UniProtKB - P68553 (COX2_BOSIN)
Cytochrome c oxidase subunit 2
MT-CO2
Functioni
Catalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 161 | Copper A1By similarity | 1 | |
Metal bindingi | 196 | Copper A1By similarity | 1 | |
Metal bindingi | 196 | Copper A2By similarity | 1 | |
Metal bindingi | 198 | Copper A2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 198 | Magnesium; shared with MT-CO1By similarity | 1 | |
Metal bindingi | 200 | Copper A1By similarity | 1 | |
Metal bindingi | 200 | Copper A2By similarity | 1 | |
Metal bindingi | 204 | Copper A2By similarity | 1 | |
Metal bindingi | 207 | Copper A1By similarity | 1 |
GO - Molecular functioni
- copper ion binding Source: InterPro
- cytochrome-c oxidase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Translocase |
Biological process | Electron transport, Respiratory chain, Transport |
Ligand | Copper, Magnesium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c oxidase subunit 2 (EC:7.1.1.9)Alternative name(s): Cytochrome c oxidase polypeptide II |
Gene namesi | Name:MT-CO2 Synonyms:COII, COX2, COXII, MTCO2 |
Encoded oni | Mitochondrion |
Organismi | Bos indicus (Zebu) |
Taxonomic identifieri | 9915 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- respiratory chain complex IV Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 14 | Mitochondrial intermembraneBy similarityAdd BLAST | 14 | |
Transmembranei | 15 – 45 | Helical; Name=IBy similarityAdd BLAST | 31 | |
Topological domaini | 46 – 59 | Mitochondrial matrixBy similarityAdd BLAST | 14 | |
Transmembranei | 60 – 87 | Helical; Name=IIBy similarityAdd BLAST | 28 | |
Topological domaini | 88 – 227 | Mitochondrial intermembraneBy similarityAdd BLAST | 140 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183513 | 1 – 227 | Cytochrome c oxidase subunit 2Add BLAST | 227 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-formylmethionineBy similarity | 1 | |
Modified residuei | 218 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
Formylation, PhosphoproteinInteractioni
Subunit structurei
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2) (By similarity).
Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2.
Interacts with TMEM177 in a COX20-dependent manner.
Interacts with COX20.
Interacts with COX16 (By similarity).
By similarityFamily & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
OrthoDBi | 1432833at2759 |
Family and domain databases
CDDi | cd13912, CcO_II_C, 1 hit |
Gene3Di | 1.10.287.90, 1 hit 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR002429, CcO_II-like_C IPR034210, CcO_II_C IPR001505, Copper_CuA IPR008972, Cupredoxin IPR014222, Cyt_c_oxidase_su2 IPR011759, Cyt_c_oxidase_su2_TM_dom IPR036257, Cyt_c_oxidase_su2_TM_sf |
Pfami | View protein in Pfam PF00116, COX2, 1 hit PF02790, COX2_TM, 1 hit |
SUPFAMi | SSF49503, SSF49503, 1 hit SSF81464, SSF81464, 1 hit |
TIGRFAMsi | TIGR02866, CoxB, 1 hit |
PROSITEi | View protein in PROSITE PS00078, COX2, 1 hit PS50857, COX2_CUA, 1 hit PS50999, COX2_TM, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAYPMQLGFQ DATSPIMEEL LHFHDHTLMI VFLISSLVLY IISLMLTTKL
60 70 80 90 100
THTSTMDAQE VETIWTILPA IILILIALPS LRILYMMDEI NNPSLTVKTM
110 120 130 140 150
GHQWYWSYEY TDYEDLSFDS YMIPTSELKP GELRLLEVDN RVVLPMEMTI
160 170 180 190 200
RMLVSSEDVL HSWAVPSLGL KTDAIPGRLN QTTLMSSRPG LYYGQCSEIC
210 220
GSNHSFMPIV LELVPLKYFE KWSASML
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18820 Genomic DNA Translation: AAA75607.1 AF384025 Genomic DNA Translation: AAM45662.1 AF492350 Genomic DNA Translation: AAQ06583.1 AY126697 Genomic DNA Translation: AAM95733.1 |
RefSeqi | YP_052700.1, NC_005971.1 |
Genome annotation databases
GeneIDi | 2885980 |
KEGGi | biu:2885980 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18820 Genomic DNA Translation: AAA75607.1 AF384025 Genomic DNA Translation: AAM45662.1 AF492350 Genomic DNA Translation: AAQ06583.1 AY126697 Genomic DNA Translation: AAM95733.1 |
RefSeqi | YP_052700.1, NC_005971.1 |
3D structure databases
SMRi | P68553 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 2885980 |
KEGGi | biu:2885980 |
Organism-specific databases
CTDi | 4513 |
Phylogenomic databases
OrthoDBi | 1432833at2759 |
Family and domain databases
CDDi | cd13912, CcO_II_C, 1 hit |
Gene3Di | 1.10.287.90, 1 hit 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR002429, CcO_II-like_C IPR034210, CcO_II_C IPR001505, Copper_CuA IPR008972, Cupredoxin IPR014222, Cyt_c_oxidase_su2 IPR011759, Cyt_c_oxidase_su2_TM_dom IPR036257, Cyt_c_oxidase_su2_TM_sf |
Pfami | View protein in Pfam PF00116, COX2, 1 hit PF02790, COX2_TM, 1 hit |
SUPFAMi | SSF49503, SSF49503, 1 hit SSF81464, SSF81464, 1 hit |
TIGRFAMsi | TIGR02866, CoxB, 1 hit |
PROSITEi | View protein in PROSITE PS00078, COX2, 1 hit PS50857, COX2_CUA, 1 hit PS50999, COX2_TM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COX2_BOSIN | |
Accessioni | P68553Primary (citable) accession number: P68553 Secondary accession number(s): P00404, Q6EMS8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | April 7, 2021 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |