UniProtKB - P68252 (1433G_BOVIN)
14-3-3 protein gamma
YWHAG
Functioni
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
1 PublicationGO - Molecular functioni
- insulin-like growth factor receptor binding Source: UniProtKB
- protein domain specific binding Source: AgBase
GO - Biological processi
- regulation of neuron differentiation Source: UniProtKB
- regulation of synaptic plasticity Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: 14-3-3 protein gammaAlternative name(s): Protein kinase C inhibitor protein 1 Short name: KCIP-1 Cleaved into the following chain: |
Gene namesi | Name:YWHAG |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058605 | 1 – 247 | 14-3-3 protein gammaAdd BLAST | 247 | |
Initiator methioninei | Removed; alternateBy similarity | |||
ChainiPRO_0000367906 | 2 – 247 | 14-3-3 protein gamma, N-terminally processedAdd BLAST | 246 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 2 | N-acetylvaline; in 14-3-3 protein gamma, N-terminally processedBy similarity | 1 | |
Modified residuei | 71 | PhosphoserineBy similarity | 1 | |
Modified residuei | 133 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 145 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 215 | PhosphoserineBy similarity | 1 | |
Modified residuei | 234 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 235 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | P68252 |
PeptideAtlasi | P68252 |
PRIDEi | P68252 |
Interactioni
Subunit structurei
Homodimer.
Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53.
Interacts with RAF1, SSH1 and CRTC2/TORC2.
Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm.
Interacts with GAB2 and SAMSN1.
Interacts with PKA-phosphorylated AANAT and SIRT2 (By similarity).
Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity).
Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity).
Interacts with SLITRK1 (By similarity).
Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (By similarity).
Interacts with MARK2 and MARK3 (By similarity).
Interacts with MEFV (By similarity).
Interacts with ENDOG, TSC2 and PIK3C3; interaction with ENDOG weakens its interaction with TSC2 and PIK3C3 (By similarity).
Interacts with TH (phosphorylated form); one YWHAG dimer bounds to one TH tetramer, this interaction may influence the phosphorylation and dephosphorylation of TH (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 57 | Interaction with phosphoserine on interacting proteinBy similarity | 1 | |
Sitei | 132 | Interaction with phosphoserine on interacting proteinBy similarity | 1 |
GO - Molecular functioni
- insulin-like growth factor receptor binding Source: UniProtKB
- protein domain specific binding Source: AgBase
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000005327 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
InParanoidi | P68252 |
Family and domain databases
Gene3Di | 1.20.190.20, 1 hit |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK
60 70 80 90 100
NVVGARRSSW RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV
110 120 130 140 150
LSLLDNYLIK NCSETQIESK VFYLKMKGDY YRYLAEVATG EKRATVVESS
160 170 180 190 200
EKAYSEAHEI SKEHMQPTHP IRLGLALNYS VFYYEIQNAP EQACHLAKTA
210 220 230 240
FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD DGGEGNN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF043737 mRNA Translation: AAC02091.1 |
PIRi | S13610 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF043737 mRNA Translation: AAC02091.1 |
PIRi | S13610 |
3D structure databases
AlphaFoldDBi | P68252 |
SMRi | P68252 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000005327 |
Proteomic databases
PaxDbi | P68252 |
PeptideAtlasi | P68252 |
PRIDEi | P68252 |
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
InParanoidi | P68252 |
Family and domain databases
Gene3Di | 1.20.190.20, 1 hit |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 1433G_BOVIN | |
Accessioni | P68252Primary (citable) accession number: P68252 Secondary accession number(s): P29359 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 101 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families