UniProtKB - P68871 (HBB_HUMAN)
Hemoglobin subunit beta
HBB
Functioni
Involved in oxygen transport from the lung to the various peripheral tissues.
1 PublicationLVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.
Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
Miscellaneous
Caution
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 2 | 2,3-bisphosphoglycerate; via amino nitrogen | 1 | |
Binding sitei | 3 | 2,3-bisphosphoglycerate | 1 | |
Sitei | 8 – 9 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Sitei | 26 – 27 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Sitei | 30 – 31 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Sitei | 36 – 37 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Sitei | 38 – 39 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Sitei | 46 – 47 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Sitei | 53 – 54 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Sitei | 57 – 58 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Metal bindingi | 64 | Iron (heme b distal ligand) | 1 | |
Sitei | 72 – 73 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Sitei | 75 – 76 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Binding sitei | 83 | 2,3-bisphosphoglycerate | 1 | |
Sitei | 85 – 86 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Sitei | 93 – 94 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Metal bindingi | 93 | Iron (heme b proximal ligand) | 1 | |
Sitei | 105 – 106 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Sitei | 111 – 112 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Sitei | 120 – 121 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Sitei | 123 – 124 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Sitei | 129 – 130 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Sitei | 141 – 142 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 | |
Binding sitei | 144 | 2,3-bisphosphoglycerate | 1 | |
Sitei | 145 – 146 | (Microbial infection) Cleavage; by N.americanus apr-21 Publication | 2 |
GO - Molecular functioni
- heme binding Source: GO_Central
- hemoglobin alpha binding Source: GO_Central
- hemoglobin binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- organic acid binding Source: GO_Central
- oxygen binding Source: UniProtKB
- oxygen carrier activity Source: GO_Central
GO - Biological processi
- carbon dioxide transport Source: ComplexPortal
- cellular oxidant detoxification Source: GOC
- hydrogen peroxide catabolic process Source: BHF-UCL
- nitric oxide transport Source: ComplexPortal
- oxygen transport Source: ComplexPortal
- platelet aggregation Source: UniProtKB
- positive regulation of cell death Source: BHF-UCL
- positive regulation of nitric oxide biosynthetic process Source: UniProtKB
- regulation of blood pressure Source: UniProtKB-KW
- renal absorption Source: UniProtKB
- response to hydrogen peroxide Source: BHF-UCL
Keywordsi
Molecular function | Hypotensive agent, Vasoactive |
Biological process | Oxygen transport, Transport |
Ligand | Heme, Iron, Metal-binding, Pyruvate |
Enzyme and pathway databases
PathwayCommonsi | P68871 |
Reactomei | R-HSA-1237044, Erythrocytes take up carbon dioxide and release oxygen R-HSA-1247673, Erythrocytes take up oxygen and release carbon dioxide R-HSA-2168880, Scavenging of heme from plasma R-HSA-6798695, Neutrophil degranulation R-HSA-9613829, Chaperone Mediated Autophagy R-HSA-9615710, Late endosomal microautophagy R-HSA-9707564, Cytoprotection by HMOX1 R-HSA-9707616, Heme signaling R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | P68871 |
SIGNORi | P68871 |
Protein family/group databases
TCDBi | 1.A.107.1.2, the pore-forming globin (globin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Hemoglobin subunit betaAlternative name(s): Beta-globin Hemoglobin beta chain Cleaved into the following 2 chains: |
Gene namesi | Name:HBB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4827, HBB |
MIMi | 141900, gene+phenotype |
neXtProti | NX_P68871 |
VEuPathDBi | HostDB:ENSG00000244734 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- hemoglobin complex Source: BHF-UCL
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Other locations
- endocytic vesicle lumen Source: Reactome
- ficolin-1-rich granule lumen Source: Reactome
- haptoglobin-hemoglobin complex Source: BHF-UCL
- tertiary granule lumen Source: Reactome
Pathology & Biotechi
Involvement in diseasei
Heinz body anemias (HEIBAN)4 Publications
Beta-thalassemia (B-THAL)6 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002907 | 27 | E → K in B-THAL; Hb E; confers resistance to severe malaria. 4 PublicationsCorresponds to variant dbSNP:rs33950507EnsemblClinVar. | 1 | |
Natural variantiVAR_010145 | 115 | L → P in B-THAL; Durham-N.C./Brescia. 3 PublicationsCorresponds to variant dbSNP:rs36015961EnsemblClinVar. | 1 | |
Natural variantiVAR_003037 | 116 | A → D in B-THAL; Hradec Kralove; unstable. 1 PublicationCorresponds to variant dbSNP:rs35485099EnsemblClinVar. | 1 | |
Natural variantiVAR_003056 | 127 | V → G in B-THAL; Dhonburi/Neapolis; unstable. 1 PublicationCorresponds to variant dbSNP:rs33925391EnsemblClinVar. | 1 |
Sickle cell anemia (SKCA)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002863 | 7 | E → V in SKCA; Hb S; at heterozygosity confers resistance to malaria. 3 PublicationsCorresponds to variant dbSNP:rs334EnsemblClinVar. | 1 |
Beta-thalassemia, dominant, inclusion body type (B-THALIB)1 Publication
Keywords - Diseasei
Congenital dyserythropoietic anemia, Disease variant, Hereditary hemolytic anemiaOrganism-specific databases
DisGeNETi | 3043 |
GeneReviewsi | HBB |
MalaCardsi | HBB |
MIMi | 140700, phenotype 141900, gene+phenotype 603902, phenotype 603903, phenotype 611162, phenotype 613985, phenotype |
OpenTargetsi | ENSG00000244734 |
Orphaneti | 231222, Beta-thalassemia intermedia 231214, Beta-thalassemia major 231237, Delta-beta-thalassemia 231226, Dominant beta-thalassemia 2132, Hemoglobin C disease 231242, Hemoglobin C-beta-thalassemia syndrome 90039, Hemoglobin D disease 2133, Hemoglobin E disease 231249, Hemoglobin E-beta-thalassemia syndrome 330032, Hemoglobin Lepore-beta-thalassemia syndrome 330041, Hemoglobin M disease 46532, Hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome 251380, Hereditary persistence of fetal hemoglobin-sickle cell disease syndrome 232, Sickle cell anemia 251359, Sickle cell-beta-thalassemia disease syndrome 251365, Sickle cell-hemoglobin C disease syndrome 251370, Sickle cell-hemoglobin D disease syndrome 251375, Sickle cell-hemoglobin E disease syndrome |
PharmGKBi | PA29202 |
Miscellaneous databases
Pharosi | P68871, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4331 |
DrugBanki | DB08262, 2,6-dicarboxynaphthalene DB07427, 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine DB08077, 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID DB07428, 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine DB02126, 4-Carboxycinnamic Acid DB09130, Copper DB08486, Efaproxiral DB09147, Ferric pyrophosphate DB13995, Ferric pyrophosphate citrate DB00893, Iron Dextran DB09112, Nitrous acid DB09140, Oxygen DB06154, Pentaerythritol tetranitrate DB07645, Sebacic acid DB09517, Sodium ferric gluconate complex DB08632, Trimesic acid DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
DrugCentrali | P68871 |
Genetic variation databases
BioMutai | HBB |
DMDMi | 56749856 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity1 Publication | |||
ChainiPRO_0000052976 | 2 – 147 | Hemoglobin subunit betaAdd BLAST | 146 | |
PeptideiPRO_0000296641 | 33 – 42 | LVV-hemorphin-7 | 10 | |
PeptideiPRO_0000424226 | 33 – 39 | Spinorphin | 7 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylvalineBy similarity | 1 | |
Modified residuei | 2 | N-pyruvate 2-iminyl-valine; in Hb A1b | 1 | |
Glycosylationi | 2 | N-linked (Glc) (glycation) valine; in Hb A1c1 Publication | 1 | |
Glycosylationi | 9 | N-linked (Glc) (glycation) lysine1 Publication | 1 | |
Modified residuei | 10 | PhosphoserineCombined sources | 1 | |
Modified residuei | 13 | PhosphothreonineCombined sources | 1 | |
Glycosylationi | 18 | N-linked (Glc) (glycation) lysine1 Publication | 1 | |
Modified residuei | 45 | PhosphoserineCombined sources | 1 | |
Modified residuei | 51 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 60 | N6-acetyllysine1 Publication | 1 | |
Glycosylationi | 67 | N-linked (Glc) (glycation) lysine1 Publication | 1 | |
Modified residuei | 83 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 88 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 94 | S-nitrosocysteine2 Publications | 1 | |
Glycosylationi | 121 | N-linked (Glc) (glycation) lysine1 Publication | 1 | |
Modified residuei | 145 | N6-acetyllysine; alternate1 Publication | 1 | |
Glycosylationi | 145 | N-linked (Glc) (glycation) lysine; alternate1 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 60 | Not glycated1 Publication | 1 | |
Sitei | 83 | Not glycated1 Publication | 1 | |
Sitei | 96 | Not glycated1 Publication | 1 |
Keywords - PTMi
Acetylation, Glycation, Glycoprotein, Phosphoprotein, S-nitrosylationProteomic databases
EPDi | P68871 |
jPOSTi | P68871 |
MassIVEi | P68871 |
MaxQBi | P68871 |
PaxDbi | P68871 |
PeptideAtlasi | P68871 |
PRIDEi | P68871 |
ProteomicsDBi | 57543 |
TopDownProteomicsi | P68871 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00654755 P68871 |
SWISS-2DPAGEi | P68871 |
UCD-2DPAGEi | P68871 |
PTM databases
CarbonylDBi | P68871 |
GlyConnecti | 2875, 1 O-Linked glycan (3 sites) |
GlyGeni | P68871, 4 sites, 2 O-linked glycans (4 sites) |
iPTMneti | P68871 |
PhosphoSitePlusi | P68871 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000244734, Expressed in blood and 249 other tissues |
ExpressionAtlasi | P68871, baseline and differential |
Genevisiblei | P68871, HS |
Organism-specific databases
HPAi | ENSG00000244734, Tissue enriched (bone) |
Interactioni
Subunit structurei
Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA). Heterotetramer of two zeta chains and two beta chains in hemoglobin Portland-2, detected in fetuses and neonates with homozygous alpha-thalassemia.
