UniProtKB - P69488 (CUTA_ECOLI)
Protein
Divalent-cation tolerance protein CutA
Gene
cutA
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in resistance toward heavy metals.1 Publication
Cofactori
Cu cation1 PublicationNote: Binds 1 copper ion per subunit.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 16 | CopperCurated | 1 | |
Metal bindingi | 83 | CopperCurated | 1 | |
Metal bindingi | 84 | CopperCurated | 1 |
GO - Molecular functioni
- copper ion binding Source: UniProtKB
- metal ion binding Source: EcoCyc
GO - Biological processi
- response to copper ion Source: EcoCyc
Keywordsi
Ligand | Copper, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12177-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Divalent-cation tolerance protein CutAAlternative name(s): C-type cytochrome biogenesis protein CycY |
Gene namesi | Name:cutA Synonyms:cutA1, cycY Ordered Locus Names:b4137, JW4097 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000157118 | 1 – 112 | Divalent-cation tolerance protein CutAAdd BLAST | 112 |
Proteomic databases
jPOSTi | P69488 |
PaxDbi | P69488 |
PRIDEi | P69488 |
Interactioni
Subunit structurei
Homotrimer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4262693, 8 interactors 852952, 1 interactor |
DIPi | DIP-47984N |
IntActi | P69488, 10 interactors |
STRINGi | 511145.b4137 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P69488 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P69488 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CutA family.Curated
Phylogenomic databases
eggNOGi | COG1324, Bacteria |
HOGENOMi | CLU_098807_3_0_6 |
InParanoidi | P69488 |
PhylomeDBi | P69488 |
Family and domain databases
Gene3Di | 3.30.70.120, 1 hit |
HAMAPi | MF_01160, CutA, 1 hit |
InterProi | View protein in InterPro IPR023700, CutA_Enterobact IPR004323, Ion_tolerance_CutA IPR011322, N-reg_PII-like_a/b IPR015867, N-reg_PII/ATP_PRibTrfase_C |
PANTHERi | PTHR23419, PTHR23419, 1 hit |
Pfami | View protein in Pfam PF03091, CutA1, 1 hit |
SUPFAMi | SSF54913, SSF54913, 1 hit |
i Sequence
Sequence statusi: Complete.
P69488-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLDEKSSNTA SVVVLCTAPD EATAQDLAAK VLAEKLAACA TLIPGATSLY
60 70 80 90 100
YWEGKLEQEY EVQMILKTTV SHQQALLECL KSHHPYQTPE LLVLPVTHGD
110
TDYLSWLNAS LR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 | A → R (PubMed:7623667).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77707 Genomic DNA Translation: CAA54780.1 Z36905 Genomic DNA Translation: CAA85374.1 U14003 Genomic DNA Translation: AAA97036.1 U00096 Genomic DNA Translation: AAC77097.1 AP009048 Genomic DNA Translation: BAE78139.1 |
PIRi | I41027 |
RefSeqi | NP_418560.1, NC_000913.3 WP_000883400.1, NZ_STEB01000014.1 |
Genome annotation databases
EnsemblBacteriai | AAC77097; AAC77097; b4137 BAE78139; BAE78139; BAE78139 |
GeneIDi | 58460971 948660 |
KEGGi | ecj:JW4097 eco:b4137 |
PATRICi | fig|1411691.4.peg.2563 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77707 Genomic DNA Translation: CAA54780.1 Z36905 Genomic DNA Translation: CAA85374.1 U14003 Genomic DNA Translation: AAA97036.1 U00096 Genomic DNA Translation: AAC77097.1 AP009048 Genomic DNA Translation: BAE78139.1 |
PIRi | I41027 |
RefSeqi | NP_418560.1, NC_000913.3 WP_000883400.1, NZ_STEB01000014.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1NAQ | X-ray | 1.70 | A/B/C/D/E/F | 1-112 | [»] | |
3AA8 | X-ray | 2.30 | A/B/C | 1-112 | [»] | |
3AA9 | X-ray | 2.30 | A/B/C | 1-112 | [»] | |
3AH6 | X-ray | 2.40 | A/B/C/D/E/F | 1-112 | [»] | |
3X3U | X-ray | 2.09 | A/B/C/D/E/F | 1-112 | [»] | |
4Y65 | X-ray | 1.70 | A/B/C | 1-112 | [»] | |
4Y6I | X-ray | 1.70 | A/B/C/D/E/F | 5-112 | [»] | |
SMRi | P69488 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262693, 8 interactors 852952, 1 interactor |
DIPi | DIP-47984N |
IntActi | P69488, 10 interactors |
STRINGi | 511145.b4137 |
Chemistry databases
DrugBanki | DB03975, Mercuribenzoic Acid |
Proteomic databases
jPOSTi | P69488 |
PaxDbi | P69488 |
PRIDEi | P69488 |
Genome annotation databases
EnsemblBacteriai | AAC77097; AAC77097; b4137 BAE78139; BAE78139; BAE78139 |
GeneIDi | 58460971 948660 |
KEGGi | ecj:JW4097 eco:b4137 |
PATRICi | fig|1411691.4.peg.2563 |
Organism-specific databases
EchoBASEi | EB2094 |
Phylogenomic databases
eggNOGi | COG1324, Bacteria |
HOGENOMi | CLU_098807_3_0_6 |
InParanoidi | P69488 |
PhylomeDBi | P69488 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12177-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P69488 |
PROi | PR:P69488 |
Family and domain databases
Gene3Di | 3.30.70.120, 1 hit |
HAMAPi | MF_01160, CutA, 1 hit |
InterProi | View protein in InterPro IPR023700, CutA_Enterobact IPR004323, Ion_tolerance_CutA IPR011322, N-reg_PII-like_a/b IPR015867, N-reg_PII/ATP_PRibTrfase_C |
PANTHERi | PTHR23419, PTHR23419, 1 hit |
Pfami | View protein in Pfam PF03091, CutA1, 1 hit |
SUPFAMi | SSF54913, SSF54913, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CUTA_ECOLI | |
Accessioni | P69488Primary (citable) accession number: P69488 Secondary accession number(s): P36654, Q2M6G7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | March 15, 2005 | |
Last modified: | April 7, 2021 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families