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Entry version 170 (07 Oct 2020)
Sequence version 1 (13 Aug 1987)
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Protein

Tubulin beta-4B chain

Gene

TUBB4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi140 – 146GTPSequence analysis7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P68371

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-190840, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
R-HSA-190861, Gap junction assembly
R-HSA-2132295, MHC class II antigen presentation
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-389957, Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960, Formation of tubulin folding intermediates by CCT/TriC
R-HSA-389977, Post-chaperonin tubulin folding pathway
R-HSA-437239, Recycling pathway of L1
R-HSA-5610787, Hedgehog 'off' state
R-HSA-5617833, Cilium Assembly
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-5620924, Intraflagellar transport
R-HSA-5626467, RHO GTPases activate IQGAPs
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-6798695, Neutrophil degranulation
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877, Mitotic Prometaphase
R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854518, AURKA Activation by TPX2
R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin
R-HSA-9609690, HCMV Early Events
R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors
R-HSA-9619483, Activation of AMPK downstream of NMDARs
R-HSA-9646399, Aggrephagy
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation
R-HSA-9668328, Sealing of the nuclear envelope (NE) by ESCRT-III
R-HSA-983189, Kinesins

SIGNOR Signaling Network Open Resource

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SIGNORi
P68371

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubulin beta-4B chain
Alternative name(s):
Tubulin beta-2 chain
Tubulin beta-2C chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TUBB4B
Synonyms:TUBB2C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000188229.5

Human Gene Nomenclature Database

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HGNCi
HGNC:20771, TUBB4B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602660, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P68371

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leber congenital amaurosis with early-onset deafness (LCAEOD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease characterized by severe retinal degeneration and sensorineural hearing loss. Symptoms occur within the first decade of life. Onset at birth is observed in some patients.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080782391R → C in LCAEOD; affects microtubules polymerization. 1 PublicationCorresponds to variant dbSNP:rs1554786802EnsemblClinVar.1
Natural variantiVAR_080783391R → H in LCAEOD; affects microtubules polymerization. 1 PublicationCorresponds to variant dbSNP:rs1554786803EnsemblClinVar.1

Keywords - Diseasei

Deafness, Disease mutation, Leber congenital amaurosis

Organism-specific databases

DisGeNET

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DisGeNETi
10383

MalaCards human disease database

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MalaCardsi
TUBB4B
MIMi617879, phenotype

Open Targets

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OpenTargetsi
ENSG00000188229

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142670672

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P68371, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1848

Drug and drug target database

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DrugBanki
DB00518, Albendazole
DB05147, CYT997
DB01873, Epothilone D
DB00643, Mebendazole
DB04910, Oxibendazole
DB03010, Patupilone
DB12695, Phenethyl Isothiocyanate

DrugCentral

More...
DrugCentrali
P68371

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TUBB4B

Domain mapping of disease mutations (DMDM)

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DMDMi
55977480

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000482481 – 445Tubulin beta-4B chainAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei55PhosphothreonineCombined sources1
Modified residuei58N6-acetyllysineCombined sources1
Modified residuei172Phosphoserine; by CDK11 Publication1
Modified residuei4385-glutamyl polyglutamateBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).1 Publication
Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).1 Publication
Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P68371

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P68371

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P68371

MaxQB - The MaxQuant DataBase

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MaxQBi
P68371

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P68371

PeptideAtlas

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PeptideAtlasi
P68371

PRoteomics IDEntifications database

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PRIDEi
P68371

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57535

Consortium for Top Down Proteomics

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TopDownProteomicsi
P68371

2D gel databases

USC-OGP 2-DE database

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OGPi
P05217

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00007752

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P68371

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P68371

MetOSite database of methionine sulfoxide sites

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MetOSitei
P68371

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P68371

SwissPalm database of S-palmitoylation events

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SwissPalmi
P68371

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000188229, Expressed in epithelium of bronchus and 251 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P68371, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000188229, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
115656, 214 interactors

Protein interaction database and analysis system

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IntActi
P68371, 117 interactors

Molecular INTeraction database

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MINTi
P68371

STRING: functional protein association networks

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STRINGi
9606.ENSP00000341289

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P68371, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P68371

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The highly acidic C-terminal region may bind cations such as calcium.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1375, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000154394

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_015718_1_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P68371

KEGG Orthology (KO)

