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Protein

Probable Vpr-like protein

Gene
N/A
Organism
Feline immunodeficiency virus (strain San Diego) (FIV)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Seems to function as a Vpr-like protein, since it mediates host cell cycle arrest in G2 phase. Cell cycle arrest creates a favorable environment for maximizing viral expression and production.1 Publication

Caution

Was first thought to be the equivalent of lentiviral Tat protein.Curated
PubMed:1323707 sequence does not seem to originate from isolate Petaluma as described, but rather from the strain San Diego.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Probable Vpr-like protein
Alternative name(s):
ORF2
OrfA
Protein Tat
OrganismiFeline immunodeficiency virus (strain San Diego) (FIV)
Taxonomic identifieri11675 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiFelidae (cat family) [TaxID: 9681]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000855121 – 77Probable Vpr-like proteinAdd BLAST77

Interactioni

Protein-protein interaction databases

ELMiP69469

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 42Nuclear export signal9
Motifi44 – 53Nuclear localization signal1 Publication10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 61Cys-rich7

Family and domain databases

InterProiView protein in InterPro
IPR035276 FIV_OrfA
PfamiView protein in Pfam
PF17495 DUF5430, 1 hit

Sequencei

Sequence statusi: Complete.

P69469-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVIRIFNKV AERLDKEAAI RIFVLAHQLE RDKLIRLLQG LLWRLRFRKP
60 70
KSKDCLCWFC CRLYYWQLQS TLSIDTA
Length:77
Mass (Da):9,371
Last modified:March 15, 2005 - v1
Checksum:i22FF023E0FC9792D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36968 Genomic RNA Translation: AAA43078.1
S42322 mRNA Translation: AAB22931.1
PIRiA42748

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36968 Genomic RNA Translation: AAA43078.1
S42322 mRNA Translation: AAB22931.1
PIRiA42748

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP69469

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR035276 FIV_OrfA
PfamiView protein in Pfam
PF17495 DUF5430, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVPRL_FIVSD
AccessioniPrimary (citable) accession number: P69469
Secondary accession number(s): P19033, P69468
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 20, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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