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Entry version 168 (29 Sep 2021)
Sequence version 2 (23 Jan 2007)
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Protein

cAMP-dependent protein kinase catalytic subunit beta

Gene

Prkacb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:9368018).

Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA (By similarity).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by cAMP.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei73ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei167Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi50 – 58ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, cAMP, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.11, 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-163615, PKA activation
R-MMU-164378, PKA activation in glucagon signalling
R-MMU-180024, DARPP-32 events
R-MMU-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-392517, Rap1 signalling
R-MMU-422356, Regulation of insulin secretion
R-MMU-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-4420097, VEGFA-VEGFR2 Pathway
R-MMU-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase
R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome
R-MMU-5610787, Hedgehog 'off' state
R-MMU-5621575, CD209 (DC-SIGN) signaling
R-MMU-5687128, MAPK6/MAPK4 signaling
R-MMU-8853659, RET signaling
R-MMU-8963896, HDL assembly
R-MMU-983231, Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
cAMP-dependent protein kinase catalytic subunit beta (EC:2.7.11.11)
Short name:
PKA C-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prkacb
Synonyms:Pkacb
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97594, Prkacb

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000005034

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000860612 – 351cAMP-dependent protein kinase catalytic subunit betaAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei3Deamidated asparagineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei69PhosphotyrosineCombined sources1
Modified residuei140PhosphoserineBy similarity1
Modified residuei198PhosphothreonineBy similarity1
Modified residuei322PhosphoserineBy similarity1
Modified residuei331PhosphotyrosineBy similarity1
Modified residuei339PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Asn-3 is deaminated to Asp in more than 25% of the proteins, giving rise to 2 major isoelectric variants, called CB and CA respectively (0.4 pH unit change). Deamidation proceeds via the so-called beta-aspartyl shift mechanism and yields either 'D-Asp-2' (major) or 'D-isoAsp-2' (minor), in addition to L-isomers. Deamidation occurs after the addition of myristate. The Asn-3 form reaches a significantly larger nuclear/cytoplasmic ratio than the 'Asp-2' form (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P68181

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P68181

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P68181

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P68181

PeptideAtlas

More...
PeptideAtlasi
P68181

PRoteomics IDEntifications database

More...
PRIDEi
P68181

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
263389 [P68181-1]
263390 [P68181-2]
263391 [P68181-3]
263392 [P68181-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P68181

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P68181

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P68181

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is found in all tissues examined, with the highest expression in the brain and very low levels in the testis. Isoform 2 is strongly expressed in the brain, in the prelimbic and insular cortex. Isoform 3 is also found only in the brain, but at very low levels.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000005034, Expressed in ventromedial nucleus of hypothalamus and 322 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P68181, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.

Interacts with PRKAR1A and PRKAR2B (By similarity). The cAMP-dependent protein kinase catalytic subunit binds PJA2.

Interacts with GPKOW.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
202193, 45 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P68181

Protein interaction database and analysis system

More...
IntActi
P68181, 41 interactors

Molecular INTeraction database

More...
MINTi
P68181

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000005164

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P68181, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P68181

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 298Protein kinasePROSITE-ProRule annotationAdd BLAST255
Domaini299 – 351AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST53

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0616, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161169

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_63_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P68181

Identification of Orthologs from Complete Genome Data

More...
OMAi
QVIRMKQ

Database of Orthologous Groups

More...
OrthoDBi
963519at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P68181

TreeFam database of animal gene trees

More...
TreeFami
TF313399

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14209, STKc_PKA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961, AGC-kinase_C
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
IPR044109, STKc_PKA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P68181-1) [UniParc]FASTAAdd to basket
Also known as: Beta1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNTAIAKKG SEVESVKEFL AKAKEDFLRK WENPPPSNAG LEDFERKKTL
60 70 80 90 100
GTGSFGRVML VKHKATEQYY AMKILDKQKV VKLKQIEHTL NEKRILQAVE
110 120 130 140 150
FPFLVRLEYS FKDNSNLYMV MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ
160 170 180 190 200
IVLTFEYLHS LDLIYRDLKP ENLLIDHQGY IQVTDFGFAK RVKGRTWTLC
210 220 230 240 250
GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK
260 270 280 290 300
IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVS DIKTHKWFAT
310 320 330 340 350
TDWIAIYQRK VEAPFIPKFR GSGDTSNFDD YEEEEIRVSI TEKCGKEFCE

