UniProtKB - P68431 (H31_HUMAN)

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History
Entry version 164 (18 Jul 2018)
Sequence version 2 (23 Jan 2007)
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Protein

Histone H3.1

Gene

HIST1H3A

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Miscellaneous

This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).

Caution

The original paper reporting lysine deamination at Lys-5 by LOXL2 has been retracted due to inappropriate manipulation of figure data (PubMed:22483618, PubMed:27392148). However, this modification was confirmed in a subsequent publication (PubMed:27735137).2 Publications1 Publication

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
nucleosomal DNA binding Source: GO_Central
protein heterodimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation Source: Reactome
cellular protein metabolic process Source: Reactome
chromatin organization Source: Reactome
chromatin silencing at rDNA Source: Reactome
DNA replication-dependent nucleosome assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 14718166
interleukin-7-mediated signaling pathway Source: Reactome
negative regulation of gene expression, epigenetic Source: Reactome
nucleosome assembly
Source: UniProtKB
Inferred from direct assayⁱ
protein heterotetramerization
Source: UniProtKB
Inferred from direct assayⁱ
- 20498094
regulation of gene silencing
Source: BHF-UCL
Inferred from direct assayⁱ
- 16267050
regulation of gene silencing by miRNA Source: Reactome
regulation of megakaryocyte differentiation Source: Reactome
telomere organization
Source: BHF-UCL
Traceable author statementⁱ
- 17675446

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1266695 Interleukin-7 signaling R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex R-HSA-212300 PRC2 methylates histones and DNA R-HSA-2299718 Condensation of Prophase Chromosomes R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-3214815 HDACs deacetylate histones R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3214842 HDMs demethylate histones R-HSA-3214847 HATs acetylate histones R-HSA-3214858 RMTs methylate histone arginines R-HSA-3247509 Chromatin modifying enzymes R-HSA-427359 SIRT1 negatively regulates rRNA expression R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427413 NoRC negatively regulates rRNA expression R-HSA-5250924 B-WICH complex positively regulates rRNA expression R-HSA-5334118 DNA methylation R-HSA-5578749 Transcriptional regulation by small RNAs R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-73728 RNA Polymerase I Promoter Opening R-HSA-73777 RNA Polymerase I Chain Elongation R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-9018519 Estrogen-dependent gene expression R-HSA-912446 Meiotic recombination R-HSA-977225 Amyloid fiber formation R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORⁱ	P68431

Reactomeⁱ

R-HSA-1266695 Interleukin-7 signaling
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-3214815 HDACs deacetylate histones
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3214842 HDMs demethylate histones
R-HSA-3214847 HATs acetylate histones
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-5334118 DNA methylation
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-73728 RNA Polymerase I Promoter Opening
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-912446 Meiotic recombination
R-HSA-977225 Amyloid fiber formation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

SIGNORⁱ

P68431

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histone H3.1 Alternative name(s): Histone H3/a Histone H3/b Histone H3/c Histone H3/d Histone H3/f Histone H3/h Histone H3/i Histone H3/j Histone H3/k Histone H3/l
Gene namesⁱ	Name:HIST1H3A Synonyms:H3FA AND Name:HIST1H3B Synonyms:H3FL AND Name:HIST1H3C Synonyms:H3FC AND Name:HIST1H3D Synonyms:H3FB AND Name:HIST1H3E Synonyms:H3FD AND Name:HIST1H3F Synonyms:H3FI AND Name:HIST1H3G Synonyms:H3FH AND Name:HIST1H3H Synonyms:H3FK AND Name:HIST1H3I Synonyms:H3FF AND Name:HIST1H3J Synonyms:H3FJ
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197153.4 HostDB:ENSG00000197409.7 HostDB:ENSG00000273983.1 HostDB:ENSG00000274267.1 HostDB:ENSG00000274750.2 HostDB:ENSG00000275379.1 HostDB:ENSG00000275714.1 HostDB:ENSG00000277775.1 HostDB:ENSG00000278272.1 HostDB:ENSG00000278828.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4766 HIST1H3A HGNC:4776 HIST1H3B HGNC:4768 HIST1H3C HGNC:4767 HIST1H3D HGNC:4769 HIST1H3E HGNC:4773 HIST1H3F HGNC:4772 HIST1H3G HGNC:4775 HIST1H3H HGNC:4771 HIST1H3I HGNC:4774 HIST1H3J
MIMⁱ	602810 gene 602811 gene 602812 gene 602813 gene 602814 gene 602815 gene 602816 gene 602817 gene 602818 gene 602819 gene
neXtProtⁱ	NX_P68431

Keywords - Cellular componentⁱ

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Glioma (GLM)1 Publication

The gene represented in this entry is involved in disease pathogenesis. HIST1H3B mutations affecting residue Lys-28 involved in post-translational modifications of histone H3.1 are recurrent in malignant, aggressive gliomas including pediatric non-brain stem glioblastoma and diffuse intrinsic pontine glioma (DIPG) (PubMed:22286216). The mechanism through which mutations lead to tumorigenesis involves altered histone methylation, impaired regulation of Polycomb repressive complex 2 (PRC2) activity, and aberrant epigenetic regulation of gene expression (PubMed:23603901).2 Publications

