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Protein

Melittin

Gene

MELT

Organism
Vespa velutina nigrithorax (Hornet)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Main toxin of bee venom with strong hemolytic activity. Integrates into cell membranes and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. Increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxin
Biological processCytolysis, Hemolysis, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Melittin
Gene namesi
Name:MELT
OrganismiVespa velutina nigrithorax (Hornet)
Taxonomic identifieri202809 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted, Target cell membrane, Target membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
PropeptideiPRO_000003515622 – 43Removed by a dipeptidylpeptidaseBy similarityAdd BLAST22
PeptideiPRO_000003515744 – 69MelittinAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69Glutamine amideBy similarity1

Keywords - PTMi

Amidation

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer and homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP68409
SMRiP68409
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the melittin family.Curated

Keywords - Domaini

Signal, Transmembrane

Family and domain databases

InterProiView protein in InterPro
IPR002116 Melittin/Api_allergen
PfamiView protein in Pfam
PF01372 Melittin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014636 Melittin/Api_allergen, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68409-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFLVNVALV FMVVYISFIY AAPEPEPAPE AEAEADAEAD PEAGIGAVLK
60 70
VLTTGLPALI SWIKRKRQQG
Length:70
Mass (Da):7,543
Last modified:November 23, 2004 - v1
Checksum:iDA6B17C086C9560C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF487908 mRNA Translation: AAO12202.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF487908 mRNA Translation: AAO12202.1

3D structure databases

ProteinModelPortaliP68409
SMRiP68409
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR002116 Melittin/Api_allergen
PfamiView protein in Pfam
PF01372 Melittin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014636 Melittin/Api_allergen, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMEL_VESVN
AccessioniPrimary (citable) accession number: P68409
Secondary accession number(s): P59260
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: November 22, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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