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Protein

Shiga-like toxin 1 subunit B

Gene

stxB

Organism
Bacteriophage H30
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxin, Viral exotoxin
Biological processModulation of host virulence by virus, Virulence

Protein family/group databases

TCDBi1.C.54.1.1 the shiga toxin b-chain (st-b) family

Names & Taxonomyi

Protein namesi
Recommended name:
Shiga-like toxin 1 subunit B
Short name:
SLT-1 B subunit
Short name:
SLT-1b
Short name:
SLT-Ib
Alternative name(s):
Verocytotoxin 1 subunit B
Short name:
Verotoxin 1 subunit B
Gene namesi
Name:stxB
OrganismiBacteriophage H30
Taxonomic identifieri12371 [NCBI]
Taxonomic lineageiVirusesunclassified bacterial viruses
Virus hostiEscherichia coli [TaxID: 562]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

DrugBankiDB02379 Beta-D-Glucose
DB03919 Ethyl-Carbamic Acid Methyl Ester
DB02856 Methyl-Carbamic Acid Ethyl Ester

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000003079321 – 89Shiga-like toxin 1 subunit BAdd BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 77

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Shiga-like toxin contains a single subunit A and five copies of subunit B.1 Publication

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP69178
SMRiP69178
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP69178

Family & Domainsi

Domaini

There are three Gb3-binding sites in each subunit B monomer, allowing for a tighter binding to the target cell. Binding sites 1 and 2 have higher binding affinities than site 3 (By similarity).By similarity

Sequence similaritiesi

Belongs to the stxB family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR008992 Enterotoxin
IPR003189 SLT_beta
PfamiView protein in Pfam
PF02258 SLT_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006042 SLT_beta, 1 hit
SUPFAMiSSF50203 SSF50203, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P69178-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKTLLIAAS LSFFSASALA TPDCVTGKVE YTKYNDDDTF TVKVGDKELF
60 70 80
TNRWNLQSLL LSAQITGMTV TIKTNACHNG GGFSEVIFR
Length:89
Mass (Da):9,743
Last modified:August 1, 1988 - v1
Checksum:iC78F7795CCD7242E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23980 Genomic DNA Translation: AAA72733.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23980 Genomic DNA Translation: AAA72733.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D1KX-ray2.00A/B/C/D/E21-89[»]
2C5CX-ray2.94A/B/C/D/E/F/G/H/I/J21-89[»]
ProteinModelPortaliP69178
SMRiP69178
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB02379 Beta-D-Glucose
DB03919 Ethyl-Carbamic Acid Methyl Ester
DB02856 Methyl-Carbamic Acid Ethyl Ester

Protein family/group databases

TCDBi1.C.54.1.1 the shiga toxin b-chain (st-b) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP69178

Family and domain databases

InterProiView protein in InterPro
IPR008992 Enterotoxin
IPR003189 SLT_beta
PfamiView protein in Pfam
PF02258 SLT_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006042 SLT_beta, 1 hit
SUPFAMiSSF50203 SSF50203, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTXB_BPH30
AccessioniPrimary (citable) accession number: P69178
Secondary accession number(s): P08027
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 22, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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