Disease descriptionGliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8350 8351 8352 8353 8354 8355 8356 8357 8358 8968
MalaCards human disease database More...MalaCardsⁱ	HIST1H3A
MIMⁱ	137800 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000197153 ENSG00000197409 ENSG00000273983 ENSG00000274267 ENSG00000274750 ENSG00000275379 ENSG00000275714 ENSG00000277775 ENSG00000278272 ENSG00000278828
PharmGKBⁱ	PA29148

Polymorphism and mutation databases

BioMutaⁱ	HIST1H3A
DMDMⁱ	55977055

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000221245	2 – 136	Histone H3.1Add BLAST		135

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	3	Asymmetric dimethylarginine; by PRMT6; alternate3 Publications	1
Modified residueⁱ	3	Citrulline; alternate1 Publication	1
Modified residueⁱ	4	Phosphothreonine; by HASPIN2 Publications	1
Modified residueⁱ	5	Allysine; alternate1 Publication	1
Modified residueⁱ	5	N6,N6,N6-trimethyllysine; alternate3 Publications	1
Modified residueⁱ	5	N6,N6-dimethyllysine; alternate3 Publications	1
Modified residueⁱ	5	N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	5	N6-(beta-hydroxybutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	5	N6-acetyllysine; alternate1 Publication	1
Modified residueⁱ	5	N6-crotonyllysine; alternate1 Publication	1
Modified residueⁱ	5	N6-methyllysine; alternate3 Publications	1
Modified residueⁱ	7	Phosphothreonine; by PKC1 Publication	1
Modified residueⁱ	9	Citrulline; alternate2 Publications	1
Modified residueⁱ	9	Symmetric dimethylarginine; by PRMT5; alternateBy similarity	1
Modified residueⁱ	10	N6,N6,N6-trimethyllysine; alternate5 Publications	1
Modified residueⁱ	10	N6,N6-dimethyllysine; alternate5 Publications	1
Modified residueⁱ	10	N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	10	N6-(beta-hydroxybutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	10	N6-acetyllysine; alternate6 Publications	1
Modified residueⁱ	10	N6-butyryllysine; alternate1 Publication	1
Modified residueⁱ	10	N6-crotonyllysine; alternate1 Publication	1
Modified residueⁱ	10	N6-methyllysine; alternate5 Publications	1
Modified residueⁱ	11	ADP-ribosylserine; alternate1 Publication	1
Modified residueⁱ	11	Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA56 Publications	1
Modified residueⁱ	12	Phosphothreonine; by PKC and CHEK13 Publications	1
Modified residueⁱ	15	N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	15	N6-(beta-hydroxybutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	15	N6-acetyllysine; alternate6 Publications	1
Modified residueⁱ	15	N6-succinyllysine; alternate1 Publication	1
Modified residueⁱ	18	Asymmetric dimethylarginine; by CARM1; alternate3 Publications	1
Modified residueⁱ	18	Citrulline; alternate3 Publications	1
Modified residueⁱ	19	N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	19	N6-(beta-hydroxybutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	19	N6-acetyllysine; alternate3 Publications	1
Modified residueⁱ	19	N6-butyryllysine; alternate1 Publication	1
Modified residueⁱ	19	N6-crotonyllysine; alternate1 Publication	1
Modified residueⁱ	19	N6-methyllysine; alternate2 Publications	1
Modified residueⁱ	24	N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	24	N6-(beta-hydroxybutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	24	N6-acetyllysine; alternate4 Publications	1
Modified residueⁱ	24	N6-butyryllysine; alternate1 Publication	1
Modified residueⁱ	24	N6-crotonyllysine; alternate1 Publication	1
Modified residueⁱ	24	N6-methyllysine; alternate1 Publication	1
Modified residueⁱ	27	Citrulline1 Publication	1
Modified residueⁱ	28	N6,N6,N6-trimethyllysine; alternate4 Publications	1
Modified residueⁱ	28	N6,N6-dimethyllysine; alternate4 Publications	1
Modified residueⁱ	28	N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	28	N6-(beta-hydroxybutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	28	N6-acetyllysine; alternate2 Publications	1
Modified residueⁱ	28	N6-crotonyllysine; alternate1 Publication	1
Modified residueⁱ	28	N6-methyllysine; alternate4 Publications	1
Modified residueⁱ	29	ADP-ribosylserine; alternate1 Publication	1
Modified residueⁱ	29	Phosphoserine; alternate; by AURKB, AURKC and RPS6KA56 Publications	1
Modified residueⁱ	37	N6,N6,N6-trimethyllysine; alternate5 Publications	1
Modified residueⁱ	37	N6,N6-dimethyllysine; alternate5 Publications	1
Modified residueⁱ	37	N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	37	N6-acetyllysine; alternate2 Publications	1
Modified residueⁱ	37	N6-methyllysine; alternate5 Publications	1
Modified residueⁱ	38	N6-methyllysine1 Publication	1
Modified residueⁱ	42	Phosphotyrosine1 Publication	1
Modified residueⁱ	57	N6,N6,N6-trimethyllysine; alternate2 Publications	1
Modified residueⁱ	57	N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	57	N6-(beta-hydroxybutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	57	N6-acetyllysine; alternate1 Publication	1
Modified residueⁱ	57	N6-crotonyllysine; alternate1 Publication	1
Modified residueⁱ	57	N6-methyllysine; by EHMT2; alternate2 Publications	1
Modified residueⁱ	57	N6-succinyllysine; alternate1 Publication	1
Modified residueⁱ	58	Phosphoserine1 Publication	1
Modified residueⁱ	65	N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	65	N6-methyllysine; alternate2 Publications	1
Modified residueⁱ	80	N6,N6,N6-trimethyllysine; alternateBy similarity	1
Modified residueⁱ	80	N6,N6-dimethyllysine; alternate4 Publications	1
Modified residueⁱ	80	N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	80	N6-(beta-hydroxybutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	80	N6-acetyllysine; alternate1 Publication	1
Modified residueⁱ	80	N6-methyllysine; alternate4 Publications	1
Modified residueⁱ	80	N6-succinyllysine; alternate2 Publications	1
Modified residueⁱ	81	Phosphothreonine1 Publication	1
Modified residueⁱ	87	PhosphoserineBy similarity	1
Modified residueⁱ	108	PhosphothreonineBy similarity	1
Modified residueⁱ	116	N6-acetyllysine1 Publication	1
Modified residueⁱ	123	N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	123	N6-(beta-hydroxybutyryl)lysine; alternate1 Publication	1
Modified residueⁱ	123	N6-acetyllysine; alternate2 Publications	1
Modified residueⁱ	123	N6-methyllysine; alternate2 Publications	1
Modified residueⁱ	123	N6-succinyllysine; alternate1 Publication	1

