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Protein

conotoxin S11.3

Gene
N/A
Organism
Conus striatus (Striated cone)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
conotoxin S11.3
OrganismiConus striatus (Striated cone)
Taxonomic identifieri6493 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPionoconus

Organism-specific databases

ConoServeri1391 S11.3 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003511427 – 60conotoxin S11.3Add BLAST34
PropeptideiPRO_000003511564 – 68By similarity5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 43By similarity
Disulfide bondi36 ↔ 48By similarity
Disulfide bondi42 ↔ 52By similarity
Disulfide bondi47 ↔ 56By similarity
Modified residuei60Tyrosine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiP69499
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I2 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR020242 Conotoxin_I2-superfamily
PfamiView protein in Pfam
PF17557 Conotoxin_I2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162 Conotoxin_I2-superfamily, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P69499-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFRLTSVSC FLLVIVCLNL FQVVLTRRCV PPSRYCTRHR PCCRGTCCSG
60
LCRPMCNLWY GKRATFQE
Length:68
Mass (Da):7,927
Last modified:March 15, 2005 - v1
Checksum:iE462E2ACEB3AA4C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ746188 mRNA Translation: CAG34096.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ746188 mRNA Translation: CAG34096.1

3D structure databases

SMRiP69499
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1391 S11.3 precursor

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR020242 Conotoxin_I2-superfamily
PfamiView protein in Pfam
PF17557 Conotoxin_I2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162 Conotoxin_I2-superfamily, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI2_CONST
AccessioniPrimary (citable) accession number: P69499
Secondary accession number(s): Q59AA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 10, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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