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Protein

14-3-3 protein theta

Gene

Ywhaq

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity).By similarity

GO - Molecular functioni

  • 14-3-3 protein binding Source: RGD
  • ion channel binding Source: RGD
  • protein C-terminus binding Source: RGD
  • protein domain specific binding Source: Ensembl
  • protein N-terminus binding Source: RGD

GO - Biological processi

  • negative regulation of ion transmembrane transport Source: RGD
  • protein targeting Source: Ensembl
  • small GTPase mediated signal transduction Source: Ensembl

Enzyme and pathway databases

ReactomeiR-RNO-111447 Activation of BAD and translocation to mitochondria
R-RNO-1445148 Translocation of GLUT4 to the plasma membrane
R-RNO-5625740 RHO GTPases activate PKNs
R-RNO-5628897 TP53 Regulates Metabolic Genes
R-RNO-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3 protein theta
Alternative name(s):
14-3-3 protein tau
Gene namesi
Name:Ywhaq
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi3979 Ywhaq

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000586401 – 24514-3-3 protein thetaAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei3N6-acetyllysineBy similarity1
Modified residuei49N6-acetyllysine; alternateBy similarity1
Cross-linki49Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei68N6-acetyllysineBy similarity1
Modified residuei82Nitrated tyrosineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Modified residuei104Nitrated tyrosineBy similarity1
Modified residuei115N6-acetyllysineBy similarity1
Modified residuei232Phosphoserine; by CK1By similarityCurated1

Keywords - PTMi

Acetylation, Isopeptide bond, Nitration, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP68255
PRIDEiP68255

PTM databases

iPTMnetiP68255
PhosphoSitePlusiP68255

Expressioni

Gene expression databases

BgeeiENSRNOG00000051650
GenevisibleiP68255 RN

Interactioni

Subunit structurei

Homodimer. Interacts with CDK16 (By similarity). Interacts with RGS7 (phosphorylated form). Interacts with SSH1. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with the 'Ser-241' phosphorylated form of PDPK1. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with SLITRK1 (By similarity). Interacts with RIPOR2 (By similarity). Interacts with INAVA; the interaction increases upon PRR (pattern recognition receptor) stimulation and is required for cellular signaling pathway activation and cytokine secretion (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei56Interaction with phosphoserine on interacting proteinBy similarity1
Sitei127Interaction with phosphoserine on interacting proteinBy similarity1

Binary interactionsi

WithEntry#Exp.IntActNotes
MEF2DQ148143EBI-400680,EBI-2829828From Homo sapiens.

GO - Molecular functioni

  • 14-3-3 protein binding Source: RGD
  • ion channel binding Source: RGD
  • protein C-terminus binding Source: RGD
  • protein domain specific binding Source: Ensembl
  • protein N-terminus binding Source: RGD

Protein-protein interaction databases

BioGridi247608, 4 interactors
DIPiDIP-947N
IntActiP68255, 5 interactors
MINTiP68255
STRINGi10116.ENSRNOP00000011501

Structurei

3D structure databases

ProteinModelPortaliP68255
SMRiP68255
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiKOG0841 Eukaryota
COG5040 LUCA
GeneTreeiENSGT00760000119116
HOGENOMiHOG000240379
HOVERGENiHBG050423
InParanoidiP68255
KOiK16197
OMAiPLCNEER
OrthoDBiEOG091G0VKY
PhylomeDBiP68255
TreeFamiTF102002

Family and domain databases

Gene3Di1.20.190.20, 1 hit
InterProiView protein in InterPro
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain
PANTHERiPTHR18860 PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244 14-3-3, 1 hit
PIRSFiPIRSF000868 14-3-3, 1 hit
PRINTSiPR00305 1433ZETA
SMARTiView protein in SMART
SM00101 14_3_3, 1 hit
SUPFAMiSSF48445 SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796 1433_1, 1 hit
PS00797 1433_2, 1 hit

Sequencei

Sequence statusi: Complete.

P68255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN
60 70 80 90 100
VVGGRRSAWR VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL
110 120 130 140 150
LDKYLIANAT NPESKVFYLK MKGDYFRYLA EVACGDDRKQ TIENSQGAYQ
160 170 180 190 200
EAFDISKKEM QPTHPIRLGL ALNFSVFYYE ILNNPELACT LAKTAFDEAI
210 220 230 240
AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA EGAEN
Length:245
Mass (Da):27,778
Last modified:October 25, 2004 - v1
Checksum:iE30471260E8B366E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17614 mRNA Translation: BAA04533.1
BC062409 mRNA Translation: AAH62409.1
PIRiI52647 S59927
RefSeqiNP_037185.1, NM_013053.1
UniGeneiRn.2502

Genome annotation databases

EnsembliENSRNOT00000077786; ENSRNOP00000072011; ENSRNOG00000051650
GeneIDi25577
KEGGirno:25577

Similar proteinsi

Entry informationi

Entry namei1433T_RAT
AccessioniPrimary (citable) accession number: P68255
Secondary accession number(s): P35216
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: July 18, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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