3 PublicationsBinary interactionsi
P68871
With | #Exp. | IntAct |
---|---|---|
HBA2 [P69905] | 29 | EBI-715554,EBI-714680 |
HBM [Q6B0K9] | 3 | EBI-715554,EBI-12805802 |
HBQ1 [P09105] | 3 | EBI-715554,EBI-10193656 |
HBZ [P02008] | 7 | EBI-715554,EBI-719843 |
GO - Molecular functioni
- hemoglobin alpha binding Source: GO_Central
- hemoglobin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109293, 201 interactors |
ComplexPortali | CPX-2158, Hemoglobin HbA complex CPX-2929, Hemoglobin Portland-2 complex CPX-2936, Hemoglobin HbH complex |
DIPi | DIP-35526N |
IntActi | P68871, 50 interactors |
MINTi | P68871 |
STRINGi | 9606.ENSP00000333994 |
Miscellaneous databases
RNActi | P68871, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P68871 |
BMRBi | P68871 |
SMRi | P68871 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P68871 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3378, Eukaryota |
GeneTreei | ENSGT00940000163476 |
HOGENOMi | CLU_003827_10_0_1 |
InParanoidi | P68871 |
OMAi | TPDAVMN |
OrthoDBi | 1479834at2759 |
PhylomeDBi | P68871 |
TreeFami | TF333268 |
Family and domain databases
CDDi | cd08925, Hb-beta-like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971, Globin IPR009050, Globin-like_sf IPR012292, Globin/Proto IPR002337, Hemoglobin_b |
Pfami | View protein in Pfam PF00042, Globin, 1 hit |
PRINTSi | PR00814, BETAHAEM |
SUPFAMi | SSF46458, SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033, GLOBIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MVHLTPEEKS AVTALWGKVN VDEVGGEALG RLLVVYPWTQ RFFESFGDLS
60 70 80 90 100
TPDAVMGNPK VKAHGKKVLG AFSDGLAHLD NLKGTFATLS ELHCDKLHVD
110 120 130 140
PENFRLLGNV LVCVLAHHFG KEFTPPVQAA YQKVVAGVAN ALAHKYH
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y7R2 | A0A2R8Y7R2_HUMAN | Hemoglobin subunit beta | HBB | 111 | Annotation score: | ||
F8W6P5 | F8W6P5_HUMAN | Hemoglobin subunit beta | HBB | 90 | Annotation score: | ||
A0A0J9YWK4 | A0A0J9YWK4_HUMAN | Hemoglobin subunit beta | HBB | 55 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 | Missing in ACD39349 (Ref. 15) Curated | 1 | |
Sequence conflicti | 42 | F → L in AAR96398 (Ref. 13) Curated | 1 |
Mass spectrometryi
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002856 | 2 | V → A in Raleigh; O(2) affinity down. Corresponds to variant dbSNP:rs33949930EnsemblClinVar. | 1 | |
Natural variantiVAR_002857 | 3 | H → L in Graz. 1 PublicationCorresponds to variant dbSNP:rs33983205EnsemblClinVar. | 1 | |
Natural variantiVAR_002858 | 3 | H → Q in Okayama; O(2) affinity up. Corresponds to variant dbSNP:rs713040EnsemblClinVar. | 1 | |
Natural variantiVAR_002859 | 3 | H → R in Deer Lodge; O(2) affinity up. Corresponds to variant dbSNP:rs33983205EnsemblClinVar. | 1 | |
Natural variantiVAR_002860 | 3 | H → Y in Fukuoka. Corresponds to variant dbSNP:rs35906307EnsemblClinVar. | 1 | |
Natural variantiVAR_002861 | 6 | P → R in Warwickshire. Corresponds to variant dbSNP:rs34769005EnsemblClinVar. | 1 | |
Natural variantiVAR_002862 | 7 | E → A in G-Makassar. Corresponds to variant dbSNP:rs334EnsemblClinVar. | 1 | |
Natural variantiVAR_002864 | 7 | E → K in Hb C; confers resistance to severe malaria. 2 PublicationsCorresponds to variant dbSNP:rs33930165EnsemblClinVar. | 1 | |
Natural variantiVAR_002865 | 7 | E → Q in Machida. Corresponds to variant dbSNP:rs33930165EnsemblClinVar. | 1 | |
Natural variantiVAR_002863 | 7 | E → V in SKCA; Hb S; at heterozygosity confers resistance to malaria. 3 PublicationsCorresponds to variant dbSNP:rs334EnsemblClinVar. | 1 | |
Natural variantiVAR_002866 | 8 | E → G in G-San Jose; mildly unstable. Corresponds to variant dbSNP:rs34387455EnsemblClinVar. | 1 | |
Natural variantiVAR_002867 | 8 | E → K in G-Siriraj. Corresponds to variant dbSNP:rs34948328EnsemblClinVar. | 1 | |
Natural variantiVAR_002868 | 9 | K → E in N-Timone. 1 PublicationCorresponds to variant dbSNP:rs33926764EnsemblClinVar. | 1 | |
Natural variantiVAR_002869 | 9 | K → Q in J-Luhe. Corresponds to variant dbSNP:rs33926764EnsemblClinVar. | 1 | |
Natural variantiVAR_002870 | 9 | K → T in Rio Grande. 1 PublicationCorresponds to variant dbSNP:rs33932981EnsemblClinVar. | 1 | |
Natural variantiVAR_002871 | 10 | S → C in Porto Alegre; O(2) affinity up. Corresponds to variant dbSNP:rs33918131EnsemblClinVar. | 1 | |
Natural variantiVAR_002872 | 11 | A → D in Ankara. 1 PublicationCorresponds to variant dbSNP:rs33947457EnsemblClinVar. | 1 | |
Natural variantiVAR_025393 | 11 | A → V in Iraq-Halabja. 1 PublicationCorresponds to variant dbSNP:rs33947457EnsemblClinVar. | 1 | |
Natural variantiVAR_002873 | 12 | V → D in Windsor; O(2) affinity up; unstable. 1 PublicationCorresponds to variant dbSNP:rs35140348EnsemblClinVar. | 1 | |
Natural variantiVAR_002874 | 12 | V → I in Hamilton. Corresponds to variant dbSNP:rs33974228EnsemblClinVar. | 1 | |
Natural variantiVAR_002875 | 14 | A → D in J-Lens. Corresponds to variant dbSNP:rs35203747EnsemblClinVar. | 1 | |
Natural variantiVAR_002876 | 15 | L → P in Saki; unstable. Corresponds to variant dbSNP:rs33935445EnsemblClinVar. | 1 | |
Natural variantiVAR_002877 | 15 | L → R in Soegn; unstable. Corresponds to variant dbSNP:rs33935445EnsemblClinVar. | 1 | |
Natural variantiVAR_002878 | 16 | W → G in Randwick; unstable. 1 PublicationCorresponds to variant dbSNP:rs33946157EnsemblClinVar. | 1 | |
Natural variantiVAR_002879 | 16 | W → R in Belfast; O(2) affinity up; unstable. Corresponds to variant dbSNP:rs33946157EnsemblClinVar. | 1 | |
Natural variantiVAR_002880 | 17 | G → D in J-Baltimore/J-Trinidad/J-Ireland/J-Georgia/N-New Haven. Corresponds to variant dbSNP:rs33962676EnsemblClinVar. | 1 | |
Natural variantiVAR_002881 | 17 | G → R in D-Bushman. Corresponds to variant dbSNP:rs63751285EnsemblClinVar. | 1 | |
Natural variantiVAR_002882 | 18 | K → E in Nagasaki. Corresponds to variant dbSNP:rs33986703Ensembl. | 1 | |
Natural variantiVAR_002883 | 18 | K → N in J-Amiens. Corresponds to variant dbSNP:rs36006214EnsemblClinVar. | 1 | |
Natural variantiVAR_002884 | 18 | K → Q in Nikosia. Corresponds to variant dbSNP:rs33986703Ensembl. | 1 | |
Natural variantiVAR_002885 | 19 | V → M in Baden; slightly unstable. Corresponds to variant dbSNP:rs35802118EnsemblClinVar. | 1 | |
Natural variantiVAR_002886 | 20 | N → D in Alamo. Corresponds to variant dbSNP:rs34866629EnsemblClinVar. | 1 | |
Natural variantiVAR_002887 | 20 | N → K in D-Ouleh RABAH. Corresponds to variant dbSNP:rs63750840EnsemblClinVar. | 1 | |
Natural variantiVAR_002888 | 20 | N → S in Malay. Corresponds to variant dbSNP:rs33972047EnsemblClinVar. | 1 | |
Natural variantiVAR_002889 | 21 | V → M in Olympia; O(2) affinity up. Corresponds to variant dbSNP:rs35890959EnsemblClinVar. | 1 | |
Natural variantiVAR_002890 | 22 | D → G in Connecticut; O(2) affinity down. Corresponds to variant dbSNP:rs33977536EnsemblClinVar. | 1 | |
Natural variantiVAR_002892 | 22 | D → H in Karlskoga. 1 PublicationCorresponds to variant dbSNP:rs33950093EnsemblClinVar. | 1 | |
Natural variantiVAR_002891 | 22 | D → N in Cocody. Corresponds to variant dbSNP:rs33950093EnsemblClinVar. | 1 | |
Natural variantiVAR_002893 | 22 | D → Y in Yusa. Corresponds to variant dbSNP:rs33950093EnsemblClinVar. | 1 | |
