UniProtKB - P68138 (ACTS_BOVIN)
Protein
Actin, alpha skeletal muscle
Gene
ACTA1
Organism
Bos taurus (Bovine)
Status
Functioni
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Miscellaneous
In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- mesenchyme migration Source: AgBase
- positive regulation of gene expression Source: AgBase
- skeletal muscle fiber development Source: UniProtKB
- skeletal muscle thin filament assembly Source: UniProtKB
Keywordsi
Molecular function | Muscle protein |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-BTA-390522, Striated Muscle Contraction |
Names & Taxonomyi
Protein namesi | Recommended name: Actin, alpha skeletal muscleAlternative name(s): Alpha-actin-1 Cleaved into the following chain: |
Gene namesi | Name:ACTA1 Synonyms:ACTA |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:25573, ACTA1 |
Subcellular locationi
Cytoskeleton
Cytoskeleton
- actin cytoskeleton Source: GO_Central
- actin filament Source: UniProtKB
- dynactin complex Source: GO_Central
- stress fiber Source: UniProtKB
- striated muscle thin filament Source: UniProtKB
Other locations
- cell body Source: AgBase
- cytoplasm Source: AgBase
- filopodium Source: AgBase
- lamellipodium Source: AgBase
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000442801 | 2 – 377 | Actin, alpha skeletal muscle, intermediate formBy similarityAdd BLAST | 376 | |
ChainiPRO_0000442802 | 3 – 377 | Actin, alpha skeletal muscle1 PublicationAdd BLAST | 375 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylcysteine; in intermediate formBy similarity | 1 | |
Modified residuei | 46 | Methionine (R)-sulfoxideBy similarity | 1 | |
Modified residuei | 49 | Methionine (R)-sulfoxideBy similarity | 1 | |
Modified residuei | 63 | N6-malonyllysineBy similarity | 1 | |
Modified residuei | 75 | Tele-methylhistidine1 Publication | 1 | |
Modified residuei | 86 | N6-methyllysineBy similarity | 1 |
Post-translational modificationi
Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.By similarity
Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.By similarity
Methylated at His-75 by SETD3.By similarity
Keywords - PTMi
Acetylation, Methylation, OxidationProteomic databases
PaxDbi | P68138 |
PeptideAtlasi | P68138 |
PRIDEi | P68138 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000046332, Expressed in skeletal muscle tissue and 15 other tissues |
Interactioni
Subunit structurei
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others (By similarity).
Interacts with alpha-actinin.
Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity).
Interacts with TTID.
Interacts (via its C-terminus) with USP25 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 158912, 1 interactor |
STRINGi | 9913.ENSBTAP00000006532 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 112 – 125 | Interaction with alpha-actininBy similarityAdd BLAST | 14 | |
Regioni | 360 – 372 | Interaction with alpha-actininBy similarityAdd BLAST | 13 |
Sequence similaritiesi
Belongs to the actin family.Curated
Phylogenomic databases
eggNOGi | KOG0676, Eukaryota |
GeneTreei | ENSGT00940000156048 |
HOGENOMi | CLU_027965_0_2_1 |
InParanoidi | P68138 |
OMAi | WIGKSEY |
OrthoDBi | 649708at2759 |
TreeFami | TF354237 |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR004001, Actin_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00406, ACTINS_1, 1 hit PS00432, ACTINS_2, 1 hit PS01132, ACTINS_ACT_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P68138-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCDEDETTAL VCDNGSGLVK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG
60 70 80 90 100
QKDSYVGDEA QSKRGILTLK YPIEHGIITN WDDMEKIWHH TFYNELRVAP
110 120 130 140 150
EEHPTLLTEA PLNPKANREK MTQIMFETFN VPAMYVAIQA VLSLYASGRT
160 170 180 190 200
TGIVLDSGDG VTHNVPIYEG YALPHAIMRL DLAGRDLTDY LMKILTERGY
210 220 230 240 250
SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK SYELPDGQVI
260 270 280 290 300
TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV
310 320 330 340 350
MSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS
360 370
LSTFQQMWIT KQEYDEAGPS IVHRKCF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 349 | A → R in AAA82873 (PubMed:7626220).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02285 Genomic DNA Translation: AAA82873.1 BC102376 mRNA Translation: AAI02377.1 |
RefSeqi | NP_776650.1, NM_174225.1 XP_005226249.1, XM_005226192.2 |
Genome annotation databases
Ensembli | ENSBTAT00000006532; ENSBTAP00000006532; ENSBTAG00000046332 ENSBTAT00000006534; ENSBTAP00000006534; ENSBTAG00000046332 |
GeneIDi | 281592 |
KEGGi | bta:281592 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02285 Genomic DNA Translation: AAA82873.1 BC102376 mRNA Translation: AAI02377.1 |
RefSeqi | NP_776650.1, NM_174225.1 XP_005226249.1, XM_005226192.2 |
3D structure databases
SMRi | P68138 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 158912, 1 interactor |
STRINGi | 9913.ENSBTAP00000006532 |
Proteomic databases
PaxDbi | P68138 |
PeptideAtlasi | P68138 |
PRIDEi | P68138 |
Genome annotation databases
Ensembli | ENSBTAT00000006532; ENSBTAP00000006532; ENSBTAG00000046332 ENSBTAT00000006534; ENSBTAP00000006534; ENSBTAG00000046332 |
GeneIDi | 281592 |
KEGGi | bta:281592 |
Organism-specific databases
CTDi | 58 |
VGNCi | VGNC:25573, ACTA1 |
Phylogenomic databases
eggNOGi | KOG0676, Eukaryota |
GeneTreei | ENSGT00940000156048 |
HOGENOMi | CLU_027965_0_2_1 |
InParanoidi | P68138 |
OMAi | WIGKSEY |
OrthoDBi | 649708at2759 |
TreeFami | TF354237 |
Enzyme and pathway databases
Reactomei | R-BTA-390522, Striated Muscle Contraction |
Gene expression databases
Bgeei | ENSBTAG00000046332, Expressed in skeletal muscle tissue and 15 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR004001, Actin_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00406, ACTINS_1, 1 hit PS00432, ACTINS_2, 1 hit PS01132, ACTINS_ACT_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACTS_BOVIN | |
Accessioni | P68138Primary (citable) accession number: P68138 Secondary accession number(s): P02568, P99020, Q3ZCG3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families