EEF1A1

Functionⁱ

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	14 – 21	GTPBy similarity	8
Nucleotide bindingⁱ	91 – 95	GTPBy similarity	5
Nucleotide bindingⁱ	153 – 156	GTPBy similarity	4

GO - Molecular functionⁱ

GTPase activity Source: GO_Central
GTP binding
Source: UniProtKB
Traceable author statementⁱ
- 3512269
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17177976
- 17595531
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
translation elongation factor activity
Source: UniProtKB
Traceable author statementⁱ
- 17595531
tRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12426392

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to epidermal growth factor stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 9852145
neutrophil degranulation Source: Reactome
regulation of chaperone-mediated autophagy
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 20797626
regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW
translational elongation
Source: UniProtKB
Traceable author statementⁱ
- 8812466

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Elongation factor
Biological process	Protein biosynthesis, Transcription, Transcription regulation
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156842 Eukaryotic Translation Elongation R-HSA-156902 Peptide chain elongation R-HSA-3371511 HSF1 activation R-HSA-6798695 Neutrophil degranulation R-HSA-8876725 Protein methylation
SignaLinkⁱ	P68104
SIGNORⁱ	P68104

Protein family/group databases

MoonProtⁱ	P68104

MoonProtⁱ

P68104

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Elongation factor 1-alpha 1 Short name: EF-1-alpha-1 Alternative name(s): Elongation factor Tu Short name: EF-Tu Eukaryotic elongation factor 1 A-1 Short name: eEF1A-1 Leukocyte receptor cluster member 7
Gene namesⁱ	Name:EEF1A1 Synonyms:EEF1A, EF1A, LENG7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000156508.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3189 EEF1A1
MIMⁱ	130590 gene
neXtProtⁱ	NX_P68104

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	36	K → R: No effect on methylation by EEF1AKMT2. Abolishes EEF1AKMT4-mediated methylation. 2 Publications	1
Mutagenesisⁱ	55	K → R: No effect on methylation by EEF1AKMT2. 1 Publication	1
Mutagenesisⁱ	79	K → R: No effect on methylation by EEF1AKMT2. 1 Publication	1
Mutagenesisⁱ	165	K → A: Abolishes methylation by EEF1AKMT3. 1 Publication	1
Mutagenesisⁱ	165	K → R: No effect on methylation by EEF1AKMT2. 1 Publication	1
Mutagenesisⁱ	318	K → R: Abolishes methylation by EEF1AKMT2. 1 Publication	1
Mutagenesisⁱ	432	T → A: Abolishes phosphorylation by PASK. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1915
Open Targets More...OpenTargetsⁱ	ENSG00000156508
PharmGKBⁱ	PA27625

Chemistry databases

ChEMBLⁱ	CHEMBL1795120
Drug and drug target database More...DrugBankⁱ	DB04315 Guanosine-5'-Diphosphate

Polymorphism and mutation databases

BioMutaⁱ	EEF1A1
DMDMⁱ	55584035

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000090885	2 – 462	Elongation factor 1-alpha 1Add BLAST		461

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N,N,N-trimethylglycine1 Publication	1
Modified residueⁱ	36	N6,N6,N6-trimethyllysine; alternate; by EEF1AKMT41 Publication	1
Modified residueⁱ	36	N6,N6-dimethyllysine; alternate; by EEF1AKMT41 Publication	1
Modified residueⁱ	36	N6-methyllysine; alternate; by EEF1AKMT41 Publication	1
Modified residueⁱ	55	N6,N6-dimethyllysine1 Publication	1
Modified residueⁱ	79	N6,N6,N6-trimethyllysine; by EEF1AKMT11 Publication	1
Modified residueⁱ	165	N6,N6,N6-trimethyllysine; alternate; by EEF1AKMT31 Publication	1
Modified residueⁱ	165	N6,N6-dimethyllysine; alternate; by EEF1AKMT32 Publications	1
Modified residueⁱ	165	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	165	N6-methyllysine; alternate; by EEF1AKMT31 Publication	1
Modified residueⁱ	172	N6-acetyllysineBy similarity	1
Modified residueⁱ	273	N6-acetyllysineBy similarity	1
Modified residueⁱ	300	Phosphoserine; by TGFBR11 Publication	1
Modified residueⁱ	301	5-glutamyl glycerylphosphorylethanolamine1 Publication	1
Modified residueⁱ	318	N6,N6,N6-trimethyllysine; by EEF1AKMT21 Publication	1
Modified residueⁱ	374	5-glutamyl glycerylphosphorylethanolamine1 Publication	1
Modified residueⁱ	392	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	392	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	432	Phosphothreonine; by PASK1 Publication	1
Modified residueⁱ	439	N6-acetyllysineBy similarity	1