Natural variantiVAR_002894 | 23 | E → A in G-Coushatta/G-Saskatoon/G-Taegu/Hsin Chu. Corresponds to variant dbSNP:rs33936254EnsemblClinVar. | 1 | |
Natural variantiVAR_002895 | 23 | E → G in G-Taipei. Corresponds to variant dbSNP:rs33936254EnsemblClinVar. | 1 | |
Natural variantiVAR_002896 | 23 | E → K in E-Saskatoon. Corresponds to variant dbSNP:rs33959855EnsemblClinVar. | 1 | |
Natural variantiVAR_002897 | 23 | E → Q in D-Iran. Corresponds to variant dbSNP:rs33959855EnsemblClinVar. | 1 | |
Natural variantiVAR_002898 | 23 | E → V in D-Granada. Corresponds to variant dbSNP:rs33936254EnsemblClinVar. | 1 | |
Natural variantiVAR_002899 | 24 | V → D in Strasbourg; O(2) affinity up. Corresponds to variant dbSNP:rs33945546EnsemblClinVar. | 1 | |
Natural variantiVAR_002900 | 24 | V → F in Palmerston North; O(2) affinity up; unstable. 1 PublicationCorresponds to variant dbSNP:rs33929459EnsemblClinVar. | 1 | |
Natural variantiVAR_002901 | 24 | V → G in Miyashiro; O(2) affinity up; unstable. 1 PublicationCorresponds to variant dbSNP:rs33945546EnsemblClinVar. | 1 | |
Natural variantiVAR_069169 | 24 | Missing in Freiburg. 1 PublicationCorresponds to variant dbSNP:rs34160180Ensembl. | 1 | |
Natural variantiVAR_002902 | 25 | G → D in Moscva; O(2) affinity down; unstable. Corresponds to variant dbSNP:rs33968721EnsemblClinVar. | 1 | |
Natural variantiVAR_002903 | 25 | G → R in Riverdale-Bronx; O(2) affinity up; unstable. Corresponds to variant dbSNP:rs33972975EnsemblClinVar. | 1 | |
Natural variantiVAR_002904 | 25 | G → V in Savannah; unstable. Corresponds to variant dbSNP:rs33968721EnsemblClinVar. | 1 | |
Natural variantiVAR_002905 | 26 | G → D in J-Auckland; unstable; O(2) affinity down. 1 PublicationCorresponds to variant dbSNP:rs35474880EnsemblClinVar. | 1 | |
Natural variantiVAR_002906 | 26 | G → R in G-Taiwan Ami. Corresponds to variant dbSNP:rs34404985EnsemblClinVar. | 1 | |
Natural variantiVAR_002907 | 27 | E → K in B-THAL; Hb E; confers resistance to severe malaria. 4 PublicationsCorresponds to variant dbSNP:rs33950507EnsemblClinVar. | 1 | |
Natural variantiVAR_002908 | 27 | E → V in Henri Mondor; slightly unstable. Corresponds to variant dbSNP:rs33915112EnsemblClinVar. | 1 | |
Natural variantiVAR_002909 | 28 | A → D in Volga/Drenthe; unstable. Corresponds to variant dbSNP:rs33954632EnsemblClinVar. | 1 | |
Natural variantiVAR_002910 | 28 | A → S in Knossos. 1 PublicationCorresponds to variant dbSNP:rs35424040EnsemblClinVar. | 1 | |
Natural variantiVAR_002911 | 28 | A → V in Grange-blanche; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs33954632EnsemblClinVar. | 1 | |
Natural variantiVAR_002912 | 29 | L → P in Genova/Hyogo; unstable. Corresponds to variant dbSNP:rs33916412EnsemblClinVar. | 1 | |
Natural variantiVAR_035236 | 29 | L → Q in St Louis. 1 PublicationCorresponds to variant dbSNP:rs33916412EnsemblClinVar. | 1 | |
Natural variantiVAR_002913 | 30 | G → D in Lufkin; unstable. Corresponds to variant dbSNP:rs35685286EnsemblClinVar. | 1 | |
Natural variantiVAR_002914 | 31 | R → S in Tacoma; unstable. Corresponds to variant dbSNP:rs1135071EnsemblClinVar. | 1 | |
Natural variantiVAR_002915 | 32 | L → P in Yokohama; unstable. 1 PublicationCorresponds to variant dbSNP:rs33920173EnsemblClinVar. | 1 | |
Natural variantiVAR_002916 | 33 | L → R in Castilla; unstable. Corresponds to variant dbSNP:rs33948578EnsemblClinVar. | 1 | |
Natural variantiVAR_002917 | 33 | L → V in Muscat; slightly unstable. 1 PublicationCorresponds to variant dbSNP:rs34314652Ensembl. | 1 | |
Natural variantiVAR_025394 | 35 | V → D in Santander; unstable. 1 PublicationCorresponds to variant dbSNP:rs1135101EnsemblClinVar. | 1 | |
Natural variantiVAR_002918 | 35 | V → F in Pitie-Salpetriere; O(2) affinity up. Corresponds to variant dbSNP:rs1141387EnsemblClinVar. | 1 | |
Natural variantiVAR_025395 | 35 | V → L in Nantes; increased oxygen affinity. 1 PublicationCorresponds to variant dbSNP:rs1141387EnsemblClinVar. | 1 | |
Natural variantiVAR_002919 | 36 | Y → F in Philly; O(2) affinity up; unstable. Corresponds to variant dbSNP:rs35857380EnsemblClinVar. | 1 | |
Natural variantiVAR_002920 | 37 | P → R in Sunnybrook. Corresponds to variant dbSNP:rs33993004EnsemblClinVar. | 1 | |
Natural variantiVAR_002921 | 37 | P → S in North Chicago; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs33948615EnsemblClinVar. | 1 | |
Natural variantiVAR_002922 | 37 | P → T in Linkoping/Finlandia; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs33948615EnsemblClinVar. | 1 | |
Natural variantiVAR_002923 | 38 | W → G in Howick. 1 PublicationCorresponds to variant dbSNP:rs33994623EnsemblClinVar. | 1 | |
Natural variantiVAR_002925 | 38 | W → R in Rothschild; O(2) affinity down. 1 PublicationCorresponds to variant dbSNP:rs33994623EnsemblClinVar. | 1 | |
Natural variantiVAR_002924 | 38 | W → S in Hirose; O(2) affinity up. Corresponds to variant dbSNP:rs33991059EnsemblClinVar. | 1 | |
Natural variantiVAR_002926 | 39 | T → N in Hinwil; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs34703513EnsemblClinVar. | 1 | |
Natural variantiVAR_002927 | 40 | Q → E in Vaasa; unstable. Corresponds to variant dbSNP:rs11549407EnsemblClinVar. | 1 | |
Natural variantiVAR_002928 | 40 | Q → K in Alabama. 1 PublicationCorresponds to variant dbSNP:rs11549407EnsemblClinVar. | 1 | |
Natural variantiVAR_002929 | 40 | Q → R in Tianshui. Corresponds to variant dbSNP:rs35973315EnsemblClinVar. | 1 | |
Natural variantiVAR_002930 | 42 | F → Y in Mequon. Corresponds to variant dbSNP:rs33926796EnsemblClinVar. | 1 | |
Natural variantiVAR_035237 | 42 | Missing in Bruxelles. 1 Publication | 1 | |
Natural variantiVAR_002931 | 43 | F → L in Louisville; unstable. 1 PublicationCorresponds to variant dbSNP:rs33924146EnsemblClinVar. | 1 | |
Natural variantiVAR_035239 | 43 | F → S in Hammersmith. 1 PublicationCorresponds to variant dbSNP:rs34378160EnsemblClinVar. | 1 | |
Natural variantiVAR_035238 | 43 | Missing in Bruxelles. 1 Publication | 1 | |
Natural variantiVAR_002932 | 44 | E → Q in Hoshida/Chaya. Corresponds to variant dbSNP:rs33922842EnsemblClinVar. | 1 | |
Natural variantiVAR_002933 | 45 | S → C in Mississippi. Corresponds to variant dbSNP:rs34868397EnsemblClinVar. | 1 | |
Natural variantiVAR_002934 | 46 | F → S in Cheverly; unstable. Corresponds to variant dbSNP:rs33978338EnsemblClinVar. | 1 | |
Natural variantiVAR_002935 | 47 | G → E in K-Ibadan. Corresponds to variant dbSNP:rs35303218EnsemblClinVar. | 1 | |
Natural variantiVAR_002936 | 48 | D → A in Avicenna. Corresponds to variant dbSNP:rs33980484EnsemblClinVar. | 1 | |
Natural variantiVAR_002937 | 48 | D → G in Gavello. Corresponds to variant dbSNP:rs33980484EnsemblClinVar. | 1 | |
Natural variantiVAR_002938 | 48 | D → Y in Maputo. 1 PublicationCorresponds to variant dbSNP:rs33932070EnsemblClinVar. | 1 | |
Natural variantiVAR_002939 | 49 | L → P in Bab-Saadoum; slightly unstable. Corresponds to variant dbSNP:rs33952850EnsemblClinVar. | 1 | |
Natural variantiVAR_002940 | 50 | S → F in Las Palmas; slightly unstable. 2 PublicationsCorresponds to variant dbSNP:rs33960931EnsemblClinVar. | 1 | |
Natural variantiVAR_002941 | 51 | T → K in Edmonton. | 1 | |
Natural variantiVAR_002942 | 52 | P → R in Willamette; O(2) affinity up; unstable. Corresponds to variant dbSNP:rs33969727EnsemblClinVar. | 1 | |