Post-translational modificationⁱ

Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.11 Publications

Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.4 Publications

Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters.9 Publications

Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication.15 Publications

Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Thr-12 (H3T11ph) by chromatin-associated CHEK1 regulates the transcription of cell cycle regulatory genes by modulating acetylation of Lys-10 (H3K9ac). Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin.17 Publications

Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.By similarity1 Publication

Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression.1 Publication

Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication

Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.By similarity

Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes (PubMed:29211711). It gives a specific tag for epigenetic transcription activation (PubMed:29211711).1 Publication

Keywords - PTMⁱ

Acetylation, ADP-ribosylation, Citrullination, Hydroxylation, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P68431
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P68431
PaxDbⁱ	P68431
PeptideAtlas More...PeptideAtlasⁱ	P68431
PRIDEⁱ	P68431
ProteomicsDBⁱ	57541
TopDownProteomicsⁱ	P68431

PTM databases

iPTMnetⁱ	P68431
PhosphoSitePlusⁱ	P68431
SwissPalmⁱ	P68431

Expressionⁱ

Developmental stageⁱ

Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.

Gene expression databases

Bgeeⁱ	ENSG00000197153
CleanExⁱ	HS_HIST1H3A HS_HIST1H3B HS_HIST1H3C HS_HIST1H3D HS_HIST1H3E HS_HIST1H3F HS_HIST1H3G HS_HIST1H3H HS_HIST1H3I
Genevisibleⁱ	P68431 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB070190 HPA042570

HPAⁱ

CAB070190
HPA042570

Interactionⁱ

Subunit structureⁱ

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AIRE	O43918	20	EBI-79722,EBI-1753081
ASF1A	Q9Y294	9	EBI-79722,EBI-749553
ASF1B	Q9NVP2	8	EBI-79722,EBI-1055650
BRD7	Q9NPI1	2	EBI-79722,EBI-711221
CBX1	P83916	13	EBI-79722,EBI-78129
CBX3	Q13185	5	EBI-79722,EBI-78176
CBX5	P45973	9	EBI-79722,EBI-78219
CDYL	Q9Y232	5	EBI-79722,EBI-1387386
DAXX	Q9UER7-1	6	EBI-79722,EBI-287635
DNAJC9	Q8WXX5	13	EBI-79722,EBI-2349100
FBLIM1	Q8WUP2	11	EBI-79722,EBI-3864120
HIST2H4B	P62805	6	EBI-79722,EBI-302023
HTT	P42858	2	EBI-79722,EBI-466029
ING4	Q9UNL4	3	EBI-79722,EBI-2866661
IPL1	P38991	2	EBI-79722,EBI-9319	From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
KDM4A	O75164	7	EBI-79722,EBI-936709
KMT2A	Q03164	11	EBI-79722,EBI-591370
L3MBTL1	Q9Y468	2	EBI-79722,EBI-1265089
MCM2	P49736	5	EBI-79722,EBI-374819
MPHOSPH8	Q99549	5	EBI-79722,EBI-2653928
NASP	P49321	6	EBI-79722,EBI-716205
NASP	P49321-2	16	EBI-79722,EBI-7038920
PHF20	Q9BVI0	6	EBI-79722,EBI-2560802
PHF20L1	A8MW92	2	EBI-79722,EBI-2560834
PKM	P14618-1	3	EBI-79722,EBI-4304679
SETD7	Q8WTS6	3	EBI-79722,EBI-1268586
SGF29	P25554	11	EBI-79722,EBI-21678	From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SGF29	Q96ES7	25	EBI-79722,EBI-743117
TP53BP1	Q12888	5	EBI-79722,EBI-396540
Uhrf1	Q8VDF2	3	EBI-79722,EBI-7144545	From Mus musculus.
WDR5	P61964	11	EBI-79722,EBI-540834
YWHAZ	P63104	3	EBI-79722,EBI-347088
Zmynd11	Q8R5C8	4	EBI-79722,EBI-647813	From Mus musculus.

