UniProtKB - P68403 (KPCB_RAT)
Protein kinase C beta type
Prkcb
Functioni
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity).
Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.
By similarity3 PublicationsCatalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 186 | Calcium 1; via carbonyl oxygen2 Publications | 1 | |
Metal bindingi | 187 | Calcium 12 Publications | 1 | |
Metal bindingi | 187 | Calcium 22 Publications | 1 | |
Metal bindingi | 193 | Calcium 22 Publications | 1 | |
Metal bindingi | 246 | Calcium 12 Publications | 1 | |
Metal bindingi | 246 | Calcium 22 Publications | 1 | |
Metal bindingi | 247 | Calcium 2; via carbonyl oxygen2 Publications | 1 | |
Metal bindingi | 248 | Calcium 12 Publications | 1 | |
Metal bindingi | 248 | Calcium 22 Publications | 1 | |
Metal bindingi | 248 | Calcium 32 Publications | 1 | |
Metal bindingi | 251 | Calcium 32 Publications | 1 | |
Metal bindingi | 252 | Calcium 3; via carbonyl oxygen2 Publications | 1 | |
Metal bindingi | 254 | Calcium 12 Publications | 1 | |
Metal bindingi | 254 | Calcium 32 Publications | 1 | |
Binding sitei | 371 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 466 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 36 – 86 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 101 – 151 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 51 | |
Nucleotide bindingi | 348 – 356 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- androgen receptor binding Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- calcium channel regulator activity Source: RGD
- calcium-dependent protein kinase C activity Source: UniProtKB-EC
- chromatin binding Source: UniProtKB
- histone binding Source: UniProtKB
- histone kinase activity (H3-T6 specific) Source: UniProtKB
- nuclear receptor coactivator activity Source: UniProtKB
- protein kinase C activity Source: RGD
- protein kinase C binding Source: RGD
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: RGD
- protein serine kinase activity Source: RHEA
- zinc ion binding Source: InterPro
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- apoptotic process Source: UniProtKB-KW
- B cell activation Source: UniProtKB
- B cell receptor signaling pathway Source: UniProtKB
- calcium ion transport Source: RGD
- cellular calcium ion homeostasis Source: RGD
- cellular response to carbohydrate stimulus Source: RGD
- chromatin organization Source: UniProtKB-KW
- dibenzo-p-dioxin metabolic process Source: RGD
- histone H3-T6 phosphorylation Source: UniProtKB
- intracellular signal transduction Source: GO_Central
- negative regulation of glucose transmembrane transport Source: UniProtKB
- negative regulation of insulin receptor signaling pathway Source: UniProtKB
- peptidyl-serine phosphorylation Source: GO_Central
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of B cell receptor signaling pathway Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of odontogenesis of dentin-containing tooth Source: RGD
- positive regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
- presynaptic modulation of chemical synaptic transmission Source: RGD
- protein phosphorylation Source: RGD
- regulation of dopamine secretion Source: RGD
- regulation of glucose transmembrane transport Source: UniProtKB
- regulation of growth Source: RGD
- regulation of synaptic vesicle exocytosis Source: RGD
- regulation of transcription by RNA polymerase II Source: UniProtKB
- response to ethanol Source: RGD
- response to glucose Source: RGD
- response to vitamin D Source: RGD
- response to xenobiotic stimulus Source: RGD
Keywordsi
Molecular function | Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Adaptive immunity, Apoptosis, Immunity, Transcription, Transcription regulation |
Ligand | ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 2.7.1.107, 5301 |
Reactomei | R-RNO-114516, Disinhibition of SNARE formation R-RNO-1169091, Activation of NF-kappaB in B cells R-RNO-416993, Trafficking of GluR2-containing AMPA receptors R-RNO-4419969, Depolymerisation of the Nuclear Lamina R-RNO-5099900, WNT5A-dependent internalization of FZD4 R-RNO-5218921, VEGFR2 mediated cell proliferation R-RNO-5668599, RHO GTPases Activate NADPH Oxidases R-RNO-76005, Response to elevated platelet cytosolic Ca2+ |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Prkcb Synonyms:Pkcb, Prkcb1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3396, Prkcb |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoplasm and Cytosol