Natural variantiVAR_002943 | 53 | D → A in Ocho Rios. Corresponds to variant dbSNP:rs33919924EnsemblClinVar. | 1 | |
Natural variantiVAR_002944 | 53 | D → H in Summer Hill. Corresponds to variant dbSNP:rs33961886EnsemblClinVar. | 1 | |
Natural variantiVAR_002945 | 55 | V → D in Jacksonville; O(2) affinity up; unstable. 1 PublicationCorresponds to variant dbSNP:rs34037627EnsemblClinVar. | 1 | |
Natural variantiVAR_002946 | 56 | M → K in Matera; unstable. 1 PublicationCorresponds to variant dbSNP:rs35094013EnsemblClinVar. | 1 | |
Natural variantiVAR_002947 | 57 | G → R in Hamadan. Corresponds to variant dbSNP:rs33935983EnsemblClinVar. | 1 | |
Natural variantiVAR_002948 | 58 | N → K in G-ferrara; unstable. Corresponds to variant dbSNP:rs35278874EnsemblClinVar. | 1 | |
Natural variantiVAR_002949 | 59 | P → R in Dhofar/Yukuhashi. Corresponds to variant dbSNP:rs33991472EnsemblClinVar. | 1 | |
Natural variantiVAR_002950 | 60 | K → E in I-High Wycombe. Corresponds to variant dbSNP:rs33969400EnsemblClinVar. | 1 | |
Natural variantiVAR_002951 | 61 | V → A in Collingwood; unstable. Corresponds to variant dbSNP:rs33931779EnsemblClinVar. | 1 | |
Natural variantiVAR_002952 | 62 | K → E in N-Seatlle. Corresponds to variant dbSNP:rs33995148EnsemblClinVar. | 1 | |
Natural variantiVAR_002953 | 62 | K → M in Bologna; O(2) affinity down. Corresponds to variant dbSNP:rs34974709EnsemblClinVar. | 1 | |
Natural variantiVAR_002954 | 62 | K → N in Hikari. Corresponds to variant dbSNP:rs34446260EnsemblClinVar. | 1 | |
Natural variantiVAR_002955 | 63 | A → D in J-Europa. 1 PublicationCorresponds to variant dbSNP:rs34151786EnsemblClinVar. | 1 | |
Natural variantiVAR_002956 | 63 | A → P in Duarte; unstable. Corresponds to variant dbSNP:rs34933455EnsemblClinVar. | 1 | |
Natural variantiVAR_002957 | 64 | H → Y in M-Saskatoon; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs33922873EnsemblClinVar. | 1 | |
Natural variantiVAR_002958 | 66 | K → M in J-Antakya. 1 PublicationCorresponds to variant dbSNP:rs33932548EnsemblClinVar. | 1 | |
Natural variantiVAR_002959 | 66 | K → N in J-Sicilia. 1 PublicationCorresponds to variant dbSNP:rs35747961EnsemblClinVar. | 1 | |
Natural variantiVAR_002960 | 66 | K → Q in J-Cairo. 1 PublicationCorresponds to variant dbSNP:rs35353749EnsemblClinVar. | 1 | |
Natural variantiVAR_079528 | 67 | K → I in Vigo; O(2) affinity down. 1 Publication | 1 | |
Natural variantiVAR_002961 | 67 | K → T in Chico; O(2) affinity down. Corresponds to variant dbSNP:rs35939489EnsemblClinVar. | 1 | |
Natural variantiVAR_002962 | 68 | V → A in Sydney; unstable. Corresponds to variant dbSNP:rs33918343EnsemblClinVar. | 1 | |
Natural variantiVAR_035240 | 68 | V → D in Bristol. 1 Publication | 1 | |
Natural variantiVAR_040060 | 68 | V → G in non-spherocytic haemolytic anemia; Manukau. 1 PublicationCorresponds to variant dbSNP:rs33918343EnsemblClinVar. | 1 | |
Natural variantiVAR_002963 | 68 | V → M in Alesha; unstable. 1 PublicationCorresponds to variant dbSNP:rs36008922EnsemblClinVar. | 1 | |
Natural variantiVAR_002964 | 69 | L → H in Brisbane; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs33972593EnsemblClinVar. | 1 | |
Natural variantiVAR_002965 | 69 | L → P in Mizuho; unstable. 1 PublicationCorresponds to variant dbSNP:rs33972593EnsemblClinVar. | 1 | |
Natural variantiVAR_002966 | 70 | G → D in Rambam. 1 PublicationCorresponds to variant dbSNP:rs34718174EnsemblClinVar. | 1 | |
Natural variantiVAR_002967 | 70 | G → R in Kenitra. Corresponds to variant dbSNP:rs33947415EnsemblClinVar. | 1 | |
Natural variantiVAR_002968 | 70 | G → S in City of Hope. 1 PublicationCorresponds to variant dbSNP:rs33947415EnsemblClinVar. | 1 | |
Natural variantiVAR_002969 | 71 | A → D in Seattle; O(2) affinity down; unstable. Corresponds to variant dbSNP:rs33946401EnsemblClinVar. | 1 | |
Natural variantiVAR_002970 | 72 | F → S in Christchurch; unstable. Corresponds to variant dbSNP:rs34362537EnsemblClinVar. | 1 | |
Natural variantiVAR_002971 | 74 | D → G in Tilburg; O(2) affinity down. Corresponds to variant dbSNP:rs33967755EnsemblClinVar. | 1 | |
Natural variantiVAR_002972 | 74 | D → V in Mobile; O(2) affinity down. Corresponds to variant dbSNP:rs33967755EnsemblClinVar. | 1 | |
Natural variantiVAR_002973 | 74 | D → Y in Vancouver; O(2) affinity down. Corresponds to variant dbSNP:rs33945705EnsemblClinVar. | 1 | |
Natural variantiVAR_002974 | 75 | G → R in Aalborg; unstable. Corresponds to variant dbSNP:rs33916541EnsemblClinVar. | 1 | |
Natural variantiVAR_002975 | 75 | G → V in Bushwick; unstable. Corresponds to variant dbSNP:rs33976006EnsemblClinVar. | 1 | |
Natural variantiVAR_002976 | 76 | L → P in Atlanta; unstable. 1 PublicationCorresponds to variant dbSNP:rs33950542EnsemblClinVar. | 1 | |
Natural variantiVAR_002977 | 76 | L → R in Pasadena; O(2) affinity up; unstable. Corresponds to variant dbSNP:rs33950542EnsemblClinVar. | 1 | |
Natural variantiVAR_002978 | 77 | A → D in J-Chicago. Corresponds to variant dbSNP:rs33985847EnsemblClinVar. | 1 | |
Natural variantiVAR_002979 | 78 | H → D in J-Iran. Corresponds to variant dbSNP:rs33991294EnsemblClinVar. | 1 | |
Natural variantiVAR_002980 | 78 | H → R in Costa Rica. 1 PublicationCorresponds to variant dbSNP:rs33952543EnsemblClinVar. | 1 | |
Natural variantiVAR_002981 | 78 | H → Y in Fukuyama. Corresponds to variant dbSNP:rs33991294EnsemblClinVar. | 1 | |
Natural variantiVAR_002982 | 79 | L → R in Quin-hai. 1 PublicationCorresponds to variant dbSNP:rs34870172EnsemblClinVar. | 1 | |
Natural variantiVAR_002983 | 80 | D → Y in Tampa. Corresponds to variant dbSNP:rs33990858EnsemblClinVar. | 1 | |
Natural variantiVAR_002984 | 81 | N → K in G-Szuhu/Gifu. Corresponds to variant dbSNP:rs35890380EnsemblClinVar. | 1 | |
Natural variantiVAR_012663 | 82 | L → H in La Roche-sur-Yon; unstable and O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs33936967EnsemblClinVar. | 1 | |
Natural variantiVAR_002985 | 82 | L → R in Baylor; unstable. Corresponds to variant dbSNP:rs33936967EnsemblClinVar. | 1 | |
Natural variantiVAR_049273 | 82 | L → V. Corresponds to variant dbSNP:rs11549406Ensembl. | 1 | |
Natural variantiVAR_002986 | 83 | K → M in Helsinki; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs33987903EnsemblClinVar. | 1 | |
Natural variantiVAR_012664 | 83 | K → N in Providence. Corresponds to variant dbSNP:rs33991993EnsemblClinVar. | 1 | |
Natural variantiVAR_025396 | 84 | G → D in Pyrgos. 1 PublicationCorresponds to variant dbSNP:rs1803195EnsemblClinVar. | 1 | |
Natural variantiVAR_002987 | 84 | G → R in Muskegon. Corresponds to variant dbSNP:rs33930385EnsemblClinVar. | 1 | |
Natural variantiVAR_002988 | 85 | T → I in Kofu. 1 PublicationCorresponds to variant dbSNP:rs35914488EnsemblClinVar. | 1 | |
Natural variantiVAR_002989 | 87 | A → D in Olomouc; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs35819837EnsemblClinVar. | 1 | |
Natural variantiVAR_002990 | 88 | T → I in Quebec-Chori. Corresponds to variant dbSNP:rs33993568EnsemblClinVar. | 1 | |
Natural variantiVAR_002991 | 88 | T → K in D-Ibadan. Corresponds to variant dbSNP:rs33993568EnsemblClinVar. | 1 | |
Natural variantiVAR_002992 | 88 | T → P in Valletta. Corresponds to variant dbSNP:rs35553496EnsemblClinVar. | 1 | |
