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Protein

Adenosylhomocysteinase

Gene

SAHH

Organism
Nicotiana sylvestris (Wood tobacco) (South American tobacco)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.By similarity

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.

Cofactori

NAD+By similarityNote: Binds 1 NAD+ per subunit.By similarity

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (SAHH), Adenosylhomocysteinase (LOC104246750), Adenosylhomocysteinase (LOC104235111), Adenosylhomocysteinase
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64SubstrateBy similarity1
Binding sitei139SubstrateBy similarity1
Binding sitei205SubstrateBy similarity1
Binding sitei235SubstrateBy similarity1
Binding sitei239SubstrateBy similarity1
Binding sitei240NADBy similarity1
Binding sitei292NADBy similarity1
Binding sitei327NADBy similarity1
Binding sitei397NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi206 – 208NADBy similarity3
Nucleotide bindingi269 – 274NADBy similarity6
Nucleotide bindingi348 – 350NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayi
UPA00314;UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylhomocysteinase (EC:3.3.1.1)
Short name:
AdoHcyase
Alternative name(s):
Cytokinin-binding protein CBP57
S-adenosyl-L-homocysteine hydrolase
Gene namesi
Name:SAHH
OrganismiNicotiana sylvestris (Wood tobacco) (South American tobacco)
Taxonomic identifieri4096 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
Proteomesi
  • UP000189701 Componenti: Genome assembly

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169271 – 485AdenosylhomocysteinaseAdd BLAST485

Proteomic databases

PRIDEiP68172

Structurei

3D structure databases

ProteinModelPortaliP68172
SMRiP68172
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.Curated

Phylogenomic databases

KOiK01251

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 1 hit
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P68172-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLVEKTTS GREYKVKDMS QADFGRLEIE LAEVEMPGLM ACRTEFGPSQ
60 70 80 90 100
PFKGAKITGS LHMTIQTAVL IETLTALGAE VRWCSCNIFS TQDHAAAAIA
110 120 130 140 150
RDSAAVFAWK GETLQEYWWC TERALDWGPG GGPDLIVDDG GDATLLIHEG
160 170 180 190 200
VKAEEEFAKN GTIPDPNSTD NAEFQLVLTI IKESLKTDPL KYTKMKERLV
210 220 230 240 250
GVSEETTTGV KRLYQMQANG TLLFPAINVN DSVTKSKFDN LYGCRHSLPD
260 270 280 290 300
GLMRATDVMI AGKVALVAGY GDVGKGCAAA LKQAGARVIV TEIDPICALQ
310 320 330 340 350
ATMEGLQVLT LEDVVSDVDI FVTTTGNKDI IMVDHMRKMK NNAIVCNIGH
360 370 380 390 400
FDNEIDMLGL ETYPGVKRIT IKPQTDRWVF PDTNSGIIVL AEGRLMNLGC
410 420 430 440 450
ATGHPSFVMS CSFTNQVIAQ LELWNEKSSG KYEKKVYVLP KHLDEKVAAL
460 470 480
HLGKLGAKLT KLSKDQADYI SVPVEGPYKP AHYRY
Length:485
Mass (Da):53,104
Last modified:October 25, 2004 - v1
Checksum:iAA6D6844E9DF0A5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16138 mRNA Translation: BAA03709.1
RefSeqiNP_001289538.1, NM_001302609.1
XP_009800926.1, XM_009802624.1

Genome annotation databases

GeneIDi104246750
KEGGinsy:104246750

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16138 mRNA Translation: BAA03709.1
RefSeqiNP_001289538.1, NM_001302609.1
XP_009800926.1, XM_009802624.1

3D structure databases

ProteinModelPortaliP68172
SMRiP68172
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP68172

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi104246750
KEGGinsy:104246750

Phylogenomic databases

KOiK01251

Enzyme and pathway databases

UniPathwayi
UPA00314;UER00076

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 1 hit
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAHH_NICSY
AccessioniPrimary (citable) accession number: P68172
Secondary accession number(s): P50248
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: December 20, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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