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Protein

Phosphoprotein

Gene

P

Organism
Rabies virus (strain ERA) (RABV)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processCytoplasmic inwards viral transport, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host STAT1 by virus, Inhibition of host STAT2 by virus, Interferon antiviral system evasion, Microtubular inwards viral transport, Viral immunoevasion, Viral RNA replication, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoprotein
Short name:
Protein P
Alternative name(s):
Protein M1
Gene namesi
Name:P
OrganismiRabies virus (strain ERA) (RABV)
Taxonomic identifieri11295 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesRhabdoviridaeLyssavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Mammalia [TaxID: 40674]
Proteomesi
  • UP000008619 Componenti: Genome

Subcellular locationi

Isoform P3 :
Isoform P4 :
Isoform P5 :

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002228291 – 297PhosphoproteinAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63Phosphoserine; by hostBy similarity1
Modified residuei162Phosphoserine; by host PKCBy similarity1
Modified residuei210Phosphoserine; by host PKCBy similarity1
Modified residuei271Phosphoserine; by host PKCBy similarity1

Post-translational modificationi

Phosphorylated by host PKC and by an unknown kinase.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotrimer when phosphorylated. This trimer is stabilized by binding to the L protein. Binds soluble protein N, and ribonucleocapsid. Interacts with host DYNLL1 and DYNLL2; this interaction may play a role in intracellular microtubule-dependent virus transport of incoming virus. Interacts with host STAT1, STAT2 and PML. Isoform P3 binds host PML (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP69479
SMRiP69479
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 172DYNLL1 and DYNLL2 bindingBy similarityAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi49 – 58Nuclear export signalBy similarity10
Motifi211 – 214Nuclear localization signalBy similarity4

Sequence similaritiesi

Belongs to the lyssavirus protein P family.Curated

Phylogenomic databases

OrthoDBiVOG090000H9

Family and domain databases

Gene3Di1.20.120.820, 1 hit
InterProiView protein in InterPro
IPR004259 PP_M1
IPR037199 PP_M1_C
PfamiView protein in Pfam
PF03012 PP_M1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004155 PP_M1, 1 hit
SUPFAMiSSF118173 SSF118173, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform P (identifier: P69479-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKIFVNPSA IRAGLADLEM AEETVDLINR NIEDNQAHLQ GEPIEVDNLP
60 70 80 90 100
EDMGRLHLDD GKSPNPGEMA KVGEGKYRED FQMDEGEDPS FLFQSYLENV
110 120 130 140 150
GVQIVRQMRS GERFLKIWSQ TVEEIISYVA VNFPNPPGKS SEDKSTQTTG
160 170 180 190 200
RELKKETTPT PSQRESQSSK ARMAAQTASG PPALEWSATN EKDDLSVEAE
210 220 230 240 250
IAHQIAESFS KKYKFPSRSS GILLYNFEQL KMNLDDIVKE AKNVPGVTRL
260 270 280 290
AHDGSKLPLR CVLGWVALAN SKKFQLLVES DKLSKIMQDD LNRYTSC
Length:297
Mass (Da):33,213
Last modified:March 15, 2005 - v1
Checksum:iB69C4287A220A7E4
GO
Isoform P2 (identifier: P69479-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:278
Mass (Da):31,199
Checksum:i130B1FD7FBD52DFE
GO
Isoform P3 (identifier: P69479-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Show »
Length:245
Mass (Da):27,455
Checksum:i9B9CAC2044983242
GO
Isoform P4 (identifier: P69479-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Show »
Length:229
Mass (Da):25,750
Checksum:iEF02B9B6938467A8
GO
Isoform P5 (identifier: P69479-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:215
Mass (Da):24,110
Checksum:i8CEC938F7701EFFD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0268681 – 82Missing in isoform P5. CuratedAdd BLAST82
Alternative sequenceiVSP_0268691 – 68Missing in isoform P4. CuratedAdd BLAST68
Alternative sequenceiVSP_0268701 – 52Missing in isoform P3. CuratedAdd BLAST52
Alternative sequenceiVSP_0268711 – 19Missing in isoform P2. CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55728 Genomic RNA Translation: CAA39259.1
EF206707 Viral cRNA Translation: ABN11292.1
PIRiS13708

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiPHOSP_RABVE
AccessioniPrimary (citable) accession number: P69479
Secondary accession number(s): A3F5L6, P22559
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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