Natural variantiVAR_002993 | 89 | L → P in Santa Ana; unstable. Corresponds to variant dbSNP:rs33940204EnsemblClinVar. | 1 | |
Natural variantiVAR_002994 | 89 | L → R in Boras; unstable. Corresponds to variant dbSNP:rs33940204EnsemblClinVar. | 1 | |
Natural variantiVAR_002995 | 90 | S → N in Creteil; O(2) affinity up. Corresponds to variant dbSNP:rs33917628EnsemblClinVar. | 1 | |
Natural variantiVAR_002996 | 90 | S → R in Vanderbilt; O(2) affinity up. Corresponds to variant dbSNP:rs35351128EnsemblClinVar. | 1 | |
Natural variantiVAR_002997 | 91 | E → D in Pierre-Benite; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs35002698EnsemblClinVar. | 1 | |
Natural variantiVAR_002998 | 91 | E → K in Agenogi; O(2) affinity down. Corresponds to variant dbSNP:rs33913712EnsemblClinVar. | 1 | |
Natural variantiVAR_002999 | 92 | L → P in Sabine; unstable. Corresponds to variant dbSNP:rs33917785EnsemblClinVar. | 1 | |
Natural variantiVAR_003000 | 92 | L → R in Caribbean; O(2) affinity down; unstable. 1 PublicationCorresponds to variant dbSNP:rs33917785EnsemblClinVar. | 1 | |
Natural variantiVAR_003001 | 93 | H → D in J-Altgelds Gardens; unstable. 1 PublicationCorresponds to variant dbSNP:rs33924775EnsemblClinVar. | 1 | |
Natural variantiVAR_003002 | 93 | H → N in Isehara; unstable. 1 PublicationCorresponds to variant dbSNP:rs33924775EnsemblClinVar. | 1 | |
Natural variantiVAR_003003 | 93 | H → P in Newcastle and Duino; associated with S-104 in Duino; unstable. 1 PublicationCorresponds to variant dbSNP:rs33974325EnsemblClinVar. | 1 | |
Natural variantiVAR_003004 | 93 | H → Q in Istambul; unstable. 1 PublicationCorresponds to variant dbSNP:rs34083951EnsemblClinVar. | 1 | |
Natural variantiVAR_003005 | 94 | C → R in Okazaki; O(2) affinity up; unstable. Corresponds to variant dbSNP:rs33972927EnsemblClinVar. | 1 | |
Natural variantiVAR_003006 | 95 | D → G in Chandigarh. Corresponds to variant dbSNP:rs34579351EnsemblClinVar. | 1 | |
Natural variantiVAR_003007 | 95 | D → H in Barcelona; O(2) affinity up. Corresponds to variant dbSNP:rs33959340EnsemblClinVar. | 1 | |
Natural variantiVAR_003008 | 95 | D → N in Bunbury; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs33959340EnsemblClinVar. | 1 | |
Natural variantiVAR_003009 | 96 | K → M in J-Cordoba. Corresponds to variant dbSNP:rs35204496EnsemblClinVar. | 1 | |
Natural variantiVAR_003010 | 96 | K → N in Detroit. Corresponds to variant dbSNP:rs36038739EnsemblClinVar. | 1 | |
Natural variantiVAR_003011 | 97 | L → P in Debrousse; unstable; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs36081208EnsemblClinVar. | 1 | |
Natural variantiVAR_003012 | 97 | L → V in Regina; O(2) affinity up. Corresponds to variant dbSNP:rs34665886EnsemblClinVar. | 1 | |
Natural variantiVAR_003013 | 98 | H → L in Wood; O(2) affinity up. Corresponds to variant dbSNP:rs33951978EnsemblClinVar. | 1 | |
Natural variantiVAR_003014 | 98 | H → P in Nagoya; O(2) affinity up; unstable. 1 PublicationCorresponds to variant dbSNP:rs33951978EnsemblClinVar. | 1 | |
Natural variantiVAR_003015 | 98 | H → Q in Malmoe; O(2) affinity up. Corresponds to variant dbSNP:rs34515413EnsemblClinVar. | 1 | |
Natural variantiVAR_003016 | 98 | H → Y in Moriguchi. Corresponds to variant dbSNP:rs33950993EnsemblClinVar. | 1 | |
Natural variantiVAR_003017 | 99 | V → G in Nottingham; unstable. Corresponds to variant dbSNP:rs33985510EnsemblClinVar. | 1 | |
Natural variantiVAR_003018 | 100 | D → E in Coimbra; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs34013622EnsemblClinVar. | 1 | |
Natural variantiVAR_003019 | 101 | P → L in Brigham; O(2) affinity up. Corresponds to variant dbSNP:rs33965000EnsemblClinVar. | 1 | |
Natural variantiVAR_003020 | 101 | P → R in New Mexico. Corresponds to variant dbSNP:rs33965000EnsemblClinVar. | 1 | |
Natural variantiVAR_003021 | 102 | E → D in Potomac; O(2) affinity up. Corresponds to variant dbSNP:rs35209591EnsemblClinVar. | 1 | |
Natural variantiVAR_003022 | 102 | E → G in Alberta; O(2) affinity up. Corresponds to variant dbSNP:rs33937393EnsemblClinVar. | 1 | |
Natural variantiVAR_003023 | 102 | E → K in British Columbia; O(2) affinity up. Corresponds to variant dbSNP:rs33966487EnsemblClinVar. | 1 | |
Natural variantiVAR_003024 | 102 | E → Q in Rush; unstable. 1 PublicationCorresponds to variant dbSNP:rs33966487EnsemblClinVar. | 1 | |
Natural variantiVAR_003025 | 103 | N → S in Beth Israel; O(2) affinity down; unstable. Corresponds to variant dbSNP:rs33948057EnsemblClinVar. | 1 | |
Natural variantiVAR_003026 | 103 | N → Y in St Mande; O(2) affinity down. 1 PublicationCorresponds to variant dbSNP:rs33927739EnsemblClinVar. | 1 | |
Natural variantiVAR_003027 | 104 | F → L in Heathrow; O(2) affinity up. Corresponds to variant dbSNP:rs35067717EnsemblClinVar. | 1 | |
Natural variantiVAR_003028 | 105 | R → S in Camperdown and Duino; associated with P-92 in Duino; unstable. 2 PublicationsCorresponds to variant dbSNP:rs33914944EnsemblClinVar. | 1 | |
Natural variantiVAR_003029 | 105 | R → T in Sherwood Forest. Corresponds to variant dbSNP:rs33911434EnsemblClinVar. | 1 | |
Natural variantiVAR_003030 | 108 | G → R in Burke; O(2) affinity down; unstable. 1 PublicationCorresponds to variant dbSNP:rs35017910EnsemblClinVar. | 1 | |
Natural variantiVAR_003031 | 109 | N → K in Presbyterian; O(2) affinity down; unstable. 1 PublicationCorresponds to variant dbSNP:rs34933751EnsemblClinVar. | 1 | |
Natural variantiVAR_003032 | 110 | V → M in San Diego; O(2) affinity up. Corresponds to variant dbSNP:rs33969677EnsemblClinVar. | 1 | |
Natural variantiVAR_003033 | 111 | L → P in Showa-Yakushiji. Corresponds to variant dbSNP:rs35256489EnsemblClinVar. | 1 | |
Natural variantiVAR_003034 | 112 | V → A in Stanmore; O(2) affinity down; unstable. 1 PublicationCorresponds to variant dbSNP:rs35871407EnsemblClinVar. | 1 | |
Natural variantiVAR_025397 | 113 | C → F in Canterbury. 1 PublicationCorresponds to variant dbSNP:rs33932908EnsemblClinVar. | 1 | |
Natural variantiVAR_003035 | 113 | C → R in Indianapolis. 2 PublicationsCorresponds to variant dbSNP:rs35849199EnsemblClinVar. | 1 | |
Natural variantiVAR_003036 | 113 | C → Y in Yahata. 1 PublicationCorresponds to variant dbSNP:rs33932908EnsemblClinVar. | 1 | |
Natural variantiVAR_010144 | 115 | L → M in Zengcheng. 1 PublicationCorresponds to variant dbSNP:rs33917394EnsemblClinVar. | 1 | |
Natural variantiVAR_010145 | 115 | L → P in B-THAL; Durham-N.C./Brescia. 3 PublicationsCorresponds to variant dbSNP:rs36015961EnsemblClinVar. | 1 | |
Natural variantiVAR_003037 | 116 | A → D in B-THAL; Hradec Kralove; unstable. 1 PublicationCorresponds to variant dbSNP:rs35485099EnsemblClinVar. | 1 | |
Natural variantiVAR_003038 | 116 | A → P in Madrid; unstable. Corresponds to variant dbSNP:rs34945623EnsemblClinVar. | 1 | |
Natural variantiVAR_025398 | 117 | H → L in Vexin; increased oxygen affinity. 1 PublicationCorresponds to variant dbSNP:rs33978082Ensembl. | 1 | |
Natural variantiVAR_003039 | 117 | H → Q in Hafnia. Corresponds to variant dbSNP:rs35209776EnsemblClinVar. | 1 | |
Natural variantiVAR_003040 | 118 | H → P in Saitama; unstable. 1 PublicationCorresponds to variant dbSNP:rs33935673EnsemblClinVar. | 1 | |