Post-translational modificationⁱ

ISGylated.1 Publication

Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency. Phosphorylated by ROCK2 (PubMed:26497934).4 Publications

Trimethylated at Lys-79 by EEF1AKMT1 (PubMed:26545399). Methylated at Lys-165 by EEF1AKMT3, methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation (PubMed:28108655). Trimethylated at Lys-318 by EEF1AKMT2 (PubMed:25144183). Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs (PubMed:28520920).4 Publications

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P68104
PaxDbⁱ	P68104
PeptideAtlas More...PeptideAtlasⁱ	P68104
PRIDEⁱ	P68104
ProteomicsDBⁱ	57529

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P68104
SWISS-2DPAGEⁱ	P68104
UCD-2DPAGEⁱ	P68104

PTM databases

iPTMnetⁱ	P68104
PhosphoSitePlusⁱ	P68104
SwissPalmⁱ	P68104

Miscellaneous databases

PMAP-CutDBⁱ	P68104

PMAP-CutDBⁱ

P68104

Expressionⁱ

Tissue specificityⁱ

Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.

Inductionⁱ

By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000156508 Expressed in 215 organ(s), highest expression level in right ovary
CleanExⁱ	HS_EEF1A1
ExpressionAtlasⁱ	P68104 baseline and differential
Genevisibleⁱ	P68104 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051759 HPA053862 HPA056990

HPAⁱ

HPA051759
HPA053862
HPA056990

Interactionⁱ

Subunit structureⁱ

Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1, TXK, XPO5 and KARS. May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation. Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts with PPP1R16B (PubMed:26497934).By similarity8 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BBS1	Q8NFJ9	3	EBI-352162,EBI-1805484
MDM2	Q00987	9	EBI-352162,EBI-389668
RAD23A	P54725	2	EBI-352162,EBI-746453
SPHK1	Q9NYA1	2	EBI-352162,EBI-985303
YWHAZ	P63104	2	EBI-352162,EBI-347088
ZBTB16	Q05516	4	EBI-352162,EBI-711925
ZDHHC17	Q8IUH5	2	EBI-352162,EBI-524753

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17177976
- 17595531

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108237, 404 interactors
CORUMⁱ	P68104
Database of interacting proteins More...DIPⁱ	DIP-31277N
IntActⁱ	P68104, 190 interactors
Molecular INTeraction database More...MINTⁱ	P68104
STRINGⁱ	9606.ENSP00000330054

Chemistry databases

BindingDBⁱ

P68104

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P68104
SMRⁱ	P68104
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	5 – 242	tr-type GAdd BLAST		238

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	14 – 21	G1By similarity	8
Regionⁱ	70 – 74	G2By similarity	5
Regionⁱ	91 – 94	G3By similarity	4
Regionⁱ	153 – 156	G4By similarity	4
Regionⁱ	194 – 196	G5By similarity	3

Sequence similaritiesⁱ

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0052 Eukaryota COG5256 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144046
HOGENOMⁱ	HOG000229291
HOVERGENⁱ	HBG000179
InParanoidⁱ	P68104
KEGG Orthology (KO) More...KOⁱ	K03231
OMAⁱ	PAKETKM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05LW
PhylomeDBⁱ	P68104
TreeFamⁱ	TF300304

Family and domain databases

HAMAPⁱ	MF_00118_A EF_Tu_A, 1 hit
InterProⁱ	View protein in InterPro IPR004161 EFTu-like_2 IPR031157 G_TR_CS IPR027417 P-loop_NTPase IPR000795 TF_GTP-bd_dom IPR009000 Transl_B-barrel_sf IPR009001 Transl_elong_EF1A/Init_IF2_C IPR004539 Transl_elong_EF1A_euk/arc IPR004160 Transl_elong_EFTu/EF1A_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00009 GTP_EFTU, 1 hit PF03144 GTP_EFTU_D2, 1 hit PF03143 GTP_EFTU_D3, 1 hit
PRINTSⁱ	PR00315 ELONGATNFCT
SUPFAMⁱ	SSF50447 SSF50447, 1 hit SSF50465 SSF50465, 1 hit SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00483 EF-1_alpha, 1 hit
PROSITEⁱ	View protein in PROSITE PS00301 G_TR_1, 1 hit PS51722 G_TR_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P68104-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG 
        60         70         80         90        100
KGSFKYAWVL DKLKAERERG ITIDISLWKF ETSKYYVTII DAPGHRDFIK 
       110        120        130        140        150
NMITGTSQAD CAVLIVAAGV GEFEAGISKN GQTREHALLA YTLGVKQLIV 
       160        170        180        190        200
GVNKMDSTEP PYSQKRYEEI VKEVSTYIKK IGYNPDTVAF VPISGWNGDN 
       210        220        230        240        250
MLEPSANMPW FKGWKVTRKD GNASGTTLLE ALDCILPPTR PTDKPLRLPL 
       260        270        280        290        300
QDVYKIGGIG TVPVGRVETG VLKPGMVVTF APVNVTTEVK SVEMHHEALS 
       310        320        330        340        350
EALPGDNVGF NVKNVSVKDV RRGNVAGDSK NDPPMEAAGF TAQVIILNHP 
       360        370        380        390        400
GQISAGYAPV LDCHTAHIAC KFAELKEKID RRSGKKLEDG PKFLKSGDAA 
       410        420        430        440        450
IVDMVPGKPM CVESFSDYPP LGRFAVRDMR QTVAVGVIKA VDKKAAGAGK 
       460 
VTKSAQKAQK AK

