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Entry version 174 (08 May 2019)
Sequence version 1 (23 Nov 2004)
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Protein

Casein kinase II subunit alpha

Gene

CSNK2A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073).7 Publications

Miscellaneous

Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated to represent up to one quarter of the eukaryotic phosphoproteome. Casein kinase 2 has been found to be increased at protein level and up-regulated at the level of enzyme activity in the majority of cancers. However, elevated levels of casein kinase 2 are present in certain normal organs such as brain and testes.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Constitutively active protein kinase whose activity is not directly affected by phosphorylation. Seems to be regulated by level of expression and localization.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei68ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei156Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi45 – 53ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis, Biological rhythms, Cell cycle, Transcription, Transcription regulation, Wnt signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.11.1 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1483191 Synthesis of PC
R-HSA-201688 WNT mediated activation of DVL
R-HSA-2514853 Condensation of Prometaphase Chromosomes
R-HSA-445144 Signal transduction by L1
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8934903 Receptor Mediated Mitophagy
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8948751 Regulation of PTEN stability and activity

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P68400

SIGNOR Signaling Network Open Resource

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SIGNORi
P68400

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P68400 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Casein kinase II subunit alpha (EC:2.7.11.1)
Short name:
CK II alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSNK2A1
Synonyms:CK2A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:2457 CSNK2A1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
115440 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P68400

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Okur-Chung neurodevelopmental syndrome (OCNDS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant neurodevelopmental disorder characterized by developmental delay, intellectual disability, behavioral problems, hypotonia, speech problems, microcephaly, pachygyria and variable dysmorphic features.
See also OMIM:617062
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07704547R → Q in OCNDS. 1 PublicationCorresponds to variant dbSNP:rs869312845EnsemblClinVar.1
Natural variantiVAR_07704650Y → S in OCNDS. 1 PublicationCorresponds to variant dbSNP:rs869312849EnsemblClinVar.1
Natural variantiVAR_077047175D → G in OCNDS. 1 PublicationCorresponds to variant dbSNP:rs869312848EnsemblClinVar.1
Natural variantiVAR_077048198K → R in OCNDS. 1 PublicationCorresponds to variant dbSNP:rs869312840EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1457

MalaCards human disease database

More...
MalaCardsi
CSNK2A1
MIMi617062 phenotype

Open Targets

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OpenTargetsi
ENSG00000101266

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26957

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3629

Drug and drug target database

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DrugBanki
DB03127 Benzamidine
DB08846 Ellagic Acid
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
DB02709 Resveratrol
DB04462 Tetrabromo-2-Benzotriazole

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1549

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CSNK2A1

Domain mapping of disease mutations (DMDM)

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DMDMi
55977123

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000858831 – 391Casein kinase II subunit alphaAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei344Phosphothreonine; by CDK11 Publication1
Modified residuei360Phosphothreonine; by CDK11 Publication1
Modified residuei362Phosphoserine; by CDK11 Publication1
Modified residuei370Phosphoserine; by CDK1Combined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase. Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its regulation by forming binding sites for interacting proteins and/or targeting it to different compartments.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P68400

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P68400

MaxQB - The MaxQuant DataBase

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MaxQBi
P68400

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P68400

PeptideAtlas

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PeptideAtlasi
P68400

PRoteomics IDEntifications database

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PRIDEi
P68400

ProteomicsDB human proteome resource

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ProteomicsDBi
57536
57537 [P68400-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P68400

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P68400

SwissPalm database of S-palmitoylation events

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SwissPalmi
P68400

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000101266 Expressed in 231 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P68400 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P68400 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB020680
CAB069395
HPA059206
HPA061698

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha'/2 beta or 1 alpha/1 alpha'/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, which forms following UV irradiation. Interacts with RNPS1. Interacts with SNAI1. Interacts with PML (isoform PML-12). Interacts with CCAR2.9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107841, 492 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P68400

Database of interacting proteins

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DIPi
DIP-32682N

Protein interaction database and analysis system

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IntActi
P68400, 303 interactors

Molecular INTeraction database

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MINTi
P68400

STRING: functional protein association networks

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STRINGi
9606.ENSP00000217244