Show more details

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
protein heterodimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113946, 308 interactors 113947, 6 interactors 113948, 12 interactors 113949, 201 interactors 113950, 6 interactors 113951, 7 interactors 113952, 5 interactors 113953, 9 interactors 113954, 24 interactors 114458, 9 interactors
CORUMⁱ	P68431
Database of interacting proteins More...DIPⁱ	DIP-29371N
ELMⁱ	P68431
IntActⁱ	P68431, 435 interactors
Molecular INTeraction database More...MINTⁱ	P68431
STRINGⁱ	9606.ENSP00000444823

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	4 – 7	Combined sources	4
Beta strandⁱ	9 – 15	Combined sources	7
Beta strandⁱ	25 – 27	Combined sources	3
Beta strandⁱ	32 – 34	Combined sources	3
Beta strandⁱ	35 – 37	Combined sources	3
Beta strandⁱ	45 – 49	Combined sources	5
Helixⁱ	50 – 58	Combined sources	9
Helixⁱ	65 – 77	Combined sources	13
Beta strandⁱ	80 – 82	Combined sources	3
Helixⁱ	87 – 114	Combined sources	28
Beta strandⁱ	118 – 120	Combined sources	3
Helixⁱ	122 – 132	Combined sources	11

3D structure databases

ProteinModelPortalⁱ	P68431
SMRⁱ	P68431
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P68431

EvolutionaryTraceⁱ

P68431

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the histone H3 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1745 Eukaryota COG2036 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118967
HOVERGENⁱ	HBG001172
InParanoidⁱ	P68431
KEGG Orthology (KO) More...KOⁱ	K11253
OMAⁱ	ASEAYYL
Database of Orthologous Groups More...OrthoDBⁱ	EOG09370ZG5
PhylomeDBⁱ	P68431
TreeFamⁱ	TF314241

Family and domain databases

Gene3Dⁱ	1.10.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR009072 Histone-fold IPR007125 Histone_H2A/H2B/H3 IPR000164 Histone_H3/CENP-A
PANTHERⁱ	PTHR11426 PTHR11426, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00125 Histone, 1 hit
PRINTSⁱ	PR00622 HISTONEH3
SMARTⁱ	View protein in SMART SM00428 H3, 1 hit
SUPFAMⁱ	SSF47113 SSF47113, 1 hit
PROSITEⁱ	View protein in PROSITE PS00322 HISTONE_H3_1, 1 hit PS00959 HISTONE_H3_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P68431-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR 
        60         70         80         90        100
EIRRYQKSTE LLIRKLPFQR LVREIAQDFK TDLRFQSSAV MALQEACEAY 
       110        120        130 
LVGLFEDTNL CAIHAKRVTI MPKDIQLARR IRGERA

