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UniProtKB - P69525 (TMPS9_MOUSE)

Entry version 104 (07 Oct 2020)
Sequence version 1 (15 Mar 2005)
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Protein

Transmembrane protease serine 9

Gene

Tmprss9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by serine protease inhibitors PMSF and 4-(2-aminoethyl)benzenesulfonyl fluoride, but not by EDTA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei245Charge relay systemBy similarity1
Active sitei294Charge relay systemBy similarity1
Active sitei389Charge relay systemBy similarity1
Active sitei546Charge relay systemBy similarity1
Active sitei594Charge relay systemBy similarity1
Active sitei689Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protease serine 9 (EC:3.4.21.-)
Alternative name(s):
Polyserase-I
Polyserine protease 1
Short name:
Polyserase-1
Cleaved into the following 3 chains:
Serase-1
Serase-2
Serase-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tmprss9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:3612246, Tmprss9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini3 – 31CytoplasmicSequence analysisAdd BLAST29
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 1065ExtracellularSequence analysisAdd BLAST1013

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000278711 – 1065Transmembrane protease serine 9Sequence analysisAdd BLAST1065
ChainiPRO_0000027872205 – 505Serase-1Sequence analysisAdd BLAST301
ChainiPRO_0000027873506 – 833Serase-2Sequence analysisAdd BLAST328
ChainiPRO_0000027874834 – 1065Serase-3Sequence analysisAdd BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi156 ↔ 168By similarity
Disulfide bondi163 ↔ 182By similarity
Disulfide bondi176 ↔ 191By similarity
Disulfide bondi230 ↔ 246By similarity
Disulfide bondi328 ↔ 395By similarity
Disulfide bondi360 ↔ 374By similarity
Disulfide bondi385 ↔ 414By similarity
Disulfide bondi531 ↔ 547By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi549N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi628 ↔ 695By similarity
Glycosylationi640N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi660 ↔ 674By similarity
Glycosylationi665N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi685 ↔ 714By similarity
Glycosylationi792N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi860 ↔ 876By similarity
Disulfide bondi955 ↔ 1021By similarity
Disulfide bondi986 ↔ 1000By similarity
Disulfide bondi1011 ↔ 1040By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved to generate 3 independent serine protease chains. The cleaved chains may remain attached to the membrane thanks to disulfide bonds. It is unclear whether cleavage always takes place (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei204 – 205CleavageSequence analysis2
Sitei505 – 506CleavageSequence analysis2
Sitei833 – 834CleavageSequence analysis2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P69525

PRoteomics IDEntifications database

More...PRIDEi		P69525

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P69525, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P69525

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P69525

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000100970

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P69525, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P69525

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini155 – 192LDL-receptor class APROSITE-ProRule annotationAdd BLAST38
Domaini205 – 438Peptidase S1 1PROSITE-ProRule annotationAdd BLAST234
Domaini506 – 738Peptidase S1 2PROSITE-ProRule annotationAdd BLAST233
Domaini834 – 1064Peptidase S1 3PROSITE-ProRule annotationAdd BLAST231

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The serine protease 1 and 2 domains are catalytically active, whereas the serine protease 3 domain lacks the essential Ser residue of the catalytic triad at position 1015 and is predicted to be inactive.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3627, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P69525

