UniProtKB - P69063 (GLHA2_ONCKE)
Protein
Glycoprotein hormones alpha chain 2
Gene
cgab
Organism
Oncorhynchus keta (Chum salmon) (Salmo keta)
Status
Functioni
Involved in gametogenesis and steroidogenesis.
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hormone |
Names & Taxonomyi
Protein namesi | Recommended name: Glycoprotein hormones alpha chain 2Alternative name(s): GTH-alpha Gonadotropin 2 alpha chain |
Gene namesi | Name:cgab |
Organismi | Oncorhynchus keta (Chum salmon) (Salmo keta) |
Taxonomic identifieri | 8018 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Oncorhynchus |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Add BLAST | 22 | |
ChainiPRO_0000011670 | 23 – 114 | Glycoprotein hormones alpha chain 2Add BLAST | 92 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 33 ↔ 53 | By similarity | ||
Disulfide bondi | 36 ↔ 82 | By similarity | ||
Disulfide bondi | 50 ↔ 104 | By similarity | ||
Disulfide bondi | 54 ↔ 106 | By similarity | ||
Glycosylationi | 74 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 81 ↔ 109 | By similarity | ||
Glycosylationi | 100 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinInteractioni
Subunit structurei
Heterodimer of an alpha and a beta chain.
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
Family & Domainsi
Sequence similaritiesi
Belongs to the glycoprotein hormones subunit alpha family.Curated
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P69063-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCLLKSTGLS LILSALLVIA DSYPNSDKTN MGCEECTLKP NTIFPNIMQC
60 70 80 90 100
TGCCFSRAYP TPLRSKQTML VPKNITSEAT CCVAKEGERV TTKDGFPVTN
110
HTECHCSTCY YHKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27653 mRNA Translation: AAA49405.1 M27152 mRNA Translation: AAA49407.1 |
PIRi | JL0069, B60627 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27653 mRNA Translation: AAA49405.1 M27152 mRNA Translation: AAA49407.1 |
PIRi | JL0069, B60627 |
3D structure databases
SMRi | P69063 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLHA2_ONCKE | |
Accessioni | P69063Primary (citable) accession number: P69063 Secondary accession number(s): P13153 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | February 1, 2005 | |
Last modified: | October 7, 2020 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |