YWHAG

Functionⁱ

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.1 Publication

GO - Molecular functionⁱ

insulin-like growth factor receptor binding Source: UniProtKB
protein domain specific binding Source: AgBase

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of neuron differentiation Source: UniProtKB
regulation of synaptic plasticity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 14-3-3 protein gamma Alternative name(s): Protein kinase C inhibitor protein 1 Short name: KCIP-1 Cleaved into the following chain: 14-3-3 protein gamma, N-terminally processed
Gene namesⁱ	Name:YWHAG
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Unplaced

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000058605	1 – 247	14-3-3 protein gammaAdd BLAST	247
Initiator methionineⁱ		Removed; alternateBy similarity
ChainⁱPRO_0000367906	2 – 247	14-3-3 protein gamma, N-terminally processedAdd BLAST	246

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	2	N-acetylvaline; in 14-3-3 protein gamma, N-terminally processedBy similarity	1
Modified residueⁱ	71	PhosphoserineBy similarity	1
Modified residueⁱ	133	PhosphotyrosineBy similarity	1
Modified residueⁱ	145	PhosphothreonineBy similarity	1
Modified residueⁱ	215	PhosphoserineBy similarity	1
Modified residueⁱ	234	PhosphothreonineBy similarity	1
Modified residueⁱ	235	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	P68252
PeptideAtlas More...PeptideAtlasⁱ	P68252
PRIDEⁱ	P68252

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2 and SAMSN1. Interacts with PKA-phosphorylated AANAT and SIRT2 (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with SLITRK1 (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	57	Interaction with phosphoserine on interacting proteinBy similarity		1
Siteⁱ	132	Interaction with phosphoserine on interacting proteinBy similarity		1

GO - Molecular functionⁱ

insulin-like growth factor receptor binding Source: UniProtKB
protein domain specific binding Source: AgBase

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000005327

STRINGⁱ

9913.ENSBTAP00000005327

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P68252
SMRⁱ	P68252
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0841 Eukaryota COG5040 LUCA
HOGENOMⁱ	HOG000240379
HOVERGENⁱ	HBG050423
InParanoidⁱ	P68252

Family and domain databases

Gene3Dⁱ	1.20.190.20, 1 hit
InterProⁱ	View protein in InterPro IPR000308 14-3-3 IPR023409 14-3-3_CS IPR036815 14-3-3_dom_sf IPR023410 14-3-3_domain
PANTHERⁱ	PTHR18860 PTHR18860, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00244 14-3-3, 1 hit
PIRSFⁱ	PIRSF000868 14-3-3, 1 hit
PRINTSⁱ	PR00305 1433ZETA
SMARTⁱ	View protein in SMART SM00101 14_3_3, 1 hit
SUPFAMⁱ	SSF48445 SSF48445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00796 1433_1, 1 hit PS00797 1433_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P68252-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK 
        60         70         80         90        100
NVVGARRSSW RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV 
       110        120        130        140        150
LSLLDNYLIK NCSETQIESK VFYLKMKGDY YRYLAEVATG EKRATVVESS 
       160        170        180        190        200
EKAYSEAHEI SKEHMQPTHP IRLGLALNYS VFYYEIQNAP EQACHLAKTA 
       210        220        230        240 
FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD DGGEGNN

Length:247

Mass (Da):28,253

Last modified:January 23, 2007 - v2

Checksum:ⁱA481633DFAF4455D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF043737 mRNA Translation: AAC02091.1
PIRⁱ	S13610
UniGeneⁱ	Bt.107001

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P68252	14-3-3 protein gamma		CHICK		247	UniRef90_P68252
14-3-3 protein gamma-A		XENLA		247
Uncharacterized protein		MONDO		247
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma		XENTR		247
cDNA FLJ14168 fis, clone NT2RP2001440, highly similar to 14-3-3 protein gamma		HUMAN		247
+32

Protein	Similar proteins		Species	Score	Length	Source
P68252	14-3-3 protein beta/alpha		CHICK		244	UniRef50_Q5ZLQ6
14-3-3 protein beta/alpha-B		DANRE		242
14-3-3 protein gamma-A		XENLA		247
Uncharacterized protein		MELGA		246
Uncharacterized protein (Fragment)		COLVI		246
+124

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF043737 mRNA Translation: AAC02091.1
PIRⁱ	S13610
UniGeneⁱ	Bt.107001

3D structure databases

ProteinModelPortalⁱ	P68252
SMRⁱ	P68252
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000005327

STRINGⁱ

9913.ENSBTAP00000005327

Proteomic databases

PaxDbⁱ	P68252
PeptideAtlasⁱ	P68252
PRIDEⁱ	P68252

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	KOG0841 Eukaryota COG5040 LUCA
HOGENOMⁱ	HOG000240379
HOVERGENⁱ	HBG050423
InParanoidⁱ	P68252

Family and domain databases

Gene3Dⁱ	1.20.190.20, 1 hit
InterProⁱ	View protein in InterPro IPR000308 14-3-3 IPR023409 14-3-3_CS IPR036815 14-3-3_dom_sf IPR023410 14-3-3_domain
PANTHERⁱ	PTHR18860 PTHR18860, 1 hit
Pfamⁱ	View protein in Pfam PF00244 14-3-3, 1 hit
PIRSFⁱ	PIRSF000868 14-3-3, 1 hit
PRINTSⁱ	PR00305 1433ZETA
SMARTⁱ	View protein in SMART SM00101 14_3_3, 1 hit
SUPFAMⁱ	SSF48445 SSF48445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00796 1433_1, 1 hit PS00797 1433_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	1433G_BOVIN
Accessionⁱ	P68252Primary (citable) accession number: P68252 Secondary accession number(s): P29359
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 25, 2004
	Last sequence update:	January 23, 2007
	Last modified:	June 20, 2018
	This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniParc

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Supporting data

UniProtKB - P68252 (1433G_BOVIN)

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14-3-3 protein gamma

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