VACWR075

Functionⁱ

Binds to the hairpin form of the viral telomeric sequence. Might direct genome encapsidation into the virus particle.2 Publications

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

viral process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Telomere-binding protein I6
Gene namesⁱ	Ordered Locus Names:VACWR075 ORF Names:I6L
Organismⁱ	Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifierⁱ	10254 [NCBI]
Taxonomic lineageⁱ	Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Vaccinia virus
Virus hostⁱ	Bos taurus (Bovine) [TaxID: 9913]
Proteomesⁱ	UP000000344 Componentⁱ: Genome

Subcellular locationⁱ

Virion

Note:

Present in the virus core.

GO - Cellular componentⁱ

virion Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Virion

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	14 – 18	KPTKK → APTAA: Reduced plaque size at 32 degrees Celsius. 1 Publication	5
Mutagenesisⁱ	56 – 60	EDVLK → AAVLA: Reduced plaque size at 32 degrees Celsius. 1 Publication	5
Mutagenesisⁱ	103 – 105	DDD → AAA: No change in amounts of infectious virus produced during a single round of infection at 32 degrees Celsius or 40 degrees Celsius. 1 Publication	3
Mutagenesisⁱ	145 – 147	EKE → AAA: No change in amounts of infectious virus produced during a single round of infection at 32 degrees Celsius or 40 degrees Celsius. 1 Publication	3
Mutagenesisⁱ	196 – 198	KER → AAA: No change in amounts of infectious virus produced during a single round of infection at 32 degrees Celsius or 40 degrees Celsius. 1 Publication	3
Mutagenesisⁱ	305 – 306	KR → AA: No change in amounts of infectious virus produced during a single round of infection at 32 degrees Celsius or 40 degrees Celsius. 1 Publication	2
Mutagenesisⁱ	359 – 361	KKK → AAA: 100-fold reduction in viral yield at 40 degrees Celsius. Failure in genome encapsidation at 40 degrees Celsius. 1 Publication	3
Mutagenesisⁱ	364 – 365	KK → AA: Reduced plaque size at 32 degrees Celsius. 1 Publication	2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000099579	1 – 382	Telomere-binding protein I6Add BLAST		382

Structureⁱ

3D structure databases

SMRⁱ	P68462
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the chordopoxvirinae I6 family.Curated

Phylogenomic databases

Database of Orthologous Groups More...OrthoDBⁱ	VOG090000CG

OrthoDBⁱ

VOG090000CG

Family and domain databases

InterProⁱ	View protein in InterPro IPR007674 Poxvirus_36kDa_major_membrane IPR022219 Poxvirus_I6_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12562 DUF3746, 1 hit PF04595 Pox_I6, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P68462-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNNFVKQVAS KSLKPTKKLS PSDEVISLNE CIISFNLDNF YYCNDGLFTK 
        60         70         80         90        100
PINTPEDVLK SLLIMESFAY EKMIIKGLIK ILISRAYIND IYFTPFGWLT 
       110        120        130        140        150
GVDDDPETHV VIKIIFNSSL ISIKSQVIEY LKPYNVNNLS VLTTEKELSI 
       160        170        180        190        200
NTFNVPDSIP MSIISFFPFD TDFILVILFF GVYNDSYCGI SYISPKERLP 
       210        220        230        240        250
YIIEILKPLV SEINMLSDEI GRTSSIRIFN STSVKKFPTN TLTSICEIVY 
       260        270        280        290        300
SFDESSFPTP KTFTPLNASP YIPKKIVSLL DLPSNVEIKA ISRGGVDFIT 
       310        320        330        340        350
HINNKRLNTI LVIAKDNFLK NSTFSGTFIK ENIIWKGIYT YRIIKSSFPV 
       360        370        380 
PTIKSVTNKK KICKKHCFVN SQYTTRTLSH IL

Length:382

Mass (Da):43,454

Last modified:November 23, 2004 - v1

Checksum:ⁱ4D0F72666DEE1307

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03399 Genomic DNA Translation: AAB59808.1 AY243312 Genomic DNA Translation: AAO89354.1
PIRⁱ	F29889 WZVZI6
NCBI Reference Sequences More...RefSeqⁱ	YP_232957.1, NC_006998.1

Genome annotation databases

GeneIDⁱ	3707608
KEGGⁱ	vg:3707608

Protein	Similar proteins		Species	Score	Length
P68462	Telomere-binding protein I6		VACCC		382
DNA binding protein		Vaccinia virus		382
Putative 43.5k protein		VACCA		382
CPXV085 protein		COWPX		382
Uncharacterized protein		VACCW		382
+2

Protein	Similar proteins		Species	Score	Length
P68462	Telomere-binding protein I6		VAR67		382
Telomere-binding protein		VARV		382
Uncharacterized protein		VAR65		382
Uncharacterized protein		VAR46		382
CPXV085 protein		COWPX		393
+51

Protein	Similar proteins		Species	Score	Length
P68462	Telomere-binding protein I6		VAR67		382
Telomere-binding protein		VARV		382
Uncharacterized protein		VAR65		382
Uncharacterized protein		VAR46		382
CPXV085 protein		COWPX		393
+82

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03399 Genomic DNA Translation: AAB59808.1 AY243312 Genomic DNA Translation: AAO89354.1
PIRⁱ	F29889 WZVZI6
NCBI Reference Sequences More...RefSeqⁱ	YP_232957.1, NC_006998.1

3D structure databases

SMRⁱ	P68462
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	3707608
KEGGⁱ	vg:3707608

Phylogenomic databases

Database of Orthologous Groups More...OrthoDBⁱ	VOG090000CG

OrthoDBⁱ

VOG090000CG

Family and domain databases

InterProⁱ	View protein in InterPro IPR007674 Poxvirus_36kDa_major_membrane IPR022219 Poxvirus_I6_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12562 DUF3746, 1 hit PF04595 Pox_I6, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	I6_VACCW
Accessionⁱ	P68462Primary (citable) accession number: P68462 Secondary accession number(s): P12925, Q76ZU7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
	Last sequence update:	November 23, 2004
	Last modified:	March 15, 2017
	This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

UniProtKB - P68462 (I6_VACCW)

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Telomere-binding protein I6

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Mutagenesis

PTM / Processingⁱ

Molecule processing

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

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UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P68462 (I6_VACCW)

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Telomere-binding protein I6

VACWR075

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