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P68400

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1391
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JWHX-ray3.10A/B1-337[»]
1NA7X-ray2.40A1-329[»]
1PJKX-ray2.50A2-335[»]
2PVRX-ray1.60A2-335[»]
2ZJWX-ray2.40A1-335[»]
3AMYX-ray2.30A1-335[»]
3AT2X-ray1.60A1-335[»]
3AT3X-ray2.60A1-335[»]
3AT4X-ray2.20A1-335[»]
3AXWX-ray2.50A1-335[»]
3BQCX-ray1.50A1-335[»]
3C13X-ray1.95A1-335[»]
3FWQX-ray2.30A/B1-335[»]
3H30X-ray1.56A/B1-334[»]
3JUHX-ray1.66A/B1-335[»]
3MB6X-ray1.75A1-331[»]
3MB7X-ray1.65A1-331[»]
3NGAX-ray2.71A/B1-333[»]
3NSZX-ray1.30A2-331[»]
3OWJX-ray1.85A1-331[»]
3OWKX-ray1.80A1-331[»]
3OWLX-ray2.10A1-331[»]
3PE1X-ray1.60A1-337[»]
3PE2X-ray1.90A1-337[»]
3PE4X-ray1.95B/D340-352[»]
3Q04X-ray1.80A3-330[»]
3Q9WX-ray1.70A1-336[»]
3Q9XX-ray2.20A/B1-336[»]
3Q9YX-ray1.80A1-336[»]
3Q9ZX-ray2.20A/B1-336[»]
3QA0X-ray2.50A/B1-336[»]
3R0TX-ray1.75A1-337[»]
3RPSX-ray2.30A/B1-335[»]
3TAXX-ray1.88B/D340-352[»]
3U4UX-ray2.20A1-333[»]
3U87X-ray2.90A/B1-325[»]
3U9CX-ray3.20A/B1-335[»]
3W8LX-ray2.40A/B1-335[»]
3WARX-ray1.04A1-335[»]
3WIKX-ray2.00A1-335[»]
3WILX-ray2.90A1-335[»]
3WOWX-ray2.50A1-335[»]
4DGLX-ray3.00C/D1-335[»]
4FBXX-ray2.33A1-335[»]
4GRBX-ray2.15A1-333[»]
4GUBX-ray2.20A1-333[»]
4GYWX-ray1.70B/D340-352[»]
4GYYX-ray1.85B/D340-352[»]
4GZ3X-ray1.90B/D340-352[»]
4IB5X-ray2.20A/B/C1-335[»]
4KWPX-ray1.25A1-336[»]
4MD7X-ray3.10E/F/G/H1-391[»]
4MD8X-ray3.30E/F/G/H1-391[»]
4MD9X-ray3.50E/F/G/H/K/L/M/P1-336[»]
4NH1X-ray3.30A/B1-335[»]
4RLLX-ray1.85A1-335[»]
4UB7X-ray2.10A1-335[»]
4UBAX-ray3.00A/B1-335[»]
5B0XX-ray2.30A1-335[»]
5CLPX-ray1.68A/B2-329[»]
5CQUX-ray2.35A1-335[»]
5CQWX-ray2.65A/B1-335[»]
5CS6X-ray1.88A/B2-329[»]
5CSHX-ray1.59A/B2-329[»]
5CSPX-ray1.50A2-329[»]
5CSVX-ray1.38A2-329[»]
5CT0X-ray2.01A/B2-329[»]
5CTPX-ray2.03A/B2-329[»]
5CU0X-ray2.18A/B2-329[»]
5CU2X-ray1.71A/B2-329[»]
5CU3X-ray1.79A/B2-329[»]
5CU4X-ray1.56A2-329[»]
5CU6X-ray1.36A2-329[»]
5CVFX-ray1.63A2-329[»]