Length:136

Mass (Da):15,404

Last modified:January 23, 2007 - v2

Checksum:ⁱ9B89008EA50A0EF6

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	70	R → C in AAH67493 (PubMed:15489334).Curated	1
Sequence conflictⁱ	100	Y → T in CAB02546 (PubMed:9119399).Curated	1
Sequence conflictⁱ	122	P → L in AAH66884 (PubMed:15489334).Curated	1
Sequence conflictⁱ	135	Missing in AAA52651 (PubMed:3013246).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_079018	28	K → M in GLM; non-brain stem pediatric glioblastoma and diffuse intrinsic pontine glioma; somatic mutation; results in a global decrease of H3K27me3 levels. 2 PublicationsCorresponds to variant dbSNP:rs1057519904Ensembl.	1
Natural variantⁱVAR_079019	37	K → I Probable disease-associated mutation found in pediatric undifferentiated soft tissue sarcoma samples; somatic mutation; results in global decrease of H3K36me2 and H3K36me3 levels and increased H3K27me3 levels. 1 Publication	1
Natural variantⁱVAR_079020	37	K → M Probable disease-associated mutation found in pediatric undifferentiated soft tissue sarcoma samples; somatic mutation; also found in a subset of human papillomavirus-negative head and neck squamous cell carcinomas; results in global decrease of H3K36me2 and H3K36me3 levels and increased H3K27me3 levels. 2 Publications	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00090 Genomic DNA Translation: CAA24952.1 M26150 Genomic DNA Translation: AAA52651.1 M60746 Genomic DNA Translation: AAA63185.1 X57128 Genomic DNA Translation: CAA40407.1 Z46261 Genomic DNA Translation: CAA86403.1 X83550 Genomic DNA Translation: CAA58540.1 Z80784 Genomic DNA Translation: CAB02546.1 Z80785 Genomic DNA Translation: CAB02547.1 Z80786 Genomic DNA Translation: CAB02548.1 Z83735 Genomic DNA Translation: CAB06030.1 Z83737 Genomic DNA Translation: CAB06032.1 AF531274 Genomic DNA Translation: AAN10051.1 AF531275 Genomic DNA Translation: AAN10052.1 AF531276 Genomic DNA Translation: AAN10053.1 AF531277 Genomic DNA Translation: AAN10054.1 AF531278 Genomic DNA Translation: AAN10055.1 AF531279 Genomic DNA Translation: AAN10056.1 AF531280 Genomic DNA Translation: AAN10057.1 AF531281 Genomic DNA Translation: AAN10058.1 AF531282 Genomic DNA Translation: AAN10059.1 AF531283 Genomic DNA Translation: AAN10060.1 AK311991 mRNA Translation: BAG34929.1 AK313905 mRNA Translation: BAG36628.1 AK314142 mRNA Translation: BAG36832.1 AK316611 mRNA Translation: BAG38198.1 CR542014 mRNA Translation: CAG46811.1 CR542011 mRNA Translation: CAG46808.1 CR541983 mRNA Translation: CAG46780.1 CR541858 mRNA Translation: CAG46656.1 Z98744 Genomic DNA No translation available. AL009179 Genomic DNA No translation available. AL031777 Genomic DNA No translation available. BC031333 mRNA Translation: AAH31333.1 BC066245 mRNA Translation: AAH66245.1 BC066246 mRNA Translation: AAH66246.1 BC066247 mRNA Translation: AAH66247.1 BC066884 mRNA Translation: AAH66884.1 BC067490 mRNA Translation: AAH67490.1 BC067491 mRNA Translation: AAH67491.1 BC067492 mRNA Translation: AAH67492.1 BC067493 mRNA Translation: AAH67493.1 BC069133 mRNA Translation: AAH69133.1 BC069303 mRNA Translation: AAH69303.1 BC069305 mRNA Translation: AAH69305.2 BC069818 mRNA Translation: AAH69818.1 BC096128 mRNA Translation: AAH96128.1 BC096129 mRNA Translation: AAH96129.1 BC096130 mRNA Translation: AAH96130.1 BC096131 mRNA Translation: AAH96131.1 BC096132 mRNA Translation: AAH96132.1 BC096133 mRNA Translation: AAH96133.1 BC096134 mRNA Translation: AAH96134.1 BC099630 mRNA Translation: AAH99630.1 BC127610 mRNA Translation: AAI27611.1 BC143046 mRNA Translation: AAI43047.1 BC148243 mRNA Translation: AAI48244.1 BC148250 mRNA Translation: AAI48251.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4570.1 CCDS4573.1 CCDS4576.1 CCDS4590.1 CCDS4596.1 CCDS4600.1 CCDS4602.1 CCDS4627.1 CCDS4636.1 CCDS4638.1
PIRⁱ	I37446 HSHU3
NCBI Reference Sequences More...RefSeqⁱ	NP_003520.1, NM_003529.2 NP_003521.2, NM_003530.4 NP_003522.1, NM_003531.2 NP_003523.1, NM_003532.2 NP_003524.1, NM_003533.2 NP_003525.1, NM_003534.2 NP_003526.1, NM_003535.2 NP_003527.1, NM_003536.2 NP_003528.1, NM_003537.3 NP_066298.1, NM_021018.2
UniGeneⁱ	Hs.132854 Hs.247813 Hs.247814 Hs.248176 Hs.443021 Hs.484990 Hs.532144 Hs.533292 Hs.546315 Hs.586261 Hs.591778 Hs.626666

Genome annotation databases

Ensemblⁱ	ENST00000356476; ENSP00000366999; ENSG00000197409 ENST00000359303; ENSP00000352252; ENSG00000197153 ENST00000369163; ENSP00000358160; ENSG00000278828 ENST00000612966; ENSP00000484658; ENSG00000278272 ENST00000613854; ENSP00000480826; ENSG00000275714 ENST00000614378; ENSP00000484638; ENSG00000273983 ENST00000614911; ENSP00000482271; ENSG00000274750 ENST00000616365; ENSP00000483283; ENSG00000275379 ENST00000618052; ENSP00000484095; ENSG00000277775 ENST00000621411; ENSP00000484841; ENSG00000274267 ENST00000634733; ENSP00000489282; ENSG00000274750
GeneIDⁱ	8350 8351 8352 8353 8354 8355 8356 8357 8358 8968
KEGGⁱ	hsa:8350 hsa:8351 hsa:8352 hsa:8353 hsa:8354 hsa:8355 hsa:8356 hsa:8357 hsa:8358 hsa:8968
UCSC genome browser More...UCSCⁱ	uc003nfp.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P68431	Histone H3.1		BOVIN		136
Histone H3.1	)	MOUSE		136
Histone H3.1		MUSPA		136
Histone H3.1		RAT		136
Histone H3		CALJA		136
+49

Protein	Similar proteins		Species	Score	Length
P68431	Histone H3.1		BOVIN		136
Histone H3.1	)	MOUSE		136
Histone H3.1		MUSPA		136
Histone H3.1		RAT		136
Histone H3		CALJA		136
+49

Protein	Similar proteins		Species	Score	Length
P68431	Histone H3.1		BOVIN		136
Histone H3.1	)	MOUSE		136
Histone H3.1		MUSPA		136
Histone H3.1		RAT		136
Histone H3		CALJA		136
+52