Natural variantiVAR_003041 | 118 | H → R in P-Galveston. Corresponds to variant dbSNP:rs33935673EnsemblClinVar. | 1 | |
Natural variantiVAR_025399 | 118 | H → Y in Tsukumi. 1 PublicationCorresponds to variant dbSNP:rs33935527Ensembl. | 1 | |
Natural variantiVAR_003042 | 120 | G → A in Iowa. Corresponds to variant dbSNP:rs33947020EnsemblClinVar. | 1 | |
Natural variantiVAR_003043 | 121 | K → E in Hijiyama. Corresponds to variant dbSNP:rs33924134EnsemblClinVar. | 1 | |
Natural variantiVAR_003044 | 121 | K → I in Jianghua. 1 PublicationCorresponds to variant dbSNP:rs34303736EnsemblClinVar. | 1 | |
Natural variantiVAR_003045 | 121 | K → Q in Takamatsu. Corresponds to variant dbSNP:rs33924134EnsemblClinVar. | 1 | |
Natural variantiVAR_003046 | 122 | E → A in D-Neath. 1 PublicationCorresponds to variant dbSNP:rs33987957EnsemblClinVar. | 1 | |
Natural variantiVAR_003047 | 122 | E → G in St Francis. Corresponds to variant dbSNP:rs33987957EnsemblClinVar. | 1 | |
Natural variantiVAR_003049 | 122 | E → K in O-Arab. Corresponds to variant dbSNP:rs33946267EnsemblClinVar. | 1 | |
Natural variantiVAR_003048 | 122 | E → Q in D-Los Angeles/D-Punjab/D-Portugal/D-Chicago/D-Oak Ridge. Corresponds to variant dbSNP:rs33946267EnsemblClinVar. | 1 | |
Natural variantiVAR_003050 | 122 | E → V in D-Camperdown/Beograd. Corresponds to variant dbSNP:rs33987957EnsemblClinVar. | 1 | |
Natural variantiVAR_003051 | 124 | T → I in Villejuif; asymptomatic variant. 1 PublicationCorresponds to variant dbSNP:rs33935383EnsemblClinVar. | 1 | |
Natural variantiVAR_003053 | 125 | P → Q in Ty Gard; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs33983276EnsemblClinVar. | 1 | |
Natural variantiVAR_003052 | 125 | P → R in Khartoum; unstable. Corresponds to variant dbSNP:rs33983276EnsemblClinVar. | 1 | |
Natural variantiVAR_003054 | 125 | P → S in Tunis. Corresponds to variant dbSNP:rs35461710EnsemblClinVar. | 1 | |
Natural variantiVAR_003055 | 127 | V → A in Beirut. Corresponds to variant dbSNP:rs33925391EnsemblClinVar. | 1 | |
Natural variantiVAR_003057 | 127 | V → E in Hofu; unstable. Corresponds to variant dbSNP:rs33925391EnsemblClinVar. | 1 | |
Natural variantiVAR_003056 | 127 | V → G in B-THAL; Dhonburi/Neapolis; unstable. 1 PublicationCorresponds to variant dbSNP:rs33925391EnsemblClinVar. | 1 | |
Natural variantiVAR_003058 | 128 | Q → E in Complutense. 1 PublicationCorresponds to variant dbSNP:rs33971634EnsemblClinVar. | 1 | |
Natural variantiVAR_003059 | 128 | Q → K in Brest; unstable. 1 PublicationCorresponds to variant dbSNP:rs33971634EnsemblClinVar. | 1 | |
Natural variantiVAR_003060 | 129 | A → D in J-Guantanamo; unstable. Corresponds to variant dbSNP:rs33957286EnsemblClinVar. | 1 | |
Natural variantiVAR_003061 | 130 | A → P in Crete; O(2) affinity up; unstable. Corresponds to variant dbSNP:rs35939430EnsemblClinVar. | 1 | |
Natural variantiVAR_003062 | 130 | A → V in La Desirade; O(2) affinity down; unstable. 1 PublicationCorresponds to variant dbSNP:rs111645889EnsemblClinVar. | 1 | |
Natural variantiVAR_003063 | 131 | Y → D in Wien; unstable. Corresponds to variant dbSNP:rs35834416EnsemblClinVar. | 1 | |
Natural variantiVAR_003064 | 131 | Y → S in Nevers. Corresponds to variant dbSNP:rs33937535EnsemblClinVar. | 1 | |
Natural variantiVAR_003065 | 132 | Q → E in Camden/Tokuchi/Motown. Corresponds to variant dbSNP:rs33910209EnsemblClinVar. | 1 | |
Natural variantiVAR_003066 | 132 | Q → K in Shelby/Leslie/Deaconess; unstable. 1 PublicationCorresponds to variant dbSNP:rs33910209EnsemblClinVar. | 1 | |
Natural variantiVAR_003067 | 132 | Q → P in Shangai; unstable. Corresponds to variant dbSNP:rs33950778EnsemblClinVar. | 1 | |
Natural variantiVAR_003068 | 132 | Q → R in Sarrebourg; unstable. Corresponds to variant dbSNP:rs33950778EnsemblClinVar. | 1 | |
Natural variantiVAR_003069 | 133 | K → N in Yamagata; O(2) affinity down. Corresponds to variant dbSNP:rs33946775EnsemblClinVar. | 1 | |
Natural variantiVAR_003070 | 133 | K → Q in K-Woolwich. Corresponds to variant dbSNP:rs33953406EnsemblClinVar. | 1 | |
Natural variantiVAR_003071 | 134 | V → L in Extredemura. Corresponds to variant dbSNP:rs34095019EnsemblClinVar. | 1 | |
Natural variantiVAR_003072 | 135 | V → E in North Shore-Caracas; unstable. 1 PublicationCorresponds to variant dbSNP:rs33966761EnsemblClinVar. | 1 | |
Natural variantiVAR_003073 | 136 | A → D in Beckman; originally reported as E-136; O(2) affinity down; unstable. 3 PublicationsCorresponds to variant dbSNP:rs35669628EnsemblClinVar. | 1 | |
Natural variantiVAR_003074 | 136 | A → P in Altdorf; O(2) affinity up; unstable. Corresponds to variant dbSNP:rs35492035EnsemblClinVar. | 1 | |
Natural variantiVAR_003075 | 137 | G → D in Hope; O(2) affinity down; unstable. Corresponds to variant dbSNP:rs33949486EnsemblClinVar. | 1 | |
Natural variantiVAR_003076 | 139 | A → P in Brockton; unstable. Corresponds to variant dbSNP:rs33919821EnsemblClinVar. | 1 | |
Natural variantiVAR_003077 | 140 | N → D in Geelong; unstable. 1 PublicationCorresponds to variant dbSNP:rs33910475EnsemblClinVar. | 1 | |
Natural variantiVAR_003078 | 140 | N → K in Hinsdale; O(2) affinity down. 1 PublicationCorresponds to variant dbSNP:rs34240441EnsemblClinVar. | 1 | |
Natural variantiVAR_025335 | 140 | N → S in S-Wake; associated with V-6. 1 Publication | 1 | |
Natural variantiVAR_003079 | 140 | N → Y in Aurora; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs33910475EnsemblClinVar. | 1 | |
Natural variantiVAR_003080 | 141 | A → D in Himeji; unstable; O(2) affinity down. 1 PublicationCorresponds to variant dbSNP:rs33927093EnsemblClinVar. | 1 | |
Natural variantiVAR_003081 | 141 | A → T in St Jacques; O(2) affinity up. Corresponds to variant dbSNP:rs34980264EnsemblClinVar. | 1 | |
Natural variantiVAR_003082 | 141 | A → V in Puttelange; polycythemia; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs33927093EnsemblClinVar. | 1 | |
Natural variantiVAR_003083 | 142 | L → R in Olmsted; unstable. Corresponds to variant dbSNP:rs35854892EnsemblClinVar. | 1 | |
Natural variantiVAR_003084 | 143 | A → D in Ohio; O(2) affinity up. Corresponds to variant dbSNP:rs33921821EnsemblClinVar. | 1 | |
Natural variantiVAR_003085 | 144 | H → D in Rancho Mirage. Corresponds to variant dbSNP:rs33929415EnsemblClinVar. | 1 | |
Natural variantiVAR_003087 | 144 | H → P in Syracuse; O(2) affinity up. Corresponds to variant dbSNP:rs33918338EnsemblClinVar. | 1 | |
Natural variantiVAR_003086 | 144 | H → Q in Little Rock; O(2) affinity up. Corresponds to variant dbSNP:rs36020563Ensembl. | 1 | |
Natural variantiVAR_003088 | 144 | H → R in Abruzzo; O(2) affinity up. Corresponds to variant dbSNP:rs33918338EnsemblClinVar. | 1 | |
Natural variantiVAR_003089 | 145 | K → E in Mito; O(2) affinity up. Corresponds to variant dbSNP:rs33964352EnsemblClinVar. | 1 | |
Natural variantiVAR_003090 | 146 | Y → C in Rainier; O(2) affinity up. Corresponds to variant dbSNP:rs35117167EnsemblClinVar. | 1 | |
Natural variantiVAR_003091 | 146 | Y → H in Bethesda; O(2) affinity up. Corresponds to variant dbSNP:rs33949869EnsemblClinVar. | 1 | |
Natural variantiVAR_003092 | 147 | H → D in Hiroshima; O(2) affinity up. Corresponds to variant dbSNP:rs33961444EnsemblClinVar. | 1 | |
Natural variantiVAR_003093 | 147 | H → L in Cowtown; O(2) affinity up. Corresponds to variant dbSNP:rs33954264EnsemblClinVar. | 1 | |