5CVGX-ray1.25A2-329[»]
5CVHX-ray1.85A/B2-329[»]
5CX9X-ray1.73A/B2-329[»]
5H8BX-ray2.55A/B1-333[»]
5H8EX-ray2.15A/B1-333[»]
5H8GX-ray2.00A1-333[»]
5HGVX-ray2.05B/D340-352[»]
5KU8X-ray2.22A/B2-332[»]
5KWHX-ray2.12A/B1-333[»]
5M44X-ray2.71A1-335[»]
5M4CX-ray1.94A1-335[»]
5M4FX-ray1.52A1-335[»]
5M4IX-ray2.22A1-335[»]
5MMFX-ray1.99A/B2-329[»]
5MMRX-ray2.00A/B2-329[»]
5MO5X-ray2.04A/B2-329[»]
5MO6X-ray1.82A/B2-329[»]
5MO7X-ray2.15A/B2-329[»]
5MO8X-ray1.82A/B2-329[»]
5MODX-ray2.08A/B2-329[»]
5MOEX-ray1.89A/B2-329[»]
5MOHX-ray1.38A2-329[»]
5MOTX-ray2.09A2-329[»]
5MOVX-ray2.20A3-327[»]
5MOWX-ray1.86A/B2-329[»]
5MP8X-ray1.92A/B2-329[»]
5MPJX-ray2.14A/B2-329[»]
5N1VX-ray2.52A/B1-336[»]
5N9KX-ray1.64A1-335[»]
5N9LX-ray1.79A1-335[»]
5N9NX-ray1.84A1-335[»]
5NQCX-ray2.00A2-335[»]
5OMYX-ray1.95A1-391[»]
5ONIX-ray2.00A/B1-391[»]
5OQUX-ray2.32A/B2-329[»]
5ORHX-ray1.75A/B2-329[»]
5ORJX-ray1.99A/B2-329[»]
5ORKX-ray2.14A/B2-329[»]
5OS7X-ray1.66A/B2-329[»]
5OS8X-ray1.55A2-329[»]
5OSLX-ray1.95A2-329[»]
5OSPX-ray1.91A2-329[»]
5OSRX-ray1.57A2-329[»]
5OSUX-ray1.63A2-329[»]
5OSZX-ray2.00A2-329[»]
5OT5X-ray1.63A/B2-329[»]
5OT6X-ray1.94A/B2-329[»]
5OTDX-ray1.57A/B2-329[»]
5OTHX-ray1.69A/B2-329[»]
5OTIX-ray1.59A2-329[»]
5OTLX-ray1.57A/B2-329[»]
5OTOX-ray1.51A/B2-329[»]
5OTPX-ray1.57A/B2-329[»]
5OTQX-ray1.38A2-329[»]
5OTRX-ray1.52A2-329[»]
5OTSX-ray1.90A2-329[»]
5OTYX-ray1.48A2-329[»]
5OTZX-ray1.46A2-329[»]
5OUEX-ray2.01A/B2-329[»]
5OULX-ray1.34A2-329[»]
5OUMX-ray2.05A/B2-329[»]
5OUUX-ray1.81A/B2-329[»]
5OWHX-ray2.30A1-335[»]
5OWLX-ray2.23A/B1-335[»]
5OYFX-ray1.54A2-329[»]
5T1HX-ray2.11A/B1-333[»]
5VIEX-ray2.60B/D339-352[»]
5VIFX-ray2.25B339-352[»]
5ZN0Other1.10A1-329[»]
5ZN1X-ray1.05A1-329[»]
5ZN2X-ray1.20A1-329[»]
5ZN3X-ray1.50A1-329[»]
5ZN4X-ray1.65A1-329[»]
5ZN5X-ray1.70A1-329[»]
6A1CX-ray1.68A1-335[»]
6EHKX-ray1.40A2-329[»]
6EHUX-ray1.95A/B2-329[»]
6EIIX-ray1.94A/B2-329[»]
6GIHX-ray1.96A2-329[»]
6GMDX-ray1.66A/B2-329[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P68400