F
Length:351
Mass (Da):40,708
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBAC9B8041DF9F47
GO
Isoform 2 (identifier: P68181-2) [UniParc]FASTAAdd to basket
Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     14-15: ES → MN

Show »
Length:338
Mass (Da):39,449
Checksum:i346B9D8B775CA4B6
GO
Isoform 3 (identifier: P68181-3) [UniParc]FASTAAdd to basket
Also known as: Beta3

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.
     13-16: VESV → MGLL

Show »
Length:339
Mass (Da):39,520
Checksum:i5018FE723E34AC46
GO
Isoform 4 (identifier: P68181-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MGNTAIAKKGSEVESV → MAAHKELSSG...EHTASWDKSM

Show »
Length:398
Mass (Da):46,014
Checksum:iE9C32F84ED1FB98B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H6TMF5H6TMF5_MOUSE
cAMP-dependent protein kinase catal...
Prkacb
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFT9A0A0G2JFT9_MOUSE
cAMP-dependent protein kinase catal...
Prkacb
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0173761 – 16MGNTA…EVESV → MAAHKELSSGQHSGTPTALQ KLEGFASRLFHRHSRGTAQE HRAALEDDGLRASEHTASWD KSM in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0173731 – 13Missing in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0173721 – 12Missing in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_01737513 – 16VESV → MGLL in isoform 3. 1 Publication4
Alternative sequenceiVSP_01737414 – 15ES → MN in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J02626 mRNA Translation: AAA39941.1
AK048319 mRNA Translation: BAC33301.1
AK139419 mRNA Translation: BAE24005.1
AK148728 mRNA Translation: BAE28648.1
AK150122 mRNA Translation: BAE29323.1
AK150134 mRNA Translation: BAE29331.1
AK163585 mRNA Translation: BAE37407.1
BC054533 mRNA Translation: AAH54533.1
M21096 Genomic DNA Translation: AAA39938.1
AF022239 Genomic DNA No translation available.
X61434 mRNA Translation: CAA43676.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS17906.1 [P68181-1]
CCDS51090.1 [P68181-2]
CCDS51091.1 [P68181-3]
CCDS51092.1 [P68181-4]

Protein sequence database of the Protein Information Resource

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PIRi
A24596, OKMSCB

NCBI Reference Sequences

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RefSeqi
NP_001157670.1, NM_001164198.1 [P68181-2]
NP_001157671.1, NM_001164199.1 [P68181-3]
NP_001157672.1, NM_001164200.1 [P68181-4]
NP_035230.1, NM_011100.4 [P68181-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000005164; ENSMUSP00000005164; ENSMUSG00000005034 [P68181-4]
ENSMUST00000102515; ENSMUSP00000099573; ENSMUSG00000005034 [P68181-1]
ENSMUST00000106137; ENSMUSP00000101743; ENSMUSG00000005034 [P68181-2]
ENSMUST00000106138; ENSMUSP00000101744; ENSMUSG00000005034 [P68181-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
18749