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KOi
K07375

Identification of Orthologs from Complete Genome Data

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OMAi
EAESCDY

Database of Orthologous Groups

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OrthoDBi
962471at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P68371

TreeFam database of animal gene trees

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TreeFami
TF300298

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013838, Beta-tubulin_BS
IPR002453, Beta_tubulin
IPR008280, Tub_FtsZ_C
IPR000217, Tubulin
IPR018316, Tubulin/FtsZ_2-layer-sand-dom
IPR037103, Tubulin/FtsZ_C_sf
IPR036525, Tubulin/FtsZ_GTPase_sf
IPR023123, Tubulin_C
IPR017975, Tubulin_CS
IPR003008, Tubulin_FtsZ_GTPase

The PANTHER Classification System

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PANTHERi
PTHR11588, PTHR11588, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00091, Tubulin, 1 hit
PF03953, Tubulin_C, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01163, BETATUBULIN
PR01161, TUBULIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00864, Tubulin, 1 hit
SM00865, Tubulin_C, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52490, SSF52490, 1 hit
SSF55307, SSF55307, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00227, TUBULIN, 1 hit
PS00228, TUBULIN_B_AUTOREG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P68371-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MREIVHLQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY
60 70 80 90 100
YNEATGGKYV PRAVLVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN
110 120 130 140 150
WAKGHYTEGA ELVDSVLDVV RKEAESCDCL QGFQLTHSLG GGTGSGMGTL
160 170 180 190 200
LISKIREEYP DRIMNTFSVV PSPKVSDTVV EPYNATLSVH QLVENTDETY
210 220 230 240 250
CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL RFPGQLNADL
260 270 280 290 300
RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDAKNMM
310 320 330 340 350
AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LNVQNKNSSY FVEWIPNNVK
360 370 380 390 400
TAVCDIPPRG LKMSATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG
410 420 430 440
EGMDEMEFTE AESNMNDLVS EYQQYQDATA EEEGEFEEEA EEEVA
Length:445
Mass (Da):49,831
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA552C52822AFA072
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080782391R → C in LCAEOD; affects microtubules polymerization. 1 PublicationCorresponds to variant dbSNP:rs1554786802EnsemblClinVar.1
Natural variantiVAR_080783391R → H in LCAEOD; affects microtubules polymerization. 1 PublicationCorresponds to variant dbSNP:rs1554786803EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X02344 Genomic DNA Translation: CAA26203.1
BX255925 Genomic DNA No translation available.
BC001911 mRNA Translation: AAH01911.1
BC002783 mRNA Translation: AAH02783.1
BC002885 mRNA Translation: AAH02885.1
BC004188 mRNA Translation: AAH04188.1
BC007889 mRNA Translation: AAH07889.1
BC012835 mRNA Translation: AAH12835.1
BC019359 mRNA Translation: AAH19359.1
BC019829 mRNA Translation: AAH19829.1
BC039175 mRNA Translation: AAH39175.1
BC071889 mRNA Translation: AAH71889.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7039.1

Protein sequence database of the Protein Information Resource

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PIRi
I38370

NCBI Reference Sequences

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RefSeqi
NP_006079.1, NM_006088.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000340384; ENSP00000341289; ENSG00000188229

Database of genes from NCBI RefSeq genomes

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GeneIDi
10383

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10383

UCSC genome browser

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UCSCi
uc004cmh.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02344 Genomic DNA Translation: CAA26203.1
BX255925 Genomic DNA No translation available.
BC001911 mRNA Translation: AAH01911.1
BC002783 mRNA Translation: AAH02783.1
BC002885 mRNA Translation: AAH02885.1
BC004188 mRNA Translation: AAH04188.1
BC007889 mRNA Translation: AAH07889.1
BC012835 mRNA Translation: AAH12835.1
BC019359 mRNA Translation: AAH19359.1
BC019829 mRNA Translation: AAH19829.1
BC039175 mRNA Translation: AAH39175.1
BC071889 mRNA Translation: AAH71889.1
CCDSiCCDS7039.1
PIRiI38370
RefSeqiNP_006079.1, NM_006088.5

3D structure databases

SMRiP68371
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115656, 214 interactors
IntActiP68371, 117 interactors
MINTiP68371
STRINGi9606.ENSP00000341289