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P68400

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 324Protein kinasePROSITE-ProRule annotationAdd BLAST286

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni36 – 41Interaction with beta subunitBy similarity6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0668 Eukaryota
ENOG410XNPP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004215

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233021

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P68400

KEGG Orthology (KO)

More...
KOi
K03097

Identification of Orthologs from Complete Genome Data

More...
OMAi
NMPRSYW

Database of Orthologous Groups

More...
OrthoDBi
702827at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P68400

TreeFam database of animal gene trees

More...
TreeFami
TF300483

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P68400-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGPVPSRAR VYTDVNTHRP REYWDYESHV VEWGNQDDYQ LVRKLGRGKY
60 70 80 90 100
SEVFEAINIT NNEKVVVKIL KPVKKKKIKR EIKILENLRG GPNIITLADI
110 120 130 140 150
VKDPVSRTPA LVFEHVNNTD FKQLYQTLTD YDIRFYMYEI LKALDYCHSM
160 170 180 190 200
GIMHRDVKPH NVMIDHEHRK LRLIDWGLAE FYHPGQEYNV RVASRYFKGP
210 220 230 240 250
ELLVDYQMYD YSLDMWSLGC MLASMIFRKE PFFHGHDNYD QLVRIAKVLG
260 270 280 290 300
TEDLYDYIDK YNIELDPRFN DILGRHSRKR WERFVHSENQ HLVSPEALDF
310 320 330 340 350
LDKLLRYDHQ SRLTAREAME HPYFYTVVKD QARMGSSSMP GGSTPVSSAN
360 370 380 390
MMSGISSVPT PSPLGPLAGS PVIAAANPLG MPVPAAAGAQ Q
Length:391
Mass (Da):45,144
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3B6F5D13FF7422D
GO
Isoform 2 (identifier: P68400-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.

Show »
Length:255
Mass (Da):29,181
Checksum:iABCEE52F34E7431B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EU96E7EU96_HUMAN
Casein kinase II subunit alpha
CSNK2A1
385Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDY7A0A2R8YDY7_HUMAN
Casein kinase II subunit alpha
CSNK2A1
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDP2A0A2R8YDP2_HUMAN
Casein kinase II subunit alpha
CSNK2A1
354Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4H0A0A2R8Y4H0_HUMAN
Casein kinase II subunit alpha
CSNK2A1
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4D6A0A2R8Y4D6_HUMAN
Casein kinase II subunit alpha
CSNK2A1
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5A0A0A2R8Y5A0_HUMAN
Casein kinase II subunit alpha
CSNK2A1
354Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YD58A0A2R8YD58_HUMAN
Casein kinase II subunit alpha
CSNK2A1
376Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFU2A0A2R8YFU2_HUMAN
Casein kinase II subunit alpha
CSNK2A1
374Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYA2V9GYA2_HUMAN
Casein kinase II subunit alpha
CSNK2A1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYW6V9GYW6_HUMAN
Casein kinase II subunit alpha
CSNK2A1
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti128L → F in CAA49758 (PubMed:8420794).Curated1
Sequence conflicti256D → G in CAA49758 (PubMed:8420794).Curated1
Sequence conflicti287S → R in CAA49758 (PubMed:8420794).Curated1
Sequence conflicti351M → V in CAA49758 (PubMed:8420794).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07704547R → Q in OCNDS. 1 PublicationCorresponds to variant dbSNP:rs869312845EnsemblClinVar.1
Natural variantiVAR_07704650Y → S in OCNDS. 1 PublicationCorresponds to variant dbSNP:rs869312849EnsemblClinVar.1
Natural variantiVAR_077047175D → G in OCNDS. 1 PublicationCorresponds to variant dbSNP:rs869312848EnsemblClinVar.1
Natural variantiVAR_077048198K → R in OCNDS. 1 PublicationCorresponds to variant dbSNP:rs869312840EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0419251 – 136Missing in isoform 2. 1 PublicationAdd BLAST136

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J02853 mRNA Translation: AAA56821.1
M55265 mRNA Translation: AAA35503.1
S53149 mRNA Translation: ABB72474.1
X70251 Genomic DNA Translation: CAA49758.1
AK302583 mRNA Translation: BAG63838.1
BT019792 mRNA Translation: AAV38595.1
AB451279 mRNA Translation: BAG70093.1
AL049761 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10665.1
CH471133 Genomic DNA Translation: EAX10666.1
CH471133 Genomic DNA Translation: EAX10667.1
CH471133 Genomic DNA Translation: EAX10668.1
CH471133 Genomic DNA Translation: EAX10669.1
BC011668 mRNA Translation: AAH11668.1
BC053532 mRNA Translation: AAH53532.1
BC071167 mRNA Translation: AAH71167.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13003.1 [P68400-1]
CCDS13004.1 [P68400-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A30319

NCBI Reference Sequences

More...
RefSeqi
NP_001886.1, NM_001895.3 [P68400-1]
NP_808227.1, NM_177559.2 [P68400-1]
NP_808228.1, NM_177560.2 [P68400-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000217244; ENSP00000217244; ENSG00000101266 [P68400-1]
ENST00000349736; ENSP00000339247; ENSG00000101266 [P68400-2]
ENST00000400217; ENSP00000383076; ENSG00000101266 [P68400-1]
ENST00000643660; ENSP00000495248; ENSG00000101266 [P68400-1]
ENST00000644003; ENSP00000495387; ENSG00000101266 [P68400-2]
ENST00000645623; ENSP00000495998; ENSG00000101266 [P68400-1]
ENST00000646305; ENSP00000495902; ENSG00000101266 [P68400-1]
ENST00000646477; ENSP00000495439; ENSG00000101266 [P68400-2]
ENST00000646561; ENSP00000496569; ENSG00000101266 [P68400-1]
ENST00000646814; ENSP00000495422; ENSG00000101266 [P68400-1]
ENST00000647348; ENSP00000495912; ENSG00000101266 [P68400-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1457