Other locations
Cytoskeleton
- centrosome Source: RGD
- spectrin Source: RGD
Cytosol
- cytosol Source: RGD
- presynaptic cytosol Source: RGD
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- brush border membrane Source: RGD
- plasma membrane Source: RGD
Other locations
- calyx of Held Source: RGD
- cytoplasm Source: RGD
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 16 – 17 | ST → AA: No effect. 1 Publication | 2 | |
Mutagenesisi | 314 | T → A: No effect; when associated with A-323. 1 Publication | 1 | |
Mutagenesisi | 324 | T → A: No effect; when associated with A-313. 1 Publication | 1 | |
Mutagenesisi | 500 | T → E: 50% increase of enzymatic activity. 1 Publication | 1 | |
Mutagenesisi | 500 | T → S: 50% decrease of enzymatic activity. 1 Publication | 1 | |
Mutagenesisi | 500 | T → V or D: Loss of enzymatic activity. 1 Publication | 1 | |
Mutagenesisi | 635 | T → A: Loss of enzymatic activity; when associated with T-643 change in subcellular location, loss of PMA-induced down-regulation and loss of enzymatic activity. 2 Publications | 1 | |
Mutagenesisi | 642 | T → A: Loss of enzymatic activity; when associated with T-636 change in subcellular location, loss of PMA-induced down-regulation and loss of enzymatic activity. 2 Publications | 1 |
Chemistry databases
ChEMBLi | CHEMBL3020 |
DrugCentrali | P68403 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000055687 | 2 – 671 | Protein kinase C beta typeAdd BLAST | 670 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | ||
Modified residuei | 11 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 16 | Phosphoserine; by autocatalysis1 Publication | 1 | ||
Modified residuei | 17 | Phosphothreonine; by autocatalysis1 Publication | 1 | ||
Modified residuei | 206 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 250 | Phosphothreonine; by autocatalysisBy similarity | 1 | ||
Modified residuei | 314 | Phosphothreonine; by autocatalysis1 Publication | 1 | ||
Modified residuei | 324 | Phosphothreonine; by autocatalysis1 Publication | 1 | ||
Modified residuei | 500 | Phosphothreonine; by PDPK13 Publications | 1 | ||
Modified residuei | 504 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 635 | Phosphothreonine; by autocatalysis1 Publication | 1 | ||
Modified residuei | 642 | Phosphothreonine; by autocatalysisCombined sources3 Publications | 1 | ||
Modified residuei | 661 | Phosphoserine; by autocatalysis2 Publications | 1 | ||
Modified residuei | 662 | Phosphotyrosine; by SYKBy similarity | 1 | ||
Isoform Beta-II (identifier: P68403-2) | |||||
Modified residuei | 641 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 654 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 660 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 664 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | P68403 |
PaxDbi | P68403 |
PRIDEi | P68403 |
PTM databases
iPTMneti | P68403 |
PhosphoSitePlusi | P68403 |
Interactioni
Subunit structurei
Interacts with PDK1.
Interacts in vitro with PRKCBP1.
Interacts with PHLPP1 and PHLPP2; both proteins mediate its dephosphorylation.
Interacts with KDM1A/LSD1, PKN1 and ANDR (By similarity).
By similarityBinary interactionsi
P68403
With | #Exp. | IntAct |
---|---|---|
Ptpra [P18052] from Mus musculus. | 3 | EBI-397072,EBI-6597520 |
Isoform Beta-I [P68403-1]
With | #Exp. | IntAct |
---|---|---|
Pdlim5 [Q62920] | 5 | EBI-12559950,EBI-918433 |
Isoform Beta-II [P68403-2]
With | #Exp. | IntAct |
---|---|---|
TRIM41 - isoform 2 [Q8WV44-2] from Homo sapiens. | 3 | EBI-397092,EBI-726015 |
GO - Molecular functioni
- androgen receptor binding Source: UniProtKB
- histone binding Source: UniProtKB
- protein kinase C binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 247103, 17 interactors |
IntActi | P68403, 7 interactors |
MINTi | P68403 |
STRINGi | 10116.ENSRNOP00000016417 |
Chemistry databases
BindingDBi | P68403 |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P68403 |
