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Protein

Ran-binding protein 9

Gene

Ranbp9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-373760 L1CAM interactions
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8851805 MET activates RAS signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 9Curated
Short name:
RanBP9
Alternative name(s):
B-cell antigen receptor Ig beta-associated protein 1
Short name:
IBAP-1
Ran-binding protein M
Short name:
RanBPM
Gene namesi
Name:Ranbp9Imported
Synonyms:Ranbpm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1928741 Ranbp9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971701 – 653Ran-binding protein 9Add BLAST653

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei330N6-acetyllysineBy similarity1
Modified residuei402PhosphoserineCombined sources1
Modified residuei412PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in response to stress.By similarity
Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP69566
MaxQBiP69566
PaxDbiP69566
PeptideAtlasiP69566
PRIDEiP69566

PTM databases

iPTMnetiP69566
PhosphoSitePlusiP69566

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in maturating spermatocytes.2 Publications

Gene expression databases

CleanExiMM_RANBP9
ExpressionAtlasiP69566 baseline and differential

Interactioni

Subunit structurei

Part of a complex consisting of RANBP9, MKLN1 and GID8. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with GTP-bound Ran, AR, CDC2L1/p110C, CALB1, S100A7, USP11, SOS1 or SOS2, GID8, and FMR1. Interacts with the Dyrk kinases HIPK2, DYRK1A, and DYRK1B. Interacts with TP73 isoform Alpha but not with TP53. Interacts with the HGF receptor MET and the integrins ITGB1 and ITGB2, but not with ITGAL. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Directly interacts with RANBP10. Interacts with YPEL5 (By similarity). Interacts with MKLN1 (PubMed:18710924). Interacts with DDX4 (PubMed:14648869). Interacts with NGFR (PubMed:12963025). Interacts with Tex19.1 and, probably, Tex19.2 (PubMed:28254886).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Lrp1bQ9JI182EBI-772305,EBI-8294317

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208133, 11 interactors
IntActiP69566, 9 interactors
MINTiP69566
STRINGi10090.ENSMUSP00000130636

Structurei

3D structure databases

ProteinModelPortaliP69566
SMRiP69566
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 259B30.2/SPRYPROSITE-ProRule annotationAdd BLAST188
Domaini290 – 322LisHPROSITE-ProRule annotationAdd BLAST33
Domaini328 – 385CTLHPROSITE-ProRule annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni326 – 332Interaction with CALB1By similarity7
Regioni539 – 653Interaction with FMR1By similarityAdd BLAST115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 10Poly-Pro6
Compositional biasi14 – 20Poly-Pro7

Domaini

The SPRY domain mediates the interaction with MET, AR, and CDC2L1.By similarity

Sequence similaritiesi

Belongs to the RANBP9/10 family.Curated

Phylogenomic databases

eggNOGiKOG1477 Eukaryota
ENOG410XPCC LUCA
GeneTreeiENSGT00530000063160
HOGENOMiHOG000008133
HOVERGENiHBG053444
InParanoidiP69566
PhylomeDBiP69566

Family and domain databases

CDDicd12909 SPRY_RanBP9_10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR013144 CRA_dom
IPR024964 CTLH/CRA
IPR006595 CTLH_C
IPR006594 LisH
IPR003877 SPRY_dom
IPR035782 SPRY_RanBP9/10
PfamiView protein in Pfam
PF10607 CLTH, 1 hit
PF08513 LisH, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00757 CRA, 1 hit
SM00668 CTLH, 1 hit
SM00667 LisH, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P69566-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGQPPPPPP QQQPPPPPPP ASAAAPATAP PGLAVGPGPA AGVPVPGLAA
60 70 80 90 100
GSSAAAPFPH GDSALNEQEK ELQRRLKRLY PAVDEQETPL PRSWSPKDKF
110 120 130 140 150
SYIGLSQNNL RVHYKGHGKT PKDAASVRAT HPIPAACGIY YFEVKIVSKG
160 170 180 190 200
RDGYMGIGLS AQGVNMNRLP GWDKHSYGYH GDDGHSFCSS GTGQPYGPTF
210 220 230 240 250
TTGDVIGCCV NLINNTCFYT KNGHSLGIAF TDLPPNLYPT VGLQTPGEVV
260 270 280 290 300
DANFGQHPFV FDIEDYMREW RTKIQAQIDR FPIGDREGEW QTMIQKMVSS
310 320 330 340 350
YLVHHGYCAT AEAFARSTDQ TVLEELASIK NRQRIQKLVL AGRMGEAIET
360 370 380 390 400
TQQLYPSLLE RNPNLLFTLK VRQFIEMVNG TDSEVRCLGG RSPKSQDSYP
410 420 430 440 450
VSPRPFSSPS MSPSHGMSIH SLAPGKSSTA HFSGFESCSN GVISNKAHQS
460 470 480 490 500
YCHSKHQLSS LTVPELNSLN VSRSQQVNNF TSNDVDMETD HYSNGVGETS
510 520 530 540 550
SNGFLNGSSK HDHEMEDCDT EMEVDCSQLR RQLCGGSQAA IERMIHFGRE
560 570 580 590 600
LQAMSEQLRR ECGKNTANKK MLKDAFSLLA YSDPWNSPVG NQLDPIQREP
610 620 630 640 650
VCSALNSAIL ETHNLPKQPP LALAMGQATQ CLGLMARSGV GSCAFATVED