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1457

UCSC genome browser

More...
UCSCi
uc002wdw.2 human [P68400-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02853 mRNA Translation: AAA56821.1
M55265 mRNA Translation: AAA35503.1
S53149 mRNA Translation: ABB72474.1
X70251 Genomic DNA Translation: CAA49758.1
AK302583 mRNA Translation: BAG63838.1
BT019792 mRNA Translation: AAV38595.1
AB451279 mRNA Translation: BAG70093.1
AL049761 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10665.1
CH471133 Genomic DNA Translation: EAX10666.1
CH471133 Genomic DNA Translation: EAX10667.1
CH471133 Genomic DNA Translation: EAX10668.1
CH471133 Genomic DNA Translation: EAX10669.1
BC011668 mRNA Translation: AAH11668.1
BC053532 mRNA Translation: AAH53532.1
BC071167 mRNA Translation: AAH71167.1
CCDSiCCDS13003.1 [P68400-1]
CCDS13004.1 [P68400-2]
PIRiA30319
RefSeqiNP_001886.1, NM_001895.3 [P68400-1]
NP_808227.1, NM_177559.2 [P68400-1]
NP_808228.1, NM_177560.2 [P68400-2]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JWHX-ray3.10A/B1-337[»]
1NA7X-ray2.40A1-329[»]
1PJKX-ray2.50A2-335[»]
2PVRX-ray1.60A2-335[»]
2ZJWX-ray2.40A1-335[»]
3AMYX-ray2.30A1-335[»]
3AT2X-ray1.60A1-335[»]
3AT3X-ray2.60A1-335[»]
3AT4X-ray2.20A1-335[»]
3AXWX-ray2.50A1-335[»]
3BQCX-ray1.50A1-335[»]
3C13X-ray1.95A1-335[»]
3FWQX-ray2.30A/B1-335[»]
3H30X-ray1.56A/B1-334[»]
3JUHX-ray1.66A/B1-335[»]
3MB6X-ray1.75A1-331[»]
3MB7X-ray1.65A1-331[»]
3NGAX-ray2.71A/B1-333[»]
3NSZX-ray1.30A2-331[»]
3OWJX-ray1.85A1-331[»]
3OWKX-ray1.80A1-331[»]
3OWLX-ray2.10A1-331[»]
3PE1X-ray1.60A1-337[»]
3PE2X-ray1.90A1-337[»]
3PE4X-ray1.95B/D340-352[»]
3Q04X-ray1.80A3-330[»]
3Q9WX-ray1.70A1-336[»]
3Q9XX-ray2.20A/B1-336[»]
3Q9YX-ray1.80A1-336[»]
3Q9ZX-ray2.20A/B1-336[»]
3QA0X-ray2.50A/B1-336[»]
3R0TX-ray1.75A1-337[»]
3RPSX-ray2.30A/B1-335[»]
3TAXX-ray1.88B/D340-352[»]
3U4UX-ray2.20A1-333[»]
3U87X-ray2.90A/B1-325[»]
3U9CX-ray3.20A/B1-335[»]
3W8LX-ray2.40A/B1-335[»]
3WARX-ray1.04A1-335[»]
3WIKX-ray2.00A1-335[»]
3WILX-ray2.90A1-335[»]
3WOWX-ray2.50A1-335[»]
4DGLX-ray3.00C/D1-335[»]
4FBXX-ray2.33A1-335[»]
4GRBX-ray2.15A1-333[»]
4GUBX-ray2.20A1-333[»]
4GYWX-ray1.70B/D340-352[»]
4GYYX-ray1.85B/D340-352[»]
4GZ3X-ray1.90B/D340-352[»]
4IB5X-ray2.20A/B/C1-335[»]
4KWPX-ray1.25A1-336[»]
4MD7X-ray3.10E/F/G/H1-391[»]
4MD8X-ray3.30E/F/G/H1-391[»]
4MD9X-ray3.50E/F/G/H/K/L/M/P1-336[»]
4NH1X-ray3.30A/B1-335[»]
4RLLX-ray1.85A1-335[»]
4UB7X-ray2.10A1-335[»]
4UBAX-ray3.00A/B1-335[»]
5B0XX-ray2.30A1-335[»]