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:18749

UCSC genome browser

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UCSCi
uc008rrs.2, mouse [P68181-2]
uc008rrt.2, mouse [P68181-3]
uc008rru.1, mouse [P68181-4]
uc008rrv.2, mouse [P68181-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02626 mRNA Translation: AAA39941.1
AK048319 mRNA Translation: BAC33301.1
AK139419 mRNA Translation: BAE24005.1
AK148728 mRNA Translation: BAE28648.1
AK150122 mRNA Translation: BAE29323.1
AK150134 mRNA Translation: BAE29331.1
AK163585 mRNA Translation: BAE37407.1
BC054533 mRNA Translation: AAH54533.1
M21096 Genomic DNA Translation: AAA39938.1
AF022239 Genomic DNA No translation available.
X61434 mRNA Translation: CAA43676.1
CCDSiCCDS17906.1 [P68181-1]
CCDS51090.1 [P68181-2]
CCDS51091.1 [P68181-3]
CCDS51092.1 [P68181-4]
PIRiA24596, OKMSCB
RefSeqiNP_001157670.1, NM_001164198.1 [P68181-2]
NP_001157671.1, NM_001164199.1 [P68181-3]
NP_001157672.1, NM_001164200.1 [P68181-4]
NP_035230.1, NM_011100.4 [P68181-1]

3D structure databases

SMRiP68181
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi202193, 45 interactors
CORUMiP68181
IntActiP68181, 41 interactors
MINTiP68181
STRINGi10090.ENSMUSP00000005164

PTM databases

iPTMnetiP68181
PhosphoSitePlusiP68181
SwissPalmiP68181

Proteomic databases

EPDiP68181
jPOSTiP68181
MaxQBiP68181
PaxDbiP68181
PeptideAtlasiP68181
PRIDEiP68181
ProteomicsDBi263389 [P68181-1]
263390 [P68181-2]
263391 [P68181-3]
263392 [P68181-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
4160, 408 antibodies

The DNASU plasmid repository

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DNASUi
18749

Genome annotation databases

EnsembliENSMUST00000005164; ENSMUSP00000005164; ENSMUSG00000005034 [P68181-4]
ENSMUST00000102515; ENSMUSP00000099573; ENSMUSG00000005034 [P68181-1]
ENSMUST00000106137; ENSMUSP00000101743; ENSMUSG00000005034 [P68181-2]
ENSMUST00000106138; ENSMUSP00000101744; ENSMUSG00000005034 [P68181-3]
GeneIDi18749
KEGGimmu:18749
UCSCiuc008rrs.2, mouse [P68181-2]
uc008rrt.2, mouse [P68181-3]
uc008rru.1, mouse [P68181-4]
uc008rrv.2, mouse [P68181-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5567
MGIiMGI:97594, Prkacb
VEuPathDBiHostDB:ENSMUSG00000005034

Phylogenomic databases

eggNOGiKOG0616, Eukaryota
GeneTreeiENSGT00940000161169
HOGENOMiCLU_000288_63_5_1
InParanoidiP68181
OMAiQVIRMKQ
OrthoDBi963519at2759
PhylomeDBiP68181
TreeFamiTF313399

Enzyme and pathway databases

BRENDAi2.7.11.11, 3474
ReactomeiR-MMU-163615, PKA activation
R-MMU-164378, PKA activation in glucagon signalling
R-MMU-180024, DARPP-32 events
R-MMU-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-392517, Rap1 signalling
R-MMU-422356, Regulation of insulin secretion
R-MMU-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-4420097, VEGFA-VEGFR2 Pathway
R-MMU-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase
R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome
R-MMU-5610787, Hedgehog 'off' state
R-MMU-5621575, CD209 (DC-SIGN) signaling
R-MMU-5687128, MAPK6/MAPK4 signaling
R-MMU-8853659, RET signaling
R-MMU-8963896, HDL assembly
R-MMU-983231, Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
18749, 2 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Prkacb, mouse

Protein Ontology

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PROi
PR:P68181
RNActiP68181, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000005034, Expressed in ventromedial nucleus of hypothalamus and 322 other tissues
GenevisibleiP68181, MM

Family and domain databases

CDDicd14209, STKc_PKA, 1 hit
InterProiView protein in InterPro
IPR000961, AGC-kinase_C
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
IPR044109, STKc_PKA
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAPCB_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P68181
Secondary accession number(s): P05206
, Q3TQH5, Q3UDD0, Q3UTH5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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