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1CS9	NMR	-	A	131-136	[»]
1CT6	NMR	-	A	131-136	[»]
1O9S	X-ray	1.75	K/L	2-10	[»]
1Q3L	X-ray	1.64	P	2-16	[»]
2B2T	X-ray	2.45	D	2-20	[»]
2B2U	X-ray	2.95	D	2-16	[»]
2B2V	X-ray	2.65	D	2-16	[»]
2B2W	X-ray	2.40	D	2-20	[»]
2C1J	X-ray	2.60	C/D	8-15	[»]
2C1N	X-ray	2.00	C/E	8-15	[»]
2CO0	X-ray	2.25	B/D	2-16	[»]
2CV5	X-ray	2.50	A/E	1-136	[»]
2KWJ	NMR	-	B	2-21	[»]
2KWK	NMR	-	B	2-21	[»]
2L75	NMR	-	B	2-14	[»]
2LBM	NMR	-	C	2-16	[»]
2M0O	NMR	-	B	32-42	[»]
2NDF	NMR	-	B	13-25	[»]
2NDG	NMR	-	B	13-25	[»]
2OQ6	X-ray	2.00	C/D	8-15	[»]
2OT7	X-ray	2.14	C/D	8-15	[»]
2OX0	X-ray	1.95	C/D	8-15	[»]
2RI7	X-ray	1.45	P	2-10	[»]
2UXN	X-ray	2.72	E	2-22	[»]
2V85	X-ray	2.00	D/E	2-13	[»]
2V89	X-ray	1.10	D/E	2-10	[»]
2VNF	X-ray	1.76	B/D	2-11	[»]
2VPG	X-ray	1.60	P/R	2-19	[»]
2X0L	X-ray	3.00	C	6-17	[»]
3A1B	X-ray	2.29	A	2-21	[»]
3AFA	X-ray	2.50	A/E	1-136	[»]
3AVR	X-ray	1.80	B	18-39	[»]
3AYW	X-ray	2.90	A/E	1-136	[»]
3AZE	X-ray	3.00	A/E	1-136	[»]
3AZF	X-ray	2.70	A/E	1-136	[»]
3AZG	X-ray	2.40	A/E	1-136	[»]
3AZH	X-ray	3.49	A/E	1-136	[»]
3AZI	X-ray	2.70	A/E	1-136	[»]
3AZJ	X-ray	2.89	A/E	1-136	[»]
3AZK	X-ray	3.20	A/E	1-136	[»]
3AZL	X-ray	2.70	A/E	1-136	[»]
3AZM	X-ray	2.89	A/E	1-136	[»]
3AZN	X-ray	3.00	A/E	1-136	[»]
3B95	X-ray	2.99	P	2-16	[»]
3KMT	X-ray	1.78	G/H/I	26-33	[»]
3KQI	X-ray	1.78	B	2-13	[»]
3LQI	X-ray	1.92	R/S/T	2-10	[»]
3LQJ	X-ray	1.90	Q/T	2-10	[»]
3MP1	X-ray	2.60	P	2-6	[»]
3O34	X-ray	1.90	B	14-33	[»]
3O35	X-ray	1.76	D/E	24-32	[»]
3O37	X-ray	2.00	E/F/G/H	2-11	[»]
3QJ6	X-ray	2.30	T	74-84	[»]
3RIG	X-ray	2.00	C/D	5-16	[»]
3RIY	X-ray	1.55	C/D	5-16	[»]
3SOU	X-ray	1.80	D/E	2-10	[»]
3SOW	X-ray	1.95	C/D	2-10	[»]
3U31	X-ray	2.20	B	5-14	[»]
3U3D	X-ray	2.40	B	5-14	[»]
3U4S	X-ray	2.15	C/D	8-15	[»]
3U5N	X-ray	1.95	C/D	2-21	[»]
3U5O	X-ray	2.70	I/J/K/L/M/N/O/P	2-23	[»]
3U5P	X-ray	2.80	I/J/K/L/M/N/O/P	2-29	[»]
3UEE	X-ray	2.61	B/D	2-13	[»]
3UEF	X-ray	2.45	B/D	2-13	[»]
3UIG	X-ray	2.40	P/Q	2-16	[»]
3UII	X-ray	2.60	P/Q	2-11	[»]
3UIK	X-ray	2.70	P/Q	2-11	[»]
3V43	X-ray	1.47	Q	2-19	[»]
3W96	X-ray	3.00	A/E	1-136	[»]
3W97	X-ray	3.20	A/E	1-136	[»]
3W98	X-ray	3.42	A/E	29-136	[»]
3W99	X-ray	3.00	A/E	1-136	[»]
3WA9	X-ray	3.07	A/E	1-136	[»]
3WAA	X-ray	3.20	A/E	1-136	[»]
3WKJ	X-ray	2.80	A/E	1-136	[»]
3X1S	X-ray	2.81	A/E	2-136	[»]
3X1T	X-ray	2.81	A/E	2-136	[»]
3X1U	X-ray	3.25	A/E	2-136	[»]
3X1V	X-ray	2.92	A/E	2-136	[»]
3ZG6	X-ray	2.20	F	5-14	[»]
3ZVY	X-ray	1.95	C/D	2-9	[»]
4A0J	X-ray	2.80	C/D	2-7	[»]
4A0N	X-ray	2.74	C	2-7	[»]
4A7J	X-ray	1.90	B	1-16	[»]
4BD3	NMR	-	B	32-42	[»]
4C1Q	X-ray	2.30	C	2-10	[»]
4F4U	X-ray	2.00	C/D	5-16	[»]
4F56	X-ray	1.70	C/D	5-16	[»]
4FWF	X-ray	2.70	E	2-21	[»]
4HON	X-ray	1.80	F/G	7-16	[»]
4I51	X-ray	1.90	C/D	4-12	[»]
4L7X	X-ray	1.35	U	2-13	[»]
4LK9	X-ray	1.60	B	2-22	[»]
4LKA	X-ray	1.61	B	2-22	[»]
4LLB	X-ray	2.50	C/D	2-22	[»]
4LXL	X-ray	1.87	D	8-15	[»]
4N4H	X-ray	2.30	B	22-43	[»]
4QBQ	X-ray	2.41	P	2-9	[»]
4QBR	X-ray	1.90	E/P	2-8	[»]
4QBS	X-ray	1.80	P	2-8	[»]
4TN7	X-ray	2.20	E/F	30-44	[»]