5CLPX-ray1.68A/B2-329[»]
5CQUX-ray2.35A1-335[»]
5CQWX-ray2.65A/B1-335[»]
5CS6X-ray1.88A/B2-329[»]
5CSHX-ray1.59A/B2-329[»]
5CSPX-ray1.50A2-329[»]
5CSVX-ray1.38A2-329[»]
5CT0X-ray2.01A/B2-329[»]
5CTPX-ray2.03A/B2-329[»]
5CU0X-ray2.18A/B2-329[»]
5CU2X-ray1.71A/B2-329[»]
5CU3X-ray1.79A/B2-329[»]
5CU4X-ray1.56A2-329[»]
5CU6X-ray1.36A2-329[»]
5CVFX-ray1.63A2-329[»]
5CVGX-ray1.25A2-329[»]
5CVHX-ray1.85A/B2-329[»]
5CX9X-ray1.73A/B2-329[»]
5H8BX-ray2.55A/B1-333[»]
5H8EX-ray2.15A/B1-333[»]
5H8GX-ray2.00A1-333[»]
5HGVX-ray2.05B/D340-352[»]
5KU8X-ray2.22A/B2-332[»]
5KWHX-ray2.12A/B1-333[»]
5M44X-ray2.71A1-335[»]
5M4CX-ray1.94A1-335[»]
5M4FX-ray1.52A1-335[»]
5M4IX-ray2.22A1-335[»]
5MMFX-ray1.99A/B2-329[»]
5MMRX-ray2.00A/B2-329[»]
5MO5X-ray2.04A/B2-329[»]
5MO6X-ray1.82A/B2-329[»]
5MO7X-ray2.15A/B2-329[»]
5MO8X-ray1.82A/B2-329[»]
5MODX-ray2.08A/B2-329[»]
5MOEX-ray1.89A/B2-329[»]
5MOHX-ray1.38A2-329[»]
5MOTX-ray2.09A2-329[»]
5MOVX-ray2.20A3-327[»]
5MOWX-ray1.86A/B2-329[»]
5MP8X-ray1.92A/B2-329[»]
5MPJX-ray2.14A/B2-329[»]
5N1VX-ray2.52A/B1-336[»]
5N9KX-ray1.64A1-335[»]
5N9LX-ray1.79A1-335[»]
5N9NX-ray1.84A1-335[»]
5NQCX-ray2.00A2-335[»]
5OMYX-ray1.95A1-391[»]
5ONIX-ray2.00A/B1-391[»]
5OQUX-ray2.32A/B2-329[»]
5ORHX-ray1.75A/B2-329[»]
5ORJX-ray1.99A/B2-329[»]
5ORKX-ray2.14A/B2-329[»]
5OS7X-ray1.66A/B2-329[»]
5OS8X-ray1.55A2-329[»]
5OSLX-ray1.95A2-329[»]
5OSPX-ray1.91A2-329[»]
5OSRX-ray1.57A2-329[»]
5OSUX-ray1.63A2-329[»]
5OSZX-ray2.00A2-329[»]
5OT5X-ray1.63A/B2-329[»]
5OT6X-ray1.94A/B2-329[»]
5OTDX-ray1.57A/B2-329[»]
5OTHX-ray1.69A/B2-329[»]
5OTIX-ray1.59A2-329[»]
5OTLX-ray1.57A/B2-329[»]
5OTOX-ray1.51A/B2-329[»]
5OTPX-ray1.57A/B2-329[»]
5OTQX-ray1.38A2-329[»]
5OTRX-ray1.52A2-329[»]
5OTSX-ray1.90A2-329[»]
5OTYX-ray1.48A2-329[»]
5OTZX-ray1.46A2-329[»]
5OUEX-ray2.01A/B2-329[»]
5OULX-ray1.34A2-329[»]
5OUMX-ray2.05A/B2-329[»]
5OUUX-ray1.81A/B2-329[»]
5OWHX-ray2.30A1-335[»]
5OWLX-ray2.23A/B1-335[»]
5OYFX-ray1.54A2-329[»]
5T1HX-ray2.11A/B1-333[»]
5VIEX-ray2.60B/D339-352[»]
5VIFX-ray2.25B339-352[»]
5ZN0Other1.10A1-329[»]
5ZN1X-ray1.05A1-329[»]
5ZN2X-ray1.20A1-329[»]
5ZN3X-ray1.50A1-329[»]
5ZN4X-ray1.65A1-329[»]
5ZN5X-ray1.70A1-329[»]
6A1CX-ray1.68A1-335[»]
6EHKX-ray1.40A2-329[»]
6EHUX-ray1.95A/B2-329[»]
6EIIX-ray1.94A/B2-329[»]
6GIHX-ray1.96A2-329[»]
6GMDX-ray1.66A/B2-329[»]
SMRiP68400
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107841, 492 interactors
CORUMiP68400
DIPiDIP-32682N
IntActiP68400, 303 interactors
MINTiP68400
STRINGi9606.ENSP00000217244

Chemistry databases

BindingDBiP68400
ChEMBLiCHEMBL3629
DrugBankiDB03127 Benzamidine
DB08846 Ellagic Acid
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
DB02709 Resveratrol
DB04462 Tetrabromo-2-Benzotriazole
GuidetoPHARMACOLOGYi1549

Protein family/group databases

MoonDBiP68400 Predicted

PTM databases

iPTMnetiP68400
PhosphoSitePlusiP68400
SwissPalmiP68400

Polymorphism and mutation databases

BioMutaiCSNK2A1
DMDMi55977123

Proteomic databases

EPDiP68400
jPOSTiP68400
MaxQBiP68400
PaxDbiP68400
PeptideAtlasiP68400
PRIDEiP68400
ProteomicsDBi57536
57537 [P68400-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1457
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217244; ENSP00000217244; ENSG00000101266 [P68400-1]
ENST00000349736; ENSP00000339247; ENSG00000101266 [P68400-2]
ENST00000400217; ENSP00000383076; ENSG00000101266 [P68400-1]
ENST00000643660; ENSP00000495248; ENSG00000101266 [P68400-1]
ENST00000644003; ENSP00000495387; ENSG00000101266 [P68400-2]
ENST00000645623; ENSP00000495998; ENSG00000101266 [P68400-1]
ENST00000646305; ENSP00000495902; ENSG00000101266 [P68400-1]
ENST00000646477; ENSP00000495439; ENSG00000101266 [P68400-2]
ENST00000646561; ENSP00000496569; ENSG00000101266 [P68400-1]
ENST00000646814; ENSP00000495422; ENSG00000101266 [P68400-1]
ENST00000647348; ENSP00000495912; ENSG00000101266 [P68400-1]
GeneIDi1457
KEGGihsa:1457
UCSCiuc002wdw.2 human [P68400-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1457
DisGeNETi1457

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CSNK2A1
HGNCiHGNC:2457 CSNK2A1
HPAiCAB020680
CAB069395
HPA059206
HPA061698
MalaCardsiCSNK2A1
MIMi115440 gene
617062 phenotype
neXtProtiNX_P68400
OpenTargetsiENSG00000101266
PharmGKBiPA26957

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0668 Eukaryota
ENOG410XNPP LUCA
GeneTreeiENSGT00390000004215
HOGENOMiHOG000233021
InParanoidiP68400
KOiK03097
OMAiNMPRSYW
OrthoDBi702827at2759
PhylomeDBiP68400
TreeFamiTF300483

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-1483191 Synthesis of PC
R-HSA-201688 WNT mediated activation of DVL
R-HSA-2514853 Condensation of Prometaphase Chromosomes
R-HSA-445144 Signal transduction by L1
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8934903 Receptor Mediated Mitophagy
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8948751 Regulation of PTEN stability and activity
SignaLinkiP68400
SIGNORiP68400

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CSNK2A1 human
EvolutionaryTraceiP68400

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Casein_kinase_2,_alpha_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1457

Protein Ontology

More...
PROi
PR:P68400

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000101266 Expressed in 231 organ(s), highest expression level in kidney
ExpressionAtlasiP68400 baseline and differential
GenevisibleiP68400 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSK21_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P68400
Secondary accession number(s): B4DYS6
, D3DVV8, P19138, P20426, Q14013, Q5U065
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: May 8, 2019
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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