UniProtKB - P68606 (I2_VACCW)
Protein
Protein I2
Gene
VACWR071
Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Functioni
Late protein which probably plays a role in virus entry into the host cell.1 Publication
GO - Biological processi
- viral entry into host cell Source: UniProtKB-KW
Keywordsi
Biological process | Viral penetration into host cytoplasm, Virus entry into host cell |
Protein family/group databases
TCDBi | 1.G.11.1.1, the poxvirus cell entry protein complex (pep-c) family |
Names & Taxonomyi
Protein namesi | Recommended name: Protein I2 |
Gene namesi | Ordered Locus Names:VACWR071 ORF Names:I2L |
Organismi | Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) |
Taxonomic identifieri | 10254 [NCBI] |
Taxonomic lineagei | Viruses › Varidnaviria › Bamfordvirae › Nucleocytoviricota › Pokkesviricetes › Chitovirales › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Vaccinia virus |
Virus hosti | Bos taurus (Bovine) [TaxID: 9913] |
Proteomesi |
|
Subcellular locationi
- Virion membrane Curated; Single-pass membrane protein Curated Note: Component of the membrane of the mature virion.1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 49 – 69 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000099568 | 1 – 73 | Protein I2Add BLAST | 73 |
Expressioni
Inductioni
Expressed in the late phase of the viral replicative cycle.1 Publication
Keywords - Developmental stagei
Late proteinFamily & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 59 – 64 | Poly-Leu | 6 |
Sequence similaritiesi
Belongs to the chordopoxvirinae I2 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
InterProi | View protein in InterPro IPR009175, Poxvirus_I2 |
Pfami | View protein in Pfam PF12575, Pox_EPC_I2-L1, 1 hit |
PIRSFi | PIRSF003766, VAC_I2L, 1 hit |
i Sequence
Sequence statusi: Complete.
P68606-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKLYAAIFG VFMGSPEDDL TDFIEIVKSV LSDEKTVTST NNTGCWGWYW
60 70
LIIIFFIVLI LLLLIYLYLK VVW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY243312 Genomic DNA Translation: AAO89350.1 J03399 Genomic DNA Translation: AAB59804.1 |
PIRi | B29889, WZVZI2 |
RefSeqi | YP_232953.1, NC_006998.1 |
Genome annotation databases
GeneIDi | 3707604 |
KEGGi | vg:3707604 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY243312 Genomic DNA Translation: AAO89350.1 J03399 Genomic DNA Translation: AAB59804.1 |
PIRi | B29889, WZVZI2 |
RefSeqi | YP_232953.1, NC_006998.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
TCDBi | 1.G.11.1.1, the poxvirus cell entry protein complex (pep-c) family |
Genome annotation databases
GeneIDi | 3707604 |
KEGGi | vg:3707604 |
Family and domain databases
InterProi | View protein in InterPro IPR009175, Poxvirus_I2 |
Pfami | View protein in Pfam PF12575, Pox_EPC_I2-L1, 1 hit |
PIRSFi | PIRSF003766, VAC_I2L, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I2_VACCW | |
Accessioni | P68606Primary (citable) accession number: P68606 Secondary accession number(s): P12922, Q76ZV1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | December 7, 2004 | |
Last modified: | December 2, 2020 | |
This is version 46 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families