SMRi | P68403 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P68403 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 158 – 275 | C2PROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 342 – 600 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 259 | |
Domaini | 601 – 671 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 71 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 614 – 635 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 614 – 633 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 36 – 86 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 101 – 151 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 51 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0696, Eukaryota |
InParanoidi | P68403 |
OrthoDBi | 614710at2759 |
PhylomeDBi | P68403 |
Family and domain databases
CDDi | cd00029, C1, 2 hits cd05616, STKc_cPKC_beta, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR046349, C1-like_sf IPR000008, C2_dom IPR035892, C2_domain_sf IPR034664, cPKC-beta IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR002219, PE/DAG-bd IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR014375, Protein_kinase_C_a/b/g IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 2 hits PF00168, C2, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000550, PKC_alpha, 1 hit |
PRINTSi | PR00360, C2DOMAIN PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00239, C2, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF49562, SSF49562, 1 hit SSF56112, SSF56112, 1 hit SSF57889, SSF57889, 2 hits |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50004, C2, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 2 hits PS50081, ZF_DAG_PE_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADPAAGPPP SEGEESTVRF ARKGALRQKN VHEVKNHKFT ARFFKQPTFC
60 70 80 90 100
SHCTDFIWGF GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPASDDPRS
110 120 130 140 150
KHKFKIHTYS SPTFCDHCGS LLYGLIHQGM KCDTCMMNVH KRCVMNVPSL
160 170 180 190 200
CGTDHTERRG RIYIQAHIDR EVLIVVVRDA KNLVPMDPNG LSDPYVKLKL
210 220 230 240 250
IPDPKSESKQ KTKTIKCSLN PEWNETFRFQ LKESDKDRRL SVEIWDWDLT
260 270 280 290 300
SRNDFMGSLS FGISELQKAG VDGWFKLLSQ EEGEYFNVPV PPEGSEGNEE
310 320 330 340 350
LRQKFERAKI GQGTKAPEEK TANTISKFDN NGNRDRMKLT DFNFLMVLGK
360 370 380 390 400
GSFGKVMLSE RKGTDELYAV KILKKDVVIQ DDDVECTMVE KRVLALPGKP
410 420 430 440 450
PFLTQLHSCF QTMDRLYFVM EYVNGGDLMY HIQQVGRFKE PHAVFYAAEI
460 470 480 490 500
AIGLFFLQSK GIIYRDLKLD NVMLDSEGHI KIADFGMCKE NIWDGVTTKT
510 520 530 540 550
FCGTPDYIAP EIIAYQPYGK SVDWWAFGVL LYEMLAGQAP FEGEDEDELF
560 570 580 590 600
QSIMEHNVAY PKSMSKEAVA ICKGLMTKHP GKRLGCGPEG ERDIKEHAFF
610 620 630 640 650
RYIDWEKLER KEIQPPYKPK ARDKRDTSNF DKEFTRQPVE LTPTDKLFIM
660 670
NLDQNEFAGF SYTNPEFVIN V
The sequence of this isoform differs from the canonical sequence as follows:
622-671: RDKRDTSNFD...YTNPEFVINV → CGRNAENFDR...SEFLKPEVKS
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K5Q0 | A0A0G2K5Q0_RAT | Protein kinase C | Prkcb | 652 | Annotation score: | ||
F1LS42 | F1LS42_RAT | Protein kinase C | Prkcb | 672 | Annotation score: | ||
F1LS36 | F1LS36_RAT | Protein kinase C | Prkcb | 615 | Annotation score: | ||
A0A8I5XW57 | A0A8I5XW57_RAT | Protein kinase C beta type | Prkcb | 629 | Annotation score: | ||
A0A8I5Y861 | A0A8I5Y861_RAT | Protein kinase C beta type | Prkcb | 635 | Annotation score: | ||
A0A8I5ZQS9 | A0A8I5ZQS9_RAT | Protein kinase C beta type | Prkcb | 667 | Annotation score: | ||
A0A8I5ZUY0 | A0A8I5ZUY0_RAT | Protein kinase C beta type | Prkcb | 631 | Annotation score: | ||
A0A8I6AM65 | A0A8I6AM65_RAT | Protein kinase C beta type | Prkcb | 633 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 25 | A → P in AAA41868 (PubMed:3345563).Curated | 1 | |
Sequence conflicti | 126 | I → V in AAA41875 (PubMed:3755379).Curated | 1 | |
Sequence conflicti | 138 | N → S in AAA41875 (PubMed:3755379).Curated | 1 | |
Sequence conflicti | 141 | K → R in AAA41875 (PubMed:3755379).Curated | 1 | |
Sequence conflicti | 149 | S → G in AAA41875 (PubMed:3755379).Curated | 1 | |
Sequence conflicti | 164 | I → V in AAA41875 (PubMed:3755379).Curated | 1 | |
Sequence conflicti | 170 – 171 | RE → GG in AAA41875 (PubMed:3755379).Curated | 2 | |
Sequence conflicti | 174 | I → V in AAA41875 (PubMed:3755379).Curated | 1 | |
Sequence conflicti | 294 | G → E in AAA41868 (PubMed:3345563).Curated | 1 | |
