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Entry version 121 (08 May 2019)
Sequence version 1 (23 Nov 2004)
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Protein

UBX domain-containing protein 2A

Gene

UBXN2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UBX domain-containing protein 2A
Alternative name(s):
UBX domain-containing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBXN2A
Synonyms:UBXD4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27265 UBXN2A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P68543

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
165324

Open Targets

More...
OpenTargetsi
ENSG00000173960

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162408375

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UBXN2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
55976658

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002110311 – 259UBX domain-containing protein 2AAdd BLAST259

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P68543

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P68543

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P68543

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P68543

PeptideAtlas

More...
PeptideAtlasi
P68543

PRoteomics IDEntifications database

More...
PRIDEi
P68543

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57542

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P68543

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P68543

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173960 Expressed in 216 organ(s), highest expression level in buccal mucosa cell

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P68543 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA065482
HPA069096

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
VCPP5507212EBI-1993668,EBI-355164

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127913, 22 interactors

Protein interaction database and analysis system

More...
IntActi
P68543, 14 interactors

Molecular INTeraction database

More...
MINTi
P68543

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000312107

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P68543

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini60 – 124SEPPROSITE-ProRule annotationAdd BLAST65
Domaini169 – 246UBXPROSITE-ProRule annotationAdd BLAST78

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2086 Eukaryota
ENOG410YGXU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055567

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000088627

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P68543

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTAEPFR

Database of Orthologous Groups

More...
OrthoDBi
1175850at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P68543

TreeFam database of animal gene trees

More...
TreeFami
TF312973

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036241 NSFL1C_SEP_dom_sf
IPR012989 SEP_domain
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08059 SEP, 1 hit
PF00789 UBX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00553 SEP, 1 hit
SM00166 UBX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF102848 SSF102848, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51399 SEP, 1 hit
PS50033 UBX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P68543-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKDVDNLKSI KEEWVCETGS DNQPLGNNQQ SNCEYFVDSL FEEAQKVSSK
60 70 80 90 100
CVSPAEQKKQ VDVNIKLWKN GFTVNDDFRS YSDGASQQFL NSIKKGELPS
110 120 130 140 150
ELQGIFDKEE VDVKVEDKKN EICLSTKPVF QPFSGQGHRL GSATPKIVSK
160 170 180 190 200
AKNIEVENKN NLSAVPLNNL EPITNIQIWL ANGKRIVQKF NITHRVSHIK
210 220 230 240 250
DFIEKYQGSQ RSPPFSLATA LPVLRLLDET LTLEEADLQN AVIIQRLQKT

ASFRELSEH
Length:259
Mass (Da):29,278
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B2CD68375A0BABD
GO
Isoform 2 (identifier: P68543-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-194: Missing.

Note: No experimental confirmation available.
Show »
Length:206
Mass (Da):23,373
Checksum:i21A49C25EEFF98C3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056306142 – 194Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK291192 mRNA Translation: BAF83881.1
AL832079 mRNA No translation available.
AC066692 Genomic DNA No translation available.
BC092484 mRNA Translation: AAH92484.1
BC093681 mRNA Translation: AAH93681.1
BC111997 mRNA Translation: AAI11998.1
BC143298 mRNA Translation: AAI43299.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1704.1 [P68543-1]

NCBI Reference Sequences

More...
RefSeqi
NP_859064.2, NM_181713.3 [P68543-1]
XP_005264223.1, XM_005264166.4 [P68543-1]
XP_005264224.1, XM_005264167.4 [P68543-1]
XP_005264225.1, XM_005264168.4 [P68543-1]
XP_005264226.1, XM_005264169.4 [P68543-1]
XP_011530935.1, XM_011532633.2 [P68543-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000309033; ENSP00000312107; ENSG00000173960 [P68543-1]
ENST00000404924; ENSP00000385525; ENSG00000173960 [P68543-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
165324

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:165324

UCSC genome browser

More...
UCSCi
uc002ren.4 human [P68543-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291192 mRNA Translation: BAF83881.1
AL832079 mRNA No translation available.
AC066692 Genomic DNA No translation available.
BC092484 mRNA Translation: AAH92484.1
BC093681 mRNA Translation: AAH93681.1
BC111997 mRNA Translation: AAI11998.1
BC143298 mRNA Translation: AAI43299.1
CCDSiCCDS1704.1 [P68543-1]
RefSeqiNP_859064.2, NM_181713.3 [P68543-1]
XP_005264223.1, XM_005264166.4 [P68543-1]
XP_005264224.1, XM_005264167.4 [P68543-1]
XP_005264225.1, XM_005264168.4 [P68543-1]
XP_005264226.1, XM_005264169.4 [P68543-1]
XP_011530935.1, XM_011532633.2 [P68543-1]

3D structure databases

SMRiP68543
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127913, 22 interactors
IntActiP68543, 14 interactors
MINTiP68543
STRINGi9606.ENSP00000312107

PTM databases

iPTMnetiP68543
PhosphoSitePlusiP68543

Polymorphism and mutation databases

BioMutaiUBXN2A
DMDMi55976658

Proteomic databases

EPDiP68543
jPOSTiP68543
MaxQBiP68543
PaxDbiP68543
PeptideAtlasiP68543
PRIDEiP68543
ProteomicsDBi57542

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309033; ENSP00000312107; ENSG00000173960 [P68543-1]
ENST00000404924; ENSP00000385525; ENSG00000173960 [P68543-1]
GeneIDi165324
KEGGihsa:165324
UCSCiuc002ren.4 human [P68543-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
165324
DisGeNETi165324

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UBXN2A
HGNCiHGNC:27265 UBXN2A
HPAiHPA065482
HPA069096
neXtProtiNX_P68543
OpenTargetsiENSG00000173960
PharmGKBiPA162408375

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2086 Eukaryota
ENOG410YGXU LUCA
GeneTreeiENSGT00520000055567
HOGENOMiHOG000088627
InParanoidiP68543
OMAiKTAEPFR
OrthoDBi1175850at2759
PhylomeDBiP68543
TreeFamiTF312973

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
UBXN2A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
165324

Protein Ontology

More...
PROi
PR:P68543

Gene expression databases

BgeeiENSG00000173960 Expressed in 216 organ(s), highest expression level in buccal mucosa cell
GenevisibleiP68543 HS

Family and domain databases

Gene3Di3.30.420.210, 1 hit
InterProiView protein in InterPro
IPR036241 NSFL1C_SEP_dom_sf
IPR012989 SEP_domain
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF08059 SEP, 1 hit
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00553 SEP, 1 hit
SM00166 UBX, 1 hit
SUPFAMiSSF102848 SSF102848, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51399 SEP, 1 hit
PS50033 UBX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBX2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P68543
Secondary accession number(s): A8K577, B7ZKP8, Q569G8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: May 8, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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