein NUniRule annotation
Gene namesi
Name:NUniRule annotation
ORF Names:6
OrganismiAvian infectious bronchitis virus (strain Beaudette) (IBV)
Taxonomic identifieri11122 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeGammacoronavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
Proteomesi
  • UP000006717 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001059761 – 409NucleoproteinAdd BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei190Phosphoserine; by hostUniRule annotation1 Publication1
Modified residuei192Phosphoserine; by hostUniRule annotation1 Publication1
Disulfide bondi281 ↔ 308UniRule annotation1 Publication
Disulfide bondi320 ↔ 323UniRule annotation1 Publication
Modified residuei378Phosphothreonine; by hostUniRule annotation1 Publication1
Modified residuei379Phosphoserine; by hostUniRule annotation1 Publication1

Post-translational modificationi

ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.UniRule annotation
Phosphorylated on serine and threonine residues.UniRule annotation1 Publication

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP69596

PTM databases

iPTMnetiP69596

Interactioni

Subunit structurei

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-15561295,EBI-15561295

GO - Molecular functioni

Structurei

Secondary structure

1409
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP69596
SMRiP69596
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP69596

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 160RNA-bindingUniRule annotationAdd BLAST132
Regioni226 – 333DimerizationUniRule annotationAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi165 – 190Ser-richUniRule annotationAdd BLAST26

Sequence similaritiesi

Belongs to the gammacoronavirus nucleocapsid protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900008T

Family and domain databases

HAMAPiMF_04097 GAMMA_CORONA_NCAP, 1 hit
InterProiView protein in InterPro
IPR001218 Corona_nucleocap
IPR037179 Nucleocapsid_C
IPR037195 Nucleocapsid_N
PfamiView protein in Pfam
PF00937 Corona_nucleoca, 1 hit
PIRSFiPIRSF003888 Corona_nucleocap, 1 hit
SUPFAMiSSF103068 SSF103068, 1 hit
SSF110304 SSF110304, 1 hit

Sequencei

Sequence statusi: Complete.

P69596-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGKAAGKT DAPAPVIKLG GPKPPKVGSS GNASWFQAIK AKKLNTPPPK
60 70 80 90 100
FEGSGVPDNE NIKPSQQHGY WRRQARFKPG KGGRKPVPDA WYFYYTGTGP
110 120 130 140 150
AADLNWGDTQ DGIVWVAAKG ADTKSRSNQG TRDPDKFDQY PLRFSDGGPD
160 170 180 190 200
GNFRWDFIPL NRGRSGRSTA ASSAAASRAP SREGSRGRRS DSGDDLIARA
210 220 230 240 250
AKIIQDQQKK GSRITKAKAD EMAHRRYCKR TIPPNYRVDQ VFGPRTKGKE
260 270 280 290 300
GNFGDDKMNE EGIKDGRVTA MLNLVPSSHA CLFGSRVTPK LQLDGLHLRF
310 320 330 340 350
EFTTVVPCDD PQFDNYVKIC DQCVDGVGTR PKDDEPKPKS RSSSRPATRG
360 370 380 390 400
NSPAPRQQRP KKEKKLKKQD DEADKALTSD EERNNAQLEF YDEPKVINWG

DAALGENEL
Length:409
Mass (Da):45,032
Last modified:March 29, 2005 - v1
Checksum:i562F39C475DB8872
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti108D → Y in strain: Isolate Vero cell-adapted p65. 1
Natural varianti208Q → H in strain: Isolate Vero cell-adapted p65. 1
Natural varianti391 – 392YD → DY in strain: Isolate Vero cell-adapted p65. 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95169 Genomic RNA Translation: AAA70242.1
M28565 Genomic RNA Translation: AAA46214.1
DQ001339 Genomic RNA Translation: AAY24440.1
RefSeqiNP_040838.1, NC_001451.1

Genome annotation databases

GeneIDi1489745
KEGGivg:1489745

Similar proteinsi

Entry informationi

Entry nameiNCAP_IBVB
AccessioniPrimary (citable) accession number: P69596
Secondary accession number(s): Q4ZJS4, Q89902
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: June 20, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again