Length:462

Mass (Da):50,141

Last modified:August 13, 1987 - v1

Checksum:ⁱD465615545AF686A

GO

Isoform 2 (identifier: P68104-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
141-161: Missing.

« Hide

        10         20         30         40         50
MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG 
        60         70         80         90        100
KGSFKYAWVL DKLKAERERG ITIDISLWKF ETSKYYVTII DAPGHRDFIK 
       110        120        130        140        150
NMITGTSQAD CAVLIVAAGV GEFEAGISKN GQTREHALLA YSQKRYEEIV 
       160        170        180        190        200
KEVSTYIKKI GYNPDTVAFV PISGWNGDNM LEPSANMPWF KGWKVTRKDG 
       210        220        230        240        250
NASGTTLLEA LDCILPPTRP TDKPLRLPLQ DVYKIGGIGT VPVGRVETGV 
       260        270        280        290        300
LKPGMVVTFA PVNVTTEVKS VEMHHEALSE ALPGDNVGFN VKNVSVKDVR 
       310        320        330        340        350
RGNVAGDSKN DPPMEAAGFT AQVIILNHPG QISAGYAPVL DCHTAHIACK 
       360        370        380        390        400
FAELKEKIDR RSGKKLEDGP KFLKSGDAAI VDMVPGKPMC VESFSDYPPL 
       410        420        430        440 
GRFAVRDMRQ TVAVGVIKAV DKKAAGAGKV TKSAQKAQKA K

Note: No experimental confirmation available.

Show »

Length:441

Mass (Da):47,869

Checksum:ⁱ7BF0B64CAEB4B0F6

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WV01	A0A087WV01_HUMAN	Elongation factor 1-alpha Elongation factor 1-alpha	EEF1A1	426	Annotation score:
Q5JR01	Q5JR01_HUMAN	Elongation factor 1-alpha 1 Elongation factor 1-alpha 1	EEF1A1	145	Annotation score:
A6PW80	A6PW80_HUMAN	Elongation factor 1-alpha 1 Elongation factor 1-alpha 1	EEF1A1	106	Annotation score:
A0A087WVQ9	A0A087WVQ9_HUMAN	Elongation factor 1-alpha 1 Elongation factor 1-alpha 1	EEF1A1	441	Annotation score:

Sequence cautionⁱ

The sequence AAA52367 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	83	S → A in CAA27325 (PubMed:3960725).Curated		1
Sequence conflictⁱ	232	L → V in CAA34756 (PubMed:2183196).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_057184	141 – 161	Missing in isoform 2. 1 PublicationAdd BLAST		21

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03558 mRNA Translation: CAA27245.1 J04617 Genomic DNA Translation: AAA52343.1 X16869 mRNA Translation: CAA34756.1 AY043301 mRNA Translation: AAK95378.1 BC008587 mRNA Translation: AAH08587.1 BC009733 mRNA Translation: AAH09733.1 BC009875 mRNA Translation: AAH09875.1 BC010735 mRNA Translation: AAH10735.1 BC012891 mRNA Translation: AAH12891.1 BC014224 mRNA Translation: AAH14224.1 BC018150 mRNA Translation: AAH18150.1 BC018641 mRNA Translation: AAH18641.1 BC021686 mRNA Translation: AAH21686.1 BC028674 mRNA Translation: AAH28674.1 BC038339 mRNA Translation: AAH38339.1 BC057391 mRNA Translation: AAH57391.1 BC066893 mRNA Translation: AAH66893.1 BC071619 mRNA Translation: AAH71619.1 BC072385 mRNA Translation: AAH72385.1 BC082268 mRNA Translation: AAH82268.1 X03689 mRNA Translation: CAA27325.1 M29548 mRNA Translation: AAA52367.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4980.1 [P68104-1]
PIRⁱ	B24977 EFHU1
NCBI Reference Sequences More...RefSeqⁱ	NP_001393.1, NM_001402.5 [P68104-1] XP_011533816.1, XM_011535514.2
UniGeneⁱ	Hs.535192 Hs.586423 Hs.745122