4U68	X-ray	1.80	D/E/F	5-15	[»]
4UP0	X-ray	1.28	F	2-16	[»]
4UY4	X-ray	1.86	C/D	2-7	[»]
4X3K	X-ray	1.45	C/D	24-30	[»]
4Y6L	X-ray	1.60	C/D	7-13	[»]
4YHP	X-ray	2.53	P/Q	2-17	[»]
4YHZ	X-ray	2.30	P	2-13	[»]
4YM5	X-ray	4.00	A/E	1-136	[»]
4YM6	X-ray	3.51	A/E	1-136	[»]
4Z0R	X-ray	1.75	D	2-16	[»]
4Z2M	X-ray	2.98	G/I	35-136	[»]
5AV5	X-ray	2.40	A/E	1-136	[»]
5AV6	X-ray	2.20	A/E	1-136	[»]
5AV8	X-ray	2.20	A/E	1-136	[»]
5AV9	X-ray	2.20	A/E	1-136	[»]
5AVB	X-ray	2.40	A/E	1-136	[»]
5AVC	X-ray	2.40	A/E	1-136	[»]
5B24	X-ray	3.60	A/E	1-136	[»]
5B2I	X-ray	3.00	A/E	1-136	[»]
5B2J	X-ray	2.60	A/E	1-136	[»]
5B31	X-ray	2.20	A/E	1-136	[»]
5C11	X-ray	2.80	B	2-11	[»]
5C13	X-ray	2.10	D/F/H/P	2-11	[»]
5C3I	X-ray	3.50	B/F/J/N/R/V	1-136	[»]
5CPI	X-ray	2.90	A/E	1-136	[»]
5CPJ	X-ray	3.15	A/E	1-136	[»]
5CPK	X-ray	2.63	A/E	1-136	[»]
5D6Y	X-ray	2.29	a/b/c/d	20-29	[»]
5DAH	X-ray	2.61	C/D	20-30	[»]
5FB0	X-ray	2.70	D/F	2-16	[»]
5FB1	X-ray	2.10	C	2-16	[»]
5FFV	X-ray	1.30	C/D	10-20	[»]
5GH9	X-ray	1.45	B	45-58	[»]
5GSE	X-ray	3.14	A/E/K/O	1-136	[»]
5GSU	X-ray	3.10	A/E	2-136	[»]
5GT0	X-ray	2.82	A/E	2-136	[»]
5GT3	X-ray	2.91	A/E	2-136	[»]
5GTC	X-ray	2.70	A/E	1-136	[»]
5H6Q	X-ray	2.53	C	2-21	[»]
5H6R	X-ray	2.60	C	2-21	[»]
5HJB	X-ray	2.70	B	4-9	[»]
5HJC	X-ray	2.60	B	16-24	[»]
5HJD	X-ray	2.81	B/D/F/H/I/J/L/M	15-21	[»]
5HYN	X-ray	2.95	D/I/O/T	22-34	[»]
5IQL	X-ray	2.10	B	25-32	[»]
5J3V	X-ray	3.05	C/D	12-28	[»]
5J9S	X-ray	2.70	B	16-40	[»]
5JHN	X-ray	1.67	F/G	4-14	[»]
5JIN	X-ray	1.85	F/G	4-14	[»]
5JIY	X-ray	1.48	F/G	4-14	[»]
5JJ0	X-ray	1.72	F/G	4-14	[»]
5JRG	X-ray	2.50	A/E	1-136	[»]
5KJH	X-ray	2.27	D	23-33	[»]
	E	19-38	[»]
5KJI	X-ray	2.71	E	19-38	[»]
5KKL	X-ray	2.94	B	23-27	[»]
5LUG	X-ray	1.70	E/F/G/H	2-11	[»]
5M5G	X-ray	2.27	D	23-33	[»]
5MR8	X-ray	1.74	C	2-10	[»]
5OY3	X-ray	2.14	B	18-34	[»]
5SVX	X-ray	1.56	B	2-12	[»]
5SVY	X-ray	1.05	B	2-12	[»]
5SZB	X-ray	1.20	H	2-19	[»]
5SZC	X-ray	1.19	H	2-19	[»]
5T0K	X-ray	1.70	P/Q	2-16	[»]
5T0M	X-ray	1.90	C/P	2-16	[»]
5T1G	X-ray	1.90	B	39-53	[»]
5T1I	X-ray	1.60	C	39-53	[»]
5T8R	X-ray	2.40	E/G	2-11	[»]
5TBN	NMR	-	C	2-12	[»]
5TDR	X-ray	1.42	B	2-12	[»]
5TDW	X-ray	1.70	B	2-12	[»]
5U2J	X-ray	1.60	C/D	2-17	[»]
5V21	X-ray	2.42	B	30-44	[»]
5V22	X-ray	2.40	B	30-44	[»]
5VA6	X-ray	2.40	C/D	20-37	[»]
5VAB	X-ray	1.70	F	2-11	[»]
5VGE	X-ray	2.60	C	41-49	[»]
5WLE	X-ray	1.95	C	2-13	[»]
5WVO	X-ray	2.00	D	2-37	[»]
5WXG	X-ray	1.70	P	2-8	[»]
5WXH	X-ray	1.30	D/P	2-8	[»]
5WYI	X-ray	2.00	E	120-127	[»]
5X60	X-ray	2.69	C	2-21	[»]
5XF3	X-ray	2.60	A/E	1-136	[»]
5XF4	X-ray	2.87	A/E	1-136	[»]
5XF5	X-ray	2.82	A/E	1-136	[»]
5XFQ	X-ray	2.40	E/F	30-42	[»]
5XFR	X-ray	2.25	C/D	34-41	[»]
5XNV	X-ray	2.70	B	25-32	[»]
5Y20	X-ray	2.41	P	2-8	[»]
6AXJ	X-ray	2.38	E/F/G/H	22-32	[»]
6BHD	X-ray	1.25	B	4-20	[»]
6BHE	X-ray	1.35	B	4-20	[»]
6BHG	X-ray	1.45	B	4-20	[»]
6BHH	X-ray	1.85	B	4-20	[»]
6BHI	X-ray	1.40	B	5-20	[»]
6ETX	electron microscopy	4.80	I/M	1-136	[»]
ProteinModelPortalⁱ	P68431
SMRⁱ	P68431
ModBaseⁱ	Search...
MobiDBⁱ	Search...

