UniProtKB - P68462 (I6_VACCW)
Protein
Telomere-binding protein I6
Gene
VACWR075
Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Functioni
Binds to the hairpin form of the viral telomeric sequence. Might direct genome encapsidation into the virus particle.2 Publications
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- viral process Source: InterPro
Keywordsi
Molecular function | DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Telomere-binding protein I6 |
Gene namesi | Ordered Locus Names:VACWR075 ORF Names:I6L |
Organismi | Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) |
Taxonomic identifieri | 10254 [NCBI] |
Taxonomic lineagei | Viruses › Varidnaviria › Bamfordvirae › Nucleocytoviricota › Pokkesviricetes › Chitovirales › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Vaccinia virus |
Virus hosti | Bos taurus (Bovine) [TaxID: 9913] |
Proteomesi |
|
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 14 – 18 | KPTKK → APTAA: Reduced plaque size at 32 degrees Celsius. 1 Publication | 5 | |
Mutagenesisi | 56 – 60 | EDVLK → AAVLA: Reduced plaque size at 32 degrees Celsius. 1 Publication | 5 | |
Mutagenesisi | 103 – 105 | DDD → AAA: No change in amounts of infectious virus produced during a single round of infection at 32 degrees Celsius or 40 degrees Celsius. 1 Publication | 3 | |
Mutagenesisi | 145 – 147 | EKE → AAA: No change in amounts of infectious virus produced during a single round of infection at 32 degrees Celsius or 40 degrees Celsius. 1 Publication | 3 | |
Mutagenesisi | 196 – 198 | KER → AAA: No change in amounts of infectious virus produced during a single round of infection at 32 degrees Celsius or 40 degrees Celsius. 1 Publication | 3 | |
Mutagenesisi | 305 – 306 | KR → AA: No change in amounts of infectious virus produced during a single round of infection at 32 degrees Celsius or 40 degrees Celsius. 1 Publication | 2 | |
Mutagenesisi | 359 – 361 | KKK → AAA: 100-fold reduction in viral yield at 40 degrees Celsius. Failure in genome encapsidation at 40 degrees Celsius. 1 Publication | 3 | |
Mutagenesisi | 364 – 365 | KK → AA: Reduced plaque size at 32 degrees Celsius. 1 Publication | 2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000099579 | 1 – 382 | Telomere-binding protein I6Add BLAST | 382 |
Family & Domainsi
Sequence similaritiesi
Belongs to the chordopoxvirinae I6 family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR007674, Poxvirus_36kDa_major_membrane IPR022219, Poxvirus_I6_C |
Pfami | View protein in Pfam PF12562, DUF3746, 1 hit PF04595, Pox_I6, 1 hit |
i Sequence
Sequence statusi: Complete.
P68462-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNNFVKQVAS KSLKPTKKLS PSDEVISLNE CIISFNLDNF YYCNDGLFTK
60 70 80 90 100
PINTPEDVLK SLLIMESFAY EKMIIKGLIK ILISRAYIND IYFTPFGWLT
110 120 130 140 150
GVDDDPETHV VIKIIFNSSL ISIKSQVIEY LKPYNVNNLS VLTTEKELSI
160 170 180 190 200
NTFNVPDSIP MSIISFFPFD TDFILVILFF GVYNDSYCGI SYISPKERLP
210 220 230 240 250
YIIEILKPLV SEINMLSDEI GRTSSIRIFN STSVKKFPTN TLTSICEIVY
260 270 280 290 300
SFDESSFPTP KTFTPLNASP YIPKKIVSLL DLPSNVEIKA ISRGGVDFIT
310 320 330 340 350
HINNKRLNTI LVIAKDNFLK NSTFSGTFIK ENIIWKGIYT YRIIKSSFPV
360 370 380
PTIKSVTNKK KICKKHCFVN SQYTTRTLSH IL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03399 Genomic DNA Translation: AAB59808.1 AY243312 Genomic DNA Translation: AAO89354.1 |
PIRi | F29889, WZVZI6 |
RefSeqi | YP_232957.1, NC_006998.1 |
Genome annotation databases
GeneIDi | 3707608 |
KEGGi | vg:3707608 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03399 Genomic DNA Translation: AAB59808.1 AY243312 Genomic DNA Translation: AAO89354.1 |
PIRi | F29889, WZVZI6 |
RefSeqi | YP_232957.1, NC_006998.1 |
3D structure databases
SMRi | P68462 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 3707608 |
KEGGi | vg:3707608 |
Family and domain databases
InterProi | View protein in InterPro IPR007674, Poxvirus_36kDa_major_membrane IPR022219, Poxvirus_I6_C |
Pfami | View protein in Pfam PF12562, DUF3746, 1 hit PF04595, Pox_I6, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | I6_VACCW | |
Accessioni | P68462Primary (citable) accession number: P68462 Secondary accession number(s): P12925, Q76ZU7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | November 23, 2004 | |
Last modified: | December 2, 2020 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families