Genome annotation databases

Ensemblⁱ	ENST00000309268; ENSP00000339053; ENSG00000156508 [P68104-1] ENST00000316292; ENSP00000339063; ENSG00000156508 [P68104-1] ENST00000331523; ENSP00000330054; ENSG00000156508 [P68104-1]
GeneIDⁱ	1915
KEGGⁱ	hsa:1915

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P68104	Elongation factor 1-alpha 1		BOVIN		462	UniRef100_P68104
Elongation factor 1-alpha 1		FELCA		462
Elongation factor 1-alpha 1		PANTR		462
Elongation factor 1-alpha 1		PONAB		462
Elongation factor 1-alpha 1	)	RABIT		462
+57

Protein	Similar proteins		Species	Score	Length	Source
P68104	Elongation factor 1-alpha 1		BOVIN		462	UniRef90_P68104
Elongation factor 1-alpha 1		FELCA		462
Elongation factor 1-alpha 1		PANTR		462
Elongation factor 1-alpha 1		PONAB		462
Elongation factor 1-alpha 1	)	RABIT		462
+98
P68104-2	Elongation factor 1-alpha 1		CRIGR		503	UniRef90_P68104-2
Polypeptide chain elongation factor 1alpha (Fragment)		MERUN		96
Elongation factor 1-alpha		RHIRO		442
Elongation factor 1-alpha 1		HUMAN		441
EEF1A1 isoform 5		PONAB		441
+13

Protein	Similar proteins		Species	Score	Length	Source
P68104	Elongation factor 1-alpha 1		BOVIN		462	UniRef50_P68104
Elongation factor 1-alpha 1		FELCA		462
Elongation factor 1-alpha 1		PANTR		462
Elongation factor 1-alpha 1		PONAB		462
Elongation factor 1-alpha 1	)	RABIT		462
+8125
P68104-2	Elongation factor 1-alpha-A		SCHPO		460	UniRef50_P68104-2
Elongation factor 1-alpha	)	YEAST		458
Elongation factor 1-alpha		ORYLA		461
Elongation factor 1-alpha		DICDI		453
Elongation factor 1-alpha		HYDVU		468
+6799

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03558 mRNA Translation: CAA27245.1 J04617 Genomic DNA Translation: AAA52343.1 X16869 mRNA Translation: CAA34756.1 AY043301 mRNA Translation: AAK95378.1 BC008587 mRNA Translation: AAH08587.1 BC009733 mRNA Translation: AAH09733.1 BC009875 mRNA Translation: AAH09875.1 BC010735 mRNA Translation: AAH10735.1 BC012891 mRNA Translation: AAH12891.1 BC014224 mRNA Translation: AAH14224.1 BC018150 mRNA Translation: AAH18150.1 BC018641 mRNA Translation: AAH18641.1 BC021686 mRNA Translation: AAH21686.1 BC028674 mRNA Translation: AAH28674.1 BC038339 mRNA Translation: AAH38339.1 BC057391 mRNA Translation: AAH57391.1 BC066893 mRNA Translation: AAH66893.1 BC071619 mRNA Translation: AAH71619.1 BC072385 mRNA Translation: AAH72385.1 BC082268 mRNA Translation: AAH82268.1 X03689 mRNA Translation: CAA27325.1 M29548 mRNA Translation: AAA52367.1 Different initiation.
CCDSⁱ	CCDS4980.1 [P68104-1]
PIRⁱ	B24977 EFHU1
RefSeqⁱ	NP_001393.1, NM_001402.5 [P68104-1] XP_011533816.1, XM_011535514.2
UniGeneⁱ	Hs.535192 Hs.586423 Hs.745122

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1SYW	model	-	A	2-443	[»]
	3C5J	X-ray	1.80	C	343-355	[»]
ProteinModelPortalⁱ	P68104
SMRⁱ	P68104
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108237, 404 interactors
CORUMⁱ	P68104
DIPⁱ	DIP-31277N
IntActⁱ	P68104, 190 interactors
MINTⁱ	P68104
STRINGⁱ	9606.ENSP00000330054

Chemistry databases

BindingDBⁱ	P68104
ChEMBLⁱ	CHEMBL1795120
DrugBankⁱ	DB04315 Guanosine-5'-Diphosphate

Protein family/group databases

MoonProtⁱ	P68104

MoonProtⁱ

P68104

PTM databases

iPTMnetⁱ	P68104
PhosphoSitePlusⁱ	P68104
SwissPalmⁱ	P68104

Polymorphism and mutation databases

BioMutaⁱ	EEF1A1
DMDMⁱ	55584035

2D gel databases

OGPⁱ	P68104
SWISS-2DPAGEⁱ	P68104
UCD-2DPAGEⁱ	P68104

Proteomic databases

EPDⁱ	P68104
PaxDbⁱ	P68104
PeptideAtlasⁱ	P68104
PRIDEⁱ	P68104
ProteomicsDBⁱ	57529

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1915
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000309268; ENSP00000339053; ENSG00000156508 [P68104-1] ENST00000316292; ENSP00000339063; ENSG00000156508 [P68104-1] ENST00000331523; ENSP00000330054; ENSG00000156508 [P68104-1]
GeneIDⁱ	1915
KEGGⁱ	hsa:1915

Organism-specific databases

CTDⁱ	1915
DisGeNETⁱ	1915
EuPathDBⁱ	HostDB:ENSG00000156508.17
GeneCardsⁱ	EEF1A1
H-InvDBⁱ	HIX0020005 HIX0032108 HIX0033669 HIX0169110
HGNCⁱ	HGNC:3189 EEF1A1
HPAⁱ	HPA051759 HPA053862 HPA056990
MIMⁱ	130590 gene
neXtProtⁱ	NX_P68104
OpenTargetsⁱ	ENSG00000156508
PharmGKBⁱ	PA27625
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0052 Eukaryota COG5256 LUCA
GeneTreeⁱ	ENSGT00910000144046
HOGENOMⁱ	HOG000229291
HOVERGENⁱ	HBG000179
InParanoidⁱ	P68104
KOⁱ	K03231
OMAⁱ	PAKETKM
OrthoDBⁱ	EOG091G05LW
PhylomeDBⁱ	P68104
TreeFamⁱ	TF300304

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156842 Eukaryotic Translation Elongation R-HSA-156902 Peptide chain elongation R-HSA-3371511 HSF1 activation R-HSA-6798695 Neutrophil degranulation R-HSA-8876725 Protein methylation
SignaLinkⁱ	P68104
SIGNORⁱ	P68104

Miscellaneous databases

ChiTaRSⁱ	EEF1A1 human
GeneWikiⁱ	Eukaryotic_translation_elongation_factor_1_alpha_1
GenomeRNAiⁱ	1915
PMAP-CutDBⁱ	P68104
Protein Ontology More...PROⁱ	PR:P68104
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000156508 Expressed in 215 organ(s), highest expression level in right ovary
CleanExⁱ	HS_EEF1A1
ExpressionAtlasⁱ	P68104 baseline and differential
Genevisibleⁱ	P68104 HS

Family and domain databases

HAMAPⁱ	MF_00118_A EF_Tu_A, 1 hit
InterProⁱ	View protein in InterPro IPR004161 EFTu-like_2 IPR031157 G_TR_CS IPR027417 P-loop_NTPase IPR000795 TF_GTP-bd_dom IPR009000 Transl_B-barrel_sf IPR009001 Transl_elong_EF1A/Init_IF2_C IPR004539 Transl_elong_EF1A_euk/arc IPR004160 Transl_elong_EFTu/EF1A_C
Pfamⁱ	View protein in Pfam PF00009 GTP_EFTU, 1 hit PF03144 GTP_EFTU_D2, 1 hit PF03143 GTP_EFTU_D3, 1 hit
PRINTSⁱ	PR00315 ELONGATNFCT
SUPFAMⁱ	SSF50447 SSF50447, 1 hit SSF50465 SSF50465, 1 hit SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00483 EF-1_alpha, 1 hit
PROSITEⁱ	View protein in PROSITE PS00301 G_TR_1, 1 hit PS51722 G_TR_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EF1A1_HUMAN
Accessionⁱ	P68104Primary (citable) accession number: P68104 Secondary accession number(s): P04719, P04720, Q6IQ15
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
	Last sequence update:	August 13, 1987
	Last modified:	October 10, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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Help

UniRef

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UniProtKB - P68104 (EF1A1_HUMAN)

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Elongation factor 1-alpha 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Plasma membrane

Other locations

Cytoskeleton

Cytosol

Extracellular region or secreted

Lysosome

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