YLH
Length:653
Mass (Da):71,012
Last modified:March 29, 2005 - v1
Checksum:iBE810E69B238BBD5
GO
Isoform 2 (identifier: P69566-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.
     108-115: NNLRVHYK → MWESSWVL

Note: No experimental confirmation available.
Show »
Length:546
Mass (Da):60,086
Checksum:i8B74E3D4F271875F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q5D6E9Q5D6_MOUSE
Ran-binding protein 9
Ranbp9
710Annotation score:
A0A1Y7VLC4A0A1Y7VLC4_MOUSE
Ran-binding protein 9
Ranbp9
96Annotation score:
A0A1Y7VIP5A0A1Y7VIP5_MOUSE
Ran-binding protein 9
Ranbp9
64Annotation score:
A0A1Y7VLX7A0A1Y7VLX7_MOUSE
Ran-binding protein 9
Ranbp9
148Annotation score:
A0A1Y7VP77A0A1Y7VP77_MOUSE
Ran-binding protein 9
Ranbp9
37Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92R → P (PubMed:12963025).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0282661 – 107Missing in isoform 2. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_028267108 – 115NNLRVHYK → MWESSWVL in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006465 mRNA Translation: AAD01272.1
AK132714 mRNA Translation: BAE21317.1
PIRiJC8013
RefSeqiNP_064314.2, NM_019930.2
UniGeneiMm.148781

Genome annotation databases

EnsembliENSMUST00000222651; ENSMUSP00000152620; ENSMUSG00000038546 [P69566-2]
GeneIDi56705
KEGGimmu:56705

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006465 mRNA Translation: AAD01272.1
AK132714 mRNA Translation: BAE21317.1
PIRiJC8013
RefSeqiNP_064314.2, NM_019930.2
UniGeneiMm.148781

3D structure databases

ProteinModelPortaliP69566
SMRiP69566
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208133, 11 interactors
IntActiP69566, 9 interactors
MINTiP69566
STRINGi10090.ENSMUSP00000130636

PTM databases

iPTMnetiP69566
PhosphoSitePlusiP69566

Proteomic databases

EPDiP69566
MaxQBiP69566
PaxDbiP69566
PeptideAtlasiP69566
PRIDEiP69566

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000222651; ENSMUSP00000152620; ENSMUSG00000038546 [P69566-2]
GeneIDi56705
KEGGimmu:56705

Organism-specific databases

CTDi10048
MGIiMGI:1928741 Ranbp9

Phylogenomic databases

eggNOGiKOG1477 Eukaryota
ENOG410XPCC LUCA
GeneTreeiENSGT00530000063160
HOGENOMiHOG000008133
HOVERGENiHBG053444
InParanoidiP69566
PhylomeDBiP69566

Enzyme and pathway databases

ReactomeiR-MMU-373760 L1CAM interactions
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8851805 MET activates RAS signaling

Miscellaneous databases

ChiTaRSiRanbp9 mouse
PROiPR:P69566
SOURCEiSearch...

Gene expression databases

CleanExiMM_RANBP9
ExpressionAtlasiP69566 baseline and differential

Family and domain databases

CDDicd12909 SPRY_RanBP9_10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR013144 CRA_dom
IPR024964 CTLH/CRA
IPR006595 CTLH_C
IPR006594 LisH
IPR003877 SPRY_dom
IPR035782 SPRY_RanBP9/10
PfamiView protein in Pfam
PF10607 CLTH, 1 hit
PF08513 LisH, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00757 CRA, 1 hit
SM00668 CTLH, 1 hit
SM00667 LisH, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRANB9_MOUSE
AccessioniPrimary (citable) accession number: P69566
Secondary accession number(s): P84500, Q3V136
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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