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Protein

Conotoxin Im11.4

Gene
N/A
Organism
Conus imperialis (Imperial cone)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Im11.4
OrganismiConus imperialis (Imperial cone)
Taxonomic identifieri35631 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusStephanoconus

Organism-specific databases

ConoServeri1393 Im11.4 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003509027 – 57Conotoxin Im11.4Add BLAST31
PropeptideiPRO_000003509161 – 64By similarity4

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 41By similarity
Disulfide bondi34 ↔ 46By similarity
Disulfide bondi40 ↔ 50By similarity
Disulfide bondi45 ↔ 54By similarity
Modified residuei57Histidine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiP69495
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I2 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR020242 Conotoxin_I2-superfamily
PfamiView protein in Pfam
PF17557 Conotoxin_I2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162 Conotoxin_I2-superfamily, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P69495-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFRLTSVSC ILLVIAFLNL VGLTNACTSE GYSCSSDSNC CKNVCCWNVC
60
ESHCGHHGKR ATFQ
Length:64
Mass (Da):6,995
Last modified:March 15, 2005 - v1
Checksum:iC3C68304E3E6D414
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ746186 mRNA Translation: CAG34094.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ746186 mRNA Translation: CAG34094.1

3D structure databases

SMRiP69495
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1393 Im11.4 precursor

Family and domain databases

InterProiView protein in InterPro
IPR013141 Conotoxin-I_CS
IPR020242 Conotoxin_I2-superfamily
PfamiView protein in Pfam
PF17557 Conotoxin_I2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD267162 Conotoxin_I2-superfamily, 1 hit
PROSITEiView protein in PROSITE
PS60019 I_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI21_CONIM
AccessioniPrimary (citable) accession number: P69495
Secondary accession number(s): Q59AA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 10, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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