Chemistry databases

ChEMBLiCHEMBL1848
DrugBankiDB00518, Albendazole
DB05147, CYT997
DB01873, Epothilone D
DB00643, Mebendazole
DB04910, Oxibendazole
DB03010, Patupilone
DB12695, Phenethyl Isothiocyanate
DrugCentraliP68371

PTM databases

iPTMnetiP68371
MetOSiteiP68371
PhosphoSitePlusiP68371
SwissPalmiP68371

Polymorphism and mutation databases

BioMutaiTUBB4B
DMDMi55977480

2D gel databases

OGPiP05217
REPRODUCTION-2DPAGEiIPI00007752
SWISS-2DPAGEiP68371

Proteomic databases

EPDiP68371
jPOSTiP68371
MassIVEiP68371
MaxQBiP68371
PaxDbiP68371
PeptideAtlasiP68371
PRIDEiP68371
ProteomicsDBi57535
TopDownProteomicsiP68371

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
4391, 143 antibodies

The DNASU plasmid repository

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DNASUi
10383

Genome annotation databases

EnsembliENST00000340384; ENSP00000341289; ENSG00000188229
GeneIDi10383
KEGGihsa:10383
UCSCiuc004cmh.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10383
DisGeNETi10383
EuPathDBiHostDB:ENSG00000188229.5

GeneCards: human genes, protein and diseases

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GeneCardsi
TUBB4B
HGNCiHGNC:20771, TUBB4B
HPAiENSG00000188229, Tissue enhanced (testis)
MalaCardsiTUBB4B
MIMi602660, gene
617879, phenotype
neXtProtiNX_P68371
OpenTargetsiENSG00000188229
PharmGKBiPA142670672

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1375, Eukaryota
GeneTreeiENSGT00940000154394
HOGENOMiCLU_015718_1_1_1
InParanoidiP68371
KOiK07375
OMAiEAESCDY
OrthoDBi962471at2759
PhylomeDBiP68371
TreeFamiTF300298

Enzyme and pathway databases

PathwayCommonsiP68371
ReactomeiR-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-190840, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
R-HSA-190861, Gap junction assembly
R-HSA-2132295, MHC class II antigen presentation
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-389957, Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960, Formation of tubulin folding intermediates by CCT/TriC
R-HSA-389977, Post-chaperonin tubulin folding pathway
R-HSA-437239, Recycling pathway of L1
R-HSA-5610787, Hedgehog 'off' state
R-HSA-5617833, Cilium Assembly
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-5620924, Intraflagellar transport
R-HSA-5626467, RHO GTPases activate IQGAPs
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-6798695, Neutrophil degranulation
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877, Mitotic Prometaphase
R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854518, AURKA Activation by TPX2
R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin
R-HSA-9609690, HCMV Early Events
R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors
R-HSA-9619483, Activation of AMPK downstream of NMDARs
R-HSA-9646399, Aggrephagy
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation
R-HSA-9668328, Sealing of the nuclear envelope (NE) by ESCRT-III
R-HSA-983189, Kinesins
SIGNORiP68371

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
10383, 170 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TUBB4B, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TUBB2C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10383
PharosiP68371, Tclin

Protein Ontology

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PROi
PR:P68371
RNActiP68371, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000188229, Expressed in epithelium of bronchus and 251 other tissues
GenevisibleiP68371, HS

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR013838, Beta-tubulin_BS
IPR002453, Beta_tubulin
IPR008280, Tub_FtsZ_C
IPR000217, Tubulin
IPR018316, Tubulin/FtsZ_2-layer-sand-dom
IPR037103, Tubulin/FtsZ_C_sf
IPR036525, Tubulin/FtsZ_GTPase_sf
IPR023123, Tubulin_C
IPR017975, Tubulin_CS
IPR003008, Tubulin_FtsZ_GTPase
PANTHERiPTHR11588, PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091, Tubulin, 1 hit
PF03953, Tubulin_C, 1 hit
PRINTSiPR01163, BETATUBULIN
PR01161, TUBULIN
SMARTiView protein in SMART
SM00864, Tubulin, 1 hit
SM00865, Tubulin_C, 1 hit
SUPFAMiSSF52490, SSF52490, 1 hit
SSF55307, SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227, TUBULIN, 1 hit
PS00228, TUBULIN_B_AUTOREG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBB4B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P68371
Secondary accession number(s): A2BFA2, P05217
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: October 7, 2020
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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