Database for complete collections of gene phylogenies

More...PhylomeDBi		P69525

Family and domain databases

Conserved Domains Database

More...CDDi		cd00112, LDLa, 1 hit
cd00190, Tryp_SPc, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.10.10, 5 hits
4.10.400.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036055, LDL_receptor-like_sf
IPR002172, LDrepeatLR_classA_rpt
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR017324, Tmprss9
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00057, Ldl_recept_a, 1 hit
PF00089, Trypsin, 3 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037931, TMPRSS9_polyserase-1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00722, CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00192, LDLa, 1 hit
SM00020, Tryp_SPc, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494, SSF50494, 3 hits
SSF57424, SSF57424, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS50240, TRYPSIN_DOM, 3 hits
PS00134, TRYPSIN_HIS, 3 hits
PS00135, TRYPSIN_SER, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P69525-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPTAPDLQL VPEVTKAVSV SAPDPGPCRT AVIAVVGISM AIVTLGVLSA 
        60         70         80         90        100
FFSAQGAHVE HIAELHGIRF TSSLQQENSD FYRLLTHALQ TLLHFLLRAL 
       110        120        130        140        150
QPLSLKQEAD ILQKGIQARL QEQGLSLAAY GTIVSVELTG RCEGPVTERD 
       160        170        180        190        200
LKSGHCPGNV FSCQNGQCVS KENPECDDRV DCSDESDEAQ CDCGWQPAWR 
       210        220        230        240        250
SAGRIVGGVE AAPGEFPWQV SLRENHEHFC GATIIGARWL VSAAHCFNEF 
       260        270        280        290        300
QDPAQWAAQA GSVHLSGSEA SAVRTRVLRI AKHPAYDADT ADFDVAVLEL 
       310        320        330        340        350
ARPLPFGRYV QPACLPAATH VFPPGKKCLI SGWGYLKEDF LVKPEVLQKA 
       360        370        380        390        400
TVELLDQSLC SSLYGHSLTD RMVCAGYLDG KVDSCQGDSG GPLVCEEPSG 
       410        420        430        440        450
RFFLAGIVSW GIGCAEARRP GVYTRVTRLR DWILEVTSAA DMPVVPTATP 
       460        470        480        490        500
APATPSTPWP TSPESWAPNT FAKPTAAPSP VPLHPSTTAK PQECGARPAM 
       510        520        530        540        550
DKPTRIVGGI SAVSGEVPWQ ASLKEGPRHF CGATVVGDRW LLSAAHCFNH 
       560        570        580        590        600
TKVEQVQAHL GTVSLLGVGG SPVKLGLRRV ALHPRYNPGI LDFDVALLEL 
       610        620        630        640        650
AQPLVFNKYI QPVCLPLAIH KFPVGRKCMI SGWGNMQEGN ATKPDILQKA 
       660        670        680        690        700
SVGIIEQKMC GALYNFSLTD RMLCAGFLEG RVDSCQGDSG GPLACEETPG 
       710        720        730        740        750
VFYLAGIVSW GIGCAQAKKP GVYARITRLK DWILKAMSSD PSSMARPHTS 
       760        770        780        790        800
STRLIPSEPP KTTAAGLIIP EATTSRLATP RATIRVTTRP LNTTLSARST 
       810        820        830        840        850
TTRGQTAAPS APGTTIHSHL PDCGLAPPGA LTRIVGGSAA SLGEWPWQVS 
       860        870        880        890        900
LWLRRREHRC GAVLVAERWL LSAAHCFDIY GDPMQWAAFL GTPFLSSTEG 
       910        920        930        940        950
QLERVARIYR HPFYNIYTLD YDVALLELAG PVRRSRLVRP ICLPGPARPP 
       960        970        980        990       1000
DGARCVITGW GSLREGGSMA RQLQKAAVRV LSEQTCRRFY PVQISSRMLC 
      1010       1020       1030       1040       1050
AGFPQGGVDS CSGDAGGPLA CREPSGQWVL TGVTSWGYGC GRPHFPGVYT 
      1060 
RVAAVLGWIG QNIQE
Length:1,065
Mass (Da):114,486
Last modified:March 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0EAD1D515D18D4F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YTR8D3YTR8_MOUSE
Transmembrane protease serine 9
Tmprss9
1,099Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC152413 Genomic DNA No translation available.
AC166937 Genomic DNA No translation available.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152413 Genomic DNA No translation available.
AC166937 Genomic DNA No translation available.

3D structure databases

SMRiP69525
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100970

PTM databases

GlyGeniP69525, 4 sites
iPTMnetiP69525
PhosphoSitePlusiP69525

Proteomic databases

PaxDbiP69525
PRIDEiP69525

Organism-specific databases

MGIiMGI:3612246, Tmprss9

Phylogenomic databases

eggNOGiKOG3627, Eukaryota
InParanoidiP69525
PhylomeDBiP69525

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Tmprss9, mouse

Protein Ontology

More...PROi		PR:P69525
RNActiP69525, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Family and domain databases

CDDicd00112, LDLa, 1 hit
cd00190, Tryp_SPc, 3 hits
Gene3Di2.40.10.10, 5 hits
4.10.400.10, 1 hit
InterProiView protein in InterPro
IPR036055, LDL_receptor-like_sf
IPR002172, LDrepeatLR_classA_rpt
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR017324, Tmprss9
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER
PfamiView protein in Pfam
PF00057, Ldl_recept_a, 1 hit
PF00089, Trypsin, 3 hits
PIRSFiPIRSF037931, TMPRSS9_polyserase-1, 1 hit
PRINTSiPR00722, CHYMOTRYPSIN
SMARTiView protein in SMART
SM00192, LDLa, 1 hit
SM00020, Tryp_SPc, 3 hits
SUPFAMiSSF50494, SSF50494, 3 hits
SSF57424, SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS50240, TRYPSIN_DOM, 3 hits
PS00134, TRYPSIN_HIS, 3 hits
PS00135, TRYPSIN_SER, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMPS9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P69525
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 7, 2020
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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