Natural variantiVAR_003094 | 147 | H → P in York; O(2) affinity up. Corresponds to variant dbSNP:rs33954264EnsemblClinVar. | 1 | |
Natural variantiVAR_003095 | 147 | H → Q in Kodaira; O(2) affinity up. 1 PublicationCorresponds to variant dbSNP:rs33985739EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M25079 mRNA Translation: AAA35597.1 V00499 Genomic DNA Translation: CAA23758.1 DQ126270 Genomic DNA Translation: AAZ39745.1 DQ126271 Genomic DNA Translation: AAZ39746.1 DQ126272 Genomic DNA Translation: AAZ39747.1 DQ126273 Genomic DNA Translation: AAZ39748.1 DQ126274 Genomic DNA Translation: AAZ39749.1 DQ126275 Genomic DNA Translation: AAZ39750.1 DQ126276 Genomic DNA Translation: AAZ39751.1 DQ126277 Genomic DNA Translation: AAZ39752.1 DQ126278 Genomic DNA Translation: AAZ39753.1 DQ126279 Genomic DNA Translation: AAZ39754.1 DQ126280 Genomic DNA Translation: AAZ39755.1 DQ126281 Genomic DNA Translation: AAZ39756.1 DQ126282 Genomic DNA Translation: AAZ39757.1 DQ126283 Genomic DNA Translation: AAZ39758.1 DQ126284 Genomic DNA Translation: AAZ39759.1 DQ126285 Genomic DNA Translation: AAZ39760.1 DQ126286 Genomic DNA Translation: AAZ39761.1 DQ126287 Genomic DNA Translation: AAZ39762.1 DQ126288 Genomic DNA Translation: AAZ39763.1 DQ126289 Genomic DNA Translation: AAZ39764.1 DQ126290 Genomic DNA Translation: AAZ39765.1 DQ126291 Genomic DNA Translation: AAZ39766.1 DQ126292 Genomic DNA Translation: AAZ39767.1 DQ126293 Genomic DNA Translation: AAZ39768.1 DQ126294 Genomic DNA Translation: AAZ39769.1 DQ126295 Genomic DNA Translation: AAZ39770.1 DQ126296 Genomic DNA Translation: AAZ39771.1 DQ126297 Genomic DNA Translation: AAZ39772.1 DQ126298 Genomic DNA Translation: AAZ39773.1 DQ126299 Genomic DNA Translation: AAZ39774.1 DQ126300 Genomic DNA Translation: AAZ39775.1 DQ126301 Genomic DNA Translation: AAZ39776.1 DQ126302 Genomic DNA Translation: AAZ39777.1 DQ126303 Genomic DNA Translation: AAZ39778.1 DQ126304 Genomic DNA Translation: AAZ39779.1 DQ126305 Genomic DNA Translation: AAZ39780.1 DQ126306 Genomic DNA Translation: AAZ39781.1 DQ126307 Genomic DNA Translation: AAZ39782.1 DQ126308 Genomic DNA Translation: AAZ39783.1 DQ126309 Genomic DNA Translation: AAZ39784.1 DQ126310 Genomic DNA Translation: AAZ39785.1 DQ126311 Genomic DNA Translation: AAZ39786.1 DQ126312 Genomic DNA Translation: AAZ39787.1 DQ126313 Genomic DNA Translation: AAZ39788.1 DQ126314 Genomic DNA Translation: AAZ39789.1 DQ126315 Genomic DNA Translation: AAZ39790.1 DQ126316 Genomic DNA Translation: AAZ39791.1 DQ126317 Genomic DNA Translation: AAZ39792.1 DQ126318 Genomic DNA Translation: AAZ39793.1 DQ126319 Genomic DNA Translation: AAZ39794.1 DQ126320 Genomic DNA Translation: AAZ39795.1 DQ126321 Genomic DNA Translation: AAZ39796.1 DQ126322 Genomic DNA Translation: AAZ39797.1 DQ126323 Genomic DNA Translation: AAZ39798.1 DQ126324 Genomic DNA Translation: AAZ39799.1 DQ126325 Genomic DNA Translation: AAZ39800.1 AF007546 Genomic DNA Translation: AAB62944.1 AF083883 Genomic DNA Translation: AAL68978.1 AF117710 mRNA Translation: AAD19696.1 AF181989 mRNA Translation: AAF00489.1 AF349114 mRNA Translation: AAK29639.1 AF527577 Genomic DNA Translation: AAM92001.1 AY136510 mRNA Translation: AAN11320.1 AY163866 Genomic DNA Translation: AAN84548.1 AY260740 Genomic DNA Translation: AAP21062.1 AY509193 mRNA Translation: AAR96398.1 EF450778 Genomic DNA Translation: ABO36678.1 EU694432 mRNA Translation: ACD39349.1 AK311825 mRNA Translation: BAG34767.1 CR536530 mRNA Translation: CAG38767.1 CR541913 mRNA Translation: CAG46711.1 CH471064 Genomic DNA Translation: EAW68806.1 BC007075 mRNA Translation: AAH07075.1 U01317 Genomic DNA Translation: AAA16334.1 V00497 mRNA Translation: CAA23756.1 V00500 mRNA Translation: CAA23759.1 Sequence problems. L26462 Genomic DNA Translation: AAA21100.1 L26463 Genomic DNA Translation: AAA21101.1 L26464 Genomic DNA Translation: AAA21102.1 L26465 Genomic DNA Translation: AAA21103.1 L26466 Genomic DNA Translation: AAA21104.1 L26467 Genomic DNA Translation: AAA21105.1 L26468 Genomic DNA Translation: AAA21106.1 L26469 Genomic DNA Translation: AAA21107.1 L26470 Genomic DNA Translation: AAA21108.1 L26471 Genomic DNA Translation: AAA21109.1 L26472 Genomic DNA Translation: AAA21110.1 L26473 Genomic DNA Translation: AAA21111.1 L26474 Genomic DNA Translation: AAA21112.1 L26475 Genomic DNA Translation: AAA21113.1 L26476 Genomic DNA Translation: AAA21114.1 L26477 Genomic DNA Translation: AAA21115.1 L26478 Genomic DNA Translation: AAA21116.1 L48213 Genomic DNA Translation: AAA88063.1 L48214 Genomic DNA Translation: AAA88061.1 L48215 Genomic DNA Translation: AAA88059.1 L48216 Genomic DNA Translation: AAA88065.1 L48217 Genomic DNA Translation: AAA88067.1 M36640 Genomic DNA Translation: AAA52634.1 M11428 mRNA Translation: AAA52633.1 M25113 mRNA Translation: AAA35966.1 L48932 Genomic DNA Translation: AAA88054.1 |
CCDSi | CCDS7753.1 |
PIRi | A53136, HBHU |
RefSeqi | NP_000509.1, NM_000518.4 |
Genome annotation databases
Ensembli | ENST00000335295.4; ENSP00000333994.3; ENSG00000244734.4 ENST00000647020.1; ENSP00000494175.1; ENSG00000244734.4 |
GeneIDi | 3043 |
KEGGi | hsa:3043 |
MANE-Selecti | ENST00000335295.4; ENSP00000333994.3; NM_000518.5; NP_000509.1 |
UCSCi | uc001mae.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
HbVar Human hemoglobin variants and thalassemias |
SHMPD The Singapore human mutation and polymorphism database |
Wikipedia Hemoglobin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M25079 mRNA Translation: AAA35597.1 V00499 Genomic DNA Translation: CAA23758.1 DQ126270 Genomic DNA Translation: AAZ39745.1 DQ126271 Genomic DNA Translation: AAZ39746.1 DQ126272 Genomic DNA Translation: AAZ39747.1 DQ126273 Genomic DNA Translation: AAZ39748.1 DQ126274 Genomic DNA Translation: AAZ39749.1 DQ126275 Genomic DNA Translation: AAZ39750.1 DQ126276 Genomic DNA Translation: AAZ39751.1 DQ126277 Genomic DNA Translation: AAZ39752.1 DQ126278 Genomic DNA Translation: AAZ39753.1 DQ126279 Genomic DNA Translation: AAZ39754.1 DQ126280 Genomic DNA Translation: AAZ39755.1 DQ126281 Genomic DNA Translation: AAZ39756.1 DQ126282 Genomic DNA Translation: AAZ39757.1 DQ126283 Genomic DNA Translation: AAZ39758.1 DQ126284 Genomic DNA Translation: AAZ39759.1 DQ126285 Genomic DNA Translation: AAZ39760.1 DQ126286 Genomic DNA Translation: AAZ39761.1 DQ126287 Genomic DNA Translation: AAZ39762.1 DQ126288 Genomic DNA Translation: AAZ39763.1 DQ126289 Genomic DNA Translation: AAZ39764.1 DQ126290 Genomic DNA Translation: AAZ39765.1 DQ126291 Genomic DNA Translation: AAZ39766.1 DQ126292 Genomic DNA Translation: AAZ39767.1 DQ126293 Genomic DNA Translation: AAZ39768.1 DQ126294 Genomic DNA Translation: AAZ39769.1 DQ126295 Genomic DNA Translation: AAZ39770.1 DQ126296 Genomic DNA Translation: AAZ39771.1 DQ126297 Genomic DNA Translation: AAZ39772.1 DQ126298 Genomic DNA Translation: AAZ39773.1 DQ126299 Genomic DNA Translation: AAZ39774.1 DQ126300 Genomic DNA Translation: AAZ39775.1 DQ126301 Genomic DNA Translation: AAZ39776.1 DQ126302 Genomic DNA Translation: AAZ39777.1 DQ126303 Genomic DNA Translation: AAZ39778.1 DQ126304 Genomic DNA Translation: AAZ39779.1 DQ126305 Genomic DNA Translation: AAZ39780.1 DQ126306 Genomic DNA Translation: AAZ39781.1 DQ126307 Genomic DNA Translation: AAZ39782.1 DQ126308 Genomic DNA Translation: AAZ39783.1 DQ126309 Genomic DNA Translation: AAZ39784.1 DQ126310 Genomic DNA Translation: AAZ39785.1 DQ126311 Genomic DNA Translation: AAZ39786.1 DQ126312 Genomic DNA Translation: AAZ39787.1 DQ126313 Genomic DNA Translation: AAZ39788.1 DQ126314 Genomic DNA Translation: AAZ39789.1 DQ126315 Genomic DNA Translation: AAZ39790.1 DQ126316 Genomic DNA Translation: AAZ39791.1 DQ126317 Genomic DNA Translation: AAZ39792.1 DQ126318 Genomic DNA Translation: AAZ39793.1 DQ126319 Genomic DNA Translation: AAZ39794.1 DQ126320 Genomic DNA Translation: AAZ39795.1 DQ126321 Genomic DNA Translation: AAZ39796.1 DQ126322 Genomic DNA Translation: AAZ39797.1 DQ126323 Genomic DNA Translation: AAZ39798.1 DQ126324 Genomic DNA Translation: AAZ39799.1 DQ126325 Genomic DNA Translation: AAZ39800.1 AF007546 Genomic DNA Translation: AAB62944.1 AF083883 Genomic DNA Translation: AAL68978.1 AF117710 mRNA Translation: AAD19696.1 AF181989 mRNA Translation: AAF00489.1 AF349114 mRNA Translation: AAK29639.1 AF527577 Genomic DNA Translation: AAM92001.1 AY136510 mRNA Translation: AAN11320.1 AY163866 Genomic DNA Translation: AAN84548.1 AY260740 Genomic DNA Translation: AAP21062.1 AY509193 mRNA Translation: AAR96398.1 EF450778 Genomic DNA Translation: ABO36678.1 EU694432 mRNA Translation: ACD39349.1 AK311825 mRNA Translation: BAG34767.1 CR536530 mRNA Translation: CAG38767.1 CR541913 mRNA Translation: CAG46711.1 CH471064 Genomic DNA Translation: EAW68806.1 BC007075 mRNA Translation: AAH07075.1 U01317 Genomic DNA Translation: AAA16334.1 V00497 mRNA Translation: CAA23756.1 V00500 mRNA Translation: CAA23759.1 Sequence problems. L26462 Genomic DNA Translation: AAA21100.1 L26463 Genomic DNA Translation: AAA21101.1 L26464 Genomic DNA Translation: AAA21102.1 L26465 Genomic DNA Translation: AAA21103.1 L26466 Genomic DNA Translation: AAA21104.1 L26467 Genomic DNA Translation: AAA21105.1 L26468 Genomic DNA Translation: AAA21106.1 L26469 Genomic DNA Translation: AAA21107.1 L26470 Genomic DNA Translation: AAA21108.1 L26471 Genomic DNA Translation: AAA21109.1 L26472 Genomic DNA Translation: AAA21110.1 L26473 Genomic DNA Translation: AAA21111.1 L26474 Genomic DNA Translation: AAA21112.1 L26475 Genomic DNA Translation: AAA21113.1 L26476 Genomic DNA Translation: AAA21114.1 L26477 Genomic DNA Translation: AAA21115.1 L26478 Genomic DNA Translation: AAA21116.1 L48213 Genomic DNA Translation: AAA88063.1 L48214 Genomic DNA Translation: AAA88061.1 L48215 Genomic DNA Translation: AAA88059.1 L48216 Genomic DNA Translation: AAA88065.1 L48217 Genomic DNA Translation: AAA88067.1 M36640 Genomic DNA Translation: AAA52634.1 M11428 mRNA Translation: AAA52633.1 M25113 mRNA Translation: AAA35966.1 L48932 Genomic DNA Translation: AAA88054.1 |
CCDSi | CCDS7753.1 |
PIRi | A53136, HBHU |
RefSeqi | NP_000509.1, NM_000518.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A00 | X-ray | 2.00 | B/D | 3-147 | [»] | |
1A01 | X-ray | 1.80 | B/D | 3-147 | [»] | |
1A0U | X-ray | 2.14 | B/D | 3-147 | [»] | |
1A0Z | X-ray | 2.00 | B/D | 3-147 | [»] | |
1A3N | X-ray | 1.80 | B/D | 2-147 | [»] | |
1A3O | X-ray | 1.80 | B/D | 2-147 | [»] | |
1ABW | X-ray | 2.00 | B/D | 3-147 | [»] | |
1ABY | X-ray | 2.60 | B/D | 3-147 | [»] | |
1AJ9 | X-ray | 2.20 | B | 2-147 | [»] | |
1B86 | X-ray | 2.50 | B/D | 2-147 | [»] | |
1BAB | X-ray | 1.50 | B/D | 2-147 | [»] | |
1BBB | X-ray | 1.70 | B/D | 2-147 | [»] | |
1BIJ | X-ray | 2.30 | B/D | 2-147 | [»] | |
1BUW | X-ray | 1.90 | B/D | 2-147 | [»] | |
1BZ0 | X-ray | 1.50 | B/D | 2-147 | [»] | |
1BZ1 | X-ray | 1.59 | B/D | 2-147 | [»] | |
1BZZ | X-ray | 1.59 | B/D | 2-147 | [»] | |
1C7B | X-ray | 1.80 | B/D | 2-147 | [»] | |
1C7C | X-ray | 1.80 | B/D | 2-147 | [»] | |
1C7D | X-ray | 1.80 | B/D | 2-147 | [»] | |
1CBL | X-ray | 1.80 | A/B/C/D | 2-147 | [»] | |
1CBM | X-ray | 1.74 | A/B/C/D | 2-147 | [»] | |
1CH4 | X-ray | 2.50 | A/B/C/D | 2-146 | [»] | |
1CLS | X-ray | 1.90 | B/D | 2-147 | [»] | |
1CMY | X-ray | 3.00 | B/D | 2-147 | [»] | |
1COH | X-ray | 2.90 | B/D | 2-147 | [»] | |
1DKE | X-ray | 2.10 | B/D | 2-147 | [»] | |
1DXT | X-ray | 1.70 | B/D | 1-147 | [»] | |
1DXU | X-ray | 1.70 | B/D | 3-147 | [»] | |
1DXV | X-ray | 1.70 | B/D | 3-147 | [»] | |
1FN3 | X-ray | 2.48 | B/D | 2-147 | [»] | |
1G9V | X-ray | 1.85 | B/D | 2-147 | [»] | |
1GBU | X-ray | 1.80 | B/D | 2-147 | [»] | |
1GBV | X-ray | 2.00 | B/D | 2-147 | [»] | |
1GLI | X-ray | 2.50 | B/D | 3-147 | [»] | |
1GZX | X-ray | 2.10 | B/D | 2-147 | [»] | |
1HAB | X-ray | 2.30 | B/D | 2-147 | [»] | |
1HAC | X-ray | 2.60 | B/D | 2-147 | [»] | |
1HBA | X-ray | 2.10 | B/D | 2-147 | [»] | |
1HBB | X-ray | 1.90 | B/D | 2-147 | [»] | |
1HBS | X-ray | 3.00 | B/D/F/H | 2-147 | [»] | |
1HCO | X-ray | 2.70 | B | 2-147 | [»] | |
1HDB | X-ray | 2.20 | B/D | 2-147 | [»] | |
1HGA | X-ray | 2.10 | B/D | 2-147 | [»] | |
1HGB | X-ray | 2.10 | B/D | 2-147 | [»] | |
1HGC | X-ray | 2.10 | B/D | 2-147 | [»] | |
1HHO | X-ray | 2.10 | B | 2-147 | [»] | |
1IRD | X-ray | 1.25 | B | 2-147 | [»] | |
1J3Y | X-ray | 1.55 | B/D/F/H | 2-147 | [»] | |
1J3Z | X-ray | 1.60 | B/D/F/H | 2-147 | [»] | |
1J40 | X-ray | 1.45 | B/D/F/H | 2-147 | [»] | |
1J41 | X-ray | 1.45 | B/D/F/H | 2-147 | [»] | |
1J7S | X-ray | 2.20 | B/D | 2-147 | [»] | |
1J7W | X-ray | 2.00 | B/D | 2-147 | [»] | |
1J7Y | X-ray | 1.70 | B/D | 2-147 | [»] | |
1JY7 | X-ray | 3.20 | B/D/Q/S/V/X | 2-147 | [»] | |
1K0Y | X-ray | 1.87 | B/D | 2-147 | [»] | |
1K1K | X-ray | 2.00 | B | 2-147 | [»] | |
1KD2 | X-ray | 1.87 | B/D | 2-147 | [»] | |
1LFL | X-ray | 2.70 | B/D/Q/S | 2-147 | [»] | |
1LFQ | X-ray | 2.60 | B | 2-147 | [»] | |
1LFT | X-ray | 2.60 | B | 2-147 | [»] | |
1LFV | X-ray | 2.80 | B | 2-147 | [»] | |
1LFY | X-ray | 3.30 | B | 2-147 | [»] | |
1LFZ | X-ray | 3.10 | B | 2-147 | [»] | |
1LJW | X-ray | 2.16 | B | 2-147 | [»] | |
1M9P | X-ray | 2.10 | B/D | 2-147 | [»] | |
1MKO | X-ray | 2.18 | B/D | 2-147 | [»] | |
1NEJ | X-ray | 2.10 | B/D | 2-147 | [»] | |
1NIH | X-ray | 2.60 | B/D | 2-147 | [»] | |
1NQP | X-ray | 1.73 | B/D | 2-147 | [»] | |
1O1I | X-ray | 2.30 | B | 2-147 | [»] | |
1O1J | X-ray | 1.90 | B/D | 2-147 | [»] | |
1O1K | X-ray | 2.00 | B/D | 2-147 | [»] | |
1O1L | X-ray | 1.80 | B/D | 2-147 | [»] | |
1O1M | X-ray | 1.85 | B/D | 2-147 | [»] | |
1O1N | X-ray | 1.80 | B/D | 2-147 | [»] | |
1O1O | X-ray | 1.80 | B/D | 2-147 | [»] | |
1O1P | X-ray | 1.80 | B/D | 2-147 | [»] | |
1QI8 | X-ray | 1.80 | B/D | 3-147 | [»] | |
1QSH | X-ray | 1.70 | B/D | 2-147 | [»] | |
1QSI | X-ray | 1.70 | B/D | 2-147 | [»] | |
1QXD | X-ray | 2.25 | B/D | 2-147 | [»] | |
1QXE | X-ray | 1.85 | B/D | 2-147 | [»] | |
1R1X | X-ray | 2.15 | B | 2-147 | [»] | |
1R1Y | X-ray | 1.80 | B/D | 2-147 | [»] | |
1RPS | X-ray | 2.11 | B/D | 2-147 | [»] | |
1RQ3 | X-ray | 1.91 | B/D | 2-147 | [»] | |
1RQ4 | X-ray | 2.11 | B/D | 2-147 | [»] | |
1RQA | X-ray | 2.11 | B/D | 2-147 | [»] | |
1RVW | X-ray | 2.50 | B | 2-147 | [»] | |
1SDK | X-ray | 1.80 | B/D | 2-147 | [»] | |
1SDL | X-ray | 1.80 | B/D | 2-147 | [»] | |
1THB | X-ray | 1.50 | B/D | 2-147 | [»] | |
1UIW | X-ray | 1.50 | B/D/F/H | 2-147 | [»] | |
1VWT | X-ray | 1.90 | B/D | 2-147 | [»] | |
1XXT | X-ray | 1.91 | B/D | 2-147 | [»] | |
1XY0 | X-ray | 1.99 | B/D |