Sequence conflicti | 419 | V → M in CAA28035 (PubMed:2428667).Curated | 1 | |
Sequence conflicti | 419 | V → M in CAA28036 (PubMed:2428667).Curated | 1 | |
Sequence conflicti | 628 | Missing in AAA41865 (PubMed:3755379).Curated | 1 | |
Sequence conflicti | 640 | Missing in AAA41865 (PubMed:3755379).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004739 | 622 – 671 | RDKRD…FVINV → CGRNAENFDRFFTRHPPVLT PPDQEVIRNIDQSEFEGFSF VNSEFLKPEVKS in isoform Beta-II. 2 PublicationsAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M13706 mRNA Translation: AAA41875.1 K03485 mRNA Translation: AAA41864.1 K03486 mRNA Translation: AAA41865.1 X04439 Genomic DNA Translation: CAA28035.1 X04440 mRNA Translation: CAA28036.1 M19007 mRNA Translation: AAA41868.1 X04139 mRNA Translation: CAA27756.1 M15522 mRNA Translation: AAA41876.1 |
PIRi | A00622, KIRTC1 |
RefSeqi | NP_001165776.1, NM_001172305.1 |
Genome annotation databases
Ensembli | ENSRNOT00000016418; ENSRNOP00000016417; ENSRNOG00000012061 [P68403-1] ENSRNOT00000078705; ENSRNOP00000073511; ENSRNOG00000012061 [P68403-2] |
GeneIDi | 25023 |
KEGGi | rno:25023 |
UCSCi | RGD:3396, rat |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M13706 mRNA Translation: AAA41875.1 K03485 mRNA Translation: AAA41864.1 K03486 mRNA Translation: AAA41865.1 X04439 Genomic DNA Translation: CAA28035.1 X04440 mRNA Translation: CAA28036.1 M19007 mRNA Translation: AAA41868.1 X04139 mRNA Translation: CAA27756.1 M15522 mRNA Translation: AAA41876.1 |
PIRi | A00622, KIRTC1 |
RefSeqi | NP_001165776.1, NM_001172305.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A25 | X-ray | 2.70 | A/B | 154-289 | [»] | |
3PFQ | X-ray | 4.00 | A | 1-661 | [»] | |
AlphaFoldDBi | P68403 | |||||
SMRi | P68403 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 247103, 17 interactors |
IntActi | P68403, 7 interactors |
MINTi | P68403 |
STRINGi | 10116.ENSRNOP00000016417 |
Chemistry databases
BindingDBi | P68403 |
ChEMBLi | CHEMBL3020 |
DrugCentrali | P68403 |
PTM databases
iPTMneti | P68403 |
PhosphoSitePlusi | P68403 |
Proteomic databases
jPOSTi | P68403 |
PaxDbi | P68403 |
PRIDEi | P68403 |
Genome annotation databases
Ensembli | ENSRNOT00000016418; ENSRNOP00000016417; ENSRNOG00000012061 [P68403-1] ENSRNOT00000078705; ENSRNOP00000073511; ENSRNOG00000012061 [P68403-2] |
GeneIDi | 25023 |
KEGGi | rno:25023 |
UCSCi | RGD:3396, rat |
Organism-specific databases
CTDi | 5579 |
RGDi | 3396, Prkcb |
Phylogenomic databases
eggNOGi | KOG0696, Eukaryota |
InParanoidi | P68403 |
OrthoDBi | 614710at2759 |
PhylomeDBi | P68403 |
Enzyme and pathway databases
BRENDAi | 2.7.1.107, 5301 |
Reactomei | R-RNO-114516, Disinhibition of SNARE formation R-RNO-1169091, Activation of NF-kappaB in B cells R-RNO-416993, Trafficking of GluR2-containing AMPA receptors R-RNO-4419969, Depolymerisation of the Nuclear Lamina R-RNO-5099900, WNT5A-dependent internalization of FZD4 R-RNO-5218921, VEGFR2 mediated cell proliferation R-RNO-5668599, RHO GTPases Activate NADPH Oxidases R-RNO-76005, Response to elevated platelet cytosolic Ca2+ |
Miscellaneous databases
EvolutionaryTracei | P68403 |
PROi | PR:P68403 |
Family and domain databases
CDDi | cd00029, C1, 2 hits cd05616, STKc_cPKC_beta, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR046349, C1-like_sf IPR000008, C2_dom IPR035892, C2_domain_sf IPR034664, cPKC-beta IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR002219, PE/DAG-bd IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR014375, Protein_kinase_C_a/b/g IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 2 hits PF00168, C2, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000550, PKC_alpha, 1 hit |
PRINTSi | PR00360, C2DOMAIN PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00239, C2, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF49562, SSF49562, 1 hit SSF56112, SSF56112, 1 hit SSF57889, SSF57889, 2 hits |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50004, C2, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 2 hits PS50081, ZF_DAG_PE_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KPCB_RAT | |
Accessioni | P68403Primary (citable) accession number: P68403 Secondary accession number(s): P04410, P04411 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 166 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families