The DNASU plasmid repository More...DNASUⁱ	8350 8352 8353 8355 8356 8357
Structural Biology Knowledgebase	Search...

CTDⁱ	8350 8351 8352 8353 8354 8355 8356 8357 8358 8968
DisGeNET More...DisGeNETⁱ	8350 8351 8352 8353 8354 8355 8356 8357 8358 8968
EuPathDBⁱ	HostDB:ENSG00000197153.4 HostDB:ENSG00000197409.7 HostDB:ENSG00000273983.1 HostDB:ENSG00000274267.1 HostDB:ENSG00000274750.2 HostDB:ENSG00000275379.1 HostDB:ENSG00000275714.1 HostDB:ENSG00000277775.1 HostDB:ENSG00000278272.1 HostDB:ENSG00000278828.1
GeneCardsⁱ	HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4766 HIST1H3A HGNC:4776 HIST1H3B HGNC:4768 HIST1H3C HGNC:4767 HIST1H3D HGNC:4769 HIST1H3E HGNC:4773 HIST1H3F HGNC:4772 HIST1H3G HGNC:4775 HIST1H3H HGNC:4771 HIST1H3I HGNC:4774 HIST1H3J
Human Protein Atlas More...HPAⁱ	CAB070190 HPA042570
MalaCards human disease database More...MalaCardsⁱ	HIST1H3A
MIMⁱ	137800 phenotype 602810 gene 602811 gene 602812 gene 602813 gene 602814 gene 602815 gene 602816 gene 602817 gene 602818 gene 602819 gene
neXtProtⁱ	NX_P68431
Open Targets More...OpenTargetsⁱ	ENSG00000197153 ENSG00000197409 ENSG00000273983 ENSG00000274267 ENSG00000274750 ENSG00000275379 ENSG00000275714 ENSG00000277775 ENSG00000278272 ENSG00000278828
PharmGKBⁱ	PA29148
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Reactomeⁱ	R-HSA-1266695 Interleukin-7 signaling R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex R-HSA-212300 PRC2 methylates histones and DNA R-HSA-2299718 Condensation of Prophase Chromosomes R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-3214815 HDACs deacetylate histones R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3214842 HDMs demethylate histones R-HSA-3214847 HATs acetylate histones R-HSA-3214858 RMTs methylate histone arginines R-HSA-3247509 Chromatin modifying enzymes R-HSA-427359 SIRT1 negatively regulates rRNA expression R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427413 NoRC negatively regulates rRNA expression R-HSA-5250924 B-WICH complex positively regulates rRNA expression R-HSA-5334118 DNA methylation R-HSA-5578749 Transcriptional regulation by small RNAs R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-73728 RNA Polymerase I Promoter Opening R-HSA-73777 RNA Polymerase I Chain Elongation R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-9018519 Estrogen-dependent gene expression R-HSA-912446 Meiotic recombination R-HSA-977225 Amyloid fiber formation R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORⁱ	P68431

ChiTaRSⁱ	HIST1H3B human HIST1H3F human
EvolutionaryTraceⁱ	P68431
GeneWikiⁱ	HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J
Protein Ontology More...PROⁱ	PR:P68431
SOURCEⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H31_HUMAN
Accessionⁱ	P68431Primary (citable) accession number: P68431 Secondary accession number(s): A0PJT7 Q93081
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	January 23, 2007
	Last modified:	July 18, 2018
	This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P68431 (H31_HUMAN)

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Histone H3.1

HIST1H3A

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