UniProtKB - P69392 (PMTXB_BATMC)
Protein
Beta-pompilidotoxin
Gene
N/A
Organism
Batozonellus maculifrons (Solitary wasp)
Status
Functioni
Inhibits sodium channel (Nav) inactivation. Shows two types of inhibitory activities on channels. Inhibition of insect DmNav1/para and hNav1.6/SCN8A shows a large increase in the steady-state current component without any increase in the slow component, whereas inhibition of hNav1.1/SCN1A, hNav1.2/SCN2A, hNav1.3/SCN3A and hNav1.7/SCN9A shows a large increase in the slow component with only a small steady-state component (PubMed:20059541). Is 5-fold more potent than alpha-PMTX for inducing repetitive action potentials in lobster neuromuscular junctions.4 Publications
Miscellaneous
Does not inactivate (neither slow nor steady-state components) hNav1.4/SCN4A and hNav1.5/SCN5A sodium channels, although some very small inhibitory effects are seen for the hNav1.5/SCN5A isoform.1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-pompilidotoxinShort name: Beta-PMTX |
Organismi | Batozonellus maculifrons (Solitary wasp) |
Taxonomic identifieri | 308766 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Hymenoptera › Apocrita › Aculeata › Pompiloidea › Pompilidae › Pompilinae › Batozonellus |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- other organism presynaptic membrane Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1 | R → K: Similar order of inhibition potency on different Nav isoforms; alone or when associated with R-3. 1 Publication | 1 | |
Mutagenesisi | 3 | K → R: Similar order of inhibition potency on different Nav isoforms; alone or when associated with K-1. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000044537 | 1 – 13 | Beta-pompilidotoxinAdd BLAST | 13 |
Expressioni
Tissue specificityi
Expressed by the venom gland.Curated
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
ProtoNeti | Search... |
Entry informationi
Entry namei | PMTXB_BATMC | |
Accessioni | P69392Primary (citable) accession number: P69392 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2005 |
Last sequence update: | March 1, 2005 | |
Last modified: | November 22, 2017 | |
This is version 33 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |