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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. Forms a nonselective ion channel with a conductance of about 3 nanosiemens. May participate in the regulation of osmotic pressure changes within the cell.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • mechanosensitive ion channel activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channelUniRule annotation
Gene namesi
Name:mscLUniRule annotation
Ordered Locus Names:MW1235
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation1 Publication; Multi-pass membrane protein UniRule annotation1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14Cytoplasmic1 PublicationAdd BLAST14
Transmembranei15 – 43Helical1 PublicationAdd BLAST29
Topological domaini44 – 62Extracellular1 PublicationAdd BLAST19
Transmembranei63 – 82Helical1 PublicationAdd BLAST20
Topological domaini83 – 120Cytoplasmic1 PublicationAdd BLAST38

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001924661 – 120Large-conductance mechanosensitive channelAdd BLAST120

Interactioni

Subunit structurei

Homopentamer (By similarity). Can form a homotetramer (in vitro), but this may not be physiologically relevant (PubMed:19701184).UniRule annotationBy similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-15799893,EBI-15799893

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-59298N

Structurei

3D structure databases

ProteinModelPortaliP68806
SMRiP68806
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68806

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.UniRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000226782
KOiK03282
OMAiYGSFIQT

Family and domain databases

Gene3Di1.10.1200.120, 1 hit
HAMAPiMF_00115 MscL, 1 hit
InterProiView protein in InterPro
IPR036019 Gated_MS_channel
IPR019823 Mechanosensitive_channel_CS
IPR001185 MS_channel
IPR037673 MSC/AndL
PANTHERiPTHR30266 PTHR30266, 1 hit
PfamiView protein in Pfam
PF01741 MscL, 1 hit
PRINTSiPR01264 MECHCHANNEL
SUPFAMiSSF81330 SSF81330, 1 hit
TIGRFAMsiTIGR00220 mscL, 1 hit
PROSITEiView protein in PROSITE
PS01327 MSCL, 1 hit

Sequencei

Sequence statusi: Complete.

P68806-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKEFKEFAL KGNVLDLAIA VVMGAAFNKI ISSLVENIIM PLIGKIFGSV
60 70 80 90 100
DFAKEWSFWG IKYGLFIQSV IDFIIIAFAL FIFVKIANTL MKKEEAEEEA
110 120
VVEENVVLLT EIRDLLREKK
Length:120
Mass (Da):13,616
Last modified:December 21, 2004 - v1
Checksum:iA4D1E6B2A7B7D2E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA Translation: BAB95100.1
RefSeqiWP_000910489.1, NC_003923.1

Genome annotation databases

EnsemblBacteriaiBAB95100; BAB95100; BAB95100
KEGGisam:MW1235

Entry informationi

Entry nameiMSCL_STAAW
AccessioniPrimary (citable) accession number: P68806
Secondary accession number(s): O68285
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: April 25, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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