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Protein

14-3-3 protein gamma

Gene

YWHAG

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3 protein gamma
Alternative name(s):
Protein kinase C inhibitor protein 1
Short name:
KCIP-1
Gene namesi
Name:YWHAG
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000058610‹1 – ›15814-3-3 protein gammaAdd BLAST›158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48PhosphoserineBy similarity1
Modified residuei60PhosphotyrosineBy similarity1
Modified residuei72PhosphothreonineBy similarity1
Modified residuei130PhosphoserineBy similarity1
Modified residuei149PhosphothreonineBy similarity1
Modified residuei150PhosphoserineBy similarity1

Post-translational modificationi

N-terminus residue is acetylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP68253

Interactioni

Subunit structurei

Homodimer. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2, SAMSN1 and SIRT2 (By similarity). Interacts with PKA-phosphorylated AANAT.Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with SLITRK1 (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei34Interaction with phosphoserine on interacting proteinBy similarity1
Sitei59Interaction with phosphoserine on interacting proteinBy similarity1

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP68253
SMRiP68253
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

HOVERGENiHBG050423

Family and domain databases

Gene3Di1.20.190.20, 2 hits
InterProiView protein in InterPro
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain
PANTHERiPTHR18860 PTHR18860, 2 hits
PfamiView protein in Pfam
PF00244 14-3-3, 2 hits
SMARTiView protein in SMART
SM00101 14_3_3, 1 hit
SUPFAMiSSF48445 SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796 1433_1, 1 hit
PS00797 1433_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragments.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P68253-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AAAMKNVTEL NEPLSNEERN LLSVAYKNVV GARRSSWRVI SSIEQKTSFY
60 70 80 90 100
LKMKGDYYRY LAEVATGEKR ATVVESSEKA YSEAHEISKE HMQPTHPIRL
110 120 130 140 150
GLALNYSVFY YEITAFDDAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS

DQQDDDGG
Length:158
Mass (Da):18,000
Last modified:October 25, 2004 - v1
Checksum:i69EC73EBA23B7B6F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
W5PWD6W5PWD6_SHEEP
14-3-3 protein gamma
YWHAG
225Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-adjacent residuesi48 – 49Curated2
Non-adjacent residuesi113 – 114Curated2
Non-terminal residuei1581

Sequence databases

PIRiS78574

Similar proteinsi

Entry informationi

Entry namei1433G_SHEEP
AccessioniPrimary (citable) accession number: P68253
Secondary accession number(s): P29359
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: October 25, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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