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Protein

Scaffold protein D13

Gene

D13L

Organism
Vaccinia virus (strain Copenhagen) (VACV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus (By similarity).By similarity

Miscellaneous

Displays structure similarities to capsid proteins.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Scaffold protein D13
Alternative name(s):
62 kDa protein
Rifampicin resistance protein
Gene namesi
ORF Names:D13L
OrganismiVaccinia virus (strain Copenhagen) (VACV)
Taxonomic identifieri10249 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008269 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000991251 – 551Scaffold protein D13Add BLAST551

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Homotrimer (By similarity). Self-assembles to form a layer. Interacts with A17 (via N-terminus); this interaction is necessary for D13 association with membranes (By similarity).By similarity

Structurei

3D structure databases

SMRiP68441
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the poxviridae protein D13 family.Curated

Phylogenomic databases

OrthoDBiVOG09000062

Family and domain databases

InterProiView protein in InterPro
IPR005008 Poxvirus_Rif-R
PfamiView protein in Pfam
PF03340 Pox_Rif, 1 hit

Sequencei

Sequence statusi: Complete.

P68441-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNTIINSLI GGDDSIKRSN VFAVDSQIPT LYMPQYISLS GVMTNDGPDN
60 70 80 90 100
QAIASFEIRD QYITALNHLV LSLELPEVKG MGRFGYVPYV GYKCINHVSI
110 120 130 140 150
SSCNGVIWEI EGEELYNNCI NNTIALKHSG YSSELNDISI GLTPNDTIKE
160 170 180 190 200
PSTVYVYIKT PFDVEDTFSS LKLSDSKITV TVTFNPVSDI VIRDSSFDFE
210 220 230 240 250
TFNKEFVYVP ELSFIGYMVK NVQIKPSFIE KPRRVIGQIN QPTATVTEVH
260 270 280 290 300
AATSLSVYTK PYYGNTDNKF ISYPGYSQDE KDYIDAYVSR LLDDLVIVSD
310 320 330 340 350
GPPTGYPESA EIVEVPEDGI VSIQDADVYV KIDNVPDNMS VYLHTNLLMF
360 370 380 390 400
GTRKNSFIYN ISKKFSAITG TYSDATKRTI FAHISHSINI IDTSIPVSLW
410 420 430 440 450
TSQRNVYNGD NRSAESKAKD LFINDPFIKG IDFKNKTDII SRLEVRFGND
460 470 480 490 500
VLYSENGPIS RIYNELLTKS NNGTRTLTFN FTPKIFFRPT TITANVSRGK
510 520 530 540 550
DKLSVRVVYS TMDVNHPIYY VQKQLVVVCN DLYKVSYDQG VSITKIMGDN

N
Length:551
Mass (Da):61,891
Last modified:March 20, 1987 - v1
Checksum:i5E75F14646330A0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16556 Genomic DNA Translation: AAA48305.1
M35027 Genomic DNA Translation: AAA48114.1
PIRiC01146 QQVZ25
RefSeqiYP_233000.1, NC_006998.1

Genome annotation databases

GeneIDi3707516
KEGGivg:3707516

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16556 Genomic DNA Translation: AAA48305.1
M35027 Genomic DNA Translation: AAA48114.1
PIRiC01146 QQVZ25
RefSeqiYP_233000.1, NC_006998.1

3D structure databases

SMRiP68441
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3707516
KEGGivg:3707516

Phylogenomic databases

OrthoDBiVOG09000062

Family and domain databases

InterProiView protein in InterPro
IPR005008 Poxvirus_Rif-R
PfamiView protein in Pfam
PF03340 Pox_Rif, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD13_VACCC
AccessioniPrimary (citable) accession number: P68441
Secondary accession number(s): P04321, Q85